Name: Drury Inn & Suites Sikeston, MO
Price range: $122 total
Rating: 9.6

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Your Southeast Missouri Vacation

Book a vacation package to Southeast Missouri and travel on your own terms. You'll be captivated by its family-friendly attractions, history and culture. Kick off your trip to Southeast Missouri with a few nights in Cape Girardeau visiting popular sights like Isle Casino Cape Girardeau and Cape Splash Family Aquatic Center. Sikeston is another city that lures travelers from all over. The Book Bug and Central Park are two of the leading places to see here. Expedia has hotels, flights, car rentals and more to help you curate your very own tailored Southeast Missouri vacation today.

The Latest Southeast Missouri vacation packages

Price found within the past 48 hours. Click for updated prices.

The Wildwood Hotel

Save 100% on your flight

$334

per person

Aug 4 - Aug 8

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

9.2/10 Wonderful! (1,649 reviews)

We were there on a Thursday night, very quiet, comfy bed. We had a king room with sitting area - sofa, chair, desk, fridge with freezer and microwave. Everything we needed and the freezer froze our ice packs overnight for the second leg of our trip. Lots of restaurant choices within a mile or 2 and walkable shopping area. Lovely area, would stay again for sure next time we are passing through.

Reviewed on May 27, 2026

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

Grand Center

$335

per person

Aug 14 - Aug 17

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

8.8/10 Excellent! (1,059 reviews)

A very unique artsy hotel. Had a fantastic stay there. The staff were all so kind and helpful. We got a complimentary upgrade to the Suite Room with a full kitchen. Location is perfect, the Commonwealth restaurant and the roof top bar were amazing. Good food, great drinks and amazing views of the city from the bar. Definitely staying here again.

Reviewed on May 23, 2026

Spacious 3-Bedroom with King Bed

Central West End

$999

per person

Aug 6 - Aug 10

found 1 day ago

Roundtrip flight included

New York (NYC) to St. Louis (STL)

8.8/10 Excellent! (11 reviews)

Clean room nice area

Reviewed on Feb 1, 2026

Homewood Suites by Hilton St. Louis Westport

$397

per person

Aug 14 - Aug 17

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

8.8/10 Excellent! (475 reviews)

Will definitely be staying here again!

Reviewed on May 23, 2026

Alhonna Resort LLC

$502

per person

Jul 3 - Jul 5

found 1 day ago

Roundtrip non-stop flight included

Philadelphia (PHL) to St. Louis (STL)

8.8/10 Excellent! (275 reviews)

This is a nice unique sprawling property. I have stayed there many times and love the character of the place. I’m pretty sure it changed hands a few years ago and the new owners are in top of making it better…

Reviewed on May 25, 2026

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Discover the most popular places to visit in Southeast Missouri

Elephant Rocks State Park

5/5(13 reviews)

You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.

Southeast Missouri State University

4.5/5(78 reviews)

Take a campus tour or just explore the area of Southeast Missouri State University, during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants.

Current River State Park

4/5(5 reviews)

Commune with nature and explore the great outdoors at Current River State Park during your travels in Salem. While you're in the area, stroll along the riverfront.

What to do in Southeast Missouri

Night Ghost Tour of Pythian Castle in Springfield Missouri

$20

per adult

100% of travellers recommend

See all activities in Southeast Missouri

Southeast Missouri Hotel Deals

Drury Plaza Hotel Cape Girardeau Conference Center

3351 Percy Drive Cape Girardeau MO

Fully refundableReserve now, pay when you stay

$100 nightly

$113 total

Jun 7 - Jun 8

Total with taxes and fees

9.6/10 Exceptional! (1,000 reviews)

"Nice choice I made, I would recommend."

Reviewed on May 26, 2026

Baymont Inn and Suites by Wyndham Farmington, MO

1625 W Columbia St Farmington MO

Fully refundableReserve now, pay when you stay

$58 nightly

$64 total

Jun 7 - Jun 8

Total with taxes and fees

8/10 Very Good! (1,003 reviews)

"Friendly and helpful staff. Quiet and clean facility. Conveniently located. Great value. Highly recommended."

Reviewed on May 27, 2026

Drury Inn & Suites Sikeston, MO

2608 East Malone Ave, Miner Sikeston MO

Fully refundableReserve now, pay when you stay

$106 nightly

$122 total

Jun 1 - Jun 2

Total with taxes and fees

9.6/10 Exceptional! (1,001 reviews)

"The breakfast and supper was great"

Reviewed on May 27, 2026

See all 662 properties in Southeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.