South Carolina Midlands Vacations from $368

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Your South Carolina Midlands Vacation

Whether you're heading to South Carolina Midlands for its rich history, spectacular views or something else entirely, this destination is one you won't forget in a hurry. Create your ultimate break with one of our South Carolina Midlands vacation packages. With so much to see and do on a trip to South Carolina Midlands, it can be difficult to know where to start. Kick off your travels in Columbia at Riverbanks Zoo and Garden and Williams Brice Stadium — two popular attractions here. Another city worthy of a spot on your itinerary is Florence. Don't miss Magnolia Mall and Mcleod Regional Medical Center. Expedia has flights, hotels, car rentals and more to help you create your very own customized South Carolina Midlands vacation today.

The Latest South Carolina Midlands vacation packages

Price found within the past 48 hours. Click for updated prices.
Sands Ocean Club Resort
Westgate Myrtle Beach Oceanfront Resort
Country Club Villas
Charlotte Marriott City Center
The Westin Charlotte
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Where to stay in South Carolina Midlands

Find the best South Carolina Midlands areas and neighborhoods for the activities you enjoy most. Learn more about South Carolina Midlands

Discover the most popular places to visit in South Carolina Midlands

South Carolina Midlands Hotel Deals

Hilton Garden Inn Columbia/Harbison
Hilton Garden Inn Columbia/Harbison
3 out of 5
434 Columbiana Dr, Columbia, SC
Fully refundableReserve now, pay when you stay
$84 nightly
The price is $94 total per night from Jul 20 to Jul 21
$94 total
Jul 20 - Jul 21
Total includes taxes and fees
8.8/10 Excellent! (1,598 reviews)
"I love the property the place is amazing and clean as always although i would have like some flavored coffee creamer for my coffee i love to drink at night."

Reviewed on Jul 1, 2025

Hilton Garden Inn Columbia/Harbison
Tru By Hilton Columbia Downtown
Tru By Hilton Columbia Downtown
2.5 out of 5
400 Gervais Street, Building 2, Columbia, SC
Fully refundableReserve now, pay when you stay
$101 nightly
The price is $113 total per night from Jul 13 to Jul 14
$113 total
Jul 13 - Jul 14
Total includes taxes and fees
9/10 Wonderful! (138 reviews)
great stay
"great new hotel with a great breakfast"

Reviewed on Jul 2, 2025

Tru By Hilton Columbia Downtown
Wyndham Garden Columbia/Ft. Jackson
Wyndham Garden Columbia/Ft. Jackson
2.5 out of 5
1539 Horseshoe Dr, Columbia, SC
Fully refundableReserve now, pay when you stay
$84 nightly
The price is $94 total per night from Jul 6 to Jul 7
$94 total
Jul 6 - Jul 7
Total includes taxes and fees
7.8/10 Good! (1,097 reviews)
"Nice big hotel. Clean overall. Carpets could be cleaned, had a smell and was stained. Hotel right off the hwy. Close by restaurants and shopping stores. Good location right off two notch road"

Reviewed on Jul 1, 2025

Wyndham Garden Columbia/Ft. Jackson
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best South Carolina Midlands Vacation Packages

South Carolina Midlands Essential Information

Language
English
Currency
U.S dollars
Closest Airport
Charlotte-Douglas Intl. Airport (CLT)

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.