Title: Santee Vacation Rentals from $120: Search Short-Term Rentals | Expedia.com

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![Cypress Trees with Spanish Moss growing on them. In Lake Marion at Santee State Park, Santee, Orangeburg County, South Carolina](https://images.trvl-media.com/place/9953/cd2a687d-b68e-41e2-9556-82dcf249bc2d.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

![](https://images.trvl-media.com/place/9953/cd2a687d-b68e-41e2-9556-82dcf249bc2d.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

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## Check prices for these dates

In two weeks

[Apr 3 - Apr 5](https://www.expedia.com/Hotel-Search?regionId=9953&startDate=2026-04-03&endDate=2026-04-05&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In two months

[May 15 - May 17](https://www.expedia.com/Hotel-Search?regionId=9953&startDate=2026-05-15&endDate=2026-05-17&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In three months

[Jun 12 - Jun 14](https://www.expedia.com/Hotel-Search?regionId=9953&startDate=2026-06-12&endDate=2026-06-14&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In four months

[Jul 10 - Jul 12](https://www.expedia.com/Hotel-Search?regionId=9953&startDate=2026-07-10&endDate=2026-07-12&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Our top choices for Santee vacation rentals

![Terrace/patio](https://images.trvl-media.com/lodging/127000000/126120000/126119300/126119247/603142c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Microwave, oven, stovetop, dishwasher](https://images.trvl-media.com/lodging/127000000/126120000/126119300/126119247/3c1a66e8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/127000000/126120000/126119300/126119247/24aca905.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/127000000/126120000/126119300/126119247/af4781e0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### LuxuryGrndFloorCornerLakeViewPoolGolfFishBoatParks

[](https://www.expedia.com/Santee-Hotels-LuxuryGrndFloorCornerLakeViewPoolGolfFishBoatParks.h126119247.Hotel-Information)

Santee

$442 nightly

$491 total

Apr 4 - Apr 5

Total with taxes and fees

[](https://www.expedia.com/Santee-Hotels-LuxuryGrndFloorCornerLakeViewPoolGolfFishBoatParks.h126119247.Hotel-Information)

![Smart TV, offices](https://images.trvl-media.com/lodging/92000000/91790000/91788500/91788460/c321e70e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![3 bedrooms, desk, iron/ironing board, travel crib](https://images.trvl-media.com/lodging/92000000/91790000/91788500/91788460/f5487ae6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Dining](https://images.trvl-media.com/lodging/92000000/91790000/91788500/91788460/431d124d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![3 bedrooms, desk, iron/ironing board, travel crib](https://images.trvl-media.com/lodging/92000000/91790000/91788500/91788460/42ada466.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!

[](https://www.expedia.com/Santee-Hotels-Experience-Purposeful-Travel-With-Our-Kindred-Spirits-Retreat-At-Lake-Marion.h91788460.Hotel-Information)

Santee

10/10

Exceptional

(41 reviews)

"This home was perfect for our Thanksgiving family getaway. We really enjoyed everything about the house, especially the fenced yard for the dogs. I would definitely stay here again. The house was exceptionally clean. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Kelly C.

$347 nightly

$385 total

Mar 27 - Mar 28

Total with taxes and fees

[](https://www.expedia.com/Santee-Hotels-Experience-Purposeful-Travel-With-Our-Kindred-Spirits-Retreat-At-Lake-Marion.h91788460.Hotel-Information)

![Property grounds](https://images.trvl-media.com/lodging/108000000/107480000/107471600/107471514/14910802.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![3 bedrooms, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/108000000/107480000/107471600/107471514/224b7c6a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Dining](https://images.trvl-media.com/lodging/108000000/107480000/107471600/107471514/c80eacb2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/108000000/107480000/107471600/107471514/3c5e3a43.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Peaceful Condo on Lake Marion in Santee, SC. Time to play golf and go fishing!

