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How can I book the best Southeast Missouri adventure trips?

Choose your own adventure in Southeast Missouri, whether that’s a white-knuckle experience or a weekend walk. Read the reviews of the adventures that have gone before to be sure your chosen stay is your idea of fun.

How can I plan the perfect Southeast Missouri family adventure vacation?

Adventure awaits when you select the family-friendly filter. There’s plenty of excitement for all ages in Southeast Missouri. Just make sure to check your chosen escapade is within the realms of can-do for the whole clan and will have the whole team grinning.

Can I book all-inclusive Southeast Missouri adventure vacation packages?

By refining your filters, you can explore all-amazing, all-adventurous, all-inclusive vacation packages. Amp up the extravagance with a few more filters too. Pick pristine pools, sensational spas, or wondrous waterparks for a sensational adventure getaway.

Why should I book a Southeast Missouri adventure vacation for couples?

Book a Southeast Missouri couples adventure vacation for the ultimate in romance and memory-making. Stunning scenery, heart-racing happenings, and the grandeur of the great outdoors—it’s the best way to bond.

How can I find the best deals on adventure packages in Southeast Missouri?

It’s easy to unleash fabulously affordable adventures. Enter the dates for your caper, then sort your search results by price or deals.

Can I book an adventure vacation package in Southeast Missouri with free cancellation and/or flexible dates?

Yes! When you’re searching for a great getaway, filter by payment option for free cancellation, so a change of plans won’t mess up your adventures. You’ll find buy now, pay later options, too, for full-on flexibility.

Why should I book a Southeast Missouri adventure trip with Expedia?

Adventure, airfare, accommodation, ATOL protection, and activities—all on one site. And that’s just the benefits that begin with A.

Top Adventure Southeast Missouri Hotels

Hampton Inn Farmington

850 Valley Creek Dr, Farmington, MO

2 hours drive from Mark Twain National Forest

Stay at this hotel in Farmington. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...

8.8/10 Excellent! (497 reviews)

"Nothing I didnt like."

Reviewed on Jun 27, 2025

Crown Pointe Lodge, BW Signature Collection

4245 Hunt Rd, Farmington, MO

2 hours drive from Mark Twain National Forest

Book a stay at this golf hotel in Farmington. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular ...

8.8/10 Excellent! (542 reviews)

"We enjoyed our stay very much! My husband and i rented a room here on a whim after leaving a not so good hotel. The people at Crown Pointe checked us in right away and were very nice and understanding. The people at the desk were so nice, friendly and personable. The room and lobby areas were very ..."

Reviewed on Jul 28, 2025

Echo Bluff State Park

34489 Echo Bluff Dr, Eminence, MO

43 min drive from Mark Twain National Forest

Book a stay at this business-friendly hotel in Eminence. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Echo Bluff State Park and ...

9.4/10 Exceptional! (207 reviews)

"The grounds were amazing. Wonderful bluff view from the 2 bedroom lodge rental. My only complaint was the kitchen amenities. There were no cups, plates cooking supplies or utensils. Not even a toaster. Don’t expect to cook anything."

Reviewed on May 26, 2025

See all 585 properties in Southeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.