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Santee hotels and places to stay

Designer Lake House - Newly Renovated
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5.32 mi from city center
4.5/5Wonderful! (21 reviews)
Fishing Santee Cooper

"This property worked out well for us. We came to fish and we were looking for a property to only sleep in. We did not cook or use the laundry facilities. We would stay here again if we come back to Santee."…"

Reviewed on Nov 23, 2019

Designer Lake House - Newly Renovated
Super 8 by Wyndham Santee
2 out of 5
9125 Old Highway 6, Santee, SC
Free CancellationReserve now, pay when you stay
The price is $60 per night
0.75 mi from city center
3.2/5 (268 reviews)

"Nothing to add. This sucks you make me add more for this."…"

Reviewed on Feb 18, 2020

Super 8 by Wyndham Santee
Travelodge by Wyndham Santee
2 out of 5
9117 Old Number Six Hwy, Santee, SC
Free CancellationReserve now, pay when you stay
The price is $55 per night
0.73 mi from city center
3.6/5Good! (82 reviews)

"I was greeted warmly and quickly I was given a very nice clean room and I started the day with a good breakfast."…"

Reviewed on Feb 8, 2020

Travelodge by Wyndham Santee
Best Western Plus Santee Inn
2.5 out of 5
I 95 Exit 98, Santee, SC
Free CancellationReserve now, pay when you stay
The price is $94 per night
0.56 mi from city center
4.3/5Excellent! (1,103 reviews)

"I liked how well kept the property is there was nothing I didn't like"…"

Reviewed on May 16, 2020

Best Western Plus Santee Inn
Fairfield Inn & Suites by Marriott Santee
2.5 out of 5
9074 Old Number Six Hwy, Santee, SC
Free CancellationReserve now, pay when you stay
The price is $112 per night
0.62 mi from city center
4.8/5Exceptional! (128 reviews)

"The hotel stayed as safe as possible, still prepared hot meal for breakfast served by one worker with gloves. Very clean and they turned away guests from high risk areas (Coronavirus) for protection of others."…"

Reviewed on Apr 1, 2020

Fairfield Inn & Suites by Marriott Santee
Hampton Inn Santee-I-95
2.5 out of 5
9060 Old Number Six Hwy, Santee, SC
Free CancellationReserve now, pay when you stay
The price is $110 per night
0.59 mi from city center
4.6/5Exceptional! (748 reviews)

"Property was under construction. The 3rd floor was totally redone and we were in one of those rooms. Everything was brand new and very clean. My problem was Expedia intercepted my reservation from being directly with the hotel website, and I asked what our room rate would be without Expedia involved ..."…"

Reviewed on May 11, 2020

Hampton Inn Santee-I-95
Red Roof Inn Santee
2 out of 5
9091 Old Hwy 6, Santee, SC
Free CancellationReserve now, pay when you stay
The price is $63 per night
0.17 mi from city center
2.9/5 (356 reviews)

"Near Hwy. Rate reflective of property expectations. Check-in/out efficient."…"

Reviewed on Feb 19, 2020

Red Roof Inn Santee
Holiday Inn Santee
3 out of 5
139 Bradford Blvd, Santee, SC
Free Cancellation
The price is $132 per night
0.1 mi from city center
4/5Very Good! (331 reviews)

"ours was a unique situation due to COVID-19. However, the staff did the best they could under the circumstances."…"

Reviewed on Apr 8, 2020

Holiday Inn Santee
Quality Inn & Suites Santee I-95
2.5 out of 5
8929 Bass Dr, Santee, SC
Free Cancellation
The price is $63 per night
0.11 mi from city center
2.9/5 (242 reviews)
Stop off

"We had a comfortable stay and we were in walking distance to eat out"…"

Reviewed on Jan 8, 2020

Quality Inn & Suites Santee I-95
Comfort Inn & Suites Santee
2.5 out of 5
221 Britain St, Santee, SC
Free Cancellation
The price is $94 per night
0.17 mi from city center
3.9/5Very Good! (506 reviews)

"Very nice and Teresa at front desk is a peach. Thank you"…"

Reviewed on Apr 28, 2020

Comfort Inn & Suites Santee
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Visiting Santee

Families will find kid-friendly activities in Santee, and visitors give high marks for the top-notch restaurants. This welcoming city also attracts tourists with its golf courses and coffeehouses.

  • You'll find 30 Expedia hotels and other accommodations in the larger area of Orangeburg
  • The closest major airport is in Columbia, SC (CAE-Columbia Metropolitan), 49 mi (78.8 km) from the city center

Sightseeing and Staying in Santee

A couple of favorite places to visit are Santee Outlets and Santee State Park. In the area, you'll also find Lake Marion and Foxboro Golf Club.

