Southeast Missouri Vacations from $306
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Your Southeast Missouri Vacation
Book a vacation package to Southeast Missouri and travel on your own terms. You'll be captivated by its family-friendly attractions, history and culture. Kick off your trip to Southeast Missouri with a few nights in Cape Girardeau visiting popular sights like Isle Casino Cape Girardeau and Cape Splash Family Aquatic Center. Sikeston is another city that lures travelers from all over. The Book Bug and Central Park are two of the leading places to see here. Expedia has hotels, flights, car rentals and more to help you curate your very own tailored Southeast Missouri vacation today.
The Latest Southeast Missouri vacation packages
Price found within the past 48 hours. Click for updated prices.
Hampton Inn By Hilton St Louis Airport
Woodson Terrace
Save 100% on your flight
Price was $465, price is now $306 per person
$306
per person
Jan 7 - Jan 11
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
8.8/10 Excellent! (96 reviews)
Staff was nice. Room was clean. Breakfast was hot!
Reviewed on Nov 23, 2025
HoteLumiere at the Arch - A Caesars Rewards Destination
Downtown St. Louis
Save 100% on your flight
Price was $646, price is now $374 per person
$374
per person
Jan 7 - Jan 11
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
6.6/10 (1,001 reviews)
It was very nice resort
Reviewed on Nov 20, 2025
The Cheshire
Save 100% on your flight
Price was $653, price is now $418 per person
$418
per person
Jan 7 - Jan 11
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
8.6/10 Excellent! (1,002 reviews)
Great stay! The room could have been a tiny bit cleaner but nothing crazy! Mainly stains on the table and some dusty areas but beds and bathrooms were clean!
The staff was super nice and the place was nicely decorated.
Reviewed on Nov 15, 2025
Home2 Suites by Hilton St. Louis/Forest Park
The Grove
Save 100% on your flight
Price was $739, price is now $484 per person
$484
per person
Jan 7 - Jan 11
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
8.6/10 Excellent! (1,000 reviews)
Everything was perfect
A bit more attention to detail is needed. A deep clean on a regular basis.
Reviewed on Nov 10, 2025
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Discover the most popular places to visit in Southeast Missouri
Elephant Rocks State Park
5/5(13 reviews)
You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.
Lake Wappapello
4/5(18 reviews)
Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants.
Rocky Falls
4.5/5(2 reviews)
Commune with nature and explore the great outdoors at Rocky Falls during your travels in Winona. While you're in the area, wander around the natural setting.
Southeast Missouri Hotel Deals
Drury Plaza Hotel Cape Girardeau Conference Center
3351 Percy Drive Cape Girardeau MO
Fully refundableReserve now, pay when you stay
$90 nightly
The price is $102 total per night from Dec 1 to Dec 2
$102 total
Dec 1 - Dec 2
Total with taxes and fees
9.4/10 Exceptional! (1,001 reviews)
Clean rooms. Very comfortable bed. Friendly staff
Reviewed on Nov 17, 2025
Baymont Inn and Suites by Wyndham Farmington, MO
1625 W Columbia St Farmington MO
Fully refundableReserve now, pay when you stay
$54 nightly
The price is $61 total per night from Dec 5 to Dec 6
$61 total
Dec 5 - Dec 6
Total with taxes and fees
8/10 Very Good! (1,000 reviews)
Yes
Reviewed on Nov 12, 2025
Motel 6 Poplar Bluff, MO
4101 Highway 67 N Poplar Bluff MO
Fully refundableReserve now, pay when you stay
$76 nightly
The price is $80 total per night from Dec 1 to Dec 2
$80 total
Dec 1 - Dec 2
Total with taxes and fees
7.8/10 Good! (1,004 reviews)
Staff was nice, rooms are small but comfortable
Reviewed on Nov 24, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Find the Best Southeast Missouri Vacation Packages
Southeast Missouri Essential Information
Language | English |
|---|---|
Currency | U.S dollars |
Closest Airport | Lambert-St. Louis Intl. Airport (STL) |
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.