Title: Seneca Vacation Packages 2026 from $378 | Expedia.com [Seneca Travel Guide](https://expedia.com/Seneca.dx6548)[Hotels in Seneca](https://expedia.com/Seneca-Hotels.d6548.Travel-Guide-Hotels)[Vacation Rentals in Seneca](https://expedia.com/Seneca-Vacation-Rentals.d6548.Travel-Guide-VacationRentals)[Flights to Seneca](https://expedia.com/Cheap-Flights-To-Seneca.d6548.Travel-Guide-Flights)[Car Rentals in Seneca](https://expedia.com/Car-Rentals-In-Seneca.d6548.Car-Rental-Guide) ![](https://images.trvl-media.com/place/6548/8356140f-bae9-4afc-8d65-c18efc5581aa.jpg?impolicy=fcrop&w=1200&h=300&q=medium) # Seneca Vacations from $378 ## Book a Hotel + Flight or Car together to unlock savings - ## Plan, book, travel with confidence - ### Better together Save up to $1,045 when you book a flight and hotel together\* - ### Find the right fit With over 300,000 hotels worldwide, it's easy to create a perfect package - ### Rest easy Plan, book, and manage your trip all in one place ## The Latest Seneca vacation packages Price found within the past 48 hours. Click for updated prices. ![Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG](https://images.trvl-media.com/lodging/1000000/10000/1400/1379/91409d5a_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG $378 per person May 8 - May 12 found 1 day ago Roundtrip flight included Newark Liberty Intl. Airport (EWR) to Greenville (GSP) 8.6/10 Excellent! (1,005 reviews) Great stay. Customer service was great. Reviewed on Feb 17, 2026 ![Horizon Inn & Suites](https://images.trvl-media.com/lodging/1000000/10000/6500/6496/1611bef6_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Horizon Inn & Suites $476 per person May 1 - May 4 found 16 hours ago Roundtrip flight included New York (NYC) to Greenville (GSP) 4.6/10 (222 reviews) Think it's an nice place at an affordable rate. Reviewed on Jan 15, 2026 ![Zoka - Modern Mountain Retreat](https://images.trvl-media.com/lodging/117000000/116630000/116623000/116622970/w1025h764x0y3-61477521_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Zoka - Modern Mountain Retreat Save 100% on your flight $1,167 per person Apr 16 - Apr 20 found 1 day ago Roundtrip flight included Detroit (DTW) to Greenville (GSP) No reviews ![Hotel Hartness](https://images.trvl-media.com/lodging/90000000/89690000/89689300/89689223/7f5c10e6_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Hotel Hartness Save 100% on your flight $696 per person May 1 - May 4 found 17 hours ago Roundtrip flight included New York (NYC) to Greenville (GSP) 9.8/10 Exceptional! (613 reviews) The room was really clean, staff very helpful and friendly. The hotel itself was really beautiful. Fitness center had nice equipment (only wish they also had a fan!) but it was well air-conditioned. Illy coffee/espresso in the room - was a plus! Really nice looking restaurant within a quick stroll from restaurant that we would have loved to check out if we had more time. Would stay again in a heartbeat and have recommended to family/friends already! Reviewed on Feb 21, 2026 ![Grand Bohemian Lodge Greenville, Autograph Collection](https://images.trvl-media.com/lodging/72000000/71770000/71762700/71762652/6a375dd3_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Grand Bohemian Lodge Greenville, Autograph Collection Greenville Downtown Save 100% on your flight $1,143 per person May 8 - May 12 found 1 day ago Roundtrip flight included Newark Liberty Intl. Airport (EWR) to Greenville (GSP) 9.6/10 Exceptional! (406 reviews) This hotel never disappoints, we had a wonderful and the staff was attentive and very welcoming. Reviewed on Feb 16, 2026 Don't see what you're looking for? See all available trips from Columbus to Seneca [View all trips](https://expedia.com/go/package/search/FlightHotel/2026-03-22/2026-03-29/?FromAirport=Columbus,%20Ohio,%20United%20States%20of%20America&Destination=GSP&NumRoom=1&NumAdult=2&NumChild=0&paandie=true) ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Vacation Sale Members save up to 40% on hotels and homes. Plan this year’s big trip and save. [Book now](https://expedia.com/deals?rfrr=PKG_SPRING_PROMO_6548) ## Where to stay in Seneca Find the best Seneca areas and neighborhoods for the activities you enjoy most. [Learn more about Seneca](https://expedia.com/Seneca.dx6548) ![Default Image](https://images.trvl-media.com/media/content/expus/graphics/deals/TE_Clouds_card_r1.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Serenity Bay Though Serenity Bay might not have many top sights, you can venture to the surrounding area to see attractions like Keowee Key Golf Course and Lake Keowee. [Find hotel + flight trips in Serenity Bay](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Serenity%20Bay&DestID=553248635976468572&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods) ![Boat Ride on Lake Hartwell](https://images.trvl-media.com/place/944725335916802048/1c54d8c1-0e1b-42ce-868f-a52d696b915a.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Downtown 3 out of top 10 points of interest in this area While visiting Downtown, you might make a stop by sights like Oconee County Library Seneca Branch and The Gauntlet. [Find hotel + flight trips in Downtown](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Downtown&DestID=944725335916802048&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods) ![Female Kayaker on Lake Keowee at Sunset](https://images.trvl-media.com/place/553248635976472456/3b558c58-c920-447c-ab12-ddbbcf97f799.