[](https://www.expedia.com/Santee-Hotels-Peaceful-Condo-On-Lake-Marion-In-Santee.h107471514.Hotel-Information)

Santee

10/10

Exceptional

(11 reviews)

"Annual golf trip with old friends. Perfect accommodations & location. Hope to stay again"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Greg M.

$456 nightly

$506 total

Apr 15 - Apr 16

Total with taxes and fees

[](https://www.expedia.com/Santee-Hotels-Peaceful-Condo-On-Lake-Marion-In-Santee.h107471514.Hotel-Information)

![Dining](https://images.trvl-media.com/lodging/69000000/68040000/68032100/68032053/876cda77.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/69000000/68040000/68032100/68032053/0c397544.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/69000000/68040000/68032100/68032053/bf924ead.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/69000000/68040000/68032100/68032053/26332b61.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Country living lake style near Santee 

[](https://www.expedia.com/Sumter-Hotels-Country-Living-Lake-Style.h68032053.Hotel-Information)

Summerton

10/10

Exceptional

(42 reviews)

"Great stay."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Tim E.

$190 nightly

$211 total

Mar 23 - Mar 24

Total with taxes and fees

[](https://www.expedia.com/Sumter-Hotels-Country-Living-Lake-Style.h68032053.Hotel-Information)

![Beach](https://images.trvl-media.com/lodging/108000000/107440000/107431600/107431587/3f704424.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 bedrooms, free WiFi, bed sheets](https://images.trvl-media.com/lodging/108000000/107440000/107431600/107431587/9998f4d6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/108000000/107440000/107431600/107431587/fa6eea82.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Terrace/patio](https://images.trvl-media.com/lodging/108000000/107440000/107431600/107431587/d1570709.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Country Resting Spot just off I95\. 12 miles west on hwy 6.

[](https://www.expedia.com/Elloree-Hotels-Country-Resting-Spot.h107431587.Hotel-Information)

Elloree

9.4/10

Exceptional

(22 reviews)

"Enjoyed the stay. Out in the country, Great!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Marty D.

$150 nightly

$167 total

Apr 5 - Apr 6

Total with taxes and fees

[](https://www.expedia.com/Elloree-Hotels-Country-Resting-Spot.h107431587.Hotel-Information)

![Panoramic Tent | Lake view](https://images.trvl-media.com/lodging/92000000/91250000/91244700/91244689/caef79e2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Cabin, 1 Bedroom, Non Smoking, Lake View | Terrace/patio](https://images.trvl-media.com/lodging/92000000/91250000/91244700/91244689/w4138h5635x0y0-48933ef4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Cabin, 1 Bedroom, Non Smoking, Lake View | Living area](https://images.trvl-media.com/lodging/92000000/91250000/91244700/91244689/ee0f57db.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Panoramic Tent | Living area](https://images.trvl-media.com/lodging/92000000/91250000/91244700/91244689/9123f55d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Bells Marina & Resort

[](https://www.expedia.com/Eutawville-Hotels-Bells-Marina-Resort.h91244689.Hotel-Information)

Eutawville

8.6/10

Excellent

(91 reviews)

"Super quaint, quiet, nice little get away."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Karen

$108 nightly

$120 total

Mar 23 - Mar 24

Total with taxes and fees

[](https://www.expedia.com/Eutawville-Hotels-Bells-Marina-Resort.h91244689.Hotel-Information)

![Property grounds](https://images.trvl-media.com/lodging/96000000/96000000/95993200/95993146/6d916484.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/96000000/96000000/95993200/95993146/cc0e968f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/96000000/96000000/95993200/95993146/dae68d51.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/96000000/96000000/95993200/95993146/24b16566.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Pet friendly country cottage with large fenced-in yard & horses on property

[](https://www.expedia.com/Holly-Hill-Hotels-Come-Relax-In-The-Country.h95993146.Hotel-Information)

Holly Hill

10/10

Exceptional

(138 reviews)

"We had the most amazing stay!! House was even nicer than pictures showed and beds were super comfy!! Host provides tons of amenities and the outdoor space is an amazing bonus! We would definitely stay again! "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Ashley E.

