Title: South Carolina Midlands Vacation Rentals from $110: Search Short-Term Rentals | Expedia.com

[South Carolina Midlands Travel Guide](https://expedia.com/South-Carolina-Midlands.dx6057938)[Hotels in South Carolina Midlands](https://expedia.com/South-Carolina-Midlands-Hotels.d6057938.Travel-Guide-Hotels)[Flights to South Carolina Midlands](https://expedia.com/Cheap-Flights-To-South-Carolina-Midlands.d6057938.Travel-Guide-Flights)[Things to do in South Carolina Midlands](https://expedia.com/Things-To-Do-In-South-Carolina-Midlands.d6057938.Travel-Guide-Activities)[Car Rentals in South Carolina Midlands](https://expedia.com/Car-Rentals-In-South-Carolina-Midlands.d6057938.Car-Rental-Guide)[South Carolina Midlands Vacation Packages](https://expedia.com/South-Carolina-Midlands.d6057938.Destination-Travel-Guides)

![South Carolina State House](https://images.trvl-media.com/place/6082681/1934af6a-1aa9-4e01-8cd3-8eb8fe4af18f.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

![](https://images.trvl-media.com/place/6082681/1934af6a-1aa9-4e01-8cd3-8eb8fe4af18f.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

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## Check prices for these dates

In two weeks

[Mar 20 - Mar 22](https://www.expedia.com/Hotel-Search?regionId=6057938&startDate=2026-03-20&endDate=2026-03-22&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In two months

[May 1 - May 3](https://www.expedia.com/Hotel-Search?regionId=6057938&startDate=2026-05-01&endDate=2026-05-03&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In three months

[May 29 - May 31](https://www.expedia.com/Hotel-Search?regionId=6057938&startDate=2026-05-29&endDate=2026-05-31&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In four months

[Jun 26 - Jun 28](https://www.expedia.com/Hotel-Search?regionId=6057938&startDate=2026-06-26&endDate=2026-06-28&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Our top choices for South Carolina Midlands vacation rentals

![Exterior](https://images.trvl-media.com/lodging/95000000/94800000/94797300/94797237/f4ad045c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Basic Cabin | Living area | Flat-screen TV](https://images.trvl-media.com/lodging/95000000/94800000/94797300/94797237/721a18d9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Basic Cabin | 2 bedrooms, free WiFi, bed sheets](https://images.trvl-media.com/lodging/95000000/94800000/94797300/94797237/665c2960.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Basic Cabin | Private kitchen | Mini-fridge, microwave, stovetop, dishwasher](https://images.trvl-media.com/lodging/95000000/94800000/94797300/94797237/4ba35d55.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Cabin in Charlotte

[](https://www.expedia.com/Charlotte-Hotels-Carowinds-Camp-Wilderness.h94797237.Hotel-Information)

9.0/10

Wonderful

(36 reviews)

"Cleanest place to stay we have ever had Staff was friendly and efficient Area is conveniently located near grocery store Aldis, and several restaraunt choices However, lots of noise from near by airport "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Kaleb

$114 nightly

$131 total

Mar 5 - Mar 6

Total with taxes and fees

[](https://www.expedia.com/Charlotte-Hotels-Carowinds-Camp-Wilderness.h94797237.Hotel-Information)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/73000000/72130000/72125100/72125029/w506h683x259y0-d0dc36b7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, books](https://images.trvl-media.com/lodging/73000000/72130000/72125100/72125029/w506h683x259y0-7c735ab0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/73000000/72130000/72125100/72125029/8db8afd1_edited_d288.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Dining](https://images.trvl-media.com/lodging/73000000/72130000/72125100/72125029/67ee2258_edited_5bc1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Vacation Home in Camden

[](https://www.expedia.com/Camden-Hotels-Camden-Cottage.h72125029.Hotel-Information)

10/10

Exceptional

(59 reviews)

"Needs more stars! Perfect place to stay and owners are fabulous. Clean, spacious, quiet, and private. Its like home. I highly recommend!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Cass

$159 nightly

$178 total

Mar 11 - Mar 12

Total with taxes and fees

[](https://www.expedia.com/Camden-Hotels-Camden-Cottage.h72125029.Hotel-Information)

![Outdoor dining](https://images.trvl-media.com/lodging/109000000/108020000/108017600/108017538/f4e6785a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV](https://images.trvl-media.com/lodging/109000000/108020000/108017600/108017538/8fe42751.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV](https://images.trvl-media.com/lodging/109000000/108020000/108017600/108017538/3d5346d7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, WiFi, bed sheets](https://images.trvl-media.com/lodging/109000000/108020000/108017600/108017538/eb799bdc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Cabin in Summerton

[](https://www.expedia.com/Summerton-Hotels-Cozy-Lakefront-Tiny-Cabin-On-Lake-Marion-With-An-Amazing-View-And-Pet-Friendly.h108017538.Hotel-Information)

9.2/10

Wonderful

(22 reviews)

"Overall an excellent stay! "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Andy K.

