Title: Uncover Seneca Vacation Book from $217 | Expedia.com

[Seneca Travel Guide](https://expedia.com/Seneca.dx6548)[Hotels in Seneca](https://expedia.com/Seneca-Hotels.d6548.Travel-Guide-Hotels)[Vacation Rentals in Seneca](https://expedia.com/Seneca-Vacation-Rentals.d6548.Travel-Guide-VacationRentals)[Flights to Seneca](https://expedia.com/Cheap-Flights-To-Seneca.d6548.Travel-Guide-Flights)[Car Rentals in Seneca](https://expedia.com/Car-Rentals-In-Seneca.d6548.Car-Rental-Guide)

![](https://images.trvl-media.com/place/6548/8356140f-bae9-4afc-8d65-c18efc5581aa.jpg?impolicy=fcrop&w=1200&h=300&q=medium)

# Seneca Vacations from $217

## Book a Hotel + Flight or Car together to unlock savings

- ##  
Plan, book, travel with confidence
- ###  
Better together  
Save up to $1,045 when you book a flight and hotel together\*
- ###  
Find the right fit  
With over 300,000 hotels worldwide, it's easy to create a perfect package
- ###  
Rest easy  
Plan, book, and manage your trip all in one place

## The Latest Seneca vacation packages

Price found within the past 48 hours. Click for updated prices.

![Quality Inn Seneca Clemson Area US-123](https://images.trvl-media.com/lodging/1000000/80000/76800/76800/375f69b2_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Quality Inn Seneca Clemson Area US-123

Downtown

$217

per person

Apr 6 - Apr 9

found 1 hour ago

Roundtrip flight included

New York (NYC) to Greenville (GSP)

8/10 Very Good! (658 reviews)

Room was very clean, the grounds was in well taken care of, was safe. Overall a good place to stay.

Reviewed on Feb 8, 2026

![Hotel Hartness](https://images.trvl-media.com/lodging/90000000/89690000/89689300/89689223/7f5c10e6_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Hotel Hartness

$481

per person

Mar 12 - Mar 15

found 6 hours ago

Roundtrip flight included

Newark Liberty Intl. Airport (EWR) to Greenville (GSP)

9.8/10 Exceptional! (613 reviews)

Cleanliness, friendliness and loved the vibe!

Reviewed on Feb 8, 2026

![Outpost Inn](https://images.trvl-media.com/lodging/12000000/11890000/11881100/11881029/0de126cd_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Outpost Inn

Save 100% on your flight

$488

per person

Mar 20 - Mar 23

found 6 hours ago

Roundtrip flight included

Philadelphia (PHL) to Greenville (GSP)

8.6/10 Excellent! (289 reviews)

The property was very welcoming to myself, my wife, and our dog! Methodical Coffee onsite in the lobby was an added bonus. Would definitely recommend the Outpost Inn to anyone looking for a great place in Highlands!

Reviewed on Dec 16, 2025

![Holiday Inn Greenville - Woodruff Road by IHG](https://images.trvl-media.com/lodging/42000000/41970000/41964400/41964398/00aa6485_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Holiday Inn Greenville - Woodruff Road by IHG

$376

per person

Mar 12 - Mar 15

found 6 hours ago

Roundtrip flight included

Newark Liberty Intl. Airport (EWR) to Greenville (GSP)

8.6/10 Excellent! (661 reviews)

A very nice experience! The only thing was the indoor pool. It was cold during the evening but considering its winter. Its expected. Other than that. One of the best hotels that I've ever stayed at!!!

Reviewed on Jan 5, 2026

![Hyatt Place Greenville Downtown](https://images.trvl-media.com/lodging/28000000/27050000/27043000/27042919/dac522c0_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Hyatt Place Greenville Downtown

Greenville Downtown

$615

per person

Apr 3 - Apr 6

found 4 hours ago

Roundtrip flight included

New York (LGA) to Greenville (GSP)

9.2/10 Wonderful! (1,001 reviews)

Great place, great experience. All it is missing an upgrade on the tv systems. Other than that, exactly what I needed. Staff is friendly too.

Reviewed on Jan 26, 2026

Don't see what you're looking for?