$183 nightly

$203 total

Mar 23 - Mar 24

Total with taxes and fees

[](https://www.expedia.com/Holly-Hill-Hotels-Come-Relax-In-The-Country.h95993146.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/77000000/76600000/76591800/76591706/38650b86.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/77000000/76600000/76591800/76591706/aff09b01.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/77000000/76600000/76591800/76591706/b53af47a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/77000000/76600000/76591800/76591706/00cecc0b_edited_986a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Beautiful country cottage with ease of access! Minutes to I-26, I-95 and Hwy 301

[](https://www.expedia.com/Beautiful-Country-Cottage-With-Ease-Of-Access-Minutes-To-I-26.h76591706.Hotel-Information)

Bowman

9.8/10

Exceptional

(32 reviews)

"Will stay again."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Robert B.

$147 nightly

$163 total

Apr 4 - Apr 5

Total with taxes and fees

[](https://www.expedia.com/Beautiful-Country-Cottage-With-Ease-Of-Access-Minutes-To-I-26.h76591706.Hotel-Information)

![Smart TV, books](https://images.trvl-media.com/lodging/115000000/114290000/114282900/114282854/65da7b16.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/115000000/114290000/114282900/114282854/4e6b13ab_edited_cc75.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/115000000/114290000/114282900/114282854/bee5a8ac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Dining](https://images.trvl-media.com/lodging/115000000/114290000/114282900/114282854/2f19f48d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Modern apartment overlooking historic downtown Elloree, SC.

[](https://www.expedia.com/Elloree-Hotels-Modern-Apartment-Overlooking-Historic-Downtown-Elloree.h114282854.Hotel-Information)

Elloree

$165 nightly

$183 total

Mar 24 - Mar 25

Total with taxes and fees

[](https://www.expedia.com/Elloree-Hotels-Modern-Apartment-Overlooking-Historic-Downtown-Elloree.h114282854.Hotel-Information)

![Outdoor dining](https://images.trvl-media.com/lodging/92000000/91020000/91012700/91012626/dd2731f8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/92000000/91020000/91012700/91012626/5efa65bb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![TV, video games](https://images.trvl-media.com/lodging/92000000/91020000/91012700/91012626/870c37c1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom](https://images.trvl-media.com/lodging/92000000/91020000/91012700/91012626/e5dece1e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Cozy Camping Cabin on Lake Marion near Congaree Nat Park

[](https://www.expedia.com/Pinewood-Hotels-Cozy-Camping-Cabin-On-Lake-Marion-Near-Congaree-Nat-Park.h91012626.Hotel-Information)

Rimini

8.4/10

Very Good

(15 reviews)

"We enjoyed our stay. The only negative would be the fishing pier is no longer useable. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Derrick W.

$120 nightly

$133 total

Mar 23 - Mar 24

Total with taxes and fees

[](https://www.expedia.com/Pinewood-Hotels-Cozy-Camping-Cabin-On-Lake-Marion-Near-Congaree-Nat-Park.h91012626.Hotel-Information)

![Terrace/patio](https://images.trvl-media.com/lodging/92000000/91220000/91218300/91218225/4d2de320.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom](https://images.trvl-media.com/lodging/92000000/91220000/91218300/91218225/86e8c2d0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/92000000/91220000/91218300/91218225/612c203e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/92000000/91220000/91218300/91218225/5bfe4281.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Cabin at the lake in Rimini, SC

[](https://www.expedia.com/Pinewood-Hotels-Cabin-At-The-Lake-In-Rimini.h91218225.Hotel-Information)

Rimini

7.8/10

Good

(7 reviews)

"Great view, excellent communication with the owners, relaxing, peaceful. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Christie

$128 nightly

$142 total

Mar 30 - Mar 31

Total with taxes and fees

[](https://www.expedia.com/Pinewood-Hotels-Cabin-At-The-Lake-In-Rimini.h91218225.Hotel-Information)