$158 nightly

$176 total

Mar 10 - Mar 11

Total with taxes and fees

[](https://www.expedia.com/Summerton-Hotels-Cozy-Lakefront-Tiny-Cabin-On-Lake-Marion-With-An-Amazing-View-And-Pet-Friendly.h108017538.Hotel-Information)

![Dining](https://images.trvl-media.com/lodging/96000000/95140000/95131100/95131059/w906h683x59y0-23945ed7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/96000000/95140000/95131100/95131059/w904h683x60y0-ed497f63.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, books](https://images.trvl-media.com/lodging/96000000/95140000/95131100/95131059/w904h683x60y0-95209402.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/96000000/95140000/95131100/95131059/w509h683x258y0-ab0a1bd7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Cottage in Columbia

[](https://www.expedia.com/Columbia-Hotels-Charming-Cottage-In-Great-Neighborhoodclose-To-Downtown.h95131059.Hotel-Information)

9.8/10

Exceptional

(37 reviews)

"Cozy, Clean... overall great place"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Donnavon

$232 nightly

$260 total

Mar 8 - Mar 9

Total with taxes and fees

[](https://www.expedia.com/Columbia-Hotels-Charming-Cottage-In-Great-Neighborhoodclose-To-Downtown.h95131059.Hotel-Information)

![Land view from property](https://images.trvl-media.com/lodging/96000000/95330000/95321700/95321677/a9a6cfbb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lake view](https://images.trvl-media.com/lodging/96000000/95330000/95321700/95321677/6076626b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Individually decorated, individually furnished, laptop workspace](https://images.trvl-media.com/lodging/96000000/95330000/95321700/95321677/fa256a38.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Standard Cabin, 1 Queen Bed, Lake View | Individually decorated, individually furnished, laptop workspace](https://images.trvl-media.com/lodging/96000000/95330000/95321700/95321677/2b7f07e0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Cabin in Steele Creek

[](https://www.expedia.com/Charlotte-Hotels-Long-Cove-Resort-Marina.h95321677.Hotel-Information)

8.6/10

Excellent

(243 reviews)

"Nice view and area"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Pranjali

$173 nightly

$189 total

Mar 5 - Mar 6

Total with taxes and fees

[](https://www.expedia.com/Charlotte-Hotels-Long-Cove-Resort-Marina.h95321677.Hotel-Information)

![1 bedroom, iron/ironing board, travel crib, free WiFi](https://images.trvl-media.com/lodging/96000000/95030000/95026900/95026870/e767c5d7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/96000000/95030000/95026900/95026870/ba3e11be.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, stovetop, coffee/tea maker](https://images.trvl-media.com/lodging/96000000/95030000/95026900/95026870/6185225b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/96000000/95030000/95026900/95026870/08dcc409.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Cottage in Sellers

[](https://www.expedia.com/Sellers-Hotels-Charming-Cottage-With-Easy-Access-To-Local-Attractions-Pet-And-Kid-Friendly.h95026870.Hotel-Information)

9.6/10

Exceptional

(23 reviews)

"So charming. The hostess is very accommodating and willing. We felt very welcome. All the accoutrements are tasteful. We had plenty of what we needed for our little celebration. Not too far of a skirt to Flo-town for a bite and some dessert. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Benjamin

$180 nightly

$196 total

Mar 5 - Mar 6

Total with taxes and fees

[](https://www.expedia.com/Sellers-Hotels-Charming-Cottage-With-Easy-Access-To-Local-Attractions-Pet-And-Kid-Friendly.h95026870.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/94000000/93560000/93552300/93552270/1b69beae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/94000000/93560000/93552300/93552270/5de77465.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/94000000/93560000/93552300/93552270/8c2c0349.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/94000000/93560000/93552300/93552270/eae9347f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Apartment in Downtown Columbia

[](https://www.expedia.com/Columbia-Hotels-Carraway-The-Vestry-On-Read.h93552270.Hotel-Information)

9.6/10

Exceptional

(4 reviews)

"My fav new place to stay"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Melissa O.

