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Southeast Missouri Vacation Rentals

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Jan 9 - Jan 11
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Jan 16 - Jan 18

Our top choices for Southeast Missouri vacation rentals

Cabin, 1 Queen Bed | Private kitchen | Mini-fridge, stovetop, cookware/dishes/utensils, paper towels
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
2.0 star property
French Village
9.8 out of 10, Exceptional, (46)
"The cabin was cozy and very peaceful such a good experience "
United States
Russhell
$116 nightly
The price is $124
Jan 12 - Jan 13
Total with taxes and fees
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
Outdoor dining
Cabin 1 at the Pallet Factory

Cabin 1 at the Pallet Factory

Cabin 1 at the Pallet Factory
Leadwood
9.6 out of 10, Exceptional, (39)
"This place was great, seen plenty of deer and other wildlife out there!! I didn’t do any fishing but during the day, watching all the catfish at the surface swimming slowly around was fun. The owners are great to deal with and I had an issue with a water heater and it was taken care of right away."
United States
Randy
$145 nightly
The price is $156
Jan 6 - Jan 7
Total with taxes and fees
Cabin 1 at the Pallet Factory
House | Living area
Tiny Houses of French Village

Tiny Houses of French Village

Tiny Houses of French Village
2.5 star property
French Village
10.0 out of 10, Exceptional, (3)
"Charming property with a space for everything and everything in its place. Would not hesitate to recommend or stay again."
United States
Norma
$304 nightly
The price is $323
Jan 6 - Jan 7
Total with taxes and fees
Tiny Houses of French Village
Interior
Charming 2-bedroom house with AC, WiFi in serene Van Buren

Charming 2-bedroom house with AC, WiFi in serene Van Buren

Charming 2-bedroom house with AC, WiFi in serene Van Buren
2.0 star property
Van Buren
9.0 out of 10, Wonderful, (15)
"It was beautiful and homey. We really enjoyed our stay. "
United States
Jessica
$160 nightly
The price is $168
Jan 6 - Jan 7
Total with taxes and fees
Charming 2-bedroom house with AC, WiFi in serene Van Buren
Exterior
Couples Retreat with hot tub (cabin2)

Couples Retreat with hot tub (cabin2)

Couples Retreat with hot tub (cabin2)
Leadwood
9.6 out of 10, Exceptional, (21)
"Nive quite lil getawaynyet close to what you needed "
United States
Do more a.
$145 nightly
The price is $156
Jan 13 - Jan 14
Total with taxes and fees
Couples Retreat with hot tub (cabin2)
Private kitchen
Charming 2-bedroom apartment in fabulous Marble Hill with AC

Charming 2-bedroom apartment in fabulous Marble Hill with AC

Charming 2-bedroom apartment in fabulous Marble Hill with AC
Marble Hill
7.6 out of 10, Good, (5)
"Host was not properly notified of the booking, but made the accommodations made several trips to make sure we were checked in and comfortable. Also gave very good advice for local points of interest."
United States
Chrystine H.
$127 nightly
The price is $133
Jan 6 - Jan 7
Total with taxes and fees
Charming 2-bedroom apartment in fabulous Marble Hill with AC
Interior
Little Blue Cottage on Spanish

Little Blue Cottage on Spanish

Little Blue Cottage on Spanish
Cape Girardeau
8.6 out of 10, Excellent, (48)
"I would definitely stay here again!"
United States
Bonita
$101 nightly
The price is $101
Jan 6 - Jan 7
Total with taxes and fees
Little Blue Cottage on Spanish
Outdoor dining
"The Hideaway 2" Charming 2-bedroom house in delightful Farmington with WiFi, AC