See all available trips from Columbus to Seneca

[View all trips](https://expedia.com/go/package/search/FlightHotel/2026-03-09/2026-03-16/?FromAirport=Columbus,%20Ohio,%20United%20States%20of%20America&Destination=GSP&NumRoom=1&NumAdult=2&NumChild=0&paandie=true)

## Where to stay in Seneca

Find the best Seneca areas and neighborhoods for the activities you enjoy most. [Learn more about Seneca](https://expedia.com/Seneca.dx6548)

![Default Image](https://images.trvl-media.com/media/content/expus/graphics/deals/TE_Clouds_card_r1.jpg?impolicy=fcrop&w=350&h=192&q=medium)

### Serenity Bay

 Though Serenity Bay might not have many top sights, you can venture to the surrounding area to see attractions like Keowee Key Golf Course and Lake Keowee. 

[Find hotel + flight trips in Serenity Bay](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Serenity%20Bay&DestID=553248635976468572&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods)

![Boat Ride on Lake Hartwell](https://images.trvl-media.com/place/944725335916802048/1c54d8c1-0e1b-42ce-868f-a52d696b915a.jpg?impolicy=fcrop&w=350&h=192&q=medium)

### Downtown

2 out of top 10 points of interest in this area

 While visiting Downtown, you might make a stop by sights like Oconee County Library Seneca Branch and The Gauntlet. 

[Find hotel + flight trips in Downtown](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Downtown&DestID=944725335916802048&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods)

![Female Kayaker on Lake Keowee at Sunset](https://images.trvl-media.com/place/553248635976472456/3b558c58-c920-447c-ab12-ddbbcf97f799.jpg?impolicy=fcrop&w=350&h=192&q=medium)

### Pine Ridge Point

 While Pine Ridge Point isn't home to many top sights, South Beach and Lake Keowee are some notable places to visit nearby. 

[Find hotel + flight trips in Pine Ridge Point](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Pine%20Ridge%20Point&DestID=553248635976472456&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods)

![Default Image](https://images.trvl-media.com/media/content/expus/graphics/deals/TE_Clouds_card_r1.jpg?impolicy=fcrop&w=350&h=192&q=medium)

### Indian Oaks

 While there might not be top attractions in Indian Oaks, you can explore the larger area and discover places like The Gauntlet and Seneca City Hall. 

[Find hotel + flight trips in Indian Oaks](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Indian%20Oaks&DestID=553248635976482027&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods)

![Default Image](https://images.trvl-media.com/media/content/expus/graphics/deals/TE_Clouds_card_r1.jpg?impolicy=fcrop&w=350&h=192&q=medium)

### Keowee Plantation

 When in Keowee Plantation, you can plan a visit to The Gauntlet and Seneca City Hall, some noteworthy sights in the nearby area. 

[Find hotel + flight trips in Keowee Plantation](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Keowee%20Plantation&DestID=553248635976477960&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods)

## Seneca Hotel Deals

![Lakeside Lodge Clemson](https://images.trvl-media.com/lodging/41000000/40220000/40217400/40217319/9732d3ff_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Lakeside Lodge Clemson

13500 Clemson Blvd Seneca SC

Fully refundableReserve now, pay when you stay

$123 nightly

$135 total

Feb 10 - Feb 11

Total with taxes and fees

8.8/10 Excellent! (1,000 reviews)

Friendly front desk staff, close to stores and Clemson U

Reviewed on Feb 2, 2026

[](https://expedia.com/Hotel-Search?startDate=2%2F10%2F2026&endDate=2%2F11%2F2026&selected=40217319&PinnedHotelID=40217319&HadPinnedHotel=true&regionId=6548)

![Hampton Inn & Suites Seneca-Clemson Area](https://images.trvl-media.com/lodging/7000000/6700000/6696900/6696886/1436aba9_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Hampton Inn & Suites Seneca-Clemson Area

1011 East North 1st Street Seneca SC

Fully refundableReserve now, pay when you stay

$122 nightly

$135 total

Mar 1 - Mar 2

Total with taxes and fees

9.2/10 Wonderful! (676 reviews)

Woman at the front desk

Reviewed on Jan 27, 2026

[](https://expedia.com/Hotel-Search?startDate=3%2F1%2F2026&endDate=3%2F2%2F2026&selected=6696886&PinnedHotelID=6696886&HadPinnedHotel=true&regionId=6548)

![Tru by Hilton Seneca Clemson](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323330/10f1fcf8_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Tru by Hilton Seneca Clemson

13050 Clemson Blvd Seneca SC

Fully refundableReserve now, pay when you stay

$110 nightly

$121 total

Feb 17 - Feb 18

Total with taxes and fees

9.2/10 Wonderful! (807 reviews)

Great staff

Reviewed on Feb 7, 2026

[](https://expedia.com/Hotel-Search?startDate=2%2F17%2F2026&endDate=2%2F18%2F2026&selected=34323330&PinnedHotelID=34323330&HadPinnedHotel=true&regionId=6548)

