Seneca Vacations from $366

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to $1,045 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

The Latest Seneca vacation packages

Price found within the past 48 hours. Click for updated prices.
Holiday Inn Greenville - Woodruff Road by IHG

Holiday Inn Greenville - Woodruff Road by IHG

3 out of 5
Price was $446, price is now $366 per person
$366
per person
Mar 12 - Mar 15
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Greenville (GSP)
8.6/10 Excellent! (661 reviews)
A very nice experience! The only thing was the indoor pool. It was cold during the evening but considering its winter. Its expected. Other than that. One of the best hotels that I've ever stayed at!!!

Reviewed on Jan 5, 2026

Zoka - Modern Mountain Retreat

Zoka - Modern Mountain Retreat

2 out of 5
Save 100% on your flight
Price was $1,925, price is now $1,252 per person
$1,252
per person
Apr 2 - Apr 6
found 19 hours ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Greenville (GSP)
No reviews
Hotel Hartness

Hotel Hartness

4 out of 5
Price was $741, price is now $535 per person
$535
per person
Mar 12 - Mar 15
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Greenville (GSP)
9.8/10 Exceptional! (613 reviews)
Everything was great as usual this is our third year. We will be back again next year for our anniversary.

Reviewed on Jan 6, 2026

Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection

4 out of 5
Greenville Downtown
Save 100% on your flight
Price was $1,132, price is now $919 per person
$919
per person
Mar 12 - Mar 15
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Greenville (GSP)
9.6/10 Exceptional! (406 reviews)
Everything was wonderful. Great restaurant and vibe. So glad we made this choice

Reviewed on Jan 15, 2026

Aloft Greenville Downtown

Aloft Greenville Downtown

3 out of 5
Greenville Downtown
Price was $744, price is now $606 per person
$606
per person
Mar 12 - Mar 15
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Greenville (GSP)
9/10 Wonderful! (1,001 reviews)
Nice hotel ….Staff was great !

Reviewed on Jan 10, 2026

Don't see what you're looking for?
See all available trips from Columbus to Seneca
View all trips

Where to stay in Seneca

Find the best Seneca areas and neighborhoods for the activities you enjoy most. Learn more about Seneca
Default Image

Serenity Bay

Though Serenity Bay might not have many top sights, you can venture to the surrounding area to see attractions like Keowee Key Golf Course and Lake Keowee.

Find hotels in Serenity Bay

Seneca Hotel Deals

Lakeside Lodge Clemson

Lakeside Lodge Clemson

2.5 out of 5
13500 Clemson Blvd Seneca SC
Fully refundableReserve now, pay when you stay
$123 nightly
The price is $135 total per night from Jan 20 to Jan 21
$135 total
Jan 20 - Jan 21
Total with taxes and fees
8.8/10 Excellent! (1,000 reviews)
Enjoyed our stay.

Reviewed on Dec 15, 2025

Lakeside Lodge Clemson
Quality Inn Seneca Clemson Area US-123

Quality Inn Seneca Clemson Area US-123

2.5 out of 5
226 Hi Tech Rd Seneca SC
Fully refundableReserve now, pay when you stay
$84 nightly
The price is $92 total per night from Jan 26 to Jan 27
$92 total
Jan 26 - Jan 27
Total with taxes and fees
7.8/10 Good! (668 reviews)
Hotel was clean, inside and out. Front desk staff was very kind and helpful.

Reviewed on Jan 4, 2026

Quality Inn Seneca Clemson Area US-123
Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson

2.5 out of 5
13050 Clemson Blvd Seneca SC
Fully refundableReserve now, pay when you stay
$106 nightly
The price is $116 total per night from Jan 26 to Jan 27
$116 total
Jan 26 - Jan 27
Total with taxes and fees
9.2/10 Wonderful! (803 reviews)
The staff here are top tier! We had to be at a meet at the university by 6am and they made breakfast early so our kids could eat before the meet! Genuine care for their guest! Love it here!

Reviewed on Jan 11, 2026

Tru by Hilton Seneca Clemson
See all 1,622 properties in Seneca
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Seneca Vacation Packages

Seneca Essential Information

Language
English
Currency
U.S dollars
Population
8,300
Max Temp Winter
50ºF
Max Temp Summer
90ºF

More vacations you might like

All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Frequently asked questions

How much does a Seneca vacation package cost?
You'll find cheap prices from $366 on Expedia for your Seneca break. However, factors like the season, choice of hotel and length of stay will determine how much your vacation to Seneca costs.
What are the cheapest months to go to Seneca?
You can typically find lower rates and better availability in September, October and December. Browse our cheap Seneca vacation packages and you could land some great off-season discounts.
How many days is enough for Seneca?
Usually, a handful of days is enough to tick off the top attractions during your Seneca vacation. But if you prefer to have more time to rest or go on day tours, consider extending your itinerary.
How to find the best Seneca package deals?
Start your search for a Seneca package deal by entering your destination and travel dates under our "Packages" tab. Then add some filters, like "Guest rating" and "Property type," to tailor the results to your exact style. You can also sort by "Package discount" and browse offers that come with irresistible savings. If you don't find the perfect Seneca package deal right away, simply tweak your dates and search again. Keep in mind that deals are only available for a limited time, so book early and get your Seneca escape underway.
Is it cheaper to book a Seneca vacation as a package?
Expedia vacation packages are designed to give you more bang for your buck. Bundle your hotel, car rental and flight into one great-value price and you could save hundreds of dollars. You'll generally get a better deal than booking each component separately. And you'll still enjoy the freedom to create a personalized Seneca vacation by choosing your preferred type of stay, airline and car class.
When to book a vacation package to Seneca?
If you've got your Seneca travel dates locked in, book as early as you can to grab some fantastic deals. With Expedia, you can typically reserve some flights up to one year ahead of time. Prefer spur-of-the-moment getaways? Our last-minute deals are great for traveling on a whim.
Does Expedia offer Book Now, Pay Later Seneca vacation packages?
Set off on your perfect escape to Seneca with help from our Book Now, Pay Later vacations. There's no need to scrimp and save or wait until your next payday — we've joined forces with online lender Affirm to give you financial flexibility. Our vacation packages with payment plans allow you to spread the total cost over 3, 6 or 12 months. With no hidden charges or late payment fees, you can easily stay on budget and snap up cheap deals before they disappear.

Explore a world of travel with Expedia

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.