South Carolina Midlands Vacations from $251

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Your South Carolina Midlands Vacation

Whether you're heading to South Carolina Midlands for its rich history, spectacular views or something else entirely, this destination is one you won't forget in a hurry. Create your ultimate break with one of our South Carolina Midlands vacation packages. With so much to see and do on a trip to South Carolina Midlands, it can be difficult to know where to start. Kick off your travels in Columbia at Riverbanks Zoo and Garden and Williams Brice Stadium — two popular attractions here. Another city worthy of a spot on your itinerary is Florence. Don't miss Magnolia Mall and Mcleod Regional Medical Center. Expedia has flights, hotels, car rentals and more to help you create your very own customized South Carolina Midlands vacation today.

The Latest South Carolina Midlands vacation packages

Price found within the past 48 hours. Click for updated prices.
315@Loso Hotel
Carolina Grande
Graduate by Hilton Columbia SC
Aqua Beach Inn
Marina Inn At Grande Dunes
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Where to stay in South Carolina Midlands

Find the best South Carolina Midlands areas and neighborhoods for the activities you enjoy most. Learn more about South Carolina Midlands

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South Carolina Midlands Hotel Deals

Hilton Garden Inn Columbia/Harbison

Hilton Garden Inn Columbia/Harbison

3 out of 5
434 Columbiana Dr Columbia SC
Fully refundableReserve now, pay when you stay
$79 nightly
The price is $89 total per night from Dec 7 to Dec 8
$89 total
Dec 7 - Dec 8
Total with taxes and fees
8.8/10 Excellent! (1,832 reviews)
Nice property, clean room.

Reviewed on Nov 24, 2025

Hilton Garden Inn Columbia/Harbison
Baymont by Wyndham Columbia Fort Jackson

Baymont by Wyndham Columbia Fort Jackson

2.5 out of 5
240 E Exchange Blvd Columbia SC
Fully refundableReserve now, pay when you stay
$53 nightly
The price is $59 total per night from Dec 14 to Dec 15
$59 total
Dec 14 - Dec 15
Total with taxes and fees
5.6/10 (1,019 reviews)
“Free” breakfast was overpriced. Simple stuff (like no salt & pepper, not to mention other missing items, like a meat offering in the chafing dish next to the scrambled eggs). Not like dish was dirty because it had been emptied. Looked like nothing had ever been in it yet, at 7:45 AM (opened at 6:30). ...

Reviewed on Nov 22, 2025

Baymont by Wyndham Columbia Fort Jackson
Wyndham Garden Columbia/Ft. Jackson

Wyndham Garden Columbia/Ft. Jackson

2.5 out of 5
1539 Horseshoe Dr Columbia SC
Fully refundableReserve now, pay when you stay
$76 nightly
The price is $85 total per night from Dec 28 to Dec 29
$85 total
Dec 28 - Dec 29
Total with taxes and fees
7.8/10 Good! (1,330 reviews)
The room was very clean, organized and a lot of space. The staff was very nice and kind people. Close to the highway, stores, fast food, restaurant and more important for me was Fort Jackson. I recommend this hotel

Reviewed on Nov 27, 2025

Wyndham Garden Columbia/Ft. Jackson
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best South Carolina Midlands Vacation Packages

South Carolina Midlands Essential Information

Language
English
Currency
U.S dollars
Closest Airport
Charlotte-Douglas Intl. Airport (CLT)

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.