View from the dike in Clemson, SC. This trail is used by runners, bikers, and lots of dog walkers.

Find hotels in Seneca, SC from $62

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Compare 1,588 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

"Great overall stay."

$112 nightly

Jul 13 - Jul 14

Total includes taxes and fees

Relax in a secluded cabin surrounded by the forest, with a cozy deck and fire pit.

"Clean and cute Wonderful getaway "

$124 nightly

Jul 13 - Jul 14

Total includes taxes and fees

Enjoy meals and gatherings with friends and family in this lakeside patio area, surrounded by trees and a scenic view.

"The rooms were super nice! Really nice bath and clean all around. We enjoyed it very much. The staff were very friendly! Would stay here again! "

$129 nightly

Jul 13 - Jul 14

Total includes taxes and fees

Welcome to our hotel lobby, featuring a reception desk, comfortable seating, and a warm atmosphere.

"The property was near the area that I needed to be in. It has ample shops and restaurants in the area "

$70 nightly

Jul 20 - Jul 21

Total includes taxes and fees

Experience the warm welcome at this inviting hotel, featuring a prominent entrance and comfortable accommodations.

"convenient to our needs"

$121 nightly

Jul 20 - Jul 21

Total includes taxes and fees

Enjoy a meal at our restaurant with a counter, display case, and comfortable seating areas.

"Really good place "

$90 nightly

Jul 18 - Jul 19

Total includes taxes and fees

Enjoy a delicious breakfast at the Daybreak Breakfast buffet, featuring a variety of cereals and pastries.

"Always enjoy staying at this location; clean rooms, easy access from highway and great restaurants nearby "

$59 nightly

Jul 20 - Jul 21

Total includes taxes and fees

Relax in a spacious room with a large bed, two bedside tables, and a beautiful dark blue artwork.

"Excellent hotel and great staff! "

$97 nightly

Jul 17 - Jul 18

Total includes taxes and fees

Welcome to our reception area, where friendly staff are available to assist with your stay. A flat-screen TV and computer monitors display information for your convenience.

"Great location"

$97 nightly

Jul 20 - Jul 21

Total includes taxes and fees

"The manager was very friendly and accommodating. The place is new and very security conscious"

$74 nightly

Jul 13 - Jul 14

Total includes taxes and fees

Welcome to our reception area, featuring a modern design with a warm glow, wood, and metal elements.

"Nice rooms. Clean rooms, Comfortable beds,Friendly staff"

$107 nightly

Jul 18 - Jul 19

Total includes taxes and fees

Welcome to Quality Inn, where guests can check in and enjoy a warm atmosphere.

"Early check-in, lots of dining and shopping options, conveniently located. Shower and toilet need maintanence"

$63 nightly

Jul 20 - Jul 21

Total includes taxes and fees

Check-in at our welcoming reception area, featuring a curved desk, a large map of the United States, and comfortable seating.

"Great all around. Pleasant staff, clean room"

$80 nightly

Jul 20 - Jul 21

Total includes taxes and fees

Relax by the pool surrounded by comfortable lounge chairs and lush greenery.

"Had an awesome time"

$68 nightly

Jul 20 - Jul 21

Total includes taxes and fees

Relax in this inviting living room with a sofa set, coffee table, and armchair, offering a view of the outdoors through large glass doors.

"Friendly staff. Convenient location. "

$86 nightly

Jul 13 - Jul 14

Total includes taxes and fees

Enjoy a serene golf experience with a tranquil lake view.

"Very nice stay. Room was very clean and hotel itself was nice and well kept. Staff was super friendly."

$149 nightly

Jul 13 - Jul 14

Total includes taxes and fees

Two large beds with white linens and a neutral-toned headboard, set against a backdrop of city views through large windows.

