Name: Drury Inn & Suites Sikeston, MO
Price range: $128 total
Rating: 9.6

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Your Southeast Missouri Vacation

Book a vacation package to Southeast Missouri and travel on your own terms. You'll be captivated by its family-friendly attractions, history and culture. Kick off your trip to Southeast Missouri with a few nights in Cape Girardeau visiting popular sights like Isle Casino Cape Girardeau and Cape Splash Family Aquatic Center. Sikeston is another city that lures travelers from all over. The Book Bug and Central Park are two of the leading places to see here. Expedia has hotels, flights, car rentals and more to help you curate your very own tailored Southeast Missouri vacation today.

The Latest Southeast Missouri vacation packages

Price found within the past 48 hours. Click for updated prices.

The Wildwood Hotel

$204

per person

Sep 23 - Sep 26

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

9.2/10 Wonderful! (1,661 reviews)

Nice quiet

Reviewed on Jul 10, 2026

The Cheshire

Save 100% on your flight

$271

per person

Sep 23 - Sep 26

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

8.8/10 Excellent! (1,001 reviews)

Bedding had blood stains. We called the front desk about the stained bedding and they went new sheets up but expected us to strip bed and put new sheets on ourselves. We were going to do that but the new sheets were damp so we requested a different room instead. Likely won’t stay here again.

Reviewed on Jul 11, 2026

Hilton Garden Inn Chesterfield

Save 100% on your flight

$222

per person

Sep 23 - Sep 26

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

8.4/10 Very Good! (831 reviews)

Very clean and very nice as a little home away from home. It’s just up the road from shops and all kinds of restaurants. When I make another trip back up there this will be my first choice again!!

Reviewed on Jul 7, 2026

Ameristar Casino Resort and Spa

Save 100% on your flight

$409

per person

Sep 23 - Sep 26

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

8.6/10 Excellent! (1,000 reviews)

We had a great time at the hotel/casino. There is a lot of places to eat and drink on site. We will definitely be back to swim in the pool.

Reviewed on Jul 10, 2026

Moonrise Hotel

Delmar Loop

Save 100% on your flight

$302

per person

Aug 21 - Aug 24

found 11 hours ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

9/10 Wonderful! (1,984 reviews)

Reviewed on Jul 10, 2026

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Stay near popular Southeast Missouri attractions

A large, reddish-brown rock formation with a smooth, rounded surface and a unique, intertwined shape.

Elephant Rocks State Park

9.6/10 (98 reviews)

You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.

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What to do in Southeast Missouri

Night Ghost Tour of Pythian Castle in Springfield Missouri

$20

per adult

100% of travellers recommend

See all activities in Southeast Missouri

Southeast Missouri Hotel Deals

Drury Plaza Hotel Cape Girardeau Conference Center

3351 Percy Drive Cape Girardeau MO

Fully refundableReserve now, pay when you stay

$100 nightly

$113 total

Aug 2 - Aug 3

Total with taxes and fees

9.6/10 Exceptional! (1,017 reviews)

"Great location excellent staff very clean room, great breakfast from 7–10 am, 5:30-7 Happy Hr w/ snack food.."

Reviewed on Jul 12, 2026

Baymont Inn and Suites by Wyndham Farmington, MO

1625 W Columbia St Farmington MO

Fully refundableReserve now, pay when you stay

$58 nightly

$63 total

Jul 26 - Jul 27

Total with taxes and fees

8/10 Very Good! (1,022 reviews)

"I have stay at this hotle over 230 times I just got done looking it up. We have a shop it doe run that we are building so we stay at hotle when we are in. We have never had a issue till last visit. We wash are clothes and the load we did all most all of the clothes came out with some kinda oil on ..."

Reviewed on Jul 11, 2026

Drury Inn & Suites Sikeston, MO

2608 East Malone Ave, Miner Sikeston MO

Fully refundableReserve now, pay when you stay

$111 nightly

$128 total

Jul 19 - Jul 20

Total with taxes and fees

9.6/10 Exceptional! (1,014 reviews)

"everything was great and super close to lamberts even though i caught a roll to the face it was still awesome 10 out of 10 would do again"

Reviewed on Jul 11, 2026

See all 662 properties in Southeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.