An aerial view of a coastal landscape with a dam, farmland, and dense forests.

Santee Vacation Rentals

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Check prices for these dates

In two weeks
Oct 2 - Oct 4
In two months
Nov 13 - Nov 15
In three months
Dec 11 - Dec 13
In four months
Jan 8 - Jan 10

Our top choices for Santee vacation rentals

Smart TV, offices

1. Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!

Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!
Santee
10.0 out of 10, Exceptional, (46 reviews)
"This was our first long trip with our dog and she loved the place! Fenced in yard and home was cozy and dog friendly. Loved the farmhouse style and large bedrooms and baths. "
United States
Lori B.
$302 nightly
The price is $335
Sep 21 - Sep 22
Total with taxes and fees
Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!
Property grounds

2. Peaceful Condo on Lake Marion in Santee, SC. Time to play golf and go fishing!

Peaceful Condo on Lake Marion in Santee, SC. Time to play golf and go fishing!
Santee
10.0 out of 10, Exceptional, (15 reviews)
"Annual golf trip with old friends. Perfect accommodations & location. Hope to stay again"
United States
Greg M.
$460 nightly
The price is $511
Sep 26 - Sep 27
Total with taxes and fees
Peaceful Condo on Lake Marion in Santee, SC. Time to play golf and go fishing!
Terrace/patio

3. LuxuryGrndFloorCornerLakeViewPoolGolfFishBoatParks

LuxuryGrndFloorCornerLakeViewPoolGolfFishBoatParks
Santee
8.8 out of 10, Excellent, (6 reviews)
"We had a wonderful stay. Couldn't have asked for better location. It was beautiful, close to everything and perfect for our family."
United States
Michelle H.
$410 nightly
The price is $455
Sep 20 - Sep 21
Total with taxes and fees
LuxuryGrndFloorCornerLakeViewPoolGolfFishBoatParks
2 bedrooms, desk, WiFi (free), bed sheets

4. Lake Marion Condo, Boat Slip Included, Pet Friendly

Lake Marion Condo, Boat Slip Included, Pet Friendly
Santee
$313 nightly
The price is $347
Sep 20 - Sep 21
Total with taxes and fees
Lake Marion Condo, Boat Slip Included, Pet Friendly
Panoramic Tent | Lake view

5. Bells Marina & Resort

Bells Marina & Resort
2.5 star property
Eutawville
8.6 out of 10, Excellent, (101 reviews)
"They would have gotten a 5-star for all but they are remodeling and when we arrived there was no one at the office to check the guys in. We had to stay at another hotel but they were more than helpful in giving us a full refund and easy to work with. I am sorry the guys couldn't stay here while they were out of town working on a cell tower site. Hopefully will get another chance to visit this place."
United States
Federico
$73 nightly
The price is $81
Oct 20 - Oct 21
Total with taxes and fees
Bells Marina & Resort
Outdoor dining

6. Lakefront tiny cabin amazing view on Lake Marion! Pet friendly.

Lakefront tiny cabin amazing view on Lake Marion! Pet friendly.
Summerton
8.8 out of 10, Excellent, (37 reviews)
"Great place to stay on the lake! "
United States
Troy S.
$154 nightly
The price is $171
Sep 21 - Sep 22
Total with taxes and fees
Lakefront tiny cabin amazing view on Lake Marion! Pet friendly.
Dining

7. Country living lake style near Santee

Country living lake style near Santee
Summerton
10.0 out of 10, Exceptional, (46 reviews)
"Very convenient to the lake."
United States
John P.
$194 nightly
The price is $215
Sep 20 - Sep 21
Total with taxes and fees
Country living lake style near Santee
Interior

8. Beautiful country cottage with ease of access! Minutes to I-26, I-95 and Hwy 301

Beautiful country cottage with ease of access! Minutes to I-26, I-95 and Hwy 301
Bowman
9.8 out of 10, Exceptional, (35 reviews)
"The place was excellent. The bed was really nice and comfortable. I'd definitely stay again."
United States
Joseph
$147 nightly
The price is $163
Sep 20 - Sep 21
Total with taxes and fees
Beautiful country cottage with ease of access! Minutes to I-26, I-95 and Hwy 301
1 bedroom, iron/ironing board, WiFi, bed sheets

9. Quiet 1-bedroom apartment in charming Elloree, SC

Quiet 1-bedroom apartment in charming Elloree, SC
Elloree
$163 nightly
The price is $180
Sep 20 - Sep 21
Total with taxes and fees
Quiet 1-bedroom apartment in charming Elloree, SC
Outdoor dining

10. Cozy Camping Cabin on Lake Marion near Congaree Nat Park

Cozy Camping Cabin on Lake Marion near Congaree Nat Park
Rimini
8.2 out of 10, Very good, (17 reviews)
"Great place to stay. "
United States
Scott J.
$112 nightly
The price is $124
Sep 21 - Sep 22
Total with taxes and fees
Cozy Camping Cabin on Lake Marion near Congaree Nat Park
Smart TV, books

11. Modern apartment overlooking historic downtown Elloree, SC.

Modern apartment overlooking historic downtown Elloree, SC.
Elloree
$177 nightly
The price is $196
Sep 20 - Sep 21
Total with taxes and fees
Modern apartment overlooking historic downtown Elloree, SC.
Terrace/patio

12. Cabin at the lake in Rimini, SC

Cabin at the lake in Rimini, SC
Rimini
7.4 out of 10, Good, (8 reviews)
"Great view, excellent communication with the owners, relaxing, peaceful. "
United States
Christie
$135 nightly
The price is $150
Sep 27 - Sep 28
Total with taxes and fees
Cabin at the lake in Rimini, SC
Beach

