Southeast Missouri Vacations from $572

A Southeast Missouri vacation package in Cape Girardeau lets you combine flights, hotel stays, and rental cars. Over half of hotels in Cape Girardeau offer free breakfast, and over half also provide airport shuttle service to Paducah, KY (PAH-Barkley Regional).


Exactly what's included will vary by hotel and package, so it's worth reviewing the details before you confirm your booking.

When you bundle, you can save up to 30%*. To save money on a Southeast Missouri package, consider traveling during the quieter months or be flexible with your dates to find more options. Bundling your flights and hotel together often unlocks savings compared to booking separately. *Members only. Savings vary.

Because it is an outdoor and nature destination, many travelers find the spring and fall months ideal for exploring the scenic views and adventure activities, thanks to milder weather conditions. It's always a good idea to check local event calendars for specific cities like Cape Girardeau or Van Buren to align your trip with any festivals or activities that might interest you.

For a Southeast Missouri vacation, consider these destinations as a base, each offering a distinct experience:

• Cape Girardeau: This city is a strong choice for romantic getaways and travelers interested in outdoor activities, scenic views, and adventure.
• Van Buren: Ideal for those prioritizing outdoor activities, scenic beauty, and adventure, with options also suitable for romantic trips.
• Eminence: A great base for eco-friendly travel, offering abundant outdoor activities, scenic views, and adventure opportunities.
• Sikeston: Families will appreciate this destination for its family-friendly attractions, alongside options for outdoor activities and romantic getaways.

Southeast Missouri is primarily an outdoor and nature destination, known for its scenic views and adventure activities. Travelers seeking a Southeast Missouri vacation will find ample opportunities for hiking, exploring state parks, and enjoying the region's natural beauty.


The area offers a mix of outdoor recreation and historical sites. For example, you can explore the natural wonders of Echo Bluff State Park near Eminence or delve into history at Fort Davidson State Historic Site in Ironton. The focus here is on engaging with the natural landscape and discovering local heritage.

For a Southeast Missouri vacation, travelers typically fly into St. Louis Lambert International Airport (STL), which serves the wider region. From there, you can arrange ground transportation to your specific destination within Southeast Missouri.


Alternatively, for closer access to the southeastern part of the region, Cape Girardeau Municipal Airport (CGI) offers a more local option.

A Southeast Missouri vacation is best explored from a base like Cape Girardeau, with many sights accessible from there:


Browse and book things to do in Southeast Missouri on Expedia.

Yes, you can cancel your vacation package via your itinerary page on Expedia or by contacting customer service. Remember that some packages are fully refundable, but the details vary based on each unique booking. A fully refundable package may depend on how far out from the travel dates you're canceling and what airline you are traveling with.

Yes, members who join our free One Key™ travel rewards program can instantly unlock additional savings and save 10% or more on over 500,000 stays worldwide with Member Prices and over 1 million car rentals.

Yes, with Expedia's Book Now, Pay Later option, powered by Affirm, you can spread the cost of your Southeast Missouri vacation over 3, 6, or 12 months. With no late payment fees or hidden costs, it's easy to secure your ideal vacation package as soon as you spot it.

To find last-minute vacation packages to Southeast Missouri, explore the last-minute deals section for the latest package offers, including flights, departing in the coming weeks. Being flexible with your travel dates and hotel preferences can help you secure the best prices.

Free cancellation on a Southeast Missouri vacation package depends on the specific hotel and rate combination you book. Many bookings allow free cancellation up to a stated deadline (often a few days before travel) where eligible. Read the cancellation terms carefully when reviewing the package, and visit Expedia help center for further details.

An Expedia vacation package could land you great savings when compared to arranging flights and hotels separately. Better still, you can tailor your Southeast Missouri getaway to match your exact preference. Pick your preferred flight time, select the hotel type and add a car rental. Explore our bundles to see how much you can save.

Booking your vacation package on Expedia makes it easier to get more out of your trip from the start. With a wide choice of hotels, you can compare prices, reviews and amenities all in one place, then bundle your hotel with flights which could help you save even more. Flexible booking options on selected stays also make it easier to plan with confidence.