
Santee Vacations from $496
Book a Hotel + Flight or Car together to unlock savings
Your Santee Vacation
Enjoy unforgettable adventures when you book a vacation package to Santee. Whether you're a foodie, art buff or just a traveler who loves discovering new places, there's something for everyone in this lively city. If your trip to Santee includes some sightseeing, don't miss famous attractions like Santee State Park, Santee Cooper Country Club and Santee Outlets. Stop daydreaming and start traveling. Browse the many options on Expedia today and put your Santee vacation plans into action!
The Latest Santee vacation packages
Price found within the past 48 hours. Click for updated prices.



Hilton Columbia Center
Downtown Columbia
$729
per person
Dec 26 - Dec 30
found 4 hours ago
Roundtrip flight included
Chicago (CHI) to Columbia (CAE)
8.8/10 Excellent! (1,000 reviews)
Hilton is a great location to downtown and the university. Hotel is clean even during some construction. My only issues were the lack of signage when exiting the elevator onto your floor. Also our check in person did not explain the self parking very well.
Reviewed on Oct 4, 2026


Stay near popular Santee attractions
Santee State Park
8.0/10 (219 reviews)
Perched on Lake Marion's shores, Santee State Park offers unique rondette cabins built over water. Hike through cypress swamps and sinkholes while spotting alligators, fox squirrels, and diverse birdlife.
Santee Cooper Country Club
7.8/10 (94 reviews)
This George Cobb-designed course winds through majestic pines with strategic doglegs and panoramic Lake Marion views. Enjoy the signature closing hole and well-maintained fairways perfect for golfers of all skill levels.
Santee National Golf Club
8.0/10 (74 reviews)
This championship course blends Lowcountry charm with highland terrain, featuring moss-draped oaks and pristine bunkers. Enjoy diverse play with wide-open front nine and wooded back nine challenges.
Santee Hotel Deals

Tru By Hilton Santee
263 Britain St. and 273 Britain St. Santee SC
Fully refundableReserve now, pay when you stay
$101 nightly
$112 total
Oct 18 - Oct 19
Total with taxes and fees

Baymont by Wyndham Santee
249 Britain Street Santee SC
Fully refundableReserve now, pay when you stay
$80 nightly
$89 total
Oct 12 - Oct 13
Total with taxes and fees
8/10 Very Good! (1,495 reviews)
"Great for an overnighter"
Reviewed on Oct 10, 2026

