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Southeast Missouri Vacation Rentals

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Dec 5 - Dec 7
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Feb 13 - Feb 15
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Mar 13 - Mar 15

Vacation Rentals in Southeast Missouri

Exterior detail
"Little Brick House on Main (1865)”

"Little Brick House on Main (1865)”

Ste. Genevieve
10.0 out of 10, Exceptional, (62)
"Great place to stay!"
United States
Lettitia B.
$159 nightly
The price is $159
Nov 20 - Nov 21
Total with taxes and fees
"Little Brick House on Main (1865)”
Exterior
Couples Retreat with hot tub (cabin2)

Couples Retreat with hot tub (cabin2)

Leadwood
9.6 out of 10, Exceptional, (21)
"it was a nice cozy stay"
United States
Alvaro
$145 nightly
The price is $156
Nov 21 - Nov 22
Total with taxes and fees
Couples Retreat with hot tub (cabin2)
Terrace/patio
The Twisted Sassafras Treehouse

The Twisted Sassafras Treehouse

Cape Girardeau
10.0 out of 10, Exceptional, (26)
"The place was awesome very clean the host was very accommodating. Nice a quiet for a relaxing stay highly recommend "
United States
Gary C.
$289 nightly
The price is $301
Nov 19 - Nov 20
Total with taxes and fees
The Twisted Sassafras Treehouse
Fridge, microwave, oven, stovetop
Artistic and Creative Vibe with Indoor Swing 2 Blocks to Downtown & near SEMO

Artistic and Creative Vibe with Indoor Swing 2 Blocks to Downtown & near SEMO

Cape Girardeau
9.6 out of 10, Exceptional, (43)
"This place is AWESOME! It's clean, artsy, fun, and if we ever have a chance, we will certainly return!"
United States
Jordan S.
$132 nightly
The price is $138
Nov 19 - Nov 20
Total with taxes and fees
Artistic and Creative Vibe with Indoor Swing 2 Blocks to Downtown & near SEMO
Beach
Your home away from home in downtown, historic Farmington!

Your home away from home in downtown, historic Farmington!

Farmington
10.0 out of 10, Exceptional, (36)
"Beautiful piece of property. Would stay here again and again. "
United States
Mary N.
$232 nightly
The price is $232
Nov 23 - Nov 24
Total with taxes and fees
Your home away from home in downtown, historic Farmington!
Cabin | 5 bedrooms
Sam A Baker State Park

Sam A Baker State Park

2.0 star property
Patterson
9.2 out of 10, Wonderful, (5)
"Pet friendly, great staff. "
United States
Charlie
$125 nightly
The price is $132
Nov 19 - Nov 20
Total with taxes and fees
Sam A Baker State Park
1 bedroom, iron/ironing board, bed sheets
Beautiful Modern Loft In Wine Country!

Beautiful Modern Loft In Wine Country!

Ste. Genevieve
10.0 out of 10, Exceptional, (270)
"We had an absolutely wonderful time at this beautiful home. It was restful and refreshing. We especially enjoyed sitting in the chairs outside as the sun set and watching the deer and lightning bugs come out at twilight. We look forward to returning when we can!"
United States
Jeremy H.
$169 nightly
The price is $180
Nov 25 - Nov 26
Total with taxes and fees
Beautiful Modern Loft In Wine Country!
2 bedrooms, iron/ironing board, free WiFi, bed sheets
Charming 2-bedroom house with 2 KING BEDS in Pleasant Poplar Bluff

Charming 2-bedroom house with 2 KING BEDS in Pleasant Poplar Bluff

Poplar Bluff
8.6 out of 10, Excellent, (8)
"The house was very clean and nicely decorated. The huge TV in the living room was a plus and the mattress was very comfortable. We would stay again!"
United States
Brian
$254 nightly
The price is $254
Nov 21 - Nov 22
Total with taxes and fees
Charming 2-bedroom house with 2 KING BEDS in Pleasant Poplar Bluff
Outdoor dining
Cabin 1 at the Pallet Factory

Cabin 1 at the Pallet Factory

Leadwood
9.6 out of 10, Exceptional, (36)
"Just what we expected. Very quiet and secluded. Close to towns. "
United States
Cheyenne F.
$145 nightly
The price is $156
Nov 19 - Nov 20
Total with taxes and fees
Cabin 1 at the Pallet Factory
Outdoor dining
Doves Nest Guest House<br> Tranquil & Relaxing

Doves Nest Guest House<br> Tranquil & Relaxing

Ste. Genevieve
10.0 out of 10, Exceptional, (54)
"Great place. Close to everything you need for a great stay in St. Genevieve. Easy check and great host."
United States
Justin S.
$268 nightly
The price is $268
Nov 20 - Nov 21
Total with taxes and fees
Doves Nest Guest House<br> Tranquil & Relaxing
Property grounds
Collier Cabin in Pine Hollow ~ Eminence, MO

Collier Cabin in Pine Hollow ~ Eminence, MO

Birch Tree
9.6 out of 10, Exceptional, (25)
"Really awesome!!"
United States
Melinda R.
Collier Cabin in Pine Hollow ~ Eminence, MO
Fridge, microwave, oven, stovetop
Springside Cottage in beautiful Eminence. Great outdoor space - NEW Hot tub!