13. Country Resting Spot just off I95. 12 miles west on hwy 6.

Country Resting Spot just off I95. 12 miles west on hwy 6.
Elloree
9.4 out of 10, Exceptional, (24 reviews)
"Everyone was pleased and said they would stay here again."
United States
Tom B.
$153 nightly
The price is $170
Sep 23 - Sep 24
Total with taxes and fees
Country Resting Spot just off I95. 12 miles west on hwy 6.
2 bedrooms, WiFi, bed sheets

14. Relax and unwind near Lake Marion - 2-bedroom 1.5 bath cabin getaway.

Relax and unwind near Lake Marion - 2-bedroom 1.5 bath cabin getaway.
Summerton
10.0 out of 10, Exceptional, (1 review)
"Great"
United States
Jeffrey T.
$274 nightly
The price is $304
Sep 21 - Sep 22
Total with taxes and fees
Relax and unwind near Lake Marion - 2-bedroom 1.5 bath cabin getaway.
Property grounds

15. Pet friendly country cottage with large fenced-in yard & horses on property

Pet friendly country cottage with large fenced-in yard & horses on property
Holly Hill
10.0 out of 10, Exceptional, (162 reviews)
"Allow us and four girls aka dogs a nice stop on way to and from Florida peaceful nice fenced yard will be back next year"
United States
Catrina C.
$187 nightly
The price is $207
Sep 21 - Sep 22
Total with taxes and fees
Pet friendly country cottage with large fenced-in yard & horses on property
Private kitchen

16. Charming 2-bedroom cottage close to I26 and I95; 1 hr from Charleston

Charming 2-bedroom cottage close to I26 and I95; 1 hr from Charleston
Holly Hill
10.0 out of 10, Exceptional, (15 reviews)
"Great stay!"
United States
Hayden S.
$145 nightly
The price is $161
Sep 20 - Sep 21
Total with taxes and fees
Charming 2-bedroom cottage close to I26 and I95; 1 hr from Charleston
TV, table tennis

17. Turtle Cove - Lake Living on Lake Marion

Turtle Cove - Lake Living on Lake Marion
Summerton
10.0 out of 10, Exceptional, (1 review)
"Great quiet and cozy home with a nice backyard and porch with the easy water access by dock. Really enjoyed our stay."
United States
Judith H.
$389 nightly
The price is $442
Sep 20 - Sep 21
Total with taxes and fees
Turtle Cove - Lake Living on Lake Marion
Microwave, oven, stovetop, dishwasher

18. Beautiful brick home w/ large porch and 3 bedrooms

Beautiful brick home w/ large porch and 3 bedrooms
Bowman
9.2 out of 10, Wonderful, (5 reviews)
"A great home and very peaceful!! The host is very friendly and very easy to work with. I recommend this home for a stay 100 percent!!We plan on staying there again when we are in the area, such a great value!!"
United States
Troy K.
$271 nightly
The price is $301
Oct 6 - Oct 7
Total with taxes and fees
Beautiful brick home w/ large porch and 3 bedrooms
Terrace/patio

19. Sweet Marion - Dock + Boat Ramp + Hot Tub!

Sweet Marion - Dock + Boat Ramp + Hot Tub!
Summerton
8.8 out of 10, Excellent, (26 reviews)
"Nice comfortable place to stay"
United States
Dylan H.
$469 nightly
The price is $534
Oct 13 - Oct 14
Total with taxes and fees
Sweet Marion - Dock + Boat Ramp + Hot Tub!
Exterior

20. Tiny Home Retreat with Lake Views & Private Patio in Eutaw Springs, South Carolina

Tiny Home Retreat with Lake Views & Private Patio in Eutaw Springs, South Carolina
Eutaw Springs
$191 nightly
The price is $212
Oct 1 - Oct 2
Total with taxes and fees
Tiny Home Retreat with Lake Views & Private Patio in Eutaw Springs, South Carolina
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Santee Hotel Reviews

Bells Marina & Resort

Bells Marina & Resort

10/10 Excellent
"Love it"
Mark 1-night trip
Posted 5 hours ago
Bells Marina & Resort

Find out more about Santee

Everything you need to know about Santee vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Santee vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Santee vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Santee vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Santee. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Santee in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $81 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on Santee rentals

At Expedia, we put the best Santee vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Santee rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Santee vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Santee. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Explore a world of travel with Expedia

Frequently asked questions

Can I find vacation rentals in Santee?

Yes, we offer vacation rentals near the most popular points of interest in Santee, or you can select a more remote option if you'd like a relaxing place to stay. Tourists appreciate the top-notch restaurants and coffeehouses in Santee. Make sure you have time to check out the golf courses and lake views during your trip.

What are some of the best vacation home rentals in Santee?

Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!: This highly rated vacation home rental in Santee is located on a lake and has a patio, a selection of games, and a barbecue grill to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family.

How many vacation rentals are there in Santee?

Expedia has 8 vacation rentals for your stay in Santee.

What can I see and do in Santee?

While you're exploring the area, Lake Marion and Santee National Wildlife Refuge are a couple of picturesque spots to get outside and enjoy nature. Santee Cooper Country Club and Santee National Golf Club are other places to visit while you're in town.

What are vacation rentals like in Santee?

Vacation rentals are private accommodations you can book for several days or more in Santee. Vacation rentals feature amenities like kitchens and laundry facilities so you'll feel just like you're at home. If you're concerned about a sanitized environment, a vacation rental can provide a sense of safety away from public hotel elevators and bustling concierge desks while still allowing you the experience of travel. You'll also get more space in a vacation rental than in a standard hotel, which is another reason why a vacation rental is a great choice for family gatherings.