Title: Seneca Vacation Packages 2026 from $385 | Expedia.com [Seneca Travel Guide](https://expedia.com/Seneca.dx6548)[Hotels in Seneca](https://expedia.com/Seneca-Hotels.d6548.Travel-Guide-Hotels)[Vacation Rentals in Seneca](https://expedia.com/Seneca-Vacation-Rentals.d6548.Travel-Guide-VacationRentals)[Flights to Seneca](https://expedia.com/Cheap-Flights-To-Seneca.d6548.Travel-Guide-Flights)[Car Rentals in Seneca](https://expedia.com/Car-Rentals-In-Seneca.d6548.Car-Rental-Guide) ![](https://images.trvl-media.com/place/6548/8356140f-bae9-4afc-8d65-c18efc5581aa.jpg?impolicy=fcrop&w=1200&h=300&q=medium) # Seneca Vacations from $385 ## Book a Hotel + Flight or Car together to unlock savings ## The Latest Seneca vacation packages Price found within the past 48 hours. Click for updated prices. ![Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG](https://images.trvl-media.com/lodging/1000000/10000/1400/1379/91409d5a_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG $385 per person Apr 22 - Apr 26 found 1 day ago Roundtrip non-stop flight included Houston (IAH) to Greenville (GSP) 8.6/10 Excellent! (1,005 reviews) Need microwaves in the rooms. Reviewed on Feb 22, 2026 ![Hotel Hartness](https://images.trvl-media.com/lodging/90000000/89690000/89689300/89689223/7f5c10e6_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Hotel Hartness $791 per person Apr 22 - Apr 26 found 1 day ago Roundtrip non-stop flight included Houston (IAH) to Greenville (GSP) 9.8/10 Exceptional! (613 reviews) I wish we had more time here. This was a short stay after we flew in and had to leave in the morning for a long drive. The hotel is stunning! There are trails around to hike and they offer bikes as well. The common areas and the room rooms are beautiful, comfortable, and very clean. Highly recommend! Reviewed on Feb 24, 2026 ![Landing Apartments - Lyman](https://images.trvl-media.com/lodging/120000000/119750000/119742800/119742739/ea508898_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Landing Apartments - Lyman $468 per person Apr 23 - Apr 26 found 4 hours ago Roundtrip non-stop flight included Houston (IAH) to Greenville (GSP) No reviews ![Grand Bohemian Lodge Greenville, Autograph Collection](https://images.trvl-media.com/lodging/72000000/71770000/71762700/71762652/6a375dd3_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Grand Bohemian Lodge Greenville, Autograph Collection Greenville Downtown $1,354 per person Apr 22 - Apr 26 found 1 day ago Roundtrip non-stop flight included Houston (IAH) to Greenville (GSP) 9.6/10 Exceptional! (406 reviews) The room was wonderful. The view amazing. The staff efficient and courteous. Loved the artwork throughout the hotel! Reviewed on Feb 24, 2026 Don't see what you're looking for? See all available trips from Columbus to Seneca [View all trips](https://expedia.com/go/package/search/FlightHotel/2026-03-25/2026-04-01/?FromAirport=Columbus,%20Ohio,%20United%20States%20of%20America&Destination=GSP&NumRoom=1&NumAdult=2&NumChild=0&paandie=true) ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Vacation Sale Members save up to 40% on hotels and homes. Plan this year’s big trip and save. [Book now](https://expedia.com/deals?rfrr=PKG_SPRING_PROMO_6548) ## Where to stay in Seneca Find the best Seneca areas and neighborhoods for the activities you enjoy most. [Learn more about Seneca](https://expedia.com/Seneca.dx6548) ![Default Image](https://images.trvl-media.com/media/content/expus/graphics/deals/TE_Clouds_card_r1.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Serenity Bay Though Serenity Bay might not have many top sights, you can venture to the surrounding area to see attractions like Keowee Key Golf Course and Lake Keowee. [Find hotel + flight trips in Serenity Bay](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Serenity%20Bay&DestID=553248635976468572&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods) ![Boat Ride on Lake Hartwell](https://images.trvl-media.com/place/944725335916802048/1c54d8c1-0e1b-42ce-868f-a52d696b915a.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Downtown 2 out of top 10 points of interest in this area While visiting Downtown, you might make a stop by sights like Seneca Historic District and Oconee County Library Seneca Branch. [Find hotel + flight trips in Downtown](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Downtown&DestID=944725335916802048&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods) ![Female Kayaker on Lake Keowee at Sunset](https://images.trvl-media.com/place/553248635976472456/3b558c58-c920-447c-ab12-ddbbcf97f799.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Pine Ridge Point While Pine Ridge Point isn't home to many top sights, Lake Keowee and Keowee Key Golf Course are some notable places to visit nearby. [Find hotel + flight trips in Pine Ridge Point](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Pine%20Ridge%20Point&DestID=553248635976472456&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods) ![Default Image](https://images.trvl-media.com/media/content/expus/graphics/deals/TE_Clouds_card_r1.