"Beautiful property, amazing staff and service, will always be my first pick when in town. "

$181 nightly

Aug 5 - Aug 6

Total includes taxes and fees

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Cabins in Seneca you'll enjoy

$124 nightly

Jul 13 - Jul 14

Total includes taxes and fees

Enjoy a warm cup of coffee in our inviting coffee bar area, featuring a chalkboard menu and a selection of mugs.

$614 nightly

Jul 29 - Jul 30

Total includes taxes and fees

Relax on the deck with a view of the surrounding forest, featuring a wooden table and benches.

$253 nightly

Jul 13 - Jul 14

Total includes taxes and fees

Relax in a, enclosed space surrounded by lush greenery, with two comfortable rocking chairs and a small table.

$180 nightly

Jul 22 - Jul 23

Total includes taxes and fees

Three cozy cabins surround a central dining area with a fire pit and rustic charm.

$181 nightly

Jul 16 - Jul 17

Total includes taxes and fees

Enjoy meals around the fire pit in the central dining area, surrounded by rustic benches and tables.

$205 nightly

Jul 20 - Jul 21

Total includes taxes and fees

Enjoy cooking in this fully equipped kitchen with an oven and range hood, featuring a large window with a view of lush greenery.

$1,004 nightly

Aug 8 - Aug 9

Total includes taxes and fees

Cozy cabin with a fireplace, comfortable sofa, and kitchen area.

$468 nightly

Aug 11 - Aug 12

Total includes taxes and fees

These pet-friendly hotels in Seneca may fit your trip

$124 nightly

Jul 13 - Jul 14

Total includes taxes and fees

$90 nightly

Jul 18 - Jul 19

Total includes taxes and fees

$70 nightly

Jul 20 - Jul 21

Total includes taxes and fees

Enjoy cooking in this well-equipped kitchen with a range hood, microwave, and ample storage.

$171 nightly

Jul 14 - Jul 15

Total includes taxes and fees

Enjoy cooking in this well-equipped kitchen with an oven, microwave, and range hood.

$313 nightly

Jul 13 - Jul 14

Total includes taxes and fees

Enjoy cooking in this kitchen with wooden cabinetry, stainless steel oven, and granite countertop.

$297 nightly

Jul 27 - Jul 28

Total includes taxes and fees

$86 nightly

Jul 13 - Jul 14

Total includes taxes and fees

Check out family-friendly hotels in Seneca

$129 nightly

Jul 13 - Jul 14

Total includes taxes and fees

Enjoy cooking in this kitchen with a central island, bar stools, stainless steel appliances, and a dishwasher.

$730 nightly

Jul 17 - Jul 18

Total includes taxes and fees

Relax in comfort with a seating area, large window, and flat-screen TV.

$64 nightly

Jul 12 - Jul 13

Total includes taxes and fees

$63 nightly

Jul 20 - Jul 21

Total includes taxes and fees

$68 nightly

Jul 20 - Jul 21

Total includes taxes and fees

$107 nightly

Jul 18 - Jul 19

Total includes taxes and fees

Relax by the pool surrounded by comfortable seating and lush greenery.

$89 nightly

Jul 20 - Jul 21

Total includes taxes and fees

Welcome to Holiday Inn Express & Suites, featuring a modern exterior with a prominent archway entrance.

$123 nightly

Jul 18 - Jul 19

Total includes taxes and fees

$181 nightly

Jul 16 - Jul 17

Total includes taxes and fees

$205 nightly

Jul 20 - Jul 21

Total includes taxes and fees

Where to stay in Seneca

Find the best Seneca areas and neighborhoods for the activities you enjoy most. Learn more about Seneca

Pine Ridge Point

While Pine Ridge Point isn't home to many top sights, Lake Keowee and Keowee Key Golf Course are some notable places to visit nearby.

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Indian Oaks

While there might not be top attractions in Indian Oaks, you can explore the larger area and discover places like Oconee County Library Seneca Branch and Keowee Reservoir.