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Pine Ridge Point While Pine Ridge Point isn't home to many top sights, Lake Keowee and Keowee Key Golf Course are some notable places to visit nearby. [Find hotel + flight trips in Pine Ridge Point](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Pine%20Ridge%20Point&DestID=553248635976472456&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods) ![Default Image](https://images.trvl-media.com/media/content/expus/graphics/deals/TE_Clouds_card_r1.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Indian Oaks While there might not be top attractions in Indian Oaks, you can explore the larger area and discover places like The Gauntlet and Seneca City Hall. [Find hotel + flight trips in Indian Oaks](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Indian%20Oaks&DestID=553248635976482027&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods) ![Default Image](https://images.trvl-media.com/media/content/expus/graphics/deals/TE_Clouds_card_r1.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Keowee Plantation When in Keowee Plantation, you can plan a visit to The Gauntlet and Seneca City Hall, some noteworthy sights in the nearby area. [Find hotel + flight trips in Keowee Plantation](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Keowee%20Plantation&DestID=553248635976477960&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods) ## Seneca Hotel Deals ![Lakeside Lodge Clemson](https://images.trvl-media.com/lodging/41000000/40220000/40217400/40217319/9732d3ff_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Lakeside Lodge Clemson 13500 Clemson Blvd Seneca SC Fully refundableReserve now, pay when you stay $123 nightly $135 total Feb 23 - Feb 24 Total with taxes and fees 9/10 Wonderful! (1,005 reviews) Everything was just okay. Nothing went above and beyond. When we arrived, the place was nearly empty. The entire outdoor halllway had sheets and garbage just piled at the doors. Our room felt like it was IN the parking lot. Reviewed on Feb 19, 2026 [](https://expedia.com/Hotel-Search?startDate=2%2F23%2F2026&endDate=2%2F24%2F2026&selected=40217319&PinnedHotelID=40217319&HadPinnedHotel=true®ionId=6548) ![Hampton Inn & Suites Seneca-Clemson Area](https://images.trvl-media.com/lodging/7000000/6700000/6696900/6696886/1436aba9_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Hampton Inn & Suites Seneca-Clemson Area 1011 East North 1st Street Seneca SC Fully refundableReserve now, pay when you stay $121 nightly $133 total Mar 8 - Mar 9 Total with taxes and fees 9.2/10 Wonderful! (680 reviews) (Rm 301)Morning after arriving, turned on shower and the faucet head fell into the shower. Called downstairs and told them what had happened and they got me a shower on the far end from my location (had to put on clothes to go to the other room and then return to my room). Very upset. Reviewed on Feb 16, 2026 [](https://expedia.com/Hotel-Search?startDate=3%2F8%2F2026&endDate=3%2F9%2F2026&selected=6696886&PinnedHotelID=6696886&HadPinnedHotel=true®ionId=6548) ![Tru by Hilton Seneca Clemson](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323330/10f1fcf8_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Tru by Hilton Seneca Clemson 13050 Clemson Blvd Seneca SC Fully refundableReserve now, pay when you stay $109 nightly $119 total Mar 15 - Mar 16 Total with taxes and fees 9.2/10 Wonderful! (810 reviews) Always clean and friendly! Reviewed on Feb 18, 2026 [](https://expedia.com/Hotel-Search?startDate=3%2F15%2F2026&endDate=3%2F16%2F2026&selected=34323330&PinnedHotelID=34323330&HadPinnedHotel=true®ionId=6548) [See all 1,642 properties in Seneca](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Package&startDate=2%2F23%2F2026&endDate=2%2F24%2F2026®ionId=6548) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Find the Best Seneca Vacation Packages ## Seneca Essential Information | Language | English | | --------------- | ----------- | | Currency | U.S dollars | | Population | 8,300 | | Max Temp Winter | 50ºF | | Max Temp Summer | 90ºF | ## More vacations you might like ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/all-inclusive_holidays_US.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) All Inclusive Vacations [](https://expedia.com/lp/theme-vacations/all-inclusive-vacations?rfrr=editorial.All_Inclusive%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/XPC_Beach_Overview_HR_v3.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Beach Vacations [](https://expedia.com/lp/theme-vacations/beach-vacations?rfrr=editorial.Beach_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/Family_holidays_US_3_.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Kid Friendly Vacations [](https://expedia.com/lp/theme-vacations/kid-friendly-vacations?rfrr=editorial.Kid_Friendly%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/04/29/frCA_Sejours_golf-Portugal.