Title: Secure Seneca Vacation Packages for 2026 | Expedia.com [Seneca Travel Guide](https://expedia.com/Seneca.dx6548)[Hotels in Seneca](https://expedia.com/Seneca-Hotels.d6548.Travel-Guide-Hotels)[Vacation Rentals in Seneca](https://expedia.com/Seneca-Vacation-Rentals.d6548.Travel-Guide-VacationRentals)[Flights to Seneca](https://expedia.com/Cheap-Flights-To-Seneca.d6548.Travel-Guide-Flights)[Car Rentals in Seneca](https://expedia.com/Car-Rentals-In-Seneca.d6548.Car-Rental-Guide) ![](https://images.trvl-media.com/place/6548/8356140f-bae9-4afc-8d65-c18efc5581aa.jpg?impolicy=fcrop&w=1200&h=300&q=medium) # Seneca Vacations from $580 ## Book a Hotel + Flight or Car together to unlock savings - ## Plan, book, travel with confidence - ### Better together Save up to $1,045 when you book a flight and hotel together\* - ### Find the right fit With over 300,000 hotels worldwide, it's easy to create a perfect package - ### Rest easy Plan, book, and manage your trip all in one place ## The Latest Seneca vacation packages Price found within the past 48 hours. Click for updated prices. ![Hotel Hartness](https://images.trvl-media.com/lodging/90000000/89690000/89689300/89689223/7f5c10e6_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Hotel Hartness $580 per person Apr 24 - Apr 27 found 1 day ago Roundtrip non-stop flight included Baltimore (BWI) to Greenville (GSP) 9.8/10 Exceptional! (613 reviews) We’ve had the most wonderful stay at Hotel Hartness. Can’t wait to return. Reviewed on Feb 17, 2026 ![Swamp Rabbit Inn](https://images.trvl-media.com/lodging/11000000/10250000/10240700/10240653/cba17315_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Swamp Rabbit Inn Greenville Downtown Save 100% on your flight $822 per person May 2 - May 7 found 22 hours ago Roundtrip flight included New York (NYC) to Greenville (GSP) 9/10 Wonderful! (361 reviews) Great location and safe, free parking on the property. Close and walkable to everything. The inn is very quaint and comfortable…as an older home sound travels…could hear the guest above us walking around in the middle of the night, he/she did fall asleep as evidenced through the audible snoring evident til morning. Reviewed on Oct 26, 2025 ![Grand Bohemian Lodge Greenville, Autograph Collection](https://images.trvl-media.com/lodging/72000000/71770000/71762700/71762652/6a375dd3_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Grand Bohemian Lodge Greenville, Autograph Collection Greenville Downtown $834 per person Apr 8 - Apr 11 found 22 hours ago Roundtrip non-stop flight included Boston (BOS) to Greenville (GSP) 9.6/10 Exceptional! (406 reviews) This hotel never disappoints, we had a wonderful and the staff was attentive and very welcoming. Reviewed on Feb 16, 2026 ![Mint House Greenville - Downtown](https://images.trvl-media.com/lodging/39000000/38600000/38593300/38593248/a4b477d7_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Mint House Greenville - Downtown Greenville Downtown $766 per person May 2 - May 7 found 22 hours ago Roundtrip flight included New York (NYC) to Greenville (GSP) 9.2/10 Wonderful! (763 reviews) The room was beautiful and very clean. The check-in process was extremely difficult. I couldn't finish checkin as requested from the original email and had to spend 30 minutes on the phone with them to complete that process and gain access to the building. Then my code to my room did not work, which prompted another call. Then I had to follow a third link to pay for parking. I do not like staying somewhere that does not have staff on site. As much as I enjoyed the room, I will not likely stay here again. Reviewed on Jan 21, 2026 Don't see what you're looking for? See all available trips from Columbus to Seneca [View all trips](https://expedia.com/go/package/search/FlightHotel/2026-03-17/2026-03-24/?FromAirport=Columbus,%20Ohio,%20United%20States%20of%20America&Destination=GSP&NumRoom=1&NumAdult=2&NumChild=0&paandie=true) ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Vacation Sale Members save up to 40% on hotels and homes. Plan this year’s big trip and save. [Book now](https://expedia.com/deals?rfrr=PKG_SPRING_PROMO_6548) ## Where to stay in Seneca Find the best Seneca areas and neighborhoods for the activities you enjoy most. [Learn more about Seneca](https://expedia.com/Seneca.dx6548) ![Default Image](https://images.trvl-media.com/media/content/expus/graphics/deals/TE_Clouds_card_r1.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Serenity Bay Though Serenity Bay might not have many top sights, you can venture to the surrounding area to see attractions like Keowee Key Golf Course and Lake Keowee. [Find hotel + flight trips in Serenity Bay](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Serenity%20Bay&DestID=553248635976468572&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods) ![Boat Ride on Lake Hartwell](https://images.trvl-media.com/place/944725335916802048/1c54d8c1-0e1b-42ce-868f-a52d696b915a.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Downtown 3 out of top 10 points of interest in this area While visiting Downtown, you might make a stop by sights like Oconee County Library Seneca Branch and The Gauntlet. [Find hotel + flight trips in Downtown](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Downtown&DestID=944725335916802048&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods) ![Female Kayaker on Lake Keowee at Sunset](https://images.trvl-media.com/place/553248635976472456/3b558c58-c920-447c-ab12-ddbbcf97f799.