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Southeast Missouri Vacation Rentals

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Check prices for these dates

In two weeks
Jan 30 - Feb 1
In two months
Mar 13 - Mar 15
In three months
Apr 10 - Apr 12
In four months
May 8 - May 10

Our top choices for Southeast Missouri vacation rentals

Cabin, 1 Queen Bed | Private kitchen | Mini-fridge, stovetop, cookware/dishes/utensils, paper towels
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Cabin in French Village

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
2.0 star property
9.8 out of 10, Exceptional, (47 reviews)
"I had a great time with my mom there!"
United States
Lily
$129 nightly
The price is $139
Jan 13 - Jan 14
Total with taxes and fees
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
Fridge, microwave, oven, stovetop
The Lux- Cozy 2-bedroom apartment with AC and WiFi in enjoyable Bonne Terre

Apartment in Bonne Terre

The Lux- Cozy 2-bedroom apartment with AC and WiFi in enjoyable Bonne Terre
9.2 out of 10, Wonderful, (17 reviews)
"Really nice and enjoyable....would stay again"
United States
mark n.
$160 nightly
The price is $164
Jan 16 - Jan 17
Total with taxes and fees
The Lux- Cozy 2-bedroom apartment with AC and WiFi in enjoyable Bonne Terre
Property grounds
Get Away Acres 1/2 mile off highway 60 extra sanitized

Vacation Home in Ellsinore

Get Away Acres 1/2 mile off highway 60 extra sanitized
10.0 out of 10, Exceptional, (95 reviews)
"We really enjoyed our stay! Host was very friendly and quick to respond to questions! We will definitely stay again!!"
United States
Anonymous traveler
$125 nightly
The price is $131
Jan 13 - Jan 14
Total with taxes and fees
Get Away Acres 1/2 mile off highway 60 extra sanitized
Dining
⚜️Rivertown Retreat⚜️ Lewis & Clark stayed here. King bed. Sleeps 4

Cottage in Ste. Genevieve

⚜️Rivertown Retreat⚜️ Lewis & Clark stayed here. King bed. Sleeps 4
2.0 star property
10.0 out of 10, Exceptional, (18 reviews)
"Great historic property!"
United States
Rhonda R.
$196 nightly
The price is $196
Jan 13 - Jan 14
Total with taxes and fees
⚜️Rivertown Retreat⚜️ Lewis & Clark stayed here. King bed. Sleeps 4
Interior
Charming 2-bedroom house with AC, WiFi in serene Van Buren

Vacation Home in Van Buren

Charming 2-bedroom house with AC, WiFi in serene Van Buren
2.0 star property
9.0 out of 10, Wonderful, (15 reviews)
"It was beautiful and homey. We really enjoyed our stay. "
United States
Jessica
$160 nightly
The price is $168
Jan 13 - Jan 14
Total with taxes and fees
Charming 2-bedroom house with AC, WiFi in serene Van Buren
Exterior detail
"The Hideaway 2" Charming 2-bedroom house in delightful Farmington with WiFi, AC

Vacation Home in Farmington

"The Hideaway 2" Charming 2-bedroom house in delightful Farmington with WiFi, AC
2.0 star property
10.0 out of 10, Exceptional, (8 reviews)
"It is a very nice place and very comfortable has everything you could possibly need for homeaway from home."
United States
Scott
$219 nightly
The price is $230
Jan 14 - Jan 15
Total with taxes and fees
"The Hideaway 2" Charming 2-bedroom house in delightful Farmington with WiFi, AC
Fridge, microwave, oven, stovetop
Relax in the country at Countryside Villas! - Villa A

Apartment in Jackson

Relax in the country at Countryside Villas! - Villa A
10.0 out of 10, Exceptional, (33 reviews)
"Great place to stay, felt like home away from home. "
United States
Brittany
$170 nightly
The price is $183
Jan 13 - Jan 14
Total with taxes and fees
Relax in the country at Countryside Villas! - Villa A
Property grounds
"Little Brick House on Main (1865)”

Vacation Home in Ste. Genevieve

"Little Brick House on Main (1865)”
10.0 out of 10, Exceptional, (63 reviews)
"Great place to stay!"
United States
Lettitia B.
$159 nightly
The price is $159
Jan 13 - Jan 14
Total with taxes and fees
"Little Brick House on Main (1865)”
Fridge, microwave, oven, stovetop
"The Hideaway 1" Charming 2-bedroom house with WiFi, AC in fabulous Farmington

Vacation Home in Farmington

"The Hideaway 1" Charming 2-bedroom house with WiFi, AC in fabulous Farmington
2.0 star property
10.0 out of 10, Exceptional, (13 reviews)
"Great place and very comfortable! Hosts were super attentive when our door code didn’t work and got us sorted out right away. "
United States
Kyser B.
$219 nightly
The price is $230
Jan 13 - Jan 14
Total with taxes and fees
"The Hideaway 1" Charming 2-bedroom house with WiFi, AC in fabulous Farmington
Living area
Little Blue Cottage on Spanish

Vacation Home in Cape Girardeau

Little Blue Cottage on Spanish
8.6 out of 10, Excellent, (48 reviews)
"I would definitely stay here again!"
United States
Bonita
$101 nightly
The price is $101
Jan 13 - Jan 14
Total with taxes and fees
Little Blue Cottage on Spanish
Exterior
Beautiful Modern Loft In Wine Country!