![TV, table tennis](https://images.trvl-media.com/lodging/120000000/119470000/119463700/119463617/b1457367.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![3 bedrooms, internet, bed sheets](https://images.trvl-media.com/lodging/120000000/119470000/119463700/119463617/a0c890ef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/120000000/119470000/119463700/119463617/85826adc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Dining](https://images.trvl-media.com/lodging/120000000/119470000/119463700/119463617/d950643a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Turtle Cove - Lake Living on Lake Marion

[](https://www.expedia.com/Summerton-Hotels-Turtle-Cove-Lake-Living-On-Lake-Marion.h119463617.Hotel-Information)

Summerton

$379 nightly

$431 total

Mar 23 - Mar 24

Total with taxes and fees

[](https://www.expedia.com/Summerton-Hotels-Turtle-Cove-Lake-Living-On-Lake-Marion.h119463617.Hotel-Information)

![Outdoor dining](https://images.trvl-media.com/lodging/109000000/108020000/108017600/108017538/f4e6785a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, WiFi, bed sheets](https://images.trvl-media.com/lodging/109000000/108020000/108017600/108017538/eb799bdc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/109000000/108020000/108017600/108017538/c1d4935b_edited_e25c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV](https://images.trvl-media.com/lodging/109000000/108020000/108017600/108017538/8fe42751.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Lakefront tiny cabin amazing view on Lake Marion! Pet friendly & sleeps 6 

[](https://www.expedia.com/Summerton-Hotels-Cozy-Lakefront-Tiny-Cabin-On-Lake-Marion-With-An-Amazing-View-And-Pet-Friendly.h108017538.Hotel-Information)

Summerton

9.2/10

Wonderful

(23 reviews)

"Overall an excellent stay! "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Andy K.

$158 nightly

$176 total

Mar 26 - Mar 27

Total with taxes and fees

[](https://www.expedia.com/Summerton-Hotels-Cozy-Lakefront-Tiny-Cabin-On-Lake-Marion-With-An-Amazing-View-And-Pet-Friendly.h108017538.Hotel-Information)

![Private kitchen](https://images.trvl-media.com/lodging/115000000/114220000/114216100/114216027/a01795f4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/115000000/114220000/114216100/114216027/efc54769.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Living area](https://images.trvl-media.com/lodging/115000000/114220000/114216100/114216027/9b473e48.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Dining](https://images.trvl-media.com/lodging/115000000/114220000/114216100/114216027/16d477ab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Charming 2-bedroom cottage close to I26 and I95; 1 hr from Charleston

[](https://www.expedia.com/Holly-Hill-Hotels-Charming-2-Bedroom-Cottage-Close-To-I26-And-I95-1-Hr-From-Charleston.h114216027.Hotel-Information)

Holly Hill

10/10

Exceptional

(9 reviews)

"Great stay!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Hayden S.

$145 nightly

$161 total

Mar 23 - Mar 24

Total with taxes and fees

[](https://www.expedia.com/Holly-Hill-Hotels-Charming-2-Bedroom-Cottage-Close-To-I26-And-I95-1-Hr-From-Charleston.h114216027.Hotel-Information)

![Exterior detail](https://images.trvl-media.com/lodging/124000000/123610000/123609000/123608930/62aee6da.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV](https://images.trvl-media.com/lodging/124000000/123610000/123609000/123608930/w1031h771x0y4-77b734eb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior detail](https://images.trvl-media.com/lodging/124000000/123610000/123609000/123608930/4a09493e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV](https://images.trvl-media.com/lodging/124000000/123610000/123609000/123608930/2ac0ad5e_edited_fd03.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Tee Vee Cove is the place to be located near great golfing, fishing and food

[](https://www.expedia.com/Elloree-Hotels-The-Tee-Vee-Cove-Is-The-Place-To-Be-Located-Near-Great-Golfing.h123608930.Hotel-Information)