$214 nightly

$237 total

Mar 9 - Mar 10

Total with taxes and fees

[](https://www.expedia.com/Columbia-Hotels-Carraway-The-Vestry-On-Read.h93552270.Hotel-Information)

![Smart TV](https://images.trvl-media.com/lodging/73000000/72090000/72082800/72082800/0519b80e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, coffee/tea maker](https://images.trvl-media.com/lodging/73000000/72090000/72082800/72082800/4bb43e83.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/73000000/72090000/72082800/72082800/8147bd55.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor dining](https://images.trvl-media.com/lodging/73000000/72090000/72082800/72082800/1b740383.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Cabin in Bradley

[](https://www.expedia.com/Bradley-Hotels-Promised-Land-Countryside-GetawayCampsite.h72082800.Hotel-Information)

8.6/10

Excellent

(21 reviews)

"Very nice, clean cabin. Beautiful setting to enjoy the outdoors. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Jacob C.

$138 nightly

$149 total

Mar 5 - Mar 6

Total with taxes and fees

[](https://www.expedia.com/Bradley-Hotels-Promised-Land-Countryside-GetawayCampsite.h72082800.Hotel-Information)

![Smart TV, fireplace, stereo](https://images.trvl-media.com/lodging/85000000/84540000/84532300/84532271/6d5a5a1e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/85000000/84540000/84532300/84532271/addb12ce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Terrace/patio](https://images.trvl-media.com/lodging/85000000/84540000/84532300/84532271/4c47534f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/85000000/84540000/84532300/84532271/3c1915d3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Cottage in Steele Creek

[](https://www.expedia.com/Charlotte-Hotels-2BR1BA-Lakefront-Cottage-W-Private-Beach-And-Dock.h84532271.Hotel-Information)

10/10

Exceptional

(41 reviews)

"Charming well equipped cabin. Great views "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

laurie H.

$386 nightly

$444 total

Mar 5 - Mar 6

Total with taxes and fees

[](https://www.expedia.com/Charlotte-Hotels-2BR1BA-Lakefront-Cottage-W-Private-Beach-And-Dock.h84532271.Hotel-Information)

![TV](https://images.trvl-media.com/lodging/111000000/110850000/110844400/110844354/3434854a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/111000000/110850000/110844400/110844354/2f8bf400.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 bedrooms, desk, iron/ironing board, WiFi](https://images.trvl-media.com/lodging/111000000/110850000/110844400/110844354/2552c7e3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Floor plan](https://images.trvl-media.com/lodging/111000000/110850000/110844400/110844354/5b4ae08c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Cottage in Hartsville

[](https://www.expedia.com/Hartsville-Hotels-Cozy-Blue-Cottage-2BR1BA.h110844354.Hotel-Information)

9.0/10

Wonderful

(8 reviews)

"Enjoyed my time in Hartsville with family "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Lori

$205 nightly

$230 total

Mar 5 - Mar 6

Total with taxes and fees

[](https://www.expedia.com/Hartsville-Hotels-Cozy-Blue-Cottage-2BR1BA.h110844354.Hotel-Information)

![Outdoor dining](https://images.trvl-media.com/lodging/92000000/91020000/91012700/91012626/dd2731f8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/92000000/91020000/91012700/91012626/825609ba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![TV, video games](https://images.trvl-media.com/lodging/92000000/91020000/91012700/91012626/870c37c1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom](https://images.trvl-media.com/lodging/92000000/91020000/91012700/91012626/e5dece1e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Cabin in Rimini

[](https://www.expedia.com/Pinewood-Hotels-Cozy-Camping-Cabin-On-Lake-Marion-Near-Congaree-Nat-Park.h91012626.Hotel-Information)

8.2/10

Very Good

(14 reviews)

"We enjoyed our stay. The only negative would be the fishing pier is no longer useable. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Derrick W.

$120 nightly

$133 total

Mar 8 - Mar 9

Total with taxes and fees

[](https://www.expedia.com/Pinewood-Hotels-Cozy-Camping-Cabin-On-Lake-Marion-Near-Congaree-Nat-Park.h91012626.Hotel-Information)

![Smart TV](https://images.trvl-media.com/lodging/73000000/72690000/72689700/72689621/af14135a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/73000000/72690000/72689700/72689621/c754668a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor dining](https://images.trvl-media.com/lodging/73000000/72690000/72689700/72689621/3e6edc10.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/73000000/72690000/72689700/72689621/7170aea3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Vacation Home in Lexington

[](https://www.expedia.com/Lexington-Hotels-The-Turquoise-Door-In-Town-Of-Lexington.h72689621.Hotel-Information)