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Pine Ridge Point While Pine Ridge Point isn't home to many top sights, Lake Keowee and Keowee Key Golf Course are some notable places to visit nearby. [Find hotel + flight trips in Pine Ridge Point](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Pine%20Ridge%20Point&DestID=553248635976472456&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods) ![Default Image](https://images.trvl-media.com/media/content/expus/graphics/deals/TE_Clouds_card_r1.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Indian Oaks While there might not be top attractions in Indian Oaks, you can explore the larger area and discover places like The Gauntlet and Seneca City Hall. [Find hotel + flight trips in Indian Oaks](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Indian%20Oaks&DestID=553248635976482027&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods) ![Default Image](https://images.trvl-media.com/media/content/expus/graphics/deals/TE_Clouds_card_r1.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Keowee Plantation When in Keowee Plantation, you can plan a visit to The Gauntlet and Seneca City Hall, some noteworthy sights in the nearby area. [Find hotel + flight trips in Keowee Plantation](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Keowee%20Plantation&DestID=553248635976477960&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods) ## Seneca Hotel Deals ![Lakeside Lodge Clemson](https://images.trvl-media.com/lodging/41000000/40220000/40217400/40217319/9732d3ff_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Lakeside Lodge Clemson 13500 Clemson Blvd Seneca SC Fully refundableReserve now, pay when you stay $123 nightly $135 total Feb 22 - Feb 23 Total with taxes and fees 8.8/10 Excellent! (1,000 reviews) Great place and location, great mattress, Reviewed on Feb 11, 2026 [](https://expedia.com/Hotel-Search?startDate=2%2F22%2F2026&endDate=2%2F23%2F2026&selected=40217319&PinnedHotelID=40217319&HadPinnedHotel=true®ionId=6548) ![Hampton Inn & Suites Seneca-Clemson Area](https://images.trvl-media.com/lodging/7000000/6700000/6696900/6696886/1436aba9_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Hampton Inn & Suites Seneca-Clemson Area 1011 East North 1st Street Seneca SC Fully refundableReserve now, pay when you stay $120 nightly $132 total Mar 8 - Mar 9 Total with taxes and fees 9.2/10 Wonderful! (677 reviews) Woman at the front desk Reviewed on Jan 27, 2026 [](https://expedia.com/Hotel-Search?startDate=3%2F8%2F2026&endDate=3%2F9%2F2026&selected=6696886&PinnedHotelID=6696886&HadPinnedHotel=true®ionId=6548) ![Tru by Hilton Seneca Clemson](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323330/10f1fcf8_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Tru by Hilton Seneca Clemson 13050 Clemson Blvd Seneca SC $109 nightly $119 total Feb 24 - Feb 25 Total with taxes and fees 9.2/10 Wonderful! (807 reviews) Great staff Reviewed on Feb 7, 2026 [](https://expedia.com/Hotel-Search?startDate=2%2F24%2F2026&endDate=2%2F25%2F2026&selected=34323330&PinnedHotelID=34323330&HadPinnedHotel=true®ionId=6548) [See all 1,649 properties in Seneca](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Package&startDate=2%2F18%2F2026&endDate=2%2F19%2F2026®ionId=6548) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Find the Best Seneca Vacation Packages ## Seneca Essential Information | Language | English | | --------------- | ----------- | | Currency | U.S dollars | | Population | 8,300 | | Max Temp Winter | 50ºF | | Max Temp Summer | 90ºF | ## More vacations you might like ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/all-inclusive_holidays_US.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) All Inclusive Vacations [](https://expedia.com/lp/theme-vacations/all-inclusive-vacations?rfrr=editorial.All_Inclusive%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/XPC_Beach_Overview_HR_v3.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Beach Vacations [](https://expedia.com/lp/theme-vacations/beach-vacations?rfrr=editorial.Beach_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/Family_holidays_US_3_.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Kid Friendly Vacations [](https://expedia.com/lp/theme-vacations/kid-friendly-vacations?rfrr=editorial.Kid_Friendly%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/04/29/frCA_Sejours_golf-Portugal.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Golf Vacations [](https://expedia.com/lp/theme-vacations/golf-vacations?rfrr=editorial.Golf_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/07/15/US_Luxury_VR_Miami.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Luxury Vacations [](https://expedia.com/lp/theme-vacations/luxury-vacations?rfrr=editorial.Luxury_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/08/29/romantic.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Romantic Vacations [](https://expedia.com/lp/theme-vacations/romantic-vacations?rfrr=editorial.Romantic_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/31952_v1_atfraraski22_insta_4.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Ski Vacations [](https://expedia.com/lp/theme-vacations/ski-vacations?rfrr=editorial.Ski_Vacations.click) ![Gay Friendly Vacations](https://forever.travel-assets.com/flex/flexmanager/images/2023/06/15/LGBTQIA_Holiday_Package.