[See all 1,652 properties in Seneca](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Package&startDate=2%2F10%2F2026&endDate=2%2F11%2F2026&regionId=6548)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

## Find the Best Seneca Vacation Packages

## Seneca Essential Information

| Language        | English     |
| --------------- | ----------- |
| Currency        | U.S dollars |
| Population      | 8,300       |
| Max Temp Winter | 50ºF        |
| Max Temp Summer | 90ºF        |

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## Frequently asked questions

### How much does a Seneca vacation package cost?

### What are the cheapest months to go to Seneca?

### How many days is enough for Seneca?

### How to find the best Seneca package deals?

### Is it cheaper to book a Seneca vacation as a package?

### When to book a vacation package to Seneca?

### Does Expedia offer Book Now, Pay Later Seneca vacation packages?

## Explore a world of travel with Expedia

- Lodging
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- [Flights from Auburn (AUO) to Clemson (CEU) ](https://www.expedia.com/lp/flights/auo/ceu/auburn-to-clemson)
- [Flights from Seattle (SEA) to Clemson (CEU) ](https://www.expedia.com/lp/flights/sea/ceu/seattle-to-clemson)
- [Flights from Washington (IAD) to Clemson (CEU) ](https://www.expedia.com/lp/flights/iad/ceu/washington-to-clemson)
- [Flights from Madison (MSN) to Clemson (CEU) ](https://www.expedia.com/lp/flights/msn/ceu/madison-to-clemson)
- [Flights from Cleveland (CLE) to Clemson (CEU) ](https://www.expedia.com/lp/flights/cle/ceu/cleveland-to-clemson)
- [Flights from Florence (FLR) to Clemson (CEU) ](https://www.expedia.com/lp/flights/flr/ceu/florence-to-clemson)
- [Flights from Harrisburg (MDT) to Clemson (CEU) ](https://www.expedia.com/lp/flights/mdt/ceu/harrisburg-to-clemson)
- [Flights from Phoenix (PHX) to Clemson (CEU) ](https://www.expedia.com/lp/flights/phx/ceu/phoenix-to-clemson)
- [Flights from Rochester (ROC) to Clemson (CEU) ](https://www.expedia.com/lp/flights/roc/ceu/rochester-to-clemson)
- [Flights from Burlington (BTV) to Clemson (CEU) ](https://www.expedia.com/lp/flights/btv/ceu/burlington-to-clemson)
- [Flights from Portland (PDX) to Clemson (CEU) ](https://www.expedia.com/lp/flights/pdx/ceu/portland-to-clemson)
- [Flights from Grand Rapids (GRR) to Clemson (CEU) ](https://www.expedia.com/lp/flights/grr/ceu/grand-rapids-to-clemson)
- [Flights from Sarasota (SRQ) to Clemson (CEU) ](https://www.expedia.com/lp/flights/srq/ceu/sarasota-to-clemson)
- [Flights from Kansas City (MCI) to Clemson (CEU) ](https://www.expedia.com/lp/flights/mci/ceu/kansas-city-to-clemson)
- [Flights from Norfolk (ORF) to Clemson (CEU) ](https://www.expedia.com/lp/flights/orf/ceu/norfolk-to-clemson)
- [Flights from Cedar Rapids (CID) to Clemson (CEU) ](https://www.expedia.com/lp/flights/cid/ceu/cedar-rapids-to-clemson)
- [Flights from Oklahoma City (OKC) to Clemson (CEU) ](https://www.expedia.com/lp/flights/okc/ceu/oklahoma-city-to-clemson)
- [Flights from Little Rock (LIT) to Clemson (CEU) ](https://www.expedia.com/lp/flights/lit/ceu/little-rock-to-clemson)
- [Flights from Wichita (ICT) to Clemson (CEU) ](https://www.expedia.com/lp/flights/ict/ceu/wichita-to-clemson)
- [Flights from London (LON) to Clemson (CEU) ](https://www.expedia.com/lp/flights/lon/ceu/london-to-clemson)
- [Flights from San Jose (SJC) to Clemson (CEU) ](https://www.expedia.com/lp/flights/sjc/ceu/san-jose-to-clemson)
- [Flights from Fayetteville (FAY) to Clemson (CEU) ](https://www.expedia.com/lp/flights/fay/ceu/fayetteville-to-clemson)
- [Flights from Toledo (TOL) to Clemson (CEU) ](https://www.expedia.com/lp/flights/tol/ceu/toledo-to-clemson)
- [Flights from Wilkes-Barre (AVP) to Clemson (CEU) ](https://www.expedia.com/lp/flights/avp/ceu/wilkes-barre-to-clemson)
- [Flights from Oakland (OAK) to Clemson (CEU) ](https://www.expedia.com/lp/flights/oak/ceu/oakland-to-clemson)
- [Flights from Orlando (SFB) to Clemson (CEU) ](https://www.expedia.com/lp/flights/sfb/ceu/orlando-to-clemson)
- [Flights from Binghamton (BGM) to Clemson (CEU) ](https://www.expedia.com/lp/flights/bgm/ceu/binghamton-to-clemson)
- [Flights from New York (NYC) to Clemson (CEU) ](https://www.expedia.com/lp/flights/nyc/ceu/new-york-to-clemson)
- [Flights from Mexico City (MEX) to Clemson (CEU) ](https://www.expedia.com/lp/flights/mex/ceu/mexico-city-to-clemson)
- [Flights from San Juan (SJU) to Clemson (CEU) ](https://www.expedia.com/lp/flights/sju/ceu/san-juan-to-clemson)
- [Flights from Gatlinburg (GKT) to Clemson (CEU) ](https://www.expedia.com/lp/flights/gkt/ceu/gatlinburg-to-clemson)
- [Flights from Panama City (PTY) to Clemson (CEU) ](https://www.expedia.com/lp/flights/pty/ceu/panama-city-to-clemson)
- [Flights from Colorado Springs (COS) to Clemson (CEU) ](https://www.expedia.com/lp/flights/cos/ceu/colorado-springs-to-clemson)
- [Flights from Fresno (FAT) to Clemson (CEU) ](https://www.expedia.com/lp/flights/fat/ceu/fresno-to-clemson)
- [Flights from Moline (MLI) to Clemson (CEU) ](https://www.expedia.com/lp/flights/mli/ceu/moline-to-clemson)
- [Flights from Tokyo (TYO) to Clemson (CEU) ](https://www.expedia.com/lp/flights/tyo/ceu/tokyo-to-clemson)
- [Flights from Sacramento (SMF) to Clemson (CEU) ](https://www.expedia.com/lp/flights/smf/ceu/sacramento-to-clemson)
- [Flights from Anderson (AND) to Clemson (CEU) ](https://www.expedia.com/lp/flights/and/ceu/anderson-to-clemson)
- [Flights from Houston (IAH) to Clemson (CEU) ](https://www.expedia.com/lp/flights/iah/ceu/houston-to-clemson)
- [Flights from Copenhagen (CPH) to Clemson (CEU) ](https://www.expedia.com/lp/flights/cph/ceu/copenhagen-to-clemson)
- [Flights from Frankfurt (FRA) to Clemson (CEU) ](https://www.expedia.com/lp/flights/fra/ceu/frankfurt-to-clemson)
- [Flights from Manchester (MAN) to Clemson (CEU) ](https://www.expedia.com/lp/flights/man/ceu/manchester-to-clemson)

