
Seneca Vacations from $441
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The Latest Seneca vacation packages
Price found within the past 48 hours. Click for updated prices.

Comfort Inn & Suites Greer - Greenville
Price was $496, price is now $441 per person
$441
per person
May 15 - May 17
found 1 day ago
Roundtrip non-stop flight included
Tampa (TPA) to Greenville (GSP)
8.6/10 Excellent! (711 reviews)
Very friendly staff. Easy check-in checkout process. Clean room and property with all the necessary amenities.
Only negative is that the bed frames are a little squeaky. I think this is because they are made of metal. The mattress and pillows themselves were comfortable. Otherwise and enjoyable stay in good value.
Reviewed on Mar 1, 2026



Grand Bohemian Lodge Greenville, Autograph Collection
Greenville Downtown
Price was $868, price is now $753 per person
$753
per person
May 15 - May 17
found 1 day ago
Roundtrip non-stop flight included
Tampa (TPA) to Greenville (GSP)
9.6/10 Exceptional! (457 reviews)
Perfectly located to walk to the river, downtown and peace center. Gorgeous asthetic, and pristine rooms, we loved the restaurant also! Staff we courteous and helpful in everyway. 10/10
Reviewed on Mar 2, 2026

Where to stay in Seneca
Find the best Seneca areas and neighborhoods for the activities you enjoy most. Learn more about Seneca

Serenity Bay
Though Serenity Bay might not have many top sights, you can venture to the surrounding area to see attractions like Keowee Key Golf Course and Lake Keowee.
Seneca Hotel Deals

Lakeside Lodge Clemson
13500 Clemson Blvd Seneca SC
Fully refundableReserve now, pay when you stay
$123 nightly
The price is $135 total per night from Mar 4 to Mar 5
$135 total
Mar 4 - Mar 5
Total with taxes and fees
9/10 Wonderful! (1,002 reviews)
spacious "lake view" room. good value
Reviewed on Mar 2, 2026

Quality Inn Seneca Clemson Area US-123
226 Hi Tech Rd Seneca SC
Fully refundableReserve now, pay when you stay
$84 nightly
The price is $92 total per night from Mar 10 to Mar 11
$92 total
Mar 10 - Mar 11
Total with taxes and fees
8/10 Very Good! (682 reviews)
All great
Reviewed on Feb 21, 2026

Hampton Inn & Suites Seneca-Clemson Area
1011 East North 1st Street Seneca SC
Fully refundableReserve now, pay when you stay
$122 nightly
The price is $135 total per night from Mar 15 to Mar 16
$135 total
Mar 15 - Mar 16
Total with taxes and fees
9.2/10 Wonderful! (683 reviews)
Great having a washer and dry available and the breakfast staff was amazing and very nice.
Reviewed on Feb 24, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Find the Best Seneca Vacation Packages
Seneca Essential Information
Language | English |
|---|---|
Currency | U.S dollars |
Population | 8,300 |
Max Temp Winter | 50ºF |
Max Temp Summer | 90ºF |
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