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) LGBTQ Friendly Vacations [](https://expedia.com/lp/theme-holidays/gay-friendly-holidays?rfrr=editorial.LGBTQ_Friendly%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2017/07/05/170615_Adventure_1320_2.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Adventure Vacations [](https://expedia.com/lp/theme-vacations/adventure-vacations?rfrr=editorial.Adventure_Vacations.click) ![Vacations in Month](https://forever.travel-assets.com/flex/flexmanager/images/2023/05/10/mesog-34434-card-venice.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Where to go when [](https://expedia.com/lp/b/where-to-go-when?rfrr=editorial.Where_to%20go%20when.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/21/honeymoon_hawaii.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Honeymoon Vacations [](https://expedia.com/lp/theme-vacations/honeymoon-vacations?rfrr=editorial.Honeymoon_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/23/Mountain-vacations.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Mountain Vacations [](https://expedia.com/lp/theme-vacations/mountain-vacations?rfrr=editorial.Mountain_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/23/fishing-vacations-2.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Fishing Vacations [](https://expedia.com/lp/theme-vacations/fishing-vacations?rfrr=editorial.Fishing_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2019/05/16/Hyatt%20Zilara%20Cancun%20-%20All%20Inclusive%20-%20Adults%20Only.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Adults Only Vacations [](https://expedia.com/lp/theme-vacations/adults-only-vacations?rfrr=editorial.Adults_Only%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/23/waterpark-vacations.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Waterpark Vacations [](https://expedia.com/lp/theme-vacations/waterpark-vacations?rfrr=editorial.Waterpark_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/08/Caribean_scuba_diving.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Scuba Diving Vacations [](https://expedia.com/lp/theme-vacations/scuba-diving-vacations?rfrr=editorial.Scuba_Diving%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/08/aruba_yoga.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Yoga Vacations [](https://expedia.com/lp/theme-vacations/yoga-vacations?rfrr=editorial.Yoga_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2023/04/04/EPS-RBC-SummerBeachVacations-AdobeStock_206356322.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Cheap Vacations [](https://expedia.com/lp/theme-vacations/cheap-vacations?rfrr=editorial.Cheap_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/06/26/1175883311.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Solo Vacations [](https://expedia.com/lp/b/vacations/solo-vacations?rfrr=editorial.Solo_Vacations.click) ## Frequently asked questions ### How much does a Seneca vacation package cost? ### What are the cheapest months to go to Seneca? ### How many days is enough for Seneca? ### How to find the best Seneca package deals? ### Is it cheaper to book a Seneca vacation as a package? ### When to book a vacation package to Seneca? ### Does Expedia offer Book Now, Pay Later Seneca vacation packages? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - [Hotels near Keowee Plantation ](https://www.expedia.com/Keowee-Plantation-Seneca-Hotels.0-n553248635976477960-0.Travel-Guide-Filter-Hotels) - [Hotels near Oconee County Regional ](https://www.expedia.com/Oconee-County-Regional-Airport-Hotels.0-aCEU-0.Travel-Guide-Filter-Hotels) - [Gay friendly Hotels in Keowee ](https://www.expedia.com/Keowee-Hotels-LGBT-Welcoming-Hotel.0-0-d553248635975848347-tLGBTWelcomingHotel.Travel-Guide-Filter-Hotels) - [Clemson Hotels ](https://www.expedia.com/Clemson-Hotels.d6594.Travel-Guide-Hotels) - [Hotels near Clemson University ](https://www.expedia.com/Clemson-University-Hotels.0-l6127431-0.Travel-Guide-Filter-Hotels) - [Hotels near Littlejohn Coliseum ](https://www.expedia.com/Littlejohn-Coliseum-Hotels.0-l6228662-0.Travel-Guide-Filter-Hotels) - [Flights from Utica ](https://www.expedia.com/lp/flights/553248634999334496/flights-from-utica) - [Flights from Oconee County Regional ](https://www.expedia.com/lp/airports/ceu/flights-from-oconee-county-regional-airport) - [Flights from Atlanta (ATL) to Clemson (CEU) ](https://www.expedia.com/lp/flights/atl/ceu/atlanta-to-clemson) - [Flights from Charlotte (CLT) to Clemson (CEU) ](https://www.expedia.com/lp/flights/clt/ceu/charlotte-to-clemson) - [Flights from New York (JFK) to Clemson (CEU) ](https://www.expedia.com/lp/flights/jfk/ceu/new-york-to-clemson) - [Flights from Boston (BOS) to Clemson (CEU) ](https://www.expedia.com/lp/flights/bos/ceu/boston-to-clemson) - [Flights from Asheville (AVL) to Clemson (CEU) ](https://www.expedia.com/lp/flights/avl/ceu/asheville-to-clemson) - [Flights from Washington (DCA) to Clemson (CEU) ](https://www.expedia.com/lp/flights/dca/ceu/washington-to-clemson) - [Flights from Philadelphia (PHL) to Clemson (CEU) ](https://www.expedia.com/lp/flights/phl/ceu/philadelphia-to-clemson) - [Flights from Miami (MIA) to Clemson (CEU) 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