Elloree

$237 nightly

$263 total

Mar 23 - Mar 24

Total with taxes and fees

[](https://www.expedia.com/Elloree-Hotels-The-Tee-Vee-Cove-Is-The-Place-To-Be-Located-Near-Great-Golfing.h123608930.Hotel-Information)

![TV, fireplace](https://images.trvl-media.com/lodging/125000000/124490000/124483900/124483821/4b88cd29.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/125000000/124490000/124483900/124483821/52ad34c4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Oven, stovetop](https://images.trvl-media.com/lodging/125000000/124490000/124483900/124483821/113f5a40.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/125000000/124490000/124483900/124483821/1a1e5f52.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Private Farm Stay on 30-Acres

[](https://www.expedia.com/Summerton-Hotels-A-Private-Cozy-Cabin-In-The-Country.h124483821.Hotel-Information)

Summerton

$407 nightly

$452 total

Mar 23 - Mar 24

Total with taxes and fees

[](https://www.expedia.com/Summerton-Hotels-A-Private-Cozy-Cabin-In-The-Country.h124483821.Hotel-Information)

![Microwave, oven, stovetop, dishwasher](https://images.trvl-media.com/lodging/113000000/112530000/112528200/112528151/w1198h1600x0y0-8fa30947.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/113000000/112530000/112528200/112528151/c0703344.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV](https://images.trvl-media.com/lodging/113000000/112530000/112528200/112528151/92a17159.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![3 bedrooms, WiFi, bed sheets](https://images.trvl-media.com/lodging/113000000/112530000/112528200/112528151/w1197h1600x0y0-a4a4fa86.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Beautiful brick home w/ large porch and 3 bedrooms

[](https://www.expedia.com/Beautiful-Brick-Home-W-Large-Porch-And-3-Bedrooms.h112528151.Hotel-Information)

Bowman

9.2/10

Wonderful

(5 reviews)

"Nice and quiet property. It served us well for the weekend "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Mick S.

$252 nightly

$279 total

Mar 24 - Mar 25

Total with taxes and fees

[](https://www.expedia.com/Beautiful-Brick-Home-W-Large-Porch-And-3-Bedrooms.h112528151.Hotel-Information)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/114000000/113030000/113026400/113026382/716e2146.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/114000000/113030000/113026400/113026382/09c89483.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/114000000/113030000/113026400/113026382/838e215b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/114000000/113030000/113026400/113026382/897763a7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Reel Haven on the Water: Modern + Comfy Home!

[](https://www.expedia.com/Eutawville-Hotels-Reel-Haven-On-The-Water-Modern-Comfy-Home.h113026382.Hotel-Information)

Eutawville

6.8/10

(5 reviews)

"Perfect place for a weekend fishing trip. Owner was responsive. Slept 6 easily. Only stayed one night but was a perfect fit"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

brandon h.

$371 nightly

$421 total

Mar 23 - Mar 24

Total with taxes and fees

[](https://www.expedia.com/Eutawville-Hotels-Reel-Haven-On-The-Water-Modern-Comfy-Home.h113026382.Hotel-Information)

![Property grounds](https://images.trvl-media.com/lodging/20000000/20000000/19993600/19993568/ec7cddf8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/20000000/20000000/19993600/19993568/0949138a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Marina](https://images.trvl-media.com/lodging/20000000/20000000/19993600/19993568/431a876d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/20000000/20000000/19993600/19993568/9b1fe174.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### SANITIZED! Lake Marion Lakefront Sandy Beach, Ramp, Sleeps 19, Wi-Fi Cable

[](https://www.expedia.com/Summerton-Hotels-SANITIZED-Lake-Marion-Lakefront-Sandy-Beach.h19993568.Hotel-Information)

Summerton

9.6/10

Exceptional

(249 reviews)

"We had a great family retreat "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Ernestine C.