As you plan your holiday getaway, you'll find 12 hotels and other lodging accommodations to select from in Santee. Below are top ones based on our user reviews:

  • Hampton Inn Santee-I-95 - This 2.5-star hotel features free breakfast, free WiFi, and free parking. It's a favorite with Expedia travelers for its breakfast and helpful staff.
  • Best Western Plus Santee Inn - Our customers like the pool and comfortable rooms at this hotel. This 2.5-star hotel features free breakfast, a restaurant, and an outdoor pool.
  • Holiday Inn Santee - This 3-star hotel features a restaurant, an indoor pool, and free WiFi. Expedia customers like its pool and convenient parking.

Dressing for Santee

  • Between January and March, you can expect average temperatures of 74°F during the day and 34°F at night
  • From April to June, the average during the day is 92°F, while the average at night is 47°F
  • July through September has daytime averages of 94°F with nighttime averages of 58°F
  • In October-December, you can expect daytime averages of 81°F and nighttime averages of 34°F
  • Santee gets about 51.06 inches of rain per year
  • Usually July and August are the hottest months with an average of 92°F, whereas January and December are often coldest, averaging 36°F

Frequently asked questions

Where is the best place for a stay in Santee?
Fairfield Inn & Suites by Marriott Santee is a favorite property for Expedia customers. This hotel offers free breakfast and free WiFi. Other top choices based on traveler reviews include Hampton Inn Santee-I-95 and Best Western Plus Santee Inn.
If I need to cancel my hotel reservation in Santee, will I receive a refund?
Yes! The majority of hotel reservations are fully refundable provided that you cancel before the accommodation’s cancellation deadline, which is usually within 24-48 hours of check in. If you have a reservation that’s non-refundable, it might still be possible to cancel it and be given a refund within 24 hours of your booking. Put your dates in and click on “Search”, then filter by “free cancellation” to review the best options available in Santee.
Where can I learn more about changing or cancelling my trip to Santee?
For more information about updating your trip to Santee or cancelling it, click here.
What's the best budget-friendly hotel in Santee?
Based on reviews, Baymont by Wyndham Santee is a popular 2-star hotel for our travelers looking for an economical choice, and features free breakfast and free WiFi. Other good choices for your budget-friendly stay include Super 8 by Wyndham Santee and Travelodge by Wyndham Santee.
What's the best hotel for a family vacation in Santee?
Hampton Inn Santee-I-95 is a hotel with free parking and free buffet breakfast, and it’s a top choice on Expedia for families. Other good choices for your kid-friendly vacation include Econo Lodge and Comfort Inn & Suites Santee. Attractions in the area like Santee National Wildlife Refuge are also fun for the whole family.
What's the best pet-friendly accommodation in Santee?
Baymont by Wyndham Santee is a top hotel for people traveling with their pets, and offers a seasonal outdoor pool and concierge services for its human guests. Other good choices for you and your pet’s trip include Red Roof Inn Santee and Econo Lodge.
Where is the best place to stay near Santee State Park?
Best Western Plus Santee Inn is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and a restaurant. It’s located 3.2 mi (5.2 km) from Santee State Park. Other good choices within a few miles include Comfort Inn & Suites Santee and Clarion Inn Santee I-95.
What about the best place to stay close to Santee Outlets?
One of the top choices for your stay is Best Western Plus Santee Inn, located a short 0.4 mi (0.7 km) from Santee Outlets, and this hotel offers free breakfast and a restaurant. Comfort Inn & Suites Santee and Clarion Inn Santee I-95 are a couple of other good and close options.
What's the best golf hotel in Santee?
Hampton Inn Santee-I-95 is a hotel featuring free breakfast and free WiFi, and it’s a top choice for playing a round of golf. Other good options to stay near a golf course include Red Roof Inn Santee and Super 8 by Wyndham Santee. Visit Santee National Golf Club or Santee Cooper Country Club to perfect your golf swing.
What are some accommodations with pools in Santee?
Baymont by Wyndham Santee is a top hotel with a seasonal outdoor pool, free breakfast, and free WiFi. A couple of other options that offer an onsite pool include Travelodge by Wyndham Santee and Super 8 by Wyndham Santee.
What's the best place to stay near Columbia Metropolitan Airport (CAE)?
Country Inn & Suites by Radisson, Columbia Airport, SC is a popular hotel, featuring free breakfast and an indoor pool. It’s located a short 1.7 mi (2.8 km) from Columbia Metropolitan Airport. Other places to stay close to the airport are Sleep Inn Airport and Red Roof Inn Columbia, SC Airport.
What is staying in Santee like?
Families will find kid-friendly activities in Santee, and visitors give high marks for the top-notch restaurants. This welcoming city also attracts tourists with its golf courses and coffeehouses. A top sight in the area is Lake Marion. In Santee, there are 21 hotels and other accommodations to choose from.

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