Name: Drury Plaza Hotel Cape Girardeau Conference Center
Price range: $102 total
Rating: 9.4

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Your Southeast Missouri Vacation

Book a vacation package to Southeast Missouri and travel on your own terms. You'll be captivated by its family-friendly attractions, history and culture. Kick off your trip to Southeast Missouri with a few nights in Cape Girardeau visiting popular sights like Isle Casino Cape Girardeau and Cape Splash Family Aquatic Center. Sikeston is another city that lures travelers from all over. The Book Bug and Central Park are two of the leading places to see here. Expedia has hotels, flights, car rentals and more to help you curate your very own tailored Southeast Missouri vacation today.

The Latest Southeast Missouri vacation packages

Price found within the past 48 hours. Click for updated prices.

Hilton Garden Inn Chesterfield

Save 100% on your flight

per person

Sep 4 - Sep 7

found 1 day ago

Roundtrip flight included

Dallas (DFW) to St. Louis (STL)

8.2/10 Very Good! (756 reviews)

I booked online and paid via the app. When I arrived on site they explained they had overbooked and had no rooms available. The staff was amazing and went above and beyond and secured a room at another location. Thank you to the staff for taking care of us.

Reviewed on Jul 26, 2025

The Wildwood Hotel

per person

Sep 4 - Sep 7

found 1 day ago

Roundtrip flight included

Dallas (DFW) to St. Louis (STL)

9/10 Wonderful! (1,549 reviews)

For the price, this hotel was great. A cheap clean stopover in St. Louis. We were very happy to have cafes and restaurants within walking distance too! And parking was free.

Reviewed on Jul 30, 2025

The Principal Hotel

Save 100% on your flight

per person

Sep 18 - Sep 22

found 10 hours ago

Roundtrip flight included

Dallas (DFW) to St. Louis (STL)

9.8/10 Exceptional! (88 reviews)

Very clean quiet , room excellent ,mattress very comfortable, extra towels Overall experience awesome.

Reviewed on Jul 26, 2025

River City Casino & Hotel

Save 100% on your flight

per person

Sep 4 - Sep 7

found 1 day ago

Roundtrip flight included

Dallas (DFW) to St. Louis (STL)

9/10 Wonderful! (1,262 reviews)

Very clean and nice room. Walls seem a little thin since the neighbors were pretty loud, but all around great experience.

Reviewed on Jul 30, 2025

Days Inn by Wyndham St Peters/St Charles

per person

Sep 21 - Sep 28

found 1 day ago

Roundtrip non-stop flight included

New York (JFK) to St. Louis (STL)

6.2/10 (953 reviews)

Nice hotel in a safe area. Normally do not stay at days inn, but this one was actually decent pricing and good area. Did not feel unsafe.

Reviewed on Jul 22, 2025

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Discover the most popular places to visit in Southeast Missouri

Taum Sauk Mountain in located in the St.Francis mountain range of south/central Missouri. It's also the highest point in Missouri. My kids are standing at the spot where the actual marker sign in

Elephant Rocks State Park

You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.

Echo Bluff is Missouri's newest State Park.

Echo Bluff State Park

You can take time to visit Echo Bluff State Park during your travels to Salem. While you're in the area, stroll along the riverfront.

Beautiful area. Easy to get up close and not too far off the main road. 🏞 #waterfalls #nature #explore #missouri

Rocky Falls

Commune with nature and explore the great outdoors at Rocky Falls during your travels in Winona. While you're in the area, wander around the natural setting.

Southeast Missouri Hotel Deals

Baymont Inn and Suites by Wyndham Farmington, MO

1625 W Columbia St, Farmington, MO

Fully refundableReserve now, pay when you stay

$56 nightly

$64 total

Aug 12 - Aug 13

Total includes taxes and fees

8/10 Very Good! (1,003 reviews)

"Fair prices and nice staff well taken care ofby the Baymont family"

Reviewed on Jul 30, 2025

The Riverview

777 Main St, Cape Girardeau, MO

Fully refundableReserve now, pay when you stay

$117 nightly

$132 total

Aug 3 - Aug 4

Total includes taxes and fees

9.2/10 Wonderful! (365 reviews)

Great Economical Place to Stay

"It was a great place to stay. Even though a casino is attached to the hotel, it seemed like we were in a nice secluded area of Cape Girardeau. Everything was like new and very nice. Even had a Starbucks so we were able to get a refreshment before we got back on the road. The only down side was that ..."

Reviewed on Jul 29, 2025

Drury Plaza Hotel Cape Girardeau Conference Center

3351 Percy Drive, Cape Girardeau, MO

Fully refundableReserve now, pay when you stay

$90 nightly

$102 total

Aug 5 - Aug 6

Total includes taxes and fees

9.4/10 Exceptional! (1,001 reviews)

5 stars

"Hotel was extremely nice and comfortable. Unfortunately my family was unable to take advantage of the drinks and snacks in the lobby due to several youth volleyball teams also staying at the hotel. They took over the lobby and pool area and were so loud we couldn’t hear the hotel staff checking us ..."

Reviewed on Jul 24, 2025

See all 588 properties in Southeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.