[](https://www.expedia.com/Summerton-Hotels-SANITIZED-Lake-Marion-Lakefront-Sandy-Beach.h19993568.Hotel-Information)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/105000000/104480000/104470400/104470344/bb6f3418.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Dining](https://images.trvl-media.com/lodging/105000000/104480000/104470400/104470344/9118d20a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/105000000/104480000/104470400/104470344/70635ea8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/105000000/104480000/104470400/104470344/7f1c7042.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hobbs Haven at Lake Marion

[](https://www.expedia.com/Summerton-Hotels-Hobbs-Haven-At-Lake-Marion.h104470344.Hotel-Information)

Summerton

9.4/10

Exceptional

(12 reviews)

"Great opportunity for family time!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

faye c.

$320 nightly

$355 total

Mar 23 - Mar 24

Total with taxes and fees

[](https://www.expedia.com/Summerton-Hotels-Hobbs-Haven-At-Lake-Marion.h104470344.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.com/Hotel-Search?startDate=2026-04-05&endDate=2026-04-06&regionId=9953&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&openPlayBack=true)

## Find vacation rentals that suit your style

Cabins

[](https://www.expedia.com/Hotel-Search?destination=Santee%2C+South+Carolina%2C+United+States+of+America&regionId=9953&latLong=33.487602%2C-80.476242&adults=2&startDate=2026-06-20&d1=2026-06-20&endDate=2026-06-23&d2=2026-06-23&lodging=CABIN)

Private vacation homes

[](https://www.expedia.com/Hotel-Search?destination=Santee%2C+South+Carolina%2C+United+States+of+America&regionId=9953&latLong=33.487602%2C-80.476242&adults=2&startDate=2026-06-20&d1=2026-06-20&endDate=2026-06-23&d2=2026-06-23&lodging=VACATION_HOME)

Cottages

[](https://www.expedia.com/Hotel-Search?destination=Santee%2C+South+Carolina%2C+United+States+of+America&regionId=9953&latLong=33.487602%2C-80.476242&adults=2&startDate=2026-06-20&d1=2026-06-20&endDate=2026-06-23&d2=2026-06-23&lodging=COTTAGE)

Condos

[](https://www.expedia.com/Hotel-Search?destination=Santee%2C+South+Carolina%2C+United+States+of+America&regionId=9953&latLong=33.487602%2C-80.476242&adults=2&startDate=2026-06-20&d1=2026-06-20&endDate=2026-06-23&d2=2026-06-23&lodging=CONDO)

Aparthotels

[](https://www.expedia.com/Hotel-Search?destination=Santee%2C+South+Carolina%2C+United+States+of+America&regionId=9953&latLong=33.487602%2C-80.476242&adults=2&startDate=2026-06-20&d1=2026-06-20&endDate=2026-06-23&d2=2026-06-23&lodging=APART_HOTEL)

Apartments

[](https://www.expedia.com/Hotel-Search?destination=Santee%2C+South+Carolina%2C+United+States+of+America&regionId=9953&latLong=33.487602%2C-80.476242&adults=2&startDate=2026-06-20&d1=2026-06-20&endDate=2026-06-23&d2=2026-06-23&lodging=APARTMENT)

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## Top Santee Hotel Reviews

![Tru By Hilton Santee](https://images.trvl-media.com/lodging/93000000/92610000/92601000/92600969/4b412627_y.jpg)

### Tru By Hilton Santee

6/10 Okay

"The only thing I can say about this place was that it was adequate. My opinion is that it was not up to Hilton standards. The room was spacious and that’s all. There was only one clothes hanger in the room. The blinds wouldn’t come go up, There was no coffee or water cups in the room. I will not stay at that location again. They gave the customer who checked in ahead of me bottled water but I got nothing. I was really not happy about it. "

[](https://expedia.com/Santee-Hotels-Tru-By-Hilton-Santee.h92600969.Hotel-Information)

![Holiday Inn Santee by IHG](https://images.trvl-media.com/lodging/2000000/1220000/1220000/1219924/278d9dc3_y.jpg)

### Holiday Inn Santee by IHG

8/10 Good

"Under construction, I’m sure it will be great when construction is done "

[](https://expedia.com/Orangeburg-Hotels-Holiday-Inn-Santee.h1219924.Hotel-Information)

![Spark by Hilton Orangeburg](https://images.trvl-media.com/lodging/2000000/1880000/1878000/1877930/w3840h2556x0y4-5cb4ef80_y.jpg)

### Spark by Hilton Orangeburg

10/10 Excellent

"Good service."

