Southeast Missouri, MO
Travel Guide
Visit Southeast Missouri
Drury Plaza Hotel Cape Girardeau Conference Center
3351 Percy Drive Cape Girardeau MO
$100 nightly
The price is $113 total per night from Jul 5 to Jul 6
$113 total
Jul 5 - Jul 6
Total with taxes and fees
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.6/10 Exceptional! (1,003 reviews)
"Excellent hotel clean, breakfast was awesome indoor pool awesome…. Excellent choice for hotel stay."
Reviewed on Jun 24, 2026
Baymont Inn and Suites by Wyndham Farmington, MO
1625 W Columbia St Farmington MO
$58 nightly
The price is $64 total per night from Jul 5 to Jul 6
$64 total
Jul 5 - Jul 6
Total with taxes and fees
Book a stay at this business-friendly hotel in Farmington. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the helpful staff and the ...
8/10 Very Good! (1,002 reviews)
"everything was as it shoiuldbe"
Reviewed on Jun 24, 2026
Drury Inn & Suites Sikeston, MO
2608 East Malone Ave, Miner Sikeston MO
$111 nightly
The price is $128 total per night from Jul 2 to Jul 3
$128 total
Jul 2 - Jul 3
Total with taxes and fees
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.6/10 Exceptional! (1,001 reviews)
"This was a wonderful stay for the night while traveling. Thankful for the recommendation from the front desk to eat at Lamberts restaurant 3 minutes down the road. So fun!"
Reviewed on Jun 15, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
7555 State Hwy Y French Village MO
Stay at this cabin in French Village. Enjoy free parking, patios, and climate control.
9.8/10 Exceptional! (79 reviews)
"Great cozy cabin with wonderful staff to ask any questions"
Reviewed on Jun 17, 2026
Lake Wappapello
8005 Missouri 172 Williamsville MO
Stay at this cabin in Williamsville. Enjoy free parking. Popular attractions North Main Street Historic District and Margaret Harwell Art Museum are located ...
8.8/10 Excellent! (3 reviews)
"I had a reservation for 4 nights, also received a confermation and itinerary number from hotes.com, but upon arrival I found that hotels.cim never made the reservation with the place I was staying. The place i was supposed to stay at were as accommodating as they could be, tried to find me a place ..."
Reviewed on Jun 19, 2026
Charming 2-bedroom house with AC, WiFi in serene Van Buren
Van Buren MO
Stay at this vacation home in Van Buren. Enjoy laundry facilities, an in-room coffeemaker, and air conditioning. Popular attractions Watercress Spring Picnic ...
8.8/10 Excellent! (20 reviews)
"Perfect for our needs. It's pretty basic and a bit run down in places (especially the bathroom which needs renovating, and shower wasn't the best in terms of heat and spray), but I really can't argue with the excellent value for money. Would probably not have rated it 5 stars due to the bathroom/shower ..."
Reviewed on Jun 23, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Check Southeast Missouri hotel availability
Popular places to visit
Elephant Rocks State Park
5/5(13 reviews)
You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.
Current River State Park
4/5(5 reviews)
Commune with nature and explore the great outdoors at Current River State Park during your travels in Salem. While you're in the area, stroll along the riverfront.
Southeast Missouri State University
4.5/5(78 reviews)
Take a campus tour or just explore the area of Southeast Missouri State University, during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants.
Alley Spring State Park
You can take time to visit Alley Spring State Park during your travels to Eminence. Wander the riverfront or discover the area's waterfalls.
Lake Wappapello
4/5(18 reviews)
Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants.
Hawn State Park
5/5(4 reviews)
You can take time to visit Hawn State Park during your travels to Ste Genevieve. Discover the area's coffeehouses or seek out the golf courses.
Things to do
Night Ghost Tour of Pythian Castle in Springfield Missouri
$20
per adult
100% of travellers recommend
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- Johnson's Shut-ins State Park
- Mark Twain National Forest
- Century Casino & Hotel Cape Girardeau
- Ozark National Scenic Riverways
- Current River
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- Rocky Falls
- Southeast Missouri State University
- Black River Coliseum
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- St. Joe State Park
- Taum Sauk Mountain State Park
- Hawn State Park
- Big Spring
- Round Spring Cave
- Villa Antonio Winery
- Pickle Springs Natural Area
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- Persimmon Ridge Winery
- Bonne Terre Mine
- Riverfront Bridge Park
- Big River