9.8/10

Exceptional

(121 reviews)

"Very cozy place! Perfect location right in the middle of everything!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Noah

$265 nightly

$294 total

Mar 17 - Mar 18

Total with taxes and fees

[](https://www.expedia.com/Lexington-Hotels-The-Turquoise-Door-In-Town-Of-Lexington.h72689621.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/104000000/103920000/103917900/103917893/b671b1e8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/104000000/103920000/103917900/103917893/6f7efc90.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Dining](https://images.trvl-media.com/lodging/104000000/103920000/103917900/103917893/1c7923fe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/104000000/103920000/103917900/103917893/b72bd02f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Cabin in Greenwood

[](https://www.expedia.com/Greenwood-Hotels-Cozy-Off-Grid-Cabin-Wpond-For-Fishing.h103917893.Hotel-Information)

10/10

Exceptional

(7 reviews)

"Home away from home. Generous and accomodating hosts that had engineered unique features to the cabin, bathrooms, camp shower and property that made the entier stay peaceful and comfortable. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Ray K.

$108 nightly

$119 total

Mar 5 - Mar 6

Total with taxes and fees

[](https://www.expedia.com/Greenwood-Hotels-Cozy-Off-Grid-Cabin-Wpond-For-Fishing.h103917893.Hotel-Information)

![Outdoor dining](https://images.trvl-media.com/lodging/112000000/111920000/111910100/111910025/d8c353af.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Dining](https://images.trvl-media.com/lodging/112000000/111920000/111910100/111910025/89327cc7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, foosball, books](https://images.trvl-media.com/lodging/112000000/111920000/111910100/111910025/bce3437b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/112000000/111920000/111910100/111910025/e211513a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Vacation Home in Rosewood

[](https://www.expedia.com/Columbia-Hotels-Aralia-5Min-To-Williams-Brice10Mins-To-FtJackson.h111910025.Hotel-Information)

9.8/10

Exceptional

(7 reviews)

"Clean and nice for our family to visit and relax after long days."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Jennifer v.

$323 nightly

$359 total

Mar 5 - Mar 6

Total with taxes and fees

[](https://www.expedia.com/Columbia-Hotels-Aralia-5Min-To-Williams-Brice10Mins-To-FtJackson.h111910025.Hotel-Information)

![Smart TV, offices](https://images.trvl-media.com/lodging/92000000/91790000/91788500/91788460/c321e70e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![3 bedrooms, desk, iron/ironing board, travel crib](https://images.trvl-media.com/lodging/92000000/91790000/91788500/91788460/42ada466.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![3 bedrooms, desk, iron/ironing board, travel crib](https://images.trvl-media.com/lodging/92000000/91790000/91788500/91788460/f5487ae6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Dining](https://images.trvl-media.com/lodging/92000000/91790000/91788500/91788460/431d124d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Vacation Home in Santee

[](https://www.expedia.com/Santee-Hotels-Experience-Purposeful-Travel-With-Our-Kindred-Spirits-Retreat-At-Lake-Marion.h91788460.Hotel-Information)

10/10

Exceptional

(39 reviews)

"This home was perfect for our Thanksgiving family getaway. We really enjoyed everything about the house, especially the fenced yard for the dogs. I would definitely stay here again. The house was exceptionally clean. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Kelly C.

$284 nightly

$315 total

Mar 9 - Mar 10

Total with taxes and fees

[](https://www.expedia.com/Santee-Hotels-Experience-Purposeful-Travel-With-Our-Kindred-Spirits-Retreat-At-Lake-Marion.h91788460.Hotel-Information)

![Dining](https://images.trvl-media.com/lodging/108000000/107970000/107966800/107966739/w1347h899x1y1-c8c480b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/108000000/107970000/107966800/107966739/w1346h899x0y1-bc56ee18.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![3 bedrooms, desk, iron/ironing board, WiFi](https://images.trvl-media.com/lodging/108000000/107970000/107966800/107966739/w1347h899x1y1-dbf6ce14.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/108000000/107970000/107966800/107966739/0b9c155c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Vacation Home in Waxhaw

[](https://www.expedia.com/Waxhaw-Hotels-Cozy-Party-House-In-The-Woods.h107966739.Hotel-Information)

8.8/10

Excellent

(8 reviews)

"Clean, roomy, quiet… lovely for our weekend getaway to quaint little town with so much to offer!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Cara G.