Springside Cottage in beautiful Eminence. Great outdoor space - NEW Hot tub!

Eminence
9.2 out of 10, Wonderful, (15)
"My family (kids 17, 16, and 7 years old plus husband and I) stayed at Springside Cottage Monday through Friday and had a wonderful little vacation. The location is perfect and the cottage was very comfortable. The host was super responsive and kind. Would stay again!"
United States
Jane L.
Springside Cottage in beautiful Eminence. Great outdoor space - NEW Hot tub!
Front of property
Lake Wappapello

Lake Wappapello

2.0 star property
Williamsville
10.0 out of 10, Exceptional, (1)
"We did loose internet connection so gps did not always help but the local stores did. Also the managers answered their phones and were so helpful in many ways! I’m very glad we went."
United States
Dyann
$138 nightly
The price is $146
Nov 19 - Nov 20
Total with taxes and fees
Lake Wappapello
Private kitchen
Cozy Cabin on the edge of town only 1/2 mile from Current River !

Cozy Cabin on the edge of town only 1/2 mile from Current River !

Van Buren
9.4 out of 10, Exceptional, (8)
"We stay here a couple times a year. In the summer to float the river and in the winter to be near relatives for the holidays. Great experience in both seasons. Very close to the river, gas, and grocery. "
United States
Shelie L.
Cozy Cabin on the edge of town only 1/2 mile from Current River !
Fridge, microwave, oven, stovetop
Beautiful, secluded cabin in the hills of the Ozarks.

Beautiful, secluded cabin in the hills of the Ozarks.

birch tree
9.8 out of 10, Exceptional, (141)
"This place was perfect. Exactly as advertised, super clean, awesome location. Secluded and private. Affordable. We will 100 percent be staying again. It was a treat!"
United States
jack w.
Beautiful, secluded cabin in the hills of the Ozarks.
Exterior
Quaint, Beautiful Home next to SEMO and Hospital

Quaint, Beautiful Home next to SEMO and Hospital

Cape Girardeau
9.8 out of 10, Exceptional, (41)
"Great stay, great location! "
United States
Deana K.
Quaint, Beautiful Home next to SEMO and Hospital
Property grounds
Charming 2 bedroom cabin on a beautiful private lake.

Charming 2 bedroom cabin on a beautiful private lake.

Ironton
9.4 out of 10, Exceptional, (16)
"Place is nice & easy to find. "
United States
Mercy
$195 nightly
The price is $195
Nov 19 - Nov 20
Total with taxes and fees
Charming 2 bedroom cabin on a beautiful private lake.
Exterior detail
Fox Pen Cabins Cabin #2 Not friendly for street bikes… Pet-Friendly

Fox Pen Cabins Cabin #2 Not friendly for street bikes… Pet-Friendly

3.0 star property
Eminence
9.2 out of 10, Wonderful, (10)
"Great little cabin, roads to cabin not the best but worth it!"
United States
Pam
Fox Pen Cabins Cabin #2 Not friendly for street bikes… Pet-Friendly
Fridge, microwave, oven, stovetop
Sunset Ridge - Peaceful 3-bedroom house with WiFi and AC in lovely Weingarten.

Sunset Ridge - Peaceful 3-bedroom house with WiFi and AC in lovely Weingarten.

New Offenburg
10.0 out of 10, Exceptional, (4)
"Relaxing setting between Farmington and St Genevieve. Both towns are rich in history and have small town charm. "
United States
Tim M.
$269 nightly
The price is $281
Nov 20 - Nov 21
Total with taxes and fees
Sunset Ridge - Peaceful 3-bedroom house with WiFi and AC in lovely Weingarten.
Dining
“The Cabin”@ Serenity Ranch. Centrally located to all the wonders of Shannon co.

“The Cabin”@ Serenity Ranch. Centrally located to all the wonders of Shannon co.

Winona
10.0 out of 10, Exceptional, (14)
"This property is beautiful. It had everything we needed to enjoy our stay. I would highly recommend this cabin. So cute."
United States
Ruth B.
“The Cabin”@ Serenity Ranch. Centrally located to all the wonders of Shannon co.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Southeast Missouri Hotel Reviews

The Farmstead Hotel

The Farmstead Hotel

10/10 Excellent
"Clean room! Very friendly and helpful staff, especially the lady from Blytheville that helped us check in the first night. Only complaint is that in the middle of the day, the lobby filled up with cigarette smoke because the back door was left open during smoke break. "
Jacki 2-night trip
Posted 1 day ago
The Farmstead Hotel

Find out more about Southeast Missouri

Everything you need to know about Southeast Missouri vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Southeast Missouri vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Southeast Missouri vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Southeast Missouri vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Southeast Missouri. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Southeast Missouri in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $132 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on Southeast Missouri rentals

At Expedia, we put the best Southeast Missouri vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Southeast Missouri rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Southeast Missouri vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Southeast Missouri. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

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