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Downtown

2 out of top 10 points of interest in this area

While visiting Downtown, you might make a stop by sights like Oconee County Library Seneca Branch and Seneca Historic District.

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Serenity Bay

Though Serenity Bay might not have many top sights, you can venture to the surrounding area to see attractions like Keowee Key Golf Course and Lake Keowee.

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Keowee Plantation

When in Keowee Plantation, you can plan a visit to Oconee County Library Seneca Branch and Keowee Reservoir, some noteworthy sights in the nearby area.

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Learn more about Seneca

Escape to Seneca! Enjoy its sports, lake views, and coffee.

See all hotels in Seneca

More cheap stays in Seneca

Days Inn by Wyndham Anderson

1007 George Smith Mill Rd, Anderson, SC

$59 nightly

$65 total

Jul 20 - Jul 21

Total includes taxes and fees

7.2/10 Good! (1,011 reviews)

Hotels in Seneca with star-rating

Stay near popular Seneca attractions

Find out more about Seneca

Top reasons to visit Seneca

Outdoor Adventures: Seneca is perfect for outdoor enthusiasts, offering scenic landscapes for hiking, golfing, and horseback riding.
Romantic Getaways: The charming atmosphere makes Seneca ideal for couples seeking a relaxing retreat.
Historic Sites: Explore local history through beautiful college campuses and cultural attractions in the area.
Family-Friendly Activities: Enjoy urban parks and recreational areas that cater to families and children.
Diverse Accommodations: A range of hotels and motels ensures a comfortable stay for every traveler, including pet-friendly options.

Find great hotels near Seneca

Discover a variety of hotel accommodations in Seneca, South Carolina, catering to every traveler's needs. From budget-friendly options to more luxurious stays, you'll find a selection of 2 to 4-star hotels and motels. Many establishments offer pet-friendly services, business amenities, and a welcoming atmosphere for the LGBTQIA community, ensuring a pleasant experience for all visitors. Explore the best hotels in Seneca for a memorable vacation!

Best Western Plus Clemson Hotel & Conference Center: Located a short drive from Seneca, the Best Western Plus Clemson Hotel & Conference Center is an ideal choice for business travelers seeking a pet-friendly environment. This hotel offers a variety of amenities tailored to corporate needs, including a 24-hour business center, multiple meeting rooms, and a dedicated conference space. Guests appreciate the flexibility to bring their pets, with special policies in place for service animals and cleaning fees for other pets. The blend of professional facilities and welcoming atmosphere makes it a top pick for those traveling for work while staying connected with their furry friends.
Comfort Inn & Suites Clemson - University Area: Situated conveniently near Seneca, Comfort Inn & Suites Clemson - University Area provides a comfortable and practical stay for both business and leisure travelers. This pet-friendly hotel features a 24-hour business center and meeting rooms, making it a great fit for professionals. Guests can relax knowing their pets are welcome, with specific policies for dogs and cats. The hotel’s modern amenities and commitment to guest satisfaction create a welcoming atmosphere that encourages both relaxation and productivity during your stay.
Inn @ Clemson: The Inn @ Clemson, located just a short distance from Seneca, is designed with business travelers in mind. Boasting a professional environment, this hotel offers essential amenities such as a business center and multiple meeting rooms to facilitate successful gatherings. While it does not focus on pet-friendly accommodations, its commitment to providing a comfortable and efficient stay for business guests is evident. The convenient location and dedicated services make the Inn @ Clemson a solid choice for those looking to balance work and relaxation during their visit.

Where to stay in and around Seneca

Seneca, South Carolina, is a hidden gem perfect for outdoor enthusiasts and romantic getaways. With its stunning scenery, friendly locals, and family-friendly atmosphere, visitors can enjoy a range of activities. Explore the nearby Clemson area for its vibrant art scene and historical charm. Whether you're a leisure traveler or on business, Seneca offers a welcoming environment with sunny weather, making it an ideal destination for all types of travelers.