$275 nightly

$295 total

Mar 5 - Mar 6

Total with taxes and fees

[](https://www.expedia.com/Waxhaw-Hotels-Cozy-Party-House-In-The-Woods.h107966739.Hotel-Information)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/89000000/88210000/88200300/88200202/677a9698.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/89000000/88210000/88200300/88200202/353409d7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![3 bedrooms, desk, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/89000000/88210000/88200300/88200202/d00eb982.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/89000000/88210000/88200300/88200202/8e4f854b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Cottage in Pineville

[](https://www.expedia.com/Charlotte-Hotels-Cozy-3BD2BA.h88200202.Hotel-Information)

10/10

Exceptional

(52 reviews)

"Convenient layout that worked well for the family to stay with our pets. Well equipped and good location. Host communication was great. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Chris B.

$327 nightly

$377 total

Mar 5 - Mar 6

Total with taxes and fees

[](https://www.expedia.com/Charlotte-Hotels-Cozy-3BD2BA.h88200202.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/78000000/77170000/77165600/77165574/f998a96b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/78000000/77170000/77165600/77165574/9ee1cf2b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, books](https://images.trvl-media.com/lodging/78000000/77170000/77165600/77165574/42176c8a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/78000000/77170000/77165600/77165574/2da54617.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Vacation Home in Aiken

[](https://www.expedia.com/Aiken-Hotels-Downtown-Aiken-The-Collins-Property.h77165574.Hotel-Information)

9.8/10

Exceptional

(59 reviews)

"Would definitely stay here again!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Eileen p. H.

$229 nightly

$256 total

Mar 5 - Mar 6

Total with taxes and fees

[](https://www.expedia.com/Aiken-Hotels-Downtown-Aiken-The-Collins-Property.h77165574.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/112000000/112000000/111993400/111993338/876e41e9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/112000000/112000000/111993400/111993338/e065578d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/112000000/112000000/111993400/111993338/07159972.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/112000000/112000000/111993400/111993338/10c9d3a4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Vacation Home in Columbia

[](https://www.expedia.com/Columbia-Hotels-Cozy-And-Quiet-Private-Upstairs-Duplex.h111993338.Hotel-Information)

10/10

Exceptional

(12 reviews)

"Clean and nicely equipped. Everything was great. Host was welcoming and extremely helpful."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Erik A.

$145 nightly

$162 total

Mar 16 - Mar 17

Total with taxes and fees

[](https://www.expedia.com/Columbia-Hotels-Cozy-And-Quiet-Private-Upstairs-Duplex.h111993338.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/80000000/79670000/79668500/79668437/c148491e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/80000000/79670000/79668500/79668437/ad5ff8fc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, books, printers](https://images.trvl-media.com/lodging/80000000/79670000/79668500/79668437/24f777ab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/80000000/79670000/79668500/79668437/d862c686.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Vacation Home in Florence

[](https://www.expedia.com/Florence-Hotels-Walking-Distance-From-One-Of-South-Carolinas-Top-Medical-Centers.h79668437.Hotel-Information)

9.8/10

Exceptional

(43 reviews)

"Everything was great!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Debra B.

$174 nightly

$194 total

Mar 9 - Mar 10

Total with taxes and fees

[](https://www.expedia.com/Florence-Hotels-Walking-Distance-From-One-Of-South-Carolinas-Top-Medical-Centers.h79668437.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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## Find vacation rentals that suit your style

Cabins

[](https://www.expedia.com/Hotel-Search?destination=South+Carolina+Midlands%2C+South+Carolina%2C+United+States+of+America&regionId=6057938&latLong=34.070287%2C-80.861504&adults=2&startDate=2026-06-02&d1=2026-06-02&endDate=2026-06-05&d2=2026-06-05&lodging=CABIN)

Private vacation homes

[](https://www.expedia.com/Hotel-Search?destination=South+Carolina+Midlands%2C+South+Carolina%2C+United+States+of+America&regionId=6057938&latLong=34.070287%2C-80.861504&adults=2&startDate=2026-06-02&d1=2026-06-02&endDate=2026-06-05&d2=2026-06-05&lodging=VACATION_HOME)

Aparthotels

[](https://www.expedia.com/Hotel-Search?destination=South+Carolina+Midlands%2C+South+Carolina%2C+United+States+of+America&regionId=6057938&latLong=34.070287%2C-80.861504&adults=2&startDate=2026-06-02&d1=2026-06-02&endDate=2026-06-05&d2=2026-06-05&lodging=APART_HOTEL)

Villas

[](https://www.expedia.com/Hotel-Search?destination=South+Carolina+Midlands%2C+South+Carolina%2C+United+States+of+America&regionId=6057938&latLong=34.070287%2C-80.861504&adults=2&startDate=2026-06-02&d1=2026-06-02&endDate=2026-06-05&d2=2026-06-05&lodging=VILLA)