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Golf Vacations [](https://expedia.com/lp/theme-vacations/golf-vacations?rfrr=editorial.Golf_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/07/15/US_Luxury_VR_Miami.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Luxury Vacations [](https://expedia.com/lp/theme-vacations/luxury-vacations?rfrr=editorial.Luxury_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/08/29/romantic.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Romantic Vacations [](https://expedia.com/lp/theme-vacations/romantic-vacations?rfrr=editorial.Romantic_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/31952_v1_atfraraski22_insta_4.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Ski Vacations [](https://expedia.com/lp/theme-vacations/ski-vacations?rfrr=editorial.Ski_Vacations.click) ![Gay Friendly Vacations](https://forever.travel-assets.com/flex/flexmanager/images/2023/06/15/LGBTQIA_Holiday_Package.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) LGBTQ Friendly Vacations [](https://expedia.com/lp/theme-holidays/gay-friendly-holidays?rfrr=editorial.LGBTQ_Friendly%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2017/07/05/170615_Adventure_1320_2.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Adventure Vacations [](https://expedia.com/lp/theme-vacations/adventure-vacations?rfrr=editorial.Adventure_Vacations.click) ![Vacations in Month](https://forever.travel-assets.com/flex/flexmanager/images/2023/05/10/mesog-34434-card-venice.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Where to go when [](https://expedia.com/lp/b/where-to-go-when?rfrr=editorial.Where_to%20go%20when.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/21/honeymoon_hawaii.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Honeymoon Vacations [](https://expedia.com/lp/theme-vacations/honeymoon-vacations?rfrr=editorial.Honeymoon_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/23/Mountain-vacations.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Mountain Vacations [](https://expedia.com/lp/theme-vacations/mountain-vacations?rfrr=editorial.Mountain_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/23/fishing-vacations-2.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Fishing Vacations [](https://expedia.com/lp/theme-vacations/fishing-vacations?rfrr=editorial.Fishing_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2019/05/16/Hyatt%20Zilara%20Cancun%20-%20All%20Inclusive%20-%20Adults%20Only.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Adults Only Vacations [](https://expedia.com/lp/theme-vacations/adults-only-vacations?rfrr=editorial.Adults_Only%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/23/waterpark-vacations.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Waterpark Vacations [](https://expedia.com/lp/theme-vacations/waterpark-vacations?rfrr=editorial.Waterpark_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/08/Caribean_scuba_diving.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Scuba Diving Vacations [](https://expedia.com/lp/theme-vacations/scuba-diving-vacations?rfrr=editorial.Scuba_Diving%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/08/aruba_yoga.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Yoga Vacations [](https://expedia.com/lp/theme-vacations/yoga-vacations?rfrr=editorial.Yoga_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2023/04/04/EPS-RBC-SummerBeachVacations-AdobeStock_206356322.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Cheap Vacations [](https://expedia.com/lp/theme-vacations/cheap-vacations?rfrr=editorial.Cheap_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/06/26/1175883311.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Solo Vacations [](https://expedia.com/lp/b/vacations/solo-vacations?rfrr=editorial.Solo_Vacations.click) ## Frequently asked questions ### How much does a Seneca vacation package cost? ### What are the cheapest months to go to Seneca? ### How many days is enough for Seneca? ### How to find the best Seneca package deals? ### Is it cheaper to book a Seneca vacation as a package? ### When to book a vacation package to Seneca? ### Does Expedia offer Book Now, Pay Later Seneca vacation packages? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - [Hotels near Keowee Plantation ](https://www.expedia.com/Keowee-Plantation-Seneca-Hotels.0-n553248635976477960-0.Travel-Guide-Filter-Hotels) - [Hotels near Oconee County Regional ](https://www.expedia.com/Oconee-County-Regional-Airport-Hotels.0-aCEU-0.Travel-Guide-Filter-Hotels) - [Gay friendly Hotels in Keowee ](https://www.expedia.com/Keowee-Hotels-LGBT-Welcoming-Hotel.0-0-d553248635975848347-tLGBTWelcomingHotel.Travel-Guide-Filter-Hotels) - [Clemson Hotels ](https://www.expedia.com/Clemson-Hotels.d6594.Travel-Guide-Hotels) - [Hotels near Clemson University ](https://www.expedia.com/Clemson-University-Hotels.0-l6127431-0.Travel-Guide-Filter-Hotels) - [Hotels near Littlejohn Coliseum ](https://www.expedia.com/Littlejohn-Coliseum-Hotels.0-l6228662-0.Travel-Guide-Filter-Hotels) - [Flights from Utica ](https://www.expedia.com/lp/flights/553248634999334496/flights-from-utica) - [Flights from Oconee County 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