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Indian Oaks While there might not be top attractions in Indian Oaks, you can explore the larger area and discover places like The Gauntlet and Seneca City Hall. [Find hotel + flight trips in Indian Oaks](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Indian%20Oaks&DestID=553248635976482027&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods) ![Default Image](https://images.trvl-media.com/media/content/expus/graphics/deals/TE_Clouds_card_r1.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Keowee Plantation When in Keowee Plantation, you can plan a visit to The Gauntlet and Seneca City Hall, some noteworthy sights in the nearby area. [Find hotel + flight trips in Keowee Plantation](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Keowee%20Plantation&DestID=553248635976477960&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods) ## Seneca Hotel Deals ![Lakeside Lodge Clemson](https://images.trvl-media.com/lodging/41000000/40220000/40217400/40217319/9732d3ff_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Lakeside Lodge Clemson 13500 Clemson Blvd Seneca SC Fully refundableReserve now, pay when you stay $123 nightly $135 total Feb 26 - Feb 27 Total with taxes and fees 9/10 Wonderful! (1,008 reviews) Clean room, great service! Reviewed on Feb 23, 2026 [](https://expedia.com/Hotel-Search?startDate=2%2F26%2F2026&endDate=2%2F27%2F2026&selected=40217319&PinnedHotelID=40217319&HadPinnedHotel=true®ionId=6548) ![Quality Inn Seneca Clemson Area US-123](https://images.trvl-media.com/lodging/1000000/80000/76800/76800/375f69b2_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Quality Inn Seneca Clemson Area US-123 226 Hi Tech Rd Seneca SC Fully refundableReserve now, pay when you stay $84 nightly $92 total Mar 3 - Mar 4 Total with taxes and fees 8/10 Very Good! (681 reviews) All great Reviewed on Feb 21, 2026 [](https://expedia.com/Hotel-Search?startDate=3%2F3%2F2026&endDate=3%2F4%2F2026&selected=76800&PinnedHotelID=76800&HadPinnedHotel=true®ionId=6548) ![Hampton Inn & Suites Seneca-Clemson Area](https://images.trvl-media.com/lodging/7000000/6700000/6696900/6696886/1436aba9_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Hampton Inn & Suites Seneca-Clemson Area 1011 East North 1st Street Seneca SC Fully refundableReserve now, pay when you stay $120 nightly $132 total Mar 1 - Mar 2 Total with taxes and fees 9.2/10 Wonderful! (682 reviews) Great having a washer and dry available and the breakfast staff was amazing and very nice. Reviewed on Feb 24, 2026 [](https://expedia.com/Hotel-Search?startDate=3%2F1%2F2026&endDate=3%2F2%2F2026&selected=6696886&PinnedHotelID=6696886&HadPinnedHotel=true®ionId=6548) [See all 1,642 properties in Seneca](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Package&startDate=2%2F26%2F2026&endDate=2%2F27%2F2026®ionId=6548) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Find the Best Seneca Vacation Packages ## Seneca Essential Information | Language | English | | --------------- | ----------- | | Currency | U.S dollars | | Population | 8,300 | | Max Temp Winter | 50ºF | | Max Temp Summer | 90ºF | ## More vacations you might like ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/all-inclusive_holidays_US.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) All Inclusive Vacations [](https://expedia.com/lp/theme-vacations/all-inclusive-vacations?rfrr=editorial.All_Inclusive%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/XPC_Beach_Overview_HR_v3.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Beach Vacations [](https://expedia.com/lp/theme-vacations/beach-vacations?rfrr=editorial.Beach_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/Family_holidays_US_3_.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Kid Friendly Vacations [](https://expedia.com/lp/theme-vacations/kid-friendly-vacations?rfrr=editorial.Kid_Friendly%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/04/29/frCA_Sejours_golf-Portugal.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Golf Vacations [](https://expedia.com/lp/theme-vacations/golf-vacations?rfrr=editorial.Golf_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/07/15/US_Luxury_VR_Miami.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Luxury Vacations [](https://expedia.com/lp/theme-vacations/luxury-vacations?rfrr=editorial.Luxury_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/08/29/romantic.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Romantic Vacations [](https://expedia.com/lp/theme-vacations/romantic-vacations?rfrr=editorial.Romantic_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/31952_v1_atfraraski22_insta_4.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Ski Vacations [](https://expedia.com/lp/theme-vacations/ski-vacations?rfrr=editorial.Ski_Vacations.click) ![Gay Friendly Vacations](https://forever.travel-assets.com/flex/flexmanager/images/2023/06/15/LGBTQIA_Holiday_Package.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) LGBTQ Friendly Vacations [](https://expedia.com/lp/theme-holidays/gay-friendly-holidays?rfrr=editorial.LGBTQ_Friendly%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2017/07/05/170615_Adventure_1320_2.