Houseboats

[](https://www.expedia.com/Hotel-Search?destination=South+Carolina+Midlands%2C+South+Carolina%2C+United+States+of+America&regionId=6057938&latLong=34.070287%2C-80.861504&adults=2&startDate=2026-06-02&d1=2026-06-02&endDate=2026-06-05&d2=2026-06-05&lodging=HOUSE_BOAT)

Cottages

[](https://www.expedia.com/Hotel-Search?destination=South+Carolina+Midlands%2C+South+Carolina%2C+United+States+of+America&regionId=6057938&latLong=34.070287%2C-80.861504&adults=2&startDate=2026-06-02&d1=2026-06-02&endDate=2026-06-05&d2=2026-06-05&lodging=COTTAGE)

Condos

[](https://www.expedia.com/Hotel-Search?destination=South+Carolina+Midlands%2C+South+Carolina%2C+United+States+of+America&regionId=6057938&latLong=34.070287%2C-80.861504&adults=2&startDate=2026-06-02&d1=2026-06-02&endDate=2026-06-05&d2=2026-06-05&lodging=CONDO)

Apartments

[](https://www.expedia.com/Hotel-Search?destination=South+Carolina+Midlands%2C+South+Carolina%2C+United+States+of+America&regionId=6057938&latLong=34.070287%2C-80.861504&adults=2&startDate=2026-06-02&d1=2026-06-02&endDate=2026-06-05&d2=2026-06-05&lodging=APARTMENT)

Chalets

[](https://www.expedia.com/Hotel-Search?destination=South+Carolina+Midlands%2C+South+Carolina%2C+United+States+of+America&regionId=6057938&latLong=34.070287%2C-80.861504&adults=2&startDate=2026-06-02&d1=2026-06-02&endDate=2026-06-05&d2=2026-06-05&lodging=CHALET)

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## Top South Carolina Midlands Hotel Reviews

![La Quinta Inn by Wyndham Columbia SE / Fort Jackson](https://images.trvl-media.com/lodging/1000000/10000/5100/5038/e9b1ea9e_y.jpg)

### La Quinta Inn by Wyndham Columbia SE / Fort Jackson

10/10 Excellent

"Yes"

[](https://expedia.com/Columbia-Hotels-La-Quinta-Inn-By-Wyndham-Columbia-SE-Fort-Jackson.h5038.Hotel-Information)

![Wyndham Garden Columbia/Ft. Jackson](https://images.trvl-media.com/lodging/78000000/77820000/77814700/77814689/e6cbdb45_y.jpg)

### Wyndham Garden Columbia/Ft. Jackson

10/10 Excellent

"Yes"

[](https://expedia.com/Columbia-Hotels-Hotel-Columbia-Inn-Suites.h77814689.Hotel-Information)

![Comfort Inn & Suites Florence Center Area](https://images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/64840011_y.jpg)

### Comfort Inn & Suites Florence Center Area

8/10 Good

"It was great"

[](https://expedia.com/Florence-Hotels-Comfort-Inn-Suites.h38336321.Hotel-Information)

![Holiday Inn Express & Suites Columbia-I-26 @ Harbison Blvd by IHG](https://images.trvl-media.com/lodging/1000000/690000/688700/688607/60336603_y.jpg)

### Holiday Inn Express & Suites Columbia-I-26 @ Harbison Blvd by IHG

10/10 Excellent

"Great hotel, clean and the staff was welcoming "

[](https://expedia.com/Columbia-Hotels-Holiday-Inn-Express-Suites-Columbia-I-26-Harbison-Blvd.h688607.Hotel-Information)

![Park Inn by Radisson Florence, SC](https://images.trvl-media.com/lodging/48000000/47090000/47086800/47086732/e4f3361f_y.jpg)

### Park Inn by Radisson Florence, SC

6/10 Okay

"They charged for service dog. I will call for a refund. Room was clean. "

[](https://expedia.com/Florence-Hotels-Park-Inn-By-Radisson-Florence.h47086732.Hotel-Information)

![Howard Johnson by Wyndham Florence](https://images.trvl-media.com/lodging/1000000/20000/11100/11037/32fd6fc1_y.jpg)

### Howard Johnson by Wyndham Florence

8/10 Good

"A bit dated but clean and convenient for a traveler's overnight stay. Just a minute off the highway with food and fuel very close by."

