Southeast Missouri Vacations from $294
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Your Southeast Missouri Vacation
Book a vacation package to Southeast Missouri and travel on your own terms. You'll be captivated by its family-friendly attractions, history and culture. Kick off your trip to Southeast Missouri with a few nights in Cape Girardeau visiting popular sights like Isle Casino Cape Girardeau and Cape Splash Family Aquatic Center. Sikeston is another city that lures travelers from all over. The Book Bug and Central Park are two of the leading places to see here. Expedia has hotels, flights, car rentals and more to help you curate your very own tailored Southeast Missouri vacation today.
The Latest Southeast Missouri vacation packages
Price found within the past 48 hours. Click for updated prices.
Angad Arts Hotel St. Louis, Tapestry Collection by Hilton
Grand Center
Price was $428, price is now $294 per person
$294
per person
Dec 15 - Dec 18
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
8.8/10 Excellent! (1,005 reviews)
Awesome hotel with awesome/helpful staff! The area around is mostly safe, nighttime can get a lil scary but the hotel itself is really safe.
Reviewed on Oct 11, 2025
The Wildwood Hotel
Save 100% on your flight
Price was $846, price is now $446 per person
$446
per person
Nov 26 - Nov 30
found 1 day ago
Roundtrip flight included
Dallas (DFW) to St. Louis (STL)
9.2/10 Wonderful! (1,581 reviews)
Has a parking garage or street parking patrolled by local police constantly. We did not try the hotel breakfast we went to “The Pancake House” for breakfast and it was awesome.
Reviewed on Oct 12, 2025
Marriott St. Louis West
Price was $663, price is now $477 per person
$477
per person
Nov 26 - Nov 30
found 1 day ago
Roundtrip flight included
Dallas (DFW) to St. Louis (STL)
8.6/10 Excellent! (1,002 reviews)
All of the staff were extremely nice and the lobby had tons of good meet up spaces, but the room wasn't amazing. I stayed here 20 years ago and remember the rooms feeling a little dated. Nothing has changed since then. Aside from that, it did feel clean and I did sleep well all three nights. I would pass on the breakfast - seemed out of basic items most mornings, like eggs, fruit, etc., but maybe I just picked the wrong time to go.
Reviewed on Sep 29, 2025
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See all available trips from Columbus to Southeast Missouri
View all tripsDiscover the most popular places to visit in Southeast Missouri
Elephant Rocks State Park
5/5(13 reviews)
You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.
Rocky Falls
4.5/5(2 reviews)
Commune with nature and explore the great outdoors at Rocky Falls during your travels in Winona. While you're in the area, wander around the natural setting.
Lake Wappapello
4/5(18 reviews)
Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants.
Southeast Missouri Hotel Deals
Drury Plaza Hotel Cape Girardeau Conference Center
3351 Percy Drive, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
$90 nightly
The price is $102 total per night from Oct 19 to Oct 20
$102 total
Oct 19 - Oct 20
Total with taxes and fees
9.4/10 Exceptional! (1,012 reviews)
"The lady that checked me in was amazing!"
Reviewed on Oct 6, 2025
Baymont Inn and Suites by Wyndham Farmington, MO
1625 W Columbia St, Farmington, MO
Fully refundableReserve now, pay when you stay
$56 nightly
The price is $64 total per night from Oct 19 to Oct 20
$64 total
Oct 19 - Oct 20
Total with taxes and fees
8/10 Very Good! (1,005 reviews)
"It was very nice. There was a problem with me being charge 2 times but that was fix right away"
Reviewed on Oct 6, 2025
The Riverview
777 Main St, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
$126 nightly
The price is $143 total per night from Oct 20 to Oct 21
$143 total
Oct 20 - Oct 21
Total with taxes and fees
9.2/10 Wonderful! (431 reviews)
"The rooms are always amazing! When we go in its always so nice and cool. Loved having a k-cup in my room again. This is my favorite place in cape. My only complaint would be no microwave in the room for snacks and things."
Reviewed on Oct 6, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Southeast Missouri Essential Information
Language | English |
|---|---|
Currency | U.S dollars |
Closest Airport | Lambert-St. Louis Intl. Airport (STL) |
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.