Clemson: Situated just 7 miles from Seneca, Clemson is a vibrant city renowned for its rich culture and outdoor activities. Visitors flock here year-round, with peak arrivals during the summer months from July to September. The city is home to a historic university, making it a hub of education and entertainment. Outdoor enthusiasts can explore scenic landscapes, while sports fans can catch events at the local stadium. Clemson offers a blend of academic atmosphere and recreational fun, ensuring a fulfilling travel experience.
Keowee: Nestled within the areas surrounding Seneca, Keowee is a charming village perfect for those seeking romance and outdoor adventure. The village welcomes visitors throughout the year, with a peak season from July to August and in October. It boasts stunning lakes and is near a historic college university and a national state park, making it an ideal spot for nature lovers. Golf enthusiasts can also enjoy the local courses. Keowee is a serene retreat for couples and families alike, offering picturesque scenery and tranquil experiences.
Normandy Shores: Also located near Seneca, Normandy Shores is a delightful village that attracts visitors with its stunning landscapes and romantic ambiance. With a similar visitor pattern to Keowee, the best times to visit are during the summer and early fall. Normandy Shores features beautiful lakes and is close to a historic college university and a national state park, providing ample opportunities for exploration and outdoor activities. This village is perfect for those looking to unwind in nature’s beauty while enjoying a peaceful getaway.

Things to do near Seneca

Seneca, South Carolina, is perfect for outdoor enthusiasts and those seeking romantic getaways. Visitors can enjoy scenic landscapes while engaging in various activities like golfing and exploring educational recreational areas. A highlight of the area is the Spokane Trail Rides, offering a unique way to experience the natural beauty of Seneca. Whether you’re looking to relax or embark on an adventure, Seneca has something for everyone.

Shopping

In Seneca, you can shop at Wyndham Plaza and Golden Corner Plaza, both offering a variety of family-friendly stores. If you're up for a drive, check out Anderson Mall, located 19 miles away, featuring a wider selection of shops and entertainment options.

Recreation

Experience the energetic atmosphere at Littlejohn Coliseum, where you can catch a game or event. Enjoy a round of golf at Walker Golf Course or Keowee Key Golf Course, both offering beautiful outdoor settings and the perfect backdrop for relaxation and recreation.

Adventure

Experience thrilling water activities at Ultimate Action Sports, located 16 miles from Seneca, where adventure and excitement await. Enjoy stunning scenery on the Bartram Trail, a 24-mile journey perfect for hiking enthusiasts. For more outdoor exploration, the Shortline Trailhead, 26 miles away, offers beautiful trails for nature lovers.

Nightlife

Experience the vibrant nightlife in Seneca by visiting the Foothills Playhouse for a captivating theater performance or head to the Highlands Playhouse for more cultural entertainment. For a cinematic experience, catch a movie at Regal Starlight in nearby Anderson, perfect for a romantic night out.

Booking tips and Expedia advantages for Seneca

To save money on your trip to Seneca, South Carolina, consider visiting from December to February when accommodation prices are lower, particularly on Mondays, the cheapest day to stay. Utilize Expedia to compare hotel rates, filter for eco-certified options, and explore package deals that combine hotels with flights and activities. Joining Expedia's One Key membership can unlock exclusive discounts and earn OneKeyCash for future bookings. For transportation, renting a bicycle is a budget-friendly way to explore the area while enjoying the natural beauty of Seneca.

The most and least expensive months on average to stay in a hotel: The cheapest months to stay in Seneca are December to February, where the prices are slightly lower. This is in comparison to September to November, where prices are slightly higher.
The most and least expensive days on average to stay in a hotel: The least expensive day to stay in Seneca is Monday. The most expensive day to stay in Seneca is Saturday.
Find cheap hotels on Expedia: Utilize Expedia’s search tool to refine your choices based on your budget, desired location, and preferred type of accommodation. For instance, selecting the "Eco-certified" filter will show you sustainable and eco-friendly hotels currently available. To find the best prices and deals, simply sort the price filter from lowest to highest.
Consider bundling your trip: You can save money by combining your Seneca hotel reservation with your flights and activities through an Expedia package deal.
Become a One Key member: Join Expedia's One Key membership program for exclusive discounts and deals on hotel bookings. You can also earn OneKeyCash to use on future selected hotels.

