Beginning of main content

Book on the go and pay later.

Search over 1,000,000 properties worldwide and 550 airlines worldwide.

Search over a million flights, hotels, packages, and more

No Expedia cancellation fee to change or cancel almost any hotel reservation.


Check prices on hotels in South Carolina Midlands

Tonight Jul 23 - Jul 24
This weekend Jul 26 - Jul 28
Next weekend Aug 2 - Aug 4

Top 10 Hotels in South Carolina Midlands

See all 636 Properties in South Carolina Midlands

Estimated price for 1 night/2 adults

Days Inn by Wyndham Florence/I-95 North

Days Inn by Wyndham Florence/I-95 North

2111 West Lucas St/I-95, I-95 & Hwy 52 Exit 164, Florence, SC
Days Inn by Wyndham Florence/I-95 North
  • Free Cancellation
  • Reserve now, pay when you stay
2.0 out of 5.0
 
 

Situated in Florence, this motel is within 6 mi (10 km) of Mcleod Regional Medical Center, Magnolia Mall, and Florence Civic Center. Florence Museum and Florence ...

Days Inn by Wyndham Florence/I-95 North$57

Aug 11 - Aug 12

Days Inn by Wyndham Rock Hill

Days Inn by Wyndham Rock Hill

875 Riverview Rd, Rock Hill, SC
Days Inn by Wyndham Rock Hill
  • Free Cancellation
  • Reserve now, pay when you stay
2.0 out of 5.0
 
 

Situated in Rock Hill, this motel is 1.1 mi (1.8 km) from Giordana Velodrome and within 3 mi (5 km) of Novant Health BMX Supercross Track and Cherry Park. Manchester ...

Days Inn by Wyndham Rock Hill$51

Aug 14 - Aug 15

La Quinta Inn & Suites by Wyndham Florence

La Quinta Inn & Suites by Wyndham Florence

2123 W Lucas St, Florence, SC
La Quinta Inn & Suites by Wyndham Florence
  • Free Cancellation
  • Reserve now, pay when you stay
2.5 out of 5.0
 
 

Situated in Florence, this hotel is within 6 mi (10 km) of Mcleod Regional Medical Center, Magnolia Mall, and Florence Civic Center. Florence Museum and Florence ...

La Quinta Inn & Suites by Wyndham Florence$104

Aug 4 - Aug 5

Baymont Inn & Suites Florence by Wyndham

Baymont Inn & Suites Florence by Wyndham

1826 W Lucas Street, Florence, SC
Baymont Inn & Suites Florence by Wyndham
  • Free Cancellation
  • Reserve now, pay when you stay
2.0 out of 5.0
 
 

Situated in Florence, this hotel is within 6 mi (10 km) of Mcleod Regional Medical Center, Magnolia Mall, and Florence Civic Center. Florence Museum and Florence ...

Baymont Inn & Suites Florence by Wyndham$58

Aug 1 - Aug 2

La Quinta Inn by Wyndham Columbia SE / Fort Jackson

La Quinta Inn by Wyndham Columbia SE / Fort Jackson

7333 Garners Ferry Rd, Columbia, SC
La Quinta Inn by Wyndham Columbia SE / Fort Jackson
  • Free Cancellation
  • Reserve now, pay when you stay
2.5 out of 5.0
 
 

Situated in Columbia, this hotel is 0.9 mi (1.5 km) from William Jennings Bryan Dorn Veterans Affairs Medical Center and within 6 mi (10 km) of Fort Jackson ...

La Quinta Inn by Wyndham Columbia SE / Fort Jackson$85

Jul 28 - Jul 29

Country Inn & Suites by Radisson, Columbia at Harbison, SC

Country Inn & Suites by Radisson, Columbia at Harbison, SC

414 Piney Grove Road, Columbia, SC
Country Inn & Suites by Radisson, Columbia at Harbison, SC
  • Free Cancellation
  • Reserve now, pay when you stay
2.5 out of 5.0
 
 

Situated near the airport, this hotel is within 3 mi (5 km) of Columbiana Centre, Frankie's Fun Park, and Harbison State Forest. South Carolina Law Enforcement ...

Country Inn & Suites by Radisson, Columbia at Harbison, SC$70

Aug 11 - Aug 12

Hyatt Place Columbia/Downtown/The Vista

Hyatt Place Columbia/Downtown/The Vista

819 Gervais Street, Columbia, SC
Hyatt Place Columbia/Downtown/The Vista
  • Free Cancellation
3.0 out of 5.0
 
 

Located in the heart of Columbia, this hotel is within a 5-minute walk of Columbia Regional Visitors Center and Columbia Metropolitan Convention Center. South ...

Hyatt Place Columbia/Downtown/The Vista$119

Jul 26 - Jul 27

Red Roof Inn Florence - Civic Center

Red Roof Inn Florence - Civic Center

2690 David H McLeod Boulevard, Florence, SC
Red Roof Inn Florence - Civic Center
  • Free Cancellation
  • Reserve now, pay when you stay
2.0 out of 5.0
 
 

Situated near the airport, this hotel is within a 10-minute walk of Magnolia Mall and Florence Civic Center. Florence Museum and Mcleod Regional Medical Center ...

Red Roof Inn Florence - Civic Center$57

Jul 28 - Jul 29

Baymont by Wyndham Columbia Northwest

Baymont by Wyndham Columbia Northwest

347 Zimalcrest Drive, Columbia, SC
Baymont by Wyndham Columbia Northwest
  • Free Cancellation
  • Reserve now, pay when you stay
3.0 out of 5.0
 
 

Situated near the airport, this hotel is 0.7 mi (1.1 km) from Three Rivers Greenway and within 6 mi (10 km) of Colonial Life Arena and Riverbanks Zoo and Garden. ...

Baymont by Wyndham Columbia Northwest$64

Jul 30 - Jul 31

Country Inn & Suites by Radisson, Columbia, SC

Country Inn & Suites by Radisson, Columbia, SC

220 E Exchange Blvd, Columbia, SC
Country Inn & Suites by Radisson, Columbia, SC
  • Free Cancellation
  • Reserve now, pay when you stay
2.5 out of 5.0
 
 

Situated in Columbia, this hotel is 1 mi (1.6 km) from William Jennings Bryan Dorn Veterans Affairs Medical Center and within 6 mi (10 km) of Fort Jackson and ...

Country Inn & Suites by Radisson, Columbia, SC$83

Aug 4 - Aug 5

Map

Recent Reviews in South Carolina Midlands

Travel to South Carolina Midlands & Explore


Explore South Carolina Midlands with Expedia's Travel Guides to find the best prices on flights, cars, vacation packages, and more!