Fairfield Inn & Suites by Marriott Santee
9074 Old Number Six Hwy Santee SC
Fully refundableReserve now, pay when you stay
$139 nightly
$154 total
Oct 18 - Oct 19
Total with taxes and fees
9.8/10 Exceptional! (1,001 reviews)
"repeat user"
Reviewed on Oct 8, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Find the Best Santee Vacation Packages
Santee Essential Information
Language | English |
|---|---|
Currency | U.S dollars |
Population | 940 |
Max Temp Winter | 55ºF |
Max Temp Summer | 90ºF |
Top Sights | Santee State Park, Santee Cooper Country Club and Santee National Golf Club |
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Frequently asked questions
What's included in a Santee vacation package?
A Santee vacation package lets you combine round-trip flights, hotel stays, and a rental car, offering a convenient way to explore this outdoor destination. Many hotels in Santee include free breakfast, providing a relaxed start to your day. For added convenience, some properties also offer airport shuttle service to and from Charleston, SC (CHS-Charleston Intl.) Airport, located about 48 miles away.Exactly what's included will vary by hotel and package, so it's worth reviewing the details before you confirm your booking.
How can I save money on a Santee vacation package?
When you bundle, you can save up to 30%*. To save money on a Santee package, consider traveling during the quieter months or be flexible with your dates to find more options. Bundling your flights and hotel together often unlocks savings compared to booking separately. *Members only. Savings vary.
What's the best vacation package for Santee?
For families seeking the best vacation packages in Santee, a Santee vacation package built around a stay at Fairfield Inn & Suites by Marriott Santee is a strong choice. This property, rated 9.4 out of 10, features family rooms and an outdoor pool, making it comfortable for all ages. Travelers frequently praise its great pool and extremely polite staff.Couples looking for a romantic Santee vacation package might consider a stay at Holiday Inn Santee by IHG. Rated 8.2 out of 10, this hotel offers a bar/lounge and an indoor pool, providing relaxing spaces for unwinding. Travelers often highlight the highly appreciated staff and the hotel's well-kept overall condition.For those seeking value, a Santee vacation package with a stay at Travelodge by Wyndham Santee is a budget-friendly option, costing around $70 per night. This hotel offers free breakfast and free WiFi, and travelers appreciate its comfy rooms and good value.*Package availability and prices may change depending on dates and demand.
Is Santee a good choice for a family vacation package?
Santee is a strong choice for family vacation packages, offering a relaxed outdoor setting with family-friendly accommodations and activities.Properties like Fairfield Inn & Suites by Marriott Santee, rated 9.4 out of 10 by travelers, provide amenities such as family rooms, an outdoor pool, and free breakfast, making it a comfortable base for families. Guests often praise the generously sized rooms and great breakfast.For outdoor fun, families can visit Santee State Park, located about 3 miles from central Santee, or explore the natural landscapes and wildlife at Santee National Wildlife Refuge, about 4 miles away.These options help create a memorable Santee vacation package for all ages.
What are the top things to do in Santee?
Santee, an outdoor and nature destination, offers a variety of activities centered around its natural beauty and recreational opportunities:Your Santee vacation can be customized around these activities. Browse and book things to do in Santee on Expedia.
Do you need to rent a car in Santee, or is public transport enough?
For a Santee vacation package, renting a car is highly recommended to fully explore this outdoor and nature destination.Santee's attractions, such as Santee State Park (about 3 miles from central Santee) and Santee National Wildlife Refuge (about 4 miles away), are spread out. A car provides the flexibility to visit these scenic spots and other recreational areas at your own pace.Charleston International Airport (CHS) is about 48 miles from Santee, making a rental car or pre-arranged shuttle service practical for airport transfers. While some hotels are walkable to central Santee, a car is essential for maximizing your Santee vacation packages with flights and exploring the wider region.
Are Santee vacation package hotels conveniently located?
Santee vacation package hotels are generally well-located, with many properties offering convenient access to the town's central area.For instance, Tru By Hilton Santee and Holiday Inn Santee by IHG are both about a 5-minute walk from central Santee. Other options like Hampton Inn Santee-I-95 and Best Western Plus Santee Inn are about a 10-minute walk away.Staying in central Santee places you within easy reach of local amenities and attractions, making it simple to enjoy your Santee vacation package.
Can I change or cancel my Santee vacation package if my plans change?
Yes, you can cancel your vacation package via your itinerary page on Expedia or by contacting customer service. Remember that some packages are fully refundable, but the details vary based on each unique booking. A fully refundable package may depend on how far out from the travel dates you're canceling and what airline you are traveling with.
Do One Key members get extra savings when booking Santee vacation packages?
Yes, members who join our free One Key™ travel rewards program can instantly unlock additional savings and save 10% or more on over 500,000 stays worldwide with Member Prices and over 1 million car rentals.
Does Expedia offer Book Now, Pay Later Santee vacation packages?
Yes, with Expedia's Book Now, Pay Later option, powered by Affirm, you can spread the cost of your Santee vacation over 3, 6, or 12 months. With no late payment fees or hidden costs, it's easy to secure your ideal vacation package as soon as you spot it.
How do I find last-minute vacation packages to Santee?
To find last-minute vacation packages to Santee, explore the last-minute deals section for the latest package offers, including flights, departing in the coming weeks. Being flexible with your travel dates and hotel preferences can help you secure the best prices.
How does free cancellation work on Santee vacation packages?
Free cancellation on a Santee vacation package depends on the specific hotel and rate combination you book. Many bookings allow free cancellation up to a stated deadline (often a few days before travel) where eligible. Read the cancellation terms carefully when reviewing the package, and visit Expedia help center for further details.
Is it cheaper to book a Santee vacation as a package or separately?
Booking flights and hotels together can unlock lower overall prices. Better still, you can tailor your Santee getaway to match your exact preference. Pick your preferred flight time, select the hotel type and add a car rental. Explore our bundles to see how much you can save.
Why should I book my Santee vacation package with Expedia?
Booking your vacation package on Expedia makes it easier to get more out of your trip from the start. With a wide choice of hotels, you can compare prices, reviews and amenities all in one place, then bundle your hotel with flights which could help you save even more. Flexible booking options on selected stays also make it easier to plan with confidence.
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.


