"The Hideaway 2" Charming 2-bedroom house in delightful Farmington with WiFi, AC

"The Hideaway 2" Charming 2-bedroom house in delightful Farmington with WiFi, AC
2.0 star property
Farmington
10.0 out of 10, Exceptional, (8)
"It is a very nice place and very comfortable has everything you could possibly need for homeaway from home."
United States
Scott
$219 nightly
The price is $230
Jan 6 - Jan 7
Total with taxes and fees
"The Hideaway 2" Charming 2-bedroom house in delightful Farmington with WiFi, AC
2 bedrooms, WiFi, bed sheets
The Lux- Cozy 2-bedroom apartment with AC and WiFi in enjoyable Bonne Terre

The Lux- Cozy 2-bedroom apartment with AC and WiFi in enjoyable Bonne Terre

The Lux- Cozy 2-bedroom apartment with AC and WiFi in enjoyable Bonne Terre
Bonne Terre
9.2 out of 10, Wonderful, (17)
"Really nice and enjoyable....would stay again"
United States
mark n.
$160 nightly
The price is $164
Jan 21 - Jan 22
Total with taxes and fees
The Lux- Cozy 2-bedroom apartment with AC and WiFi in enjoyable Bonne Terre
Outdoor dining
"The Hideaway 1" Charming 2-bedroom house with WiFi, AC in fabulous Farmington

"The Hideaway 1" Charming 2-bedroom house with WiFi, AC in fabulous Farmington

"The Hideaway 1" Charming 2-bedroom house with WiFi, AC in fabulous Farmington
2.0 star property
Farmington
10.0 out of 10, Exceptional, (13)
"Great place and very comfortable! Hosts were super attentive when our door code didn’t work and got us sorted out right away. "
United States
Kyser B.
$219 nightly
The price is $230
Jan 6 - Jan 7
Total with taxes and fees
"The Hideaway 1" Charming 2-bedroom house with WiFi, AC in fabulous Farmington
Fridge, microwave, oven, stovetop
Artistic and Creative Vibe with Indoor Swing 2 Blocks to Downtown & near SEMO

Artistic and Creative Vibe with Indoor Swing 2 Blocks to Downtown & near SEMO

Artistic and Creative Vibe with Indoor Swing 2 Blocks to Downtown & near SEMO
Cape Girardeau
9.6 out of 10, Exceptional, (47)
"This place is AWESOME! It's clean, artsy, fun, and if we ever have a chance, we will certainly return!"
United States
Jordan S.
$132 nightly
The price is $138
Jan 6 - Jan 7
Total with taxes and fees
Artistic and Creative Vibe with Indoor Swing 2 Blocks to Downtown & near SEMO
Fridge, microwave, oven, stovetop
⚜️Rivertown Retreat⚜️ Lewis & Clark stayed here. King bed. Sleeps 4

⚜️Rivertown Retreat⚜️ Lewis & Clark stayed here. King bed. Sleeps 4

⚜️Rivertown Retreat⚜️ Lewis & Clark stayed here. King bed. Sleeps 4
2.0 star property
Ste. Genevieve
10.0 out of 10, Exceptional, (18)
"Great historic property!"
United States
Rhonda R.
$200 nightly
The price is $200
Jan 6 - Jan 7
Total with taxes and fees
⚜️Rivertown Retreat⚜️ Lewis & Clark stayed here. King bed. Sleeps 4
Full-size fridge, microwave, oven, stovetop
Johnson's Shut-ins State Park

Johnson's Shut-ins State Park

Johnson's Shut-ins State Park
3.0 star property
Middle Brook
10.0 out of 10, Exceptional, (1)
"These newer cabins are clean and have everything you need. Highly recommend! "
United States
Shelly
$252 nightly
The price is $266
Jan 6 - Jan 7
Total with taxes and fees
Johnson's Shut-ins State Park
Dining
Cute town house with fenced backyard

