Santee Vacations from $256

Book a Hotel + Flight or Car together to unlock savings

    deals illustration
    Better together
    Save up to $1,045 when you book a flight and hotel together*
    stays illustration
    Find the right fit
    With over 300,000 hotels worldwide, it's easy to create a perfect package
    luggage illustration
    Rest easy
    Plan, book, and manage your trip all in one place

Your Santee Vacation

Enjoy unforgettable adventures when you book a vacation package to Santee. Whether you're a foodie, art buff or just a traveler who loves discovering new places, there's something for everyone in this lively city. If your trip to Santee includes some sightseeing, don't miss famous attractions like Santee State Park, Santee Cooper Country Club and Santee Outlets. Stop daydreaming and start traveling. Browse the many options on Expedia today and put your Santee vacation plans into action!

The Latest Santee vacation packages

Price found within the past 48 hours. Click for updated prices.
Sleep Inn Columbia

Sleep Inn Columbia

2.5 out of 5
per person
Aug 8 - Aug 12
found 1 day ago
Roundtrip flight included
Boston (BOS) to Columbia (CAE)
8.2/10 Very Good! (1,000 reviews)
Enjoyed my stay. Staff was friendly and the breakfast was good.

Reviewed on Jun 17, 2025

Graduate by Hilton Columbia SC

Graduate by Hilton Columbia SC

4 out of 5
Downtown Columbia
per person
Jul 17 - Jul 21
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Columbia (CAE)
9.4/10 Exceptional! (1,002 reviews)
We ate dinner onsite and the bartender/wait staff was amazing. Although she was super busy she was attentive and quick to take care of needs. The food was also delicious!

Reviewed on Jun 13, 2025

Hampton Inn Columbia I-26/Harbison Blvd.

Hampton Inn Columbia I-26/Harbison Blvd.

2.5 out of 5
per person
Aug 8 - Aug 12
found 1 day ago
Roundtrip flight included
Boston (BOS) to Columbia (CAE)
9.2/10 Wonderful! (1,006 reviews)
Everything was neat and clean!!!

Reviewed on Jun 15, 2025

Country Inn & Suites by Radisson, Columbia Airport, SC

Country Inn & Suites by Radisson, Columbia Airport, SC

2.5 out of 5
per person
Aug 8 - Aug 12
found 1 day ago
Roundtrip flight included
Boston (BOS) to Columbia (CAE)
8.2/10 Very Good! (1,000 reviews)
Easy check-in, excellent customer service, and clean rooms

Reviewed on May 30, 2025

Hampton Inn Camden

Hampton Inn Camden

2.5 out of 5
per person
Aug 17 - Aug 20
found 1 day ago
Roundtrip flight included
New York (NYC) to Columbia (CAE)
9.2/10 Wonderful! (305 reviews)
Clean room, nice bed. People at the front desk were very helpful. We had a good stay

Reviewed on May 27, 2025

Don't see what you're looking for?
See all available trips from Columbus to Santee
View all trips

Discover the most popular places to visit in Santee

Santee State Park

4/5(43 reviews)

You can take time to visit Santee State Park during your travels to Santee. While you're here, you can savor the top-notch restaurants.

Santee State Park

Santee Cooper Country Club

4/5(12 reviews)

Enjoy a round of golf in Santee at Santee Cooper Country Club. While you're here, you can savor the top-notch restaurants.

Santee Cooper Country Club

Santee National Golf Club

3.5/5(19 reviews)

Enjoy a round of golf in Santee at Santee National Golf Club. While you're here, you can savor the top-notch restaurants.