- [Littlejohn Coliseum ](https://www.expedia.com/Littlejohn-Coliseum-Clemson.d6228662.Vacation-Attraction)
- [Memorial Stadium ](https://www.expedia.com/Memorial-Stadium-Clemson.d6193935.Vacation-Attraction)
- [Fort Hill ](https://www.expedia.com/Fort-Hill-Clemson.d553248621532656693.Vacation-Attraction)
- [Larry W. Abernathy Waterfront Park ](https://www.expedia.com/Larry-W-Abernathy-Waterfront-Park-Clemson.d553248621532656695.Vacation-Attraction)
- [Lee Gallery ](https://www.expedia.com/Lee-Gallery-Clemson.d553248621532656692.Vacation-Attraction)

- [Car rentals near Utica ](https://www.expedia.com/Car-Rentals-In-Utica.d553248634999334496.Car-Rental-Guide)
- [Car rentals near Newry ](https://www.expedia.com/Car-Rentals-In-Newry.d553248635975874451.Car-Rental-Guide)
- [Car rental Seneca Airport (CEU) ](https://www.expedia.com/Car-Rentals-In-Oconee-County-Regional.d6026946.Car-Rental-Guide)
- [Car rentals near Keowee ](https://www.expedia.com/Car-Rentals-In-Keowee.d553248635975848347.Car-Rental-Guide)
- [Car rentals near Littlejohn Coliseum ](https://www.expedia.com/Car-Rentals-In-Littlejohn-Coliseum.d6228662.Car-Rental-Guide)

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