Find the best attractions near Seneca

Seneca, South Carolina, is perfect for outdoor enthusiasts and couples seeking a romantic getaway. Visitors can explore scenic urban parks, beautiful lakes, and historic college campuses, making it an ideal destination for families and culture lovers alike. With a variety of attractions and activities, Seneca promises a memorable experience for all travelers looking to enjoy nature and local history.

Clemson University: A historic institution located 7 miles from Seneca, Clemson University offers a vibrant campus culture, rich in tradition and academic excellence. Explore its stunning architecture, lush gardens, and engaging events, making it a great spot for both learning and leisure.
Lake Keowee: Situated 9 miles away, Lake Keowee is a picturesque destination perfect for romance and outdoor activities. Enjoy serene beaches, stunning views, and numerous water sports, making it an ideal retreat for relaxation and adventure alike.
Memorial Stadium: Located 6 miles from Seneca, Memorial Stadium is a historic venue that captures the spirit of college sports. Experience the electric atmosphere during game days, where the passionate fan base and rich traditions come together to create unforgettable moments.

Best time to go to Seneca

Visitor numbers in Seneca is generally unchanged in popularity throughout the year. The best time to visit Seneca is dependant on what kind of holiday you are seeking. July is its hottest month on average. At this time, visitor numbers are slightly high and weather is mostly sunny with light rain. January is its coolest month on average. At this time, visitor numbers are average and weather is mostly sunny with light rain.

Calendar Month	Temperature	Precipitation	Cloudiness	Occupancy	Pricing
January	41.7°F (5.4°C)	Light Rain	Mostly Sunny	Average	Slightly Low
February	45.7°F (7.6°C)	Light Rain	Mostly Sunny	Average	Slightly Low
March	52.0°F (11.1°C)	Light Rain	Mostly Sunny	Average	Average
April	59.9°F (15.5°C)	Light Rain	Mostly Sunny	Average	Average
May	68.2°F (20.1°C)	Light Rain	Mostly Sunny	Average	Average
June	75.7°F (24.3°C)	Light Rain	Mostly Sunny	Slightly High	Average
July	79.2°F (26.2°C)	Light Rain	Mostly Sunny	Slightly High	Average
August	77.4°F (25.2°C)	Light Rain	Mostly Sunny	Average	Average
September	72.1°F (22.3°C)	Light Rain	Mostly Sunny	Slightly High	Slightly High
October	62.1°F (16.7°C)	Light Rain	Mostly Sunny	Slightly Low	Slightly High
November	51.4°F (10.8°C)	Light Rain	Mostly Sunny	Slightly Low	Slightly High
December	45.7°F (7.6°C)	Light Rain	Mostly Sunny	Slightly Low	Slightly Low

The nearest major airports for your trip to Seneca

Traveling to Seneca, South Carolina, is convenient with two major airports nearby. Greenville-Spartanburg International Airport (GSP) is located 44 miles away, with hotel options like the 4-star Greenville Marriott, just 3 miles from the airport, offering easy access. The Embassy Suites Greenville Golf Resort & Conference Center, 8 miles away, provides limited shuttle service and free transportation to GSP. Asheville Regional Airport (AVL) is 57 miles from Seneca, with luxurious stays like the Grand Bohemian Asheville, 9 miles from the airport. The Abbington Green Bed & Breakfast Inn and The Black Walnut B & B Inn are also nearby, both 12 miles from AVL, offering charming accommodations.