Santee National Golf Club

Santee Hotel Deals

Baymont by Wyndham Santee
Baymont by Wyndham Santee
2.5 out of 5
249 Britain Street, Santee, SC
Fully refundableReserve now, pay when you stay
$75 nightly
The price is $83 total per night from Jun 18 to Jun 19
$83 total
Jun 18 - Jun 19
Total includes taxes and fees
7.8/10 Good! (1,301 reviews)
"Good accommodation and friendly staff. Would stay there again"

Reviewed on Jun 15, 2025

Baymont by Wyndham Santee
Tru By Hilton Santee
Tru By Hilton Santee
2.5 out of 5
263 Britain St. and 273 Britain St., Santee, SC
Fully refundableReserve now, pay when you stay
$110 nightly
The price is $122 total per night from Jul 7 to Jul 8
$122 total
Jul 7 - Jul 8
Total includes taxes and fees
9/10 Wonderful! (446 reviews)
"Absolutely amazing!!"

Reviewed on Jun 15, 2025

Tru By Hilton Santee
Fairfield Inn & Suites by Marriott Santee
Fairfield Inn & Suites by Marriott Santee
2.5 out of 5
9074 Old Number Six Hwy, Santee, SC
$130 nightly
The price is $144 total per night from Jun 24 to Jun 25
$144 total
Jun 24 - Jun 25
Total includes taxes and fees
9.8/10 Exceptional! (1,003 reviews)
"Road trip stopover while traveling with out dog. Fourth time we've stayed here and it lived up to our expectations - clean and comfortable room, friendly and efficient staff, great location, excellent breakfast."

Reviewed on Jun 16, 2025

Fairfield Inn & Suites by Marriott Santee
See all 280 properties in Santee
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Santee Vacation Packages

Santee Essential Information

Language
English
Currency
U.S dollars
Population
940
Max Temp Winter
55ºF
Max Temp Summer
90ºF
Top Sights
Santee State Park, Santee Cooper Country Club and Santee National Golf Club

More vacations you might like

All Inclusive Vacations

All Inclusive Vacations

Beach Vacations

Beach Vacations

Kid Friendly Vacations

Kid Friendly Vacations

Frequently asked questions

How much does a Santee vacation package cost?
Offering excellent value package deals from $256 on Expedia, you'll be surprised at how little a vacation to Santee costs! Our packages make travel planning easier and your savings go further.
What are the cheapest months to go to Santee?
If you're hoping to snag a cheap Santee vacation package, consider visiting in January, September and October. You're likely to find better prices on accommodations and flights during these quieter months --- ideal for budget-conscious travelers.
How many days is enough for Santee?
The ideal length for your Santee vacation depends on what you'd like to see and do. Usually, a few days to a week will give you time to hit all the leading attractions and explore some hidden treasures along the way.
Is it worth booking a vacation package to Santee?
It's no wonder a Santee vacation is on the to-do list of many travelers. Major attractions like Santee State Park are just the beginning of things to see and do here.
How to find the best Santee package deals?
Use Expedia's handy filters to help you find some fabulous Santee package deals. When you begin your search, simply set your maximum budget and then sort the results by "Price: low to high." If you're looking to save, plan your break for midweek, or search for Santee package deals in the low season. Switch up your travel dates and you may land even better discounts. As a rule of thumb, it's typically best to lock in your vacation package as early as possible.
Is it cheaper to book a Santee vacation as a package?
An Expedia vacation package could land you considerable savings when compared to booking stays and flights individually. Better still, you can customize your Santee trip to match your exact needs. Pick your preferred flight time, select the hotel type and add a rental car. Browse our great deals to see how much you can save.
When to book a vacation package to Santee?
If you have your Santee vacation dates locked in, book as soon as you can to score some incredible deals. With Expedia, you can generally reserve some flights up to one year ahead of time. Prefer spur-of-the-moment adventures? Our last-minute deals are perfect for quick escapes.
Does Expedia offer Book Now, Pay Later Santee vacation packages?
If you're anything like us, you love discovering new places but don't love the price tag that can come with it. That's why we offer Book Now, Pay Later vacations. With help from online lender Affirm, you can spread the total cost of your Santee trip across 3, 6 or 12 months. There are also no late payment fees or hidden costs, so you can snap up cheap vacation packages with payment plans as soon as you spot them.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.