Seneca Vacations from $375

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The Latest Seneca vacation packages

Price found within the past 48 hours. Click for updated prices.
Holiday Inn Greenville - Woodruff Road by IHG

Holiday Inn Greenville - Woodruff Road by IHG

3 out of 5
Price was $438, price is now $375 per person
$375
per person
Mar 7 - Mar 10
found 11 hours ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Greenville (GSP)
8.6/10 Excellent! (661 reviews)
A very nice experience! The only thing was the indoor pool. It was cold during the evening but considering its winter. Its expected. Other than that. One of the best hotels that I've ever stayed at!!!

Reviewed on Jan 5, 2026

Hotel Hartness

Hotel Hartness

4 out of 5
Price was $691, price is now $573 per person
$573
per person
Mar 7 - Mar 10
found 11 hours ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Greenville (GSP)
9.8/10 Exceptional! (613 reviews)
Everything was great as usual this is our third year. We will be back again next year for our anniversary.

Reviewed on Jan 6, 2026

Hilton Greenville

Hilton Greenville

3.5 out of 5
Price was $480, price is now $408 per person
$408
per person
Mar 7 - Mar 10
found 11 hours ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Greenville (GSP)
8.2/10 Very Good! (1,004 reviews)
Convenient and clean

Reviewed on Jan 11, 2026

Homewood Suites by Hilton Greenville Downtown

Homewood Suites by Hilton Greenville Downtown

3 out of 5
Greenville Downtown
Price was $705, price is now $606 per person
$606
per person
Mar 7 - Mar 10
found 11 hours ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Greenville (GSP)
9.6/10 Exceptional! (1,002 reviews)
Nice hotel, nice location

Reviewed on Jan 26, 2026

Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection

4 out of 5
Greenville Downtown
Price was $1,019, price is now $884 per person
$884
per person
Mar 7 - Mar 10
found 11 hours ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Greenville (GSP)
9.6/10 Exceptional! (406 reviews)
I would have given it five stars, but the only reason I didn’t is because breakfast they only serve bacon and pork sausage. I wish they would have had turkey sausage, vegan sausage or beef as well to choose from but the food is delicious.!!!!

Reviewed on Jan 28, 2026

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Where to stay in Seneca

Find the best Seneca areas and neighborhoods for the activities you enjoy most. Learn more about Seneca
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Serenity Bay

Though Serenity Bay might not have many top sights, you can venture to the surrounding area to see attractions like Keowee Key Golf Course and Lake Keowee.

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Seneca Hotel Deals

Lakeside Lodge Clemson

Lakeside Lodge Clemson

2.5 out of 5
13500 Clemson Blvd Seneca SC
Fully refundableReserve now, pay when you stay
$123 nightly
The price is $135 total per night from Jan 31 to Feb 1
$135 total
Jan 31 - Feb 1
Total with taxes and fees
8.8/10 Excellent! (1,007 reviews)
Spotless room, great staff, and amenities

Reviewed on Jan 25, 2026

Lakeside Lodge Clemson
Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson

2.5 out of 5
13050 Clemson Blvd Seneca SC
Fully refundableReserve now, pay when you stay
$98 nightly
The price is $107 total per night from Feb 4 to Feb 5
$107 total
Feb 4 - Feb 5
Total with taxes and fees
9.2/10 Wonderful! (805 reviews)
The staff here are top tier! We had to be at a meet at the university by 6am and they made breakfast early so our kids could eat before the meet! Genuine care for their guest! Love it here!

Reviewed on Jan 11, 2026

Tru by Hilton Seneca Clemson
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

2 out of 5
299 Outpost Rd Seneca SC
$116 nightly
The price is $127 total per night from Feb 2 to Feb 3
$127 total
Feb 2 - Feb 3
Total with taxes and fees
9.6/10 Exceptional! (55 reviews)
Yes so comfortable

Reviewed on Jan 18, 2026

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
See all 1,644 properties in Seneca
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Seneca Vacation Packages

Seneca Essential Information

Language
English
Currency
U.S dollars
Population
8,300
Max Temp Winter
50ºF
Max Temp Summer
90ºF

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Frequently asked questions

How much does a Seneca vacation package cost?
You'll find cheap prices from $375 on Expedia for your Seneca break. However, factors like the season, choice of hotel and length of stay will determine how much your vacation to Seneca costs.
What are the cheapest months to go to Seneca?
You can typically find lower rates and better availability in September, October and December. Browse our cheap Seneca vacation packages and you could land some great off-season discounts.
How many days is enough for Seneca?
Usually, a handful of days is enough to tick off the top attractions during your Seneca vacation. But if you prefer to have more time to rest or go on day tours, consider extending your itinerary.
How to find the best Seneca package deals?
Start your search for a Seneca package deal by entering your destination and travel dates under our "Packages" tab. Then add some filters, like "Guest rating" and "Property type," to tailor the results to your exact style. You can also sort by "Package discount" and browse offers that come with irresistible savings. If you don't find the perfect Seneca package deal right away, simply tweak your dates and search again. Keep in mind that deals are only available for a limited time, so book early and get your Seneca escape underway.
Is it cheaper to book a Seneca vacation as a package?
Expedia vacation packages are designed to give you more bang for your buck. Bundle your hotel, car rental and flight into one great-value price and you could save hundreds of dollars. You'll generally get a better deal than booking each component separately. And you'll still enjoy the freedom to create a personalized Seneca vacation by choosing your preferred type of stay, airline and car class.
When to book a vacation package to Seneca?
If you've got your Seneca travel dates locked in, book as early as you can to grab some fantastic deals. With Expedia, you can typically reserve some flights up to one year ahead of time. Prefer spur-of-the-moment getaways? Our last-minute deals are great for traveling on a whim.
Does Expedia offer Book Now, Pay Later Seneca vacation packages?
Set off on your perfect escape to Seneca with help from our Book Now, Pay Later vacations. There's no need to scrimp and save or wait until your next payday — we've joined forces with online lender Affirm to give you financial flexibility. Our vacation packages with payment plans allow you to spread the total cost over 3, 6 or 12 months. With no hidden charges or late payment fees, you can easily stay on budget and snap up cheap deals before they disappear.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.