Recent reviews of Seneca hotels

5/5 Excellent

"Perfect"

A verified traveler stayed at Tru by Hilton Seneca Clemson

Posted 1 day ago

5/5 Excellent

"ALL around a great experience. The staff was very nice and helpful. The food was incredible, the room was perfect , clean, and quiet. The whole property was amazing. You have to stay here to understand. I will for sure be back, probably monthly. And most importantly , GO TIGERS! 😁👍"

A verified traveler stayed at Lakeside Lodge Clemson

Posted 3 days ago

Beautiful waterfront home on a private cove in Lake Keowee w/ hot tub

5/5 Excellent

Summer vacation with family

"Our stay at 1400 Cool Ridge was just perfect!! The house was beautiful, clean, well stocked and comfortable. The dock was very nice, decking is top of the line. Easy on and off of our boats. The hot tub is very nice. We all had a really wonderful week that we will never forget!!"

A verified traveler stayed at Beautiful waterfront home on a private cove in Lake Keowee w/ hot tub

Posted 6 days ago

5/5 Excellent

"It was quiet and beautiful and private. The chairs outside around the firepit was great, including being provided with firewood and somores fixings! My cabin was very clean and cozy and had a lot of nooks and crannies to store things for such a tiny place. It was easy to communicate with management and they were very cooperative. I couldn't have asked for anything more except maybe a microwave or toaster :)"

A verified traveler stayed at Postcard Cabins Lake Hartwell

Posted 6 days ago

Deepwater Cove on Lake Keowee. Complete with Dock and Kayaks. EV Charger

5/5 Excellent

Annual family summer trip

"Once again our family had a wonderful annual to beautiful Lake Keowee this lovely home fit our family of 10 perfectly. Looking forward to next year "

A verified traveler from Greenville, SC stayed at Deepwater Cove on Lake Keowee. Complete with Dock and Kayaks. EV Charger

Posted 12 days ago

Hampton Inn & Suites Seneca-Clemson Area

5/5 Excellent

"It's very nice and clean hotel. Beds are very comfortable, breacfast was good and very good coffee, that actually you can have all day long what is rare. The staff was nice. If you plan to stay in Seneca I recommend this hotel."

A verified traveler stayed at Hampton Inn & Suites Seneca-Clemson Area

Posted 3 weeks ago

Frequently asked questions

What is the best area to stay in Seneca?

Normandy Shores is the premier area to stay in Seneca, South Carolina, favored by most of our travelers for its serene lakeside setting and friendly setting. This picturesque neighborhood offers easy access to Lake Hartwell, where outdoor enthusiasts can enjoy fishing, boating, and hiking along scenic trails. The area's charming parks and waterfront views create an idyllic backdrop for relaxation and adventure alike.

For LGBTQ+ travelers, Keowee presents an inclusive and vibrant option. This friendly neighborhood features a laid-back vibe with various outdoor activities, from kayaking to enjoying local festivals. The community spirit here is palpable, making it a great choice for those looking to connect with like-minded solo travelers in a welcoming environment.

What are the best budget hotels in Seneca?

Hampton Inn & Suites Seneca-Clemson Area stands out as a top choice for budget-conscious travelers seeking top hotels. Rated an impressive 9.4 by guests, this hotel offers a delightful buffet breakfast included in your stay, ensuring a great start to your day. Families will appreciate the spacious suites, which come equipped with free cribs and the option for rollaway beds, making it easy to accommodate everyone comfortably.

Another excellent family-friendly option is the Fairfield Inn & Suites Seneca Clemson Univ Area, also boasting a traveler review score of 9.4. This property features an inviting outdoor pool great for splashing around after a day of exploring. Guests can enjoy a complimentary continental breakfast, and the scenic lake view adds a tranquil touch to your stay, great for enjoying quality family time.

For parents traveling with little ones, Tru by Hilton Seneca Clemson offers a fun atmosphere with games for children and a complimentary breakfast to fuel your adventures. Rated 9.2 by guests, this hotel is located in a vibrant shopping district, providing convenience for any last-minute needs or souvenirs.