Cute town house with fenced backyard

Cute town house with fenced backyard
Barnhart
9.6 out of 10, Exceptional, (17)
"It was a great place to stay for our needs we had our little dog with us as was there for weekend, it had a nice fenced back yard we could let her just go out didn't have to have her on leash. Was very nice inside clean well kept, beds were surprising comfortable. The host stayed in contact and answered a lot questions before we arrived which put me a ease for our trip. High recommand this place if needing to stay in the area. "
United States
Terry
$240 nightly
The price is $254
Feb 1 - Feb 2
Total with taxes and fees
Cute town house with fenced backyard
Property grounds
Newly remodeled house minutes away from downtown, golf courses + BIG back yard

Newly remodeled house minutes away from downtown, golf courses + BIG back yard

Newly remodeled house minutes away from downtown, golf courses + BIG back yard
2.0 star property
Farmington
10.0 out of 10, Exceptional, (22)
"Everything about this property was amazing and perfect for our family! They were so helpful with everything and our kids loved it here!!"
United States
Heaven B.
$200 nightly
The price is $211
Jan 7 - Jan 8
Total with taxes and fees
Newly remodeled house minutes away from downtown, golf courses + BIG back yard
Classic Cabin
Sam A Baker State Park

Sam A Baker State Park

Sam A Baker State Park
2.0 star property
Patterson
9.0 out of 10, Wonderful, (6)
"Pet friendly, great staff. "
United States
Charlie
$135 nightly
The price is $143
Jan 6 - Jan 7
Total with taxes and fees
Sam A Baker State Park
Fridge, microwave, oven, stovetop
82 Acre Hobby Farm with Lincoln Log Cabin

82 Acre Hobby Farm with Lincoln Log Cabin

82 Acre Hobby Farm with Lincoln Log Cabin
De Soto
10.0 out of 10, Exceptional, (41)
"Had a great stay enjoyed the beds, porches and the chickens. Great mornings listening to the birds. "
United States
posata c.
$257 nightly
The price is $266
Jan 6 - Jan 7
Total with taxes and fees
82 Acre Hobby Farm with Lincoln Log Cabin
Property grounds
Secluded in the woods, couple’s romantic cabin & hot tub, brkfast foods provided

Secluded in the woods, couple’s romantic cabin & hot tub, brkfast foods provided

Secluded in the woods, couple’s romantic cabin & hot tub, brkfast foods provided
2.0 star property
Greenville
10.0 out of 10, Exceptional, (6)
"Cute, cozy, private getaway that you won't want to leave!"
United States
Jade G.
$239 nightly
The price is $252
Jan 8 - Jan 9
Total with taxes and fees
Secluded in the woods, couple’s romantic cabin & hot tub, brkfast foods provided
Exterior
Lake Road Cabin C — Million Dollar Ozark View!

Lake Road Cabin C — Million Dollar Ozark View!

Lake Road Cabin C — Million Dollar Ozark View!
Ironton
10.0 out of 10, Exceptional, (24)
"Girls weekend enjoyed our time. Just a great little cabin so we could enjoy the parks!"
United States
Jeanine H.
$149 nightly
The price is $158
Jan 6 - Jan 7
Total with taxes and fees
Lake Road Cabin C — Million Dollar Ozark View!
Exterior detail
"Little Brick House on Main (1865)”

"Little Brick House on Main (1865)”

"Little Brick House on Main (1865)”
Ste. Genevieve
10.0 out of 10, Exceptional, (63)
"Great place to stay!"
United States
Lettitia B.
$159 nightly
The price is $159
Jan 6 - Jan 7
Total with taxes and fees
"Little Brick House on Main (1865)”
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Southeast Missouri Hotel Reviews

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

10/10 Excellent
"Warm lights in rooms and hall ways would be great, currently white (day) lights everywhere"
Murtaza 1-night trip
Posted 9 hours ago
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

Find out more about Southeast Missouri

Everything you need to know about Southeast Missouri vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Southeast Missouri vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Southeast Missouri vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Southeast Missouri vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Southeast Missouri. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Southeast Missouri in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $101 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on Southeast Missouri rentals

At Expedia, we put the best Southeast Missouri vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Southeast Missouri rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Southeast Missouri vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Southeast Missouri. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

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