Southeast Missouri Vacation Packages 2026 from $236

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Your Southeast Missouri Vacation

Book a vacation package to Southeast Missouri and travel on your own terms. You'll be captivated by its family-friendly attractions, history and culture. Kick off your trip to Southeast Missouri with a few nights in Cape Girardeau visiting popular sights like Isle Casino Cape Girardeau and Cape Splash Family Aquatic Center. Sikeston is another city that lures travelers from all over. The Book Bug and Central Park are two of the leading places to see here. Expedia has hotels, flights, car rentals and more to help you curate your very own tailored Southeast Missouri vacation today.

The Latest Southeast Missouri vacation packages

Price found within the past 48 hours. Click for updated prices.

Hollywood Casino & Hotel St. Louis

Riverport

Save 100% on your flight

$236

per person

Nov 13 - Nov 16

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

8.6/10 Excellent! (2,245 reviews)

The Wildwood Hotel

$264

per person

Nov 13 - Nov 16

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

9.2/10 Wonderful! (1,679 reviews)

Nice and cozy room! Host was very helpful on suggesting places to eat.

Reviewed on Oct 9, 2026

The Cheshire

Save 100% on your flight

$654

per person

Nov 24 - Nov 29

found 1 day ago

Roundtrip flight included

Dallas (DFW) to St. Louis (STL)

8.8/10 Excellent! (1,011 reviews)

Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

Riverport

Save 100% on your flight

$284

per person

Nov 12 - Nov 16

found 22 hours ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

7.8/10 Good! (1,005 reviews)

Ameristar Casino Resort and Spa

Save 100% on your flight

$640

per person

Nov 12 - Nov 16

found 17 hours ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

8.6/10 Excellent! (1,062 reviews)

Wonderful stay for a small bachelorette party. Had a wonderful time!

Reviewed on Oct 10, 2026

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Stay near popular Southeast Missouri attractions

A large, reddish-brown rock formation with a smooth, rounded surface and a unique, intertwined shape.

Elephant Rocks State Park

9.6/10 (98 reviews)

You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.

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A large, historic building with a dome and columns, surrounded by well-maintained lawns and trees.

Southeast Missouri State University

8.8/10 (248 reviews)

Take a campus tour or just explore the area of Southeast Missouri State University, during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants.

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A sunset over a lake with boats and ducks.

Lake Wappapello

8.8/10 (54 reviews)

Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants.

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Century Casino & Hotel Cape Girardeau

8.4/10 (176 reviews)

Why not roll the dice with a visit to Century Casino & Hotel Cape Girardeau during your travels in Cape Girardeau? While in this family-friendly area, you can savor the top-notch restaurants.

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Century Casino Caruthersville

7.0/10 (57 reviews)

Why not roll the dice with a visit to Century Casino Caruthersville during your travels in Caruthersville? While in this family-friendly area, you can enjoy the restaurants.

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What to do in Southeast Missouri

Night Ghost Tour of Pythian Castle in Springfield Missouri

$20

per adult

96% of travellers recommend

See all activities in Southeast Missouri

Southeast Missouri Hotel Deals

Drury Plaza Hotel Cape Girardeau Conference Center

3351 Percy Drive Cape Girardeau MO

Fully refundableReserve now, pay when you stay

$100 nightly

$113 total

Nov 1 - Nov 2

Total with taxes and fees

Drury Inn & Suites Sikeston, MO

2608 East Malone Ave, Miner Sikeston MO

Fully refundableReserve now, pay when you stay

$94 nightly

$108 total

Oct 18 - Oct 19

Total with taxes and fees

Pear Tree Inn Cape Girardeau West

103 Cape West Pkwy Cape Girardeau MO

Fully refundableReserve now, pay when you stay

$72 nightly

$81 total

Oct 18 - Oct 19

Total with taxes and fees

9.2/10 Wonderful! (1,001 reviews)

"Room was clean and staff was very friendly"

Reviewed on Oct 9, 2026

See all 692 properties in Southeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.