While these hotels cater wonderfully to families, Lakeside Lodge Clemson is another gem worth mentioning. With its seasonal outdoor pool, kitchenettes, and poolside bar, it creates a relaxed environment ideal for couples looking for a romantic getaway or for groups wanting a serene spot to unwind after exploring the area. Rated 9.0, it ensures a comfortable stay with all the essential amenities.

No matter which property you choose, you can expect attentive service and a cozy atmosphere that caters to both relaxation and adventure, making your stay in Seneca memorable and stress-free. View all budget hotels in Seneca.

When is the best time to go to Seneca?

The most popular time to visit Seneca, South Carolina, is during the fall months, particularly October. With temperatures typically ranging from the mid-50s to the mid-70s Fahrenheit, this period offers a comfortable climate great for outdoor activities like hiking in the nearby Blue Ridge Mountains or exploring the scenic Lake Hartwell. The vibrant autumn foliage creates a picturesque backdrop that enhances any sightseeing adventure.

As you plan your trip, keep in mind that the peak tourist season occurs from May to October, when visitors flock to enjoy the various festivals and outdoor events that the area hosts. This lively atmosphere is ideal for those who appreciate engaging with the local community, whether through farmer's markets or seasonal celebrations featuring regional music and cuisine.

If you're someone who enjoys the tranquility of nature, October is particularly inviting. The milder temperatures make it a fantastic time for leisurely walks along the lake or picnics in the local parks, where you can soak in the stunning vistas without the summer crowds.

For travelers seeking a more budget-friendly experience, consider visiting in December. It's cooler, with temperatures dipping into the low 40s, this time of year offers a unique charm as the area embraces the holiday spirit with festive decorations and cozy events.

Can I cancel my hotel reservation on Expedia?

You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in Seneca.

How can I save on a Seneca hotel booking with Expedia?

With Expedia, you earn OneKeyCash™* on eligible Seneca hotel bookings for every dollar you spend -- just join our One Key™ travel rewards program to get started. It's free to join, and you'll unlock our lowest Member Prices as soon as you're signed in. On top of this, you could also save significantly by bundling your hotel and flights together on Expedia.

*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.

How much is the nightly rate at a Seneca hotel?

Prices for hotels in Seneca often vary, but you can find a great deal from $62 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.

Explore a world of travel with Expedia

Littlejohn Coliseum

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Find hotels in Seneca, SC from $62

Upfront pricing

Treat yourself

Be picky

Go beyond your typical stay in Seneca

Check prices for these dates

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Compare 1,588 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Lakeside Lodge Clemson

Lakeside Lodge Clemson

Cabins in Seneca you'll enjoy

Postcard Cabins Lake Hartwell

Postcard Cabins Lake Hartwell

These pet-friendly hotels in Seneca may fit your trip

Postcard Cabins Lake Hartwell

Postcard Cabins Lake Hartwell

Check out family-friendly hotels in Seneca

Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area

Where to stay in Seneca

Pine Ridge Point

Indian Oaks

Downtown

Serenity Bay

Keowee Plantation

Learn more about Seneca

More cheap stays in Seneca

More cheap stays in Seneca

Days Inn by Wyndham Anderson

Hotels in Seneca with star-rating

Hotels in Seneca with star-rating

Stay near popular Seneca attractions

Stay near popular Seneca attractions

Find out more about Seneca

Find out more about Seneca

Top reasons to visit Seneca

Find great hotels near Seneca

Where to stay in and around Seneca

Things to do near Seneca

Booking tips and Expedia advantages for Seneca

Find the best attractions near Seneca

Best time to go to Seneca

The nearest major airports for your trip to Seneca

Recent reviews of Seneca hotels

Recent reviews of Seneca hotels

Tru by Hilton Seneca Clemson