Name: Drury Plaza Hotel Cape Girardeau Conference Center
Price range: $102 total
Rating: 9.4

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Your Southeast Missouri Vacation

Book a vacation package to Southeast Missouri and travel on your own terms. You'll be captivated by its family-friendly attractions, history and culture. Kick off your trip to Southeast Missouri with a few nights in Cape Girardeau visiting popular sights like Isle Casino Cape Girardeau and Cape Splash Family Aquatic Center. Sikeston is another city that lures travelers from all over. The Book Bug and Central Park are two of the leading places to see here. Expedia has hotels, flights, car rentals and more to help you curate your very own tailored Southeast Missouri vacation today.

The Latest Southeast Missouri vacation packages

Price found within the past 48 hours. Click for updated prices.

Hilton Garden Inn Chesterfield

$347

per person

Oct 29 - Nov 2

found 1 day ago

Roundtrip flight included

Austin (AUS) to St. Louis (STL)

8.2/10 Very Good! (762 reviews)

I booked online and paid via the app. When I arrived on site they explained they had overbooked and had no rooms available. The staff was amazing and went above and beyond and secured a room at another location. Thank you to the staff for taking care of us.

Reviewed on Jul 26, 2025

The Wildwood Hotel

Save 100% on your flight

$408

per person

Oct 29 - Nov 2

found 1 day ago

Roundtrip flight included

Austin (AUS) to St. Louis (STL)

9.2/10 Wonderful! (1,561 reviews)

Always comfortable, always convenient and reliable when I'm visiting the area. It's my go-to hotel in the area.

Reviewed on Aug 25, 2025

Marriott St. Louis West

Save 100% on your flight

$426

per person

Oct 29 - Nov 2

found 1 day ago

Roundtrip flight included

Austin (AUS) to St. Louis (STL)

8.6/10 Excellent! (1,005 reviews)

Ample free self parking. Friendly staff. Clean. Free bottled water.

Reviewed on Aug 16, 2025

DoubleTree by Hilton St. Louis Forest Park

Central West End

$403

per person

Oct 29 - Nov 2

found 1 day ago

Roundtrip flight included

Austin (AUS) to St. Louis (STL)

8.2/10 Very Good! (1,000 reviews)

Parking is terrible and you shouldn’t have to pay $15 to park then charge for breakfast when your paying all that money to stay!!

Reviewed on Aug 23, 2025

The Cheshire

Save 100% on your flight

$508

per person

Oct 29 - Nov 2

found 1 day ago

Roundtrip flight included

Austin (AUS) to St. Louis (STL)

8.6/10 Excellent! (1,007 reviews)

The Cheshire kept well from of old! We felt back in to the ages yet very 21C amenities. The location is perfect to explore St. Louis. We'd like to come back!

Reviewed on Aug 23, 2025

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Discover the most popular places to visit in Southeast Missouri

Taum Sauk Mountain in located in the St.Francis mountain range of south/central Missouri. It's also the highest point in Missouri. My kids are standing at the spot where the actual marker sign in

Elephant Rocks State Park

You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.

Beautiful area. Easy to get up close and not too far off the main road. 🏞 #waterfalls #nature #explore #missouri

Rocky Falls

Commune with nature and explore the great outdoors at Rocky Falls during your travels in Winona. While you're in the area, wander around the natural setting.

Breathtaking view at the dam by the road and some small trails for walking as well!

Lake Wappapello

Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants.

Southeast Missouri Hotel Deals

Baymont Inn and Suites by Wyndham Farmington, MO

1625 W Columbia St, Farmington, MO

Fully refundableReserve now, pay when you stay

$52 nightly

$59 total

Sep 2 - Sep 3

Total with taxes and fees

8/10 Very Good! (1,002 reviews)

"I actually stay there a couple times a month. I do it for the pool most all their staff is very friendly jay is especially/. I would recommend it to anyone."

Reviewed on Aug 17, 2025

The Riverview

777 Main St, Cape Girardeau, MO

Fully refundableReserve now, pay when you stay

$117 nightly

$132 total

Aug 27 - Aug 28

Total with taxes and fees

9.2/10 Wonderful! (394 reviews)

"This hotel was very pleasant. It was very nice and we liked the casino was downstairs."

Reviewed on Aug 23, 2025

Drury Plaza Hotel Cape Girardeau Conference Center

3351 Percy Drive, Cape Girardeau, MO

$90 nightly

$102 total

Aug 31 - Sep 1

Total with taxes and fees

9.4/10 Exceptional! (1,011 reviews)

"Kickback and breakfast was the best I’ve ever had at any hotel before including service."

Reviewed on Aug 24, 2025

See all 585 properties in Southeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.