South Carolina Midlands Vacations from $274
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Your South Carolina Midlands Vacation
Whether you're heading to South Carolina Midlands for its rich history, spectacular views or something else entirely, this destination is one you won't forget in a hurry. Create your ultimate break with one of our South Carolina Midlands vacation packages. With so much to see and do on a trip to South Carolina Midlands, it can be difficult to know where to start. Kick off your travels in Columbia at Riverbanks Zoo and Garden and Williams Brice Stadium — two popular attractions here. Another city worthy of a spot on your itinerary is Florence. Don't miss Magnolia Mall and Mcleod Regional Medical Center. Expedia has flights, hotels, car rentals and more to help you create your very own customized South Carolina Midlands vacation today.
The Latest South Carolina Midlands vacation packages
Price found within the past 48 hours. Click for updated prices.
Country Inn & Suites by Radisson, Charlotte University Place, NC
University City
Save 100% on your flight
Price was $414, price is now $274 per person
$274
per person
Jan 15 - Jan 20
found 1 day ago
Roundtrip flight included
New York (NYC) to Charlotte (CLT)
8/10 Very Good! (1,011 reviews)
The room was very spotless and they helped us with every need we had!
Reviewed on Nov 9, 2025
Westgate Myrtle Beach Oceanfront Resort
Save 100% on your flight
Price was $564, price is now $336 per person
$336
per person
Jan 16 - Jan 19
found 1 day ago
Roundtrip flight included
Boston (BOS) to Myrtle Beach (MYR)
8.2/10 Very Good! (1,030 reviews)
Staff was friendly but room is nothing like the Expedia pictures - you’re in the older hotel not the towers, so the rooms are older.
Reviewed on Nov 14, 2025
Home2 Suites by Hilton Charlotte Mooresville
Save 100% on your flight
Price was $492, price is now $296 per person
$296
per person
Jan 15 - Jan 20
found 1 day ago
Roundtrip flight included
New York (NYC) to Charlotte (CLT)
17.6/10 Exceptional! (712 reviews)
Room was clean and the hotel staff was very pleasant.
Reviewed on Nov 10, 2025
The Westin Charlotte
Uptown Charlotte
Save 100% on your flight
Price was $975, price is now $634 per person
$634
per person
Feb 6 - Feb 10
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Charlotte (CLT)
9/10 Wonderful! (1,012 reviews)
The only complaint I have is that the room (bathroom) reeked of a foul smell upon our arrival. We cleansed, wiped, sprayed, and sanitized as we do at every hotel. The smell went away, but did return later.
Reviewed on Nov 10, 2025
Marina Inn At Grande Dunes
Save 100% on your flight
Price was $608, price is now $399 per person
$399
per person
Jan 22 - Jan 26
found 1 day ago
Roundtrip flight included
Boston (BOS) to Myrtle Beach (MYR)
9.4/10 Exceptional! (1,731 reviews)
No hot water in the shower. Furniture needed replacement. Bathroom sink was plugged up.
Reviewed on Nov 15, 2025
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See all available trips from Columbus to South Carolina Midlands
View all tripsWhere to stay in South Carolina Midlands
Find the best South Carolina Midlands areas and neighborhoods for the activities you enjoy most. Learn more about South Carolina Midlands
Downtown Columbia
3 out of top 10 points of interest in this area
A magnet for visitors to the southeast, this compact city is a favorite for its charm, cuisine, historic neighborhoods, world-class museums and pretty green spaces.
Discover the most popular places to visit in South Carolina Midlands
Carowinds Theme Park
Choose from 13 roller coasters, chase your friends in a bumper car, enjoy the water slides and beaches of Boomerang Bay, and walk with dinosaurs.
Riverbanks Zoo and Garden
Why not meet the animals who call Riverbanks Zoo and Garden home during your trip to Columbia? You can attend a sporting event while in the area.
Congaree National Park
While protecting southern hardwood forest for the enjoyment of future generations, this park also offers hiking, canoeing and interesting ranger-led activities.
South Carolina Midlands Hotel Deals
Hilton Garden Inn Columbia/Harbison
434 Columbiana Dr Columbia SC
Fully refundableReserve now, pay when you stay
$79 nightly
The price is $89 total per night from Nov 30 to Dec 1
$89 total
Nov 30 - Dec 1
Total with taxes and fees
8.8/10 Excellent! (1,812 reviews)
The staff was friendly and professional. I enjoyed my visit to this hotel
Reviewed on Nov 12, 2025
Wyndham Garden Columbia/Ft. Jackson
1539 Horseshoe Dr Columbia SC
Fully refundableReserve now, pay when you stay
$85 nightly
The price is $95 total per night from Nov 23 to Nov 24
$95 total
Nov 23 - Nov 24
Total with taxes and fees
7.8/10 Good! (1,310 reviews)
Excellent
Reviewed on Nov 8, 2025
La Quinta Inn by Wyndham Columbia NE/Fort Jackson
1538 Horseshoe Drive Columbia SC
Fully refundableReserve now, pay when you stay
$87 nightly
The price is $98 total per night from Nov 23 to Nov 24
$98 total
Nov 23 - Nov 24
Total with taxes and fees
8.8/10 Excellent! (1,726 reviews)
It helps that the attendant knows me by face and always makes me feel welcomed and safe.
Reviewed on Nov 11, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Find the Best South Carolina Midlands Vacation Packages
South Carolina Midlands Essential Information
Language | English |
|---|---|
Currency | U.S dollars |
Closest Airport | Charlotte-Douglas Intl. Airport (CLT) |
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.