Seneca Vacations from $355

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The Latest Seneca vacation packages

Price found within the past 48 hours. Click for updated prices.
Quality Inn & Suites Greenville - Haywood Mall

Quality Inn & Suites Greenville - Haywood Mall

2.5 out of 5
Price was $399, price is now $355 per person
$355
per person
Mar 12 - Mar 16
found 17 hours ago
Roundtrip flight included
Chicago (MDW) to Greenville (GSP)
7.4/10 Good! (1,004 reviews)
My stay was enjoyed. Clean, quiet with plenty of parking

Reviewed on Dec 29, 2025

Landing Apartments - Lyman

Landing Apartments - Lyman

3 out of 5
Price was $656, price is now $573 per person
$573
per person
Apr 19 - Apr 22
found 14 hours ago
Roundtrip flight included
Denver (DEN) to Greenville (GSP)
No reviews
Mint House Greenville - Downtown

Mint House Greenville - Downtown

4 out of 5
Greenville Downtown
Price was $1,411, price is now $1,238 per person
$1,238
per person
Mar 4 - Mar 9
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Greenville (GSP)
9.2/10 Wonderful! (763 reviews)
The room was beautiful and very clean. The check-in process was extremely difficult. I couldn't finish checkin as requested from the original email and had to spend 30 minutes on the phone with them to complete that process and gain access to the building. Then my code to my room did not work, which prompted another call. Then I had to follow a third link to pay for parking. I do not like staying somewhere that does not have staff on site. As much as I enjoyed the room, I will not likely stay here again.

Reviewed on Jan 21, 2026

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Where to stay in Seneca

Find the best Seneca areas and neighborhoods for the activities you enjoy most. Learn more about Seneca
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Serenity Bay

Though Serenity Bay might not have many top sights, you can venture to the surrounding area to see attractions like Keowee Key Golf Course and Lake Keowee.

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Seneca Hotel Deals

Lakeside Lodge Clemson

Lakeside Lodge Clemson

2.5 out of 5
13500 Clemson Blvd Seneca SC
Fully refundableReserve now, pay when you stay
$123 nightly
The price is $135 total per night from Feb 3 to Feb 4
$135 total
Feb 3 - Feb 4
Total with taxes and fees
8.8/10 Excellent! (1,002 reviews)
It wasn’t bad and the people were friendly! Surprised by $100 pet fee!

Reviewed on Jan 30, 2026

Lakeside Lodge Clemson
Quality Inn Seneca Clemson Area US-123

Quality Inn Seneca Clemson Area US-123

2.5 out of 5
226 Hi Tech Rd Seneca SC
Fully refundableReserve now, pay when you stay
$84 nightly
The price is $92 total per night from Feb 10 to Feb 11
$92 total
Feb 10 - Feb 11
Total with taxes and fees
7.8/10 Good! (673 reviews)
Our stay was very nice. Clean room. The outside was clean.

Reviewed on Jan 20, 2026

Quality Inn Seneca Clemson Area US-123
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

2 out of 5
299 Outpost Rd Seneca SC
$116 nightly
The price is $127 total per night from Feb 8 to Feb 9
$127 total
Feb 8 - Feb 9
Total with taxes and fees
9.6/10 Exceptional! (57 reviews)
Very clean! Cozy space. Great 24 hour getaway!

Reviewed on Jan 27, 2026

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
See all 1,650 properties in Seneca
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Seneca Vacation Packages

Seneca Essential Information

Language
English
Currency
U.S dollars
Population
8,300
Max Temp Winter
50ºF
Max Temp Summer
90ºF

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Frequently asked questions

How much does a Seneca vacation package cost?
You'll find cheap prices from $355 on Expedia for your Seneca break. However, factors like the season, choice of hotel and length of stay will determine how much your vacation to Seneca costs.
What are the cheapest months to go to Seneca?
You can typically find lower rates and better availability in September, October and December. Browse our cheap Seneca vacation packages and you could land some great off-season discounts.
How many days is enough for Seneca?
Usually, a handful of days is enough to tick off the top attractions during your Seneca vacation. But if you prefer to have more time to rest or go on day tours, consider extending your itinerary.
How to find the best Seneca package deals?
Start your search for a Seneca package deal by entering your destination and travel dates under our "Packages" tab. Then add some filters, like "Guest rating" and "Property type," to tailor the results to your exact style. You can also sort by "Package discount" and browse offers that come with irresistible savings. If you don't find the perfect Seneca package deal right away, simply tweak your dates and search again. Keep in mind that deals are only available for a limited time, so book early and get your Seneca escape underway.
Is it cheaper to book a Seneca vacation as a package?
Expedia vacation packages are designed to give you more bang for your buck. Bundle your hotel, car rental and flight into one great-value price and you could save hundreds of dollars. You'll generally get a better deal than booking each component separately. And you'll still enjoy the freedom to create a personalized Seneca vacation by choosing your preferred type of stay, airline and car class.
When to book a vacation package to Seneca?
If you've got your Seneca travel dates locked in, book as early as you can to grab some fantastic deals. With Expedia, you can typically reserve some flights up to one year ahead of time. Prefer spur-of-the-moment getaways? Our last-minute deals are great for traveling on a whim.
Does Expedia offer Book Now, Pay Later Seneca vacation packages?
Set off on your perfect escape to Seneca with help from our Book Now, Pay Later vacations. There's no need to scrimp and save or wait until your next payday — we've joined forces with online lender Affirm to give you financial flexibility. Our vacation packages with payment plans allow you to spread the total cost over 3, 6 or 12 months. With no hidden charges or late payment fees, you can easily stay on budget and snap up cheap deals before they disappear.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.