Apartment in Ste. Genevieve

Beautiful Modern Loft In Wine Country!
10.0 out of 10, Exceptional, (272 reviews)
"Loved our stay here! Thoughtful amenities on a beautiful property. Great communication with host. "
United States
Elsie H.
$168 nightly
The price is $179
Jan 19 - Jan 20
Total with taxes and fees
Beautiful Modern Loft In Wine Country!
Fridge, microwave, oven, stovetop
Lake Road Cabin C — Million Dollar Ozark View!

Cabin in Ironton

Lake Road Cabin C — Million Dollar Ozark View!
10.0 out of 10, Exceptional, (24 reviews)
"Girls weekend enjoyed our time. Just a great little cabin so we could enjoy the parks!"
United States
Jeanine H.
$149 nightly
The price is $158
Jan 13 - Jan 14
Total with taxes and fees
Lake Road Cabin C — Million Dollar Ozark View!
Property grounds
Newly remodeled house minutes away from downtown, golf courses + BIG back yard

Vacation Home in Farmington

Newly remodeled house minutes away from downtown, golf courses + BIG back yard
2.0 star property
10.0 out of 10, Exceptional, (22 reviews)
"Everything about this property was amazing and perfect for our family! They were so helpful with everything and our kids loved it here!!"
United States
Heaven B.
$198 nightly
The price is $209
Jan 13 - Jan 14
Total with taxes and fees
Newly remodeled house minutes away from downtown, golf courses + BIG back yard
Property grounds
Couples Retreat with hot tub (cabin2)

Cabin in Leadwood

Couples Retreat with hot tub (cabin2)
9.6 out of 10, Exceptional, (21 reviews)
"Nive quite lil getawaynyet close to what you needed "
United States
Do more a.
$145 nightly
The price is $156
Jan 13 - Jan 14
Total with taxes and fees
Couples Retreat with hot tub (cabin2)
1 bedroom, in-room safe, desk, iron/ironing board
Mountain View at Pickle & Perk

Apartment in Ironton

Mountain View at Pickle & Perk
2.5 star property
10.0 out of 10, Exceptional, (19 reviews)
"Very cute place in beautiful area. Easy check-in, clean home, and comfy bed. The coffee shop below was really good with a beautiful patio. Location was perfect to access Elephant Rocks, Johnson Shut-ins, and Taum Sauk Mountain parks. "
United States
Amber S.
$180 nightly
The price is $189
Jan 13 - Jan 14
Total with taxes and fees
Mountain View at Pickle & Perk
Fridge, microwave, oven, stovetop
Clearwater Lake, cabin minutes from Bluff View Marina & boat dock

Cabin in Piedmont

Clearwater Lake, cabin minutes from Bluff View Marina & boat dock
10.0 out of 10, Exceptional, (34 reviews)
"Beautiful property, I’d recommend to anyone going here to stay here."
United States
tom
$140 nightly
The price is $140
Jan 13 - Jan 14
Total with taxes and fees
Clearwater Lake, cabin minutes from Bluff View Marina & boat dock
Interior
Artistic and Creative Vibe with Indoor Swing 2 Blocks to Downtown & near SEMO

Apartment in Cape Girardeau

Artistic and Creative Vibe with Indoor Swing 2 Blocks to Downtown & near SEMO
9.6 out of 10, Exceptional, (47 reviews)
"This place is AWESOME! It's clean, artsy, fun, and if we ever have a chance, we will certainly return!"
United States
Jordan S.
$132 nightly
The price is $138
Jan 13 - Jan 14
Total with taxes and fees
Artistic and Creative Vibe with Indoor Swing 2 Blocks to Downtown & near SEMO
Interior
The Sutton House 2 blocks from Main Street & Courthouse Square

Vacation Home in Ironton

The Sutton House 2 blocks from Main Street & Courthouse Square
10.0 out of 10, Exceptional, (46 reviews)
"Adorable house with everyone you need provided! Super clean and the beds were very comfy. Will stay here again on our next trip to the area. "
United States
Brandi
$154 nightly
The price is $174
Jan 13 - Jan 14
Total with taxes and fees
The Sutton House 2 blocks from Main Street & Courthouse Square
Smart TV, computer monitors
Cabin 1 at the Pallet Factory

Cabin in Leadwood

Cabin 1 at the Pallet Factory
9.6 out of 10, Exceptional, (40 reviews)
"This place was great, seen plenty of deer and other wildlife out there!! I didn’t do any fishing but during the day, watching all the catfish at the surface swimming slowly around was fun. The owners are great to deal with and I had an issue with a water heater and it was taken care of right away."
United States
Randy
$145 nightly
The price is $156
Jan 13 - Jan 14
Total with taxes and fees
Cabin 1 at the Pallet Factory
Smart TV
82 Acre Hobby Farm with Lincoln Log Cabin

Cabin in De Soto

82 Acre Hobby Farm with Lincoln Log Cabin
10.0 out of 10, Exceptional, (41 reviews)
"Had a great stay enjoyed the beds, porches and the chickens. Great mornings listening to the birds. "
United States
posata c.
$257 nightly
The price is $266
Jan 13 - Jan 14
Total with taxes and fees
82 Acre Hobby Farm with Lincoln Log Cabin
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Southeast Missouri Hotel Reviews

Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO

10/10 Excellent
"Very clean room and friendly staff"
michael 1-night trip
Posted 1 day ago
Drury Inn & Suites Jackson MO

Find out more about Southeast Missouri

Everything you need to know about Southeast Missouri vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Southeast Missouri vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Southeast Missouri vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Southeast Missouri vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Southeast Missouri. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Southeast Missouri in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $101 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on Southeast Missouri rentals

At Expedia, we put the best Southeast Missouri vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Southeast Missouri rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Southeast Missouri vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Southeast Missouri. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

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