Name: Drury Inn & Suites Sikeston, MO
Price range: $122 total
Rating: 9.4

Your Southeast Missouri Vacation

Book a vacation package to Southeast Missouri and travel on your own terms. You'll be captivated by its family-friendly attractions, history and culture. Kick off your trip to Southeast Missouri with a few nights in Cape Girardeau visiting popular sights like Isle Casino Cape Girardeau and Cape Splash Family Aquatic Center. Sikeston is another city that lures travelers from all over. The Book Bug and Central Park are two of the leading places to see here. Expedia has hotels, flights, car rentals and more to help you curate your very own tailored Southeast Missouri vacation today.

The Latest Southeast Missouri vacation packages

Price found within the past 48 hours. Click for updated prices.

The Cheshire

$505

per person

Jun 8 - Jun 11

found 9 hours ago

Roundtrip flight included

Boston (BOS) to St. Louis (STL)

8.6/10 Excellent! (1,011 reviews)

It had unique decor which was fun. Staff was nice But the lights were broken and there was a leftover can under a chair

Reviewed on Apr 1, 2026

Spacious 3-Bedroom with King Bed

Central West End

$1,252

per person

Jul 2 - Jul 6

found 15 hours ago

Roundtrip flight included

Los Angeles (LAX) to St. Louis (STL)

8.8/10 Excellent! (11 reviews)

Clean room nice area

Reviewed on Feb 1, 2026

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

Grand Center

$514

per person

Jun 8 - Jun 11

found 9 hours ago

Roundtrip flight included

Boston (BOS) to St. Louis (STL)

8.8/10 Excellent! (1,049 reviews)

nice place! stayed two nights. had to ask for more towels, washcloths and room coffee , even with service thing on door. Other than that, i hope to stay there again!

Reviewed on Apr 9, 2026

Hilton Pennywell St. Louis at the Arch

Downtown St. Louis

$697

per person

Jun 29 - Jul 3

found 1 day ago

Roundtrip flight included

Newark Liberty Intl. Airport (EWR) to St. Louis (STL)

8.8/10 Excellent! (1,023 reviews)

Clean room but outdated.

Reviewed on Apr 11, 2026

Lodge Of Four Seasons Golf Resort, Marina & Spa

$595

per person

Jun 4 - Jun 8

found 21 hours ago

Roundtrip flight included

New Orleans (MSY) to St. Louis (STL)

7.4/10 Good! (1,111 reviews)

Room was semi clean and bedsheets seemed new or at least clean. The whole property is just really run down and reminded me of a summer camp horror movie.

Reviewed on Apr 10, 2026

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Discover the most popular places to visit in Southeast Missouri

Southeast Missouri State University

4.5/5(78 reviews)

Take a campus tour or just explore the area of Southeast Missouri State University, during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants.

Elephant Rocks State Park

5/5(13 reviews)

You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.

Lake Wappapello

4/5(18 reviews)

Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants.

What to do in Southeast Missouri

Night Ghost Tour of Pythian Castle in Springfield Missouri

$20

per adult

100% of travellers recommend

See all activities in Southeast Missouri

Southeast Missouri Hotel Deals

Drury Plaza Hotel Cape Girardeau Conference Center

3351 Percy Drive Cape Girardeau MO

Fully refundableReserve now, pay when you stay

$100 nightly

$113 total

Apr 19 - Apr 20

Total with taxes and fees

9.6/10 Exceptional! (1,004 reviews)

The hotel, staff and food were all top of the line. Awesome stay!

Reviewed on Apr 9, 2026

The Riverview

777 Main St Cape Girardeau MO

Fully refundableReserve now, pay when you stay

$122 nightly

$138 total

Apr 20 - Apr 21

Total with taxes and fees

9.4/10 Exceptional! (545 reviews)

Nice stay in Cape. Unfortunately I didn't have a great view from my room, but I didn't pay for the river view so that was expected. In general it was a lovely clean hotel, with everything I needed.

Reviewed on Apr 10, 2026

Drury Inn & Suites Sikeston, MO

2608 East Malone Ave, Miner Sikeston MO

Fully refundableReserve now, pay when you stay

$106 nightly

$122 total

Apr 20 - Apr 21

Total with taxes and fees

9.4/10 Exceptional! (1,004 reviews)

Helpful and friendly staff. Room and hotel was clean. A great stay!

Reviewed on Apr 10, 2026

See all 644 properties in Southeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.