Southeast Missouri Vacation Packages 2026 from $325

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Your Southeast Missouri Vacation

Book a vacation package to Southeast Missouri and travel on your own terms. You'll be captivated by its family-friendly attractions, history and culture. Kick off your trip to Southeast Missouri with a few nights in Cape Girardeau visiting popular sights like Isle Casino Cape Girardeau and Cape Splash Family Aquatic Center. Sikeston is another city that lures travelers from all over. The Book Bug and Central Park are two of the leading places to see here. Expedia has hotels, flights, car rentals and more to help you curate your very own tailored Southeast Missouri vacation today.

The Latest Southeast Missouri vacation packages

Price found within the past 48 hours. Click for updated prices.

Crowne Plaza St. Louis Airport by IHG

Save 100% on your flight

$325

per person

Sep 30 - Oct 5

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

8/10 Very Good! (1,000 reviews)

The Wildwood Hotel

$431

per person

Nov 2 - Nov 7

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

9.2/10 Wonderful! (1,665 reviews)

Absolutely BEAUTIFUL!! Small town, quiet, extremely friendly! Would recommend to everyone staying in the area!!

Reviewed on Aug 27, 2026

Remodeled and Inviting Free EV

Save 100% on your flight

$540

per person

Nov 2 - Nov 7

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

9/10 Wonderful! (2 reviews)

It was nice to stay for a weekend but the neighborhood was nice I like the location where it wasn't too far from grocery stores food areas the only thing I was saying is it's nothing for the kids to do but overall I like it

Reviewed on Aug 7, 2026

HoteLumiere at the Arch Hotel & Casino - A Caesars Rewards Destination

Downtown St. Louis

Save 100% on your flight

$394

per person

Sep 30 - Oct 5

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

6.8/10 (1,004 reviews)

The Cheshire

Save 100% on your flight

$486

per person

Sep 30 - Oct 5

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

8.8/10 Excellent! (1,005 reviews)

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Stay near popular Southeast Missouri attractions

A large, reddish-brown rock formation with a smooth, rounded surface and a unique, intertwined shape.

Elephant Rocks State Park

9.6/10 (98 reviews)

You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.

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A large, historic building with a dome and columns, surrounded by well-maintained lawns and trees.

Southeast Missouri State University

8.8/10 (248 reviews)

Take a campus tour or just explore the area of Southeast Missouri State University, during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants.

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A sunset over a lake with boats and ducks.

Lake Wappapello

8.8/10 (54 reviews)

Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants.

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Century Casino & Hotel Cape Girardeau

8.4/10 (176 reviews)

Why not roll the dice with a visit to Century Casino & Hotel Cape Girardeau during your travels in Cape Girardeau? While in this family-friendly area, you can savor the top-notch restaurants.

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Century Casino Caruthersville

7.0/10 (57 reviews)

Why not roll the dice with a visit to Century Casino Caruthersville during your travels in Caruthersville? While in this family-friendly area, you can enjoy the restaurants.

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What to do in Southeast Missouri

Night Ghost Tour of Pythian Castle in Springfield Missouri

$20

per adult

96% of travellers recommend

See all activities in Southeast Missouri

Southeast Missouri Hotel Deals

Drury Plaza Hotel Cape Girardeau Conference Center

3351 Percy Drive Cape Girardeau MO

Fully refundableReserve now, pay when you stay

$100 nightly

$113 total

Sep 6 - Sep 7

Total with taxes and fees

9.6/10 Exceptional! (1,003 reviews)

"Competitively priced. Complimentary happy hour and hot breakfast were exceptional. We stay at a Drury Inn whenever they are available."

Reviewed on Aug 27, 2026

Baymont Inn and Suites by Wyndham Farmington, MO

1625 W Columbia St Farmington MO

Fully refundableReserve now, pay when you stay

$58 nightly

$64 total

Sep 13 - Sep 14

Total with taxes and fees

8/10 Very Good! (1,001 reviews)

"It was a nice stay"

Reviewed on Aug 25, 2026

The Riverview

777 Main St Cape Girardeau MO

Fully refundableReserve now, pay when you stay

$114 nightly

$129 total

Aug 31 - Sep 1

Total with taxes and fees

9.4/10 Exceptional! (647 reviews)

"Nice view of the river. The staff was nice."

Reviewed on Aug 23, 2026

See all 686 properties in Southeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.