[](https://expedia.com/Orangeburg-Hotels-Spark-By-Hilton-Orangeburg.h1877930.Hotel-Information)

![Comfort Inn & Suites Santee](https://images.trvl-media.com/lodging/1000000/520000/518500/518401/fc94b516_y.jpg)

### Comfort Inn & Suites Santee

6/10 Okay

"This hotel worked fine as a quick overnight stop right off I-95, which is exactly what we needed. We arrived around midnight with two toddlers, and while the front desk staff was on the phone when we got there, we did have to wait about 10 minutes to check in. Thankfully, our kids handled it well. The room itself was okay for a short stay, and the beds were comfortable. There was a very bright spotlight outside the window, but the curtains did a decent job blocking most of the light. The bathroom door had a noticeable patch, like it had been damaged before, which wasn’t ideal. The parking lot also had quite a bit of trash, which wasn’t a great first impression. Breakfast was a bit disappointing—by the time we went around 9 AM, most of the food was already gone. Overall, it met our low expectations for a one-night stop, but I wouldn’t plan to stay longer than that."

[](https://expedia.com/Orangeburg-Hotels-Comfort-Inn-Suites-Santee.h518401.Hotel-Information)

![Quality Inn & Suites Santee I-95](https://images.trvl-media.com/lodging/92000000/91280000/91274500/91274426/cd0ca695_y.jpg)

### Quality Inn & Suites Santee I-95

8/10 Good

"Yes all good "

[](https://expedia.com/Santee-Hotels-Royal-Inn.h91274426.Hotel-Information)

![Best Western Plus Santee Inn](https://images.trvl-media.com/lodging/1000000/30000/21900/21863/93ba5eb3_y.jpg)

### Best Western Plus Santee Inn

10/10 Excellent

"Every thing was clean and comfortable. I enjoyed my one night stay. "

[](https://expedia.com/Orangeburg-Hotels-Best-Western-Plus-Santee-Inn.h21863.Hotel-Information)

![Super 8 by Wyndham, Orangeburg](https://images.trvl-media.com/lodging/1000000/40000/34400/34400/c9ac8d21_y.jpg)

### Super 8 by Wyndham, Orangeburg

8/10 Good

"Bed was comfortable. Staff was great, very helpful. Great value for the price we paid. "

[](https://expedia.com/Orangeburg-Hotels-Super-8-By-Wyndham.h34400.Hotel-Information)

![Hampton Inn Santee-I-95](https://images.trvl-media.com/lodging/1000000/210000/203700/203667/d82e6496_y.jpg)

### Hampton Inn Santee-I-95

8/10 Good

"Clean room, pet friendly. "

[](https://expedia.com/Orangeburg-Hotels-Hampton-Inn-Santee-I-95.h203667.Hotel-Information)

![SpringHill Suites by Marriott Orangeburg](https://images.trvl-media.com/lodging/55000000/54940000/54931500/54931475/27e78d69_y.jpg)

### SpringHill Suites by Marriott Orangeburg

10/10 Excellent

"Beautiful clean modern facility!!! We will stay again on our travels to Florida !!!"