[](https://expedia.com/Florence-Hotels-Howard-Johnson-By-Wyndham-Florence.h11037.Hotel-Information)

![Tru By Hilton Columbia Downtown](https://images.trvl-media.com/lodging/111000000/110650000/110648500/110648494/w3837h2557x3y3-06093940_y.jpg)

### Tru By Hilton Columbia Downtown

10/10 Excellent

"Clean room and kind staff "

[](https://expedia.com/Columbia-Hotels-Tru-By-Hilton-Columbia-Downtown.h110648494.Hotel-Information)

![Hyatt Place Columbia/Downtown/The Vista](https://images.trvl-media.com/lodging/9000000/8700000/8690600/8690567/w3837h2560x3y0-ca3203e9_y.jpg)

### Hyatt Place Columbia/Downtown/The Vista

8/10 Good

"The directions lead you to a door which was no longer the entrace. There is a sign on the door instructing you to enter on an entirely different street. It was a little cold that evening. You have to pay for parking which I wasn't aware since it was not stated. The ftont desk rep. Stated the parking is not owned by Hyatt. The room was nice except for yhr bathroom sink was slow to drain and the room temperature kept changing. Only tjere gor one night so we didn't change rooms. The breakfast was typical but good. Staff was pleasant."

[](https://expedia.com/Columbia-Hotels-Hyatt-Place-ColumbiaDowntownThe-Vista.h8690567.Hotel-Information)

![Hilton Garden Inn Columbia/Harbison](https://images.trvl-media.com/lodging/2000000/1520000/1513800/1513707/f8933df9_y.jpg)

### Hilton Garden Inn Columbia/Harbison

2/10 Terrible

"I wouldn’t bother paying for the breakfast, for $22 a head you get oily potatoes with a half a omlette, same menu everyday for the week days. The 4 days we stayed, none of the days house keeper came and we asked twice. "

[](https://expedia.com/Columbia-Hotels-Hilton-Garden-Inn-ColumbiaHarbison.h1513707.Hotel-Information)

## Find out more about South Carolina Midlands

**Everything you need to know about South Carolina Midlands vacation rentals**

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the South Carolina Midlands vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect South Carolina Midlands vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

**South Carolina Midlands vacation rentals: An excellent choice for every season**

Whenever you want to travel, a warm welcome awaits you in South Carolina Midlands. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit South Carolina Midlands in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $110 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

**How to find incredible deals on South Carolina Midlands rentals**

At Expedia, we put the best South Carolina Midlands vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top South Carolina Midlands rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream South Carolina Midlands vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around South Carolina Midlands. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

## Explore a world of travel with Expedia

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- [Vacation Homes in South Carolina Midlands ](https://expedia.com/South-Carolina-Midlands-Private-Vacation-Homes.d6057938-aaPrivateVacationHomes.Travel-Guide-Accommodation)
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### Expedia's Latest Trends

