Name: Drury Inn & Suites Sikeston, MO
Price range: $108 total
Rating: 9.4

Drury Plaza Hotel Cape Girardeau Conference Center

3351 Percy Drive Cape Girardeau MO

$100 nightly

$113 total

Apr 5 - Apr 6

Total with taxes and fees

Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...

9.6/10 Exceptional! (1,001 reviews)

The air conditioner was efficient too efficient lol and the breakfast was amazing. The best I’ve ever had at any hotel.

Reviewed on Mar 24, 2026

The Riverview

777 Main St Cape Girardeau MO

$122 nightly

$138 total

Apr 20 - Apr 21

Total with taxes and fees

Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free WiFi, free parking, and 2 restaurants. Popular attractions Isle Casino Cape Girardeau ...

9.4/10 Exceptional! (532 reviews)

The young man that checked me in did not have a welcoming personality nor seemed to care about any of my questions. He was very flat and inattentive.

Reviewed on Mar 23, 2026

Drury Inn & Suites Sikeston, MO

2608 East Malone Ave, Miner Sikeston MO

$94 nightly

$108 total

Apr 5 - Apr 6

Total with taxes and fees

Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...

9.4/10 Exceptional! (1,008 reviews)

Bedding needs to be updated. Pillows smelled and carpet could be cleaned. Bathroom was clean. Staff was friendly and helpful.

Reviewed on Mar 24, 2026

See all 626 properties in Southeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

7555 State Hwy Y French Village MO

Stay at this cabin in French Village. Enjoy free parking, patios, and climate control.

9.8/10 Exceptional! (57 reviews)

Beautiful , comfortable!!

Reviewed on Mar 21, 2026

St Francis River: The Blue Yurt and Hot Tub

Fredericktown MO

Stay at this cabin in Fredericktown. Enjoy air conditioning.

8.8/10 Excellent! (20 reviews)

Everything was easy to understand to find the place I wanted. Host is 5 stars

Reviewed on Jan 2, 2026

Johnson's Shut-ins State Park

148 Taum Sauk Trail Middle Brook MO

Stay at this cabin in Middle Brook. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Johnson's Shut-ins State Park and Taum Sauk ...

10/10 Exceptional! (1 review)

These newer cabins are clean and have everything you need. Highly recommend!

Reviewed on Nov 5, 2025

See all properties in Southeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Popular places to visit

An old granite quarry that has filled with water. An beautiful spring hike around the lake got me this picture

Elephant Rocks State Park

5/5(13 reviews)

You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.

Southeast Missouri State University

4.5/5(78 reviews)

Take a campus tour or just explore the area of Southeast Missouri State University, during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants.

Lake Wappapello

4/5(18 reviews)

Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants.

Current River State Park

4/5(5 reviews)

Commune with nature and explore the great outdoors at Current River State Park during your travels in Salem. While you're in the area, stroll along the riverfront.