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Adventure Vacations [](https://expedia.com/lp/theme-vacations/adventure-vacations?rfrr=editorial.Adventure_Vacations.click) ![Vacations in Month](https://forever.travel-assets.com/flex/flexmanager/images/2023/05/10/mesog-34434-card-venice.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Where to go when [](https://expedia.com/lp/b/where-to-go-when?rfrr=editorial.Where_to%20go%20when.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/21/honeymoon_hawaii.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Honeymoon Vacations [](https://expedia.com/lp/theme-vacations/honeymoon-vacations?rfrr=editorial.Honeymoon_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/23/Mountain-vacations.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Mountain Vacations [](https://expedia.com/lp/theme-vacations/mountain-vacations?rfrr=editorial.Mountain_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/23/fishing-vacations-2.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Fishing Vacations [](https://expedia.com/lp/theme-vacations/fishing-vacations?rfrr=editorial.Fishing_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2019/05/16/Hyatt%20Zilara%20Cancun%20-%20All%20Inclusive%20-%20Adults%20Only.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Adults Only Vacations [](https://expedia.com/lp/theme-vacations/adults-only-vacations?rfrr=editorial.Adults_Only%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/23/waterpark-vacations.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Waterpark Vacations [](https://expedia.com/lp/theme-vacations/waterpark-vacations?rfrr=editorial.Waterpark_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/08/Caribean_scuba_diving.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Scuba Diving Vacations [](https://expedia.com/lp/theme-vacations/scuba-diving-vacations?rfrr=editorial.Scuba_Diving%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/08/aruba_yoga.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Yoga Vacations [](https://expedia.com/lp/theme-vacations/yoga-vacations?rfrr=editorial.Yoga_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2023/04/04/EPS-RBC-SummerBeachVacations-AdobeStock_206356322.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Cheap Vacations [](https://expedia.com/lp/theme-vacations/cheap-vacations?rfrr=editorial.Cheap_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/06/26/1175883311.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Solo Vacations [](https://expedia.com/lp/b/vacations/solo-vacations?rfrr=editorial.Solo_Vacations.click) ## Frequently asked questions ### How much does a Seneca vacation package cost? ### What are the cheapest months to go to Seneca? ### How many days is enough for Seneca? ### How to find the best Seneca package deals? ### Is it cheaper to book a Seneca vacation as a package? ### When to book a vacation package to Seneca? ### Does Expedia offer Book Now, Pay Later Seneca vacation packages? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - [Hotels near Keowee Plantation ](https://www.expedia.com/Keowee-Plantation-Seneca-Hotels.0-n553248635976477960-0.Travel-Guide-Filter-Hotels) - [Hotels near Oconee County Regional ](https://www.expedia.com/Oconee-County-Regional-Airport-Hotels.0-aCEU-0.Travel-Guide-Filter-Hotels) - [Gay friendly Hotels in Keowee ](https://www.expedia.com/Keowee-Hotels-LGBT-Welcoming-Hotel.0-0-d553248635975848347-tLGBTWelcomingHotel.Travel-Guide-Filter-Hotels) - [Clemson Hotels ](https://www.expedia.com/Clemson-Hotels.d6594.Travel-Guide-Hotels) - [Hotels near Clemson University ](https://www.expedia.com/Clemson-University-Hotels.0-l6127431-0.Travel-Guide-Filter-Hotels) - [Hotels near Littlejohn Coliseum ](https://www.expedia.com/Littlejohn-Coliseum-Hotels.0-l6228662-0.Travel-Guide-Filter-Hotels) - [Flights from Utica ](https://www.expedia.com/lp/flights/553248634999334496/flights-from-utica) - [Flights from Oconee County Regional ](https://www.expedia.com/lp/airports/ceu/flights-from-oconee-county-regional-airport) - [Flights from Atlanta (ATL) to Clemson (CEU) ](https://www.expedia.com/lp/flights/atl/ceu/atlanta-to-clemson) - [Flights from Charlotte (CLT) to Clemson (CEU) ](https://www.expedia.com/lp/flights/clt/ceu/charlotte-to-clemson) - [Flights from New York (JFK) to Clemson (CEU) ](https://www.expedia.com/lp/flights/jfk/ceu/new-york-to-clemson) - [Flights from Boston (BOS) to Clemson (CEU) ](https://www.expedia.com/lp/flights/bos/ceu/boston-to-clemson) - [Flights from Asheville (AVL) to Clemson (CEU) ](https://www.expedia.com/lp/flights/avl/ceu/asheville-to-clemson) - [Flights from Washington (DCA) to Clemson (CEU) ](https://www.expedia.com/lp/flights/dca/ceu/washington-to-clemson) - [Flights from Philadelphia (PHL) to Clemson (CEU) ](https://www.expedia.com/lp/flights/phl/ceu/philadelphia-to-clemson) - [Flights from Miami (MIA) to Clemson (CEU) 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