Hotels

- [Hotels with Early Check-in in Greenville - Spartanburg](https://expedia.com/Greenville-Spartanburg-Hotels-Hotel-With-Early-Check-In.0-0-d6035267-thotelwithearlycheckin.Travel-Guide-Filter-Hotels)
- [Hotels with a Swim-up Bar in Coastal South Carolina](https://expedia.com/Coastal-South-Carolina-Hotels-Hotels-With-Swimup-Bar.0-0-d6057937-tHotelswithSwimupBar.Travel-Guide-Filter-Hotels)
- [Hyatt Hotels Hotels in Greenville - Spartanburg](https://expedia.com/Greenville-Spartanburg-Hotels-Hyatt-Hotels.0-0-d6035267--bHyattHotels.Travel-Guide-Filter-Hotels)
- [Golf Hotels in Greenville - Spartanburg](https://expedia.com/Greenville-Spartanburg-Hotels-Golf-Hotel.0-0-d6035267-tGolfHotel.Travel-Guide-Filter-Hotels)
- [Extended Stay Hotels in Greenville - Spartanburg](https://expedia.com/Greenville-Spartanburg-Hotels-Extended-Stay-Hotels.0-0-d6035267-tExtendedStayHotels.Travel-Guide-Filter-Hotels)
- [Hotels on the Lake in Upstate South Carolina](https://expedia.com/Upstate-South-Carolina-Hotels-Lakefront-Hotels.0-0-d6057939-tLakefrontHotels.Travel-Guide-Filter-Hotels)
- [Hotels with Bars in Greenville - Spartanburg](https://expedia.com/Greenville-Spartanburg-Hotels-Bar-Hotel.0-0-d6035267-tBarHotel.Travel-Guide-Filter-Hotels)
- [Resorts & Hotels with Spas in Greenville - Spartanburg](https://expedia.com/Greenville-Spartanburg-Hotels-Spa-Hotel.0-0-d6035267-tSpaHotel.Travel-Guide-Filter-Hotels)
- [Extended Stay Hotels in Upstate South Carolina](https://expedia.com/Upstate-South-Carolina-Hotels-Extended-Stay-Hotels.0-0-d6057939-tExtendedStayHotels.Travel-Guide-Filter-Hotels)
- [Adults Only Resorts & Hotels in Upstate South Carolina](https://expedia.com/Upstate-South-Carolina-Hotels-Adults-Only-Resorts.0-0-d6057939-tAdultsOnlyResorts.Travel-Guide-Filter-Hotels)
- [Hotels with Fireplaces in Greenville - Spartanburg](https://expedia.com/Greenville-Spartanburg-Hotels-Hotels-With-Fireplaces.0-0-d6035267-tHotelswithFireplaces.Travel-Guide-Filter-Hotels)
- [Adults Only Resorts & Hotels in Coastal South Carolina](https://expedia.com/Coastal-South-Carolina-Hotels-Adults-Only-Resorts.0-0-d6057937-tAdultsOnlyResorts.Travel-Guide-Filter-Hotels)
- [Hotels with Free Airport Shuttle in Greenville - Spartanburg](https://expedia.com/Greenville-Spartanburg-Hotels-Hotels-With-Free-Airport-Shuttle.0-0-d6035267-tHotelswithFreeAirportShuttle.Travel-Guide-Filter-Hotels)
- [Hotels in Greenville - Spartanburg](https://expedia.com/Greenville-Spartanburg-Hotels.d6035267.Travel-Guide-Hotels)

Flights

- [Cheap Flights to Greenville - Spartanburg](https://expedia.com/Cheap-Flights-To-Greenville-Spartanburg.d6035267.Travel-Guide-Flights)
- [Cheap Flights to Upstate South Carolina](https://expedia.com/Cheap-Flights-To-Upstate-South-Carolina.d6057939.Travel-Guide-Flights)

Cars

- [Easirent Car Rentals In Upstate South Carolina](https://expedia.com/Easirent-Car-Rentals-In-Upstate-South-Carolina.d6057939-c1039.Car-Rental-Guide-Suppliers)
- [minivan Car Rentals in Greenville - Spartanburg](https://expedia.com/Minivan-Car-Rentals-In-Greenville-Spartanburg.d6035267-tMinivan.Car-Rental-Guide-Class)
- [Orlando Car Rentals In Greenville Spartanburg](https://expedia.com/Orlando-Car-Rentals-In-Greenville-Spartanburg.d6035267-c1047.Car-Rental-Guide-Suppliers)
- [midsize Car Rentals in Greenville - Spartanburg](https://expedia.com/Midsize-Car-Rentals-In-Greenville-Spartanburg.d6035267-tMidsize.Car-Rental-Guide-Class)

Activities

- [Things to do in Greenville - Spartanburg](https://expedia.com/Things-To-Do-In-Greenville-Spartanburg.d6035267.Travel-Guide-Activities)
- [Things to do in Upstate South Carolina](https://expedia.com/Things-To-Do-In-Upstate-South-Carolina.d6057939.Travel-Guide-Activities)
- [Things to do in Coastal South Carolina](https://expedia.com/Things-To-Do-In-Coastal-South-Carolina.d6057937.Travel-Guide-Activities)

Packages

- [Coastal South Carolina Vacation](https://expedia.com/Coastal-South-Carolina.d6057937.Destination-Travel-Guides)
- [South Carolina Lowcountry All Inclusive Vacation Packages](https://expedia.com/lp/theme-vacations/yoga-vacations/553248635975748945/South-Carolina-Lowcountry)
- [Upstate South Carolina All Inclusive Vacation Packages](https://expedia.com/lp/theme-vacations/golf-vacations/6057939/Upstate-South-Carolina)

Vacation Rentals

- [Upstate South Carolina Vacation Rentals](https://expedia.com/Upstate-South-Carolina-Vacation-Rentals.d6057939.Travel-Guide-VacationRentals)

General

- [Visit Upstate South Carolina](https://expedia.com/Upstate-South-Carolina.dx6057939)
- [Visit Greenville - Spartanburg](https://expedia.com/Greenville-Spartanburg.dx6035267)
- [Visit Coastal South Carolina](https://expedia.com/Coastal-South-Carolina.dx6057937)

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