[](https://expedia.com/Orangeburg-Hotels-SpringHill-Suites-Orangeburg.h54931475.Hotel-Information)

## Find out more about Santee

**Everything you need to know about Santee vacation rentals**

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Santee vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Santee vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

**Santee vacation rentals: An excellent choice for every season**

Whenever you want to travel, a warm welcome awaits you in Santee. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Santee in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $120 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

**How to find incredible deals on Santee rentals**

At Expedia, we put the best Santee vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Santee rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Santee vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Santee. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

## Explore a world of travel with Expedia

- Trending destinations on Expedia.com
- All accommodation types in Santee

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- [Florida Keys Vacation Rentals ](https://www.expedia.com/Florida-Keys-Vacation-Rentals.d6023765.Travel-Guide-VacationRentals)
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- [Lake of the Ozarks Vacation Rentals ](https://www.expedia.com/Lake-Ozark-Vacation-Rentals.d177772.Travel-Guide-VacationRentals)
- [Florida Vacation Rentals ](https://www.expedia.com/Destinations-In-Florida.d211.Vacation-Rental-Destinations)
- [Hawaii Vacation Rentals ](https://www.expedia.com/Destinations-In-Hawaii.d213.Vacation-Rental-Destinations)
- [Michigan Vacation Rentals ](https://www.expedia.com/Destinations-In-Michigan.d224.Vacation-Rental-Destinations)

- [Vacation Homes in Santee ](https://expedia.com/Santee-Private-Vacation-Homes.d9953-aaPrivateVacationHomes.Travel-Guide-Accommodation)
- [Cottages in Santee ](https://expedia.com/Santee-Cottages.d9953-aaCottages.Travel-Guide-Accommodation)
- [Motels in Santee ](https://expedia.com/Santee-Motels.d9953-aaMotels.Travel-Guide-Accommodation)
- [Condo Rentals in Santee ](https://expedia.com/Santee-Condos.d9953-aaCondos.Travel-Guide-Accommodation)
- [Apartments in Santee ](https://expedia.com/Santee-Apartments.d9953-aaApartments.Travel-Guide-Accommodation)
- [Cabin Rentals in Santee ](https://expedia.com/Santee-Cabins.d9953-aaCabins.Travel-Guide-Accommodation)
- [Resorts in Santee ](https://expedia.com/Santee-Resorts.d9953-aaResorts.Travel-Guide-Accommodation)
- [Aparthotels in Santee ](https://expedia.com/Santee-Apart-Hotels.d9953-aaApartHotels.Travel-Guide-Accommodation)
- [RV Parks in Santee ](https://expedia.com/Santee-RV-Parks.d9953-aaRVParks.Travel-Guide-Accommodation)

## Frequently asked questions

### Can I find vacation rentals in Santee?

### What are some of the best vacation home rentals in Santee?

### How many vacation rentals are there in Santee?

### What can I see and do in Santee?

### What are vacation rentals like in Santee?

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Hotels

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Flights

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- [Cheap Flights to Myrtle Beach](https://expedia.com/Cheap-Flights-To-Myrtle-Beach.d601685.Travel-Guide-Flights)

Cars

- [Car rentals in Columbia](https://expedia.com/Car-Rentals-In-Columbia.d764.Car-Rental-Guide)
- [Car rentals in Charleston](https://expedia.com/Car-Rentals-In-Charleston.d179997.Car-Rental-Guide)
- [Car rentals in Myrtle Beach](https://expedia.com/Car-Rentals-In-Myrtle-Beach.d601685.Car-Rental-Guide)
- [Car rentals in Greenville](https://expedia.com/Car-Rentals-In-Greenville.d1388.Car-Rental-Guide)

Cruises

- [Cruises from Charleston](https://expedia.com/Cruises-from-Charleston.d179997.Cruise-Departure-Port)

Activities

- [Things to do in Myrtle Beach](https://expedia.com/Things-To-Do-In-Myrtle-Beach.d601685.Travel-Guide-Activities)

Packages

- [Myrtle Beach Vacation](https://expedia.com/Myrtle-Beach.d601685.Destination-Travel-Guides)

Vacation Rentals

- [Myrtle Beach Vacation Rentals](https://expedia.com/Myrtle-Beach-Vacation-Rentals.d601685.Travel-Guide-VacationRentals)

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