Title: Best Southern Illinois, IL Residences from $74 | Expedia.com [Southern Illinois Travel Guide](https://expedia.com/Southern-Illinois.dx6233859)[Hotels in Southern Illinois](https://expedia.com/Southern-Illinois-Hotels.d6233859.Travel-Guide-Hotels)[Vacation Rentals in Southern Illinois](https://expedia.com/Southern-Illinois-Vacation-Rentals.d6233859.Travel-Guide-VacationRentals)[Flights to Southern Illinois](https://expedia.com/Cheap-Flights-To-Southern-Illinois.d6233859.Travel-Guide-Flights)[Car Rentals in Southern Illinois](https://expedia.com/Car-Rentals-In-Southern-Illinois.d6233859.Car-Rental-Guide)[Southern Illinois Vacation Packages](https://expedia.com/Southern-Illinois.d6233859.Destination-Travel-Guides) ![Southern Illinois showing forest scenes, a sunset and landscape views](https://images.trvl-media.com/place/553248635944113522/0e29d2f8-2d58-457a-908d-4b89b13776d9.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Southernmost Illinois Tourism Bureau ![](https://images.trvl-media.com/place/553248635944113522/0e29d2f8-2d58-457a-908d-4b89b13776d9.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light_bundle_and_save.svg) ### Bundle & Save Get more, spend less whenever you see Bundle & Save deals - ![](https://a.travel-assets.com/travel-assets-manager/pictograms-expedia/light__onekey.svg) ### OneKeyCash Earn OneKeyCash on all your eligible bookings - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light_ftc.svg) ### Upfront pricing We are not like the others - we include taxes and fees ## Check prices for these dates In two weeks [Mar 13 - Mar 15](https://www.expedia.com/Hotel-Search?regionId=6233859&startDate=2026-03-13&endDate=2026-03-15&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two months [Apr 24 - Apr 26](https://www.expedia.com/Hotel-Search?regionId=6233859&startDate=2026-04-24&endDate=2026-04-26&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In three months [May 22 - May 24](https://www.expedia.com/Hotel-Search?regionId=6233859&startDate=2026-05-22&endDate=2026-05-24&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In four months [Jun 19 - Jun 21](https://www.expedia.com/Hotel-Search?regionId=6233859&startDate=2026-06-19&endDate=2026-06-21&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) No exact matches found, but these alternatives could be just right ## Recommended hotels in Southern Illinois ![Lobby lounge](https://images.trvl-media.com/lodging/1000000/50000/42100/42021/798d901b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout drapes, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/50000/42100/42021/31850cab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/42100/42021/6058a5df.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, outdoor pool](https://images.trvl-media.com/lodging/1000000/50000/42100/42021/24fa28eb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Plaza Hotel Mt. Vernon [](https://www.expedia.com/Mount-Vernon-Hotels-Drury-Inn-Suites-Mt-Vernon.h42021.Hotel-Information) Mount Vernon 9.6/10 Exceptional (1,666 reviews) "Hotel is very clean, nicely furnished and the beds were so comfy!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Christina $112 nightly $127 total Mar 6 - Mar 7 Total with taxes and fees [](https://www.expedia.com/Mount-Vernon-Hotels-Drury-Inn-Suites-Mt-Vernon.h42021.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/12000000/11480000/11474500/11474428/16f1378e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/12000000/11480000/11474500/11474428/ee5a3a7f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/12000000/11480000/11474500/11474428/24e52a5c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/12000000/11480000/11474500/11474428/953ff133.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Effingham by IHG [](https://www.expedia.com/Effingham-Hotels-Holiday-Inn-Express-And-Suites-Effingham.h11474428.Hotel-Information) Effingham 9.4/10 Exceptional (1,002 reviews) "Room was clean, staff was very pleasant, breakfast was delicious and plentiful and we were able to enjoy all amenities. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Laura $99 nightly $111 total Mar 8 - Mar 9 Total with taxes and fees [](https://www.expedia.com/Effingham-Hotels-Holiday-Inn-Express-And-Suites-Effingham.h11474428.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/42100/42025/0b9bb173.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/50000/42100/42025/94013a8d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/50000/42100/42025/a8315e37.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/50000/42100/42025/a60abbba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Inn & Suites Marion [](https://www.expedia.com/Carbondale-Hotels-Drury-Inn-Marion.h42025.Hotel-Information) Marion 9.4/10 Exceptional (1,006 reviews) "All of the above, enjoyed the evening meal and breakfast, also staff was very friendly. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Barbara $99 nightly $119 total Mar 13 - Mar 14 Total with taxes and fees [](https://www.expedia.com/Carbondale-Hotels-Drury-Inn-Marion.h42025.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/60000/50100/50093/8e4b3d15.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 1 King Bed, Non Smoking, Jetted Tub | Desk, laptop workspace, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/60000/50100/50093/47490a5e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/60000/50100/50093/3a991e8e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, open 6:00 AM to 11:00 PM, sun loungers](https://images.trvl-media.com/lodging/1000000/60000/50100/50093/453e2ca5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham Effingham [](https://www.expedia.com/Effingham-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Effingham.h50093.Hotel-Information) Effingham 9.2/10 Wonderful (1,007 reviews) "Staff was amazing and the brekfast was good too!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kevin $97 nightly $109 total Mar 1 - Mar 2 Total with taxes and fees [](https://www.expedia.com/Effingham-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Effingham.h50093.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/9000000/8080000/8070400/8070312/0418d6e4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/9000000/8080000/8070400/8070312/61933887.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/9000000/8080000/8070400/8070312/dbc5e9a4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Blackout drapes, free cribs/infant beds, rollaway beds, free WiFi](https://images.trvl-media.com/lodging/9000000/8080000/8070400/8070312/71b4e886.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Country Hearth Inn & Suites Edwardsville St. Louis [](https://www.expedia.com/St-Louis-Hotels-Country-Hearth-Inn-Suites-Edwardsville-St-Louis.h8070312.Hotel-Information) Edwardsville 8.6/10 Excellent (669 reviews) "Room was great,staff friendly! All together a great stay." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Zachary $98 nightly $113 total Feb 28 - Mar 1 Total with taxes and fees [](https://www.expedia.com/St-Louis-Hotels-Country-Hearth-Inn-Suites-Edwardsville-St-Louis.h8070312.Hotel-Information) ![Meeting facility](https://images.trvl-media.com/lodging/2000000/1120000/1113200/1113164/709a29b3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, sun loungers](https://images.trvl-media.com/lodging/2000000/1120000/1113200/1113164/416a4136.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/2000000/1120000/1113200/1113164/7cc37c20.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1120000/1113200/1113164/18787a9e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Effingham by IHG [](https://www.expedia.com/Effingham-Hotels-Holiday-Inn-Effingham.h1113164.Hotel-Information) Effingham 9.0/10 Wonderful (663 reviews) "Nice place with bar and restaurant on site." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Steve $91 nightly $102 total Feb 28 - Mar 1 Total with taxes and fees [](https://www.expedia.com/Effingham-Hotels-Holiday-Inn-Effingham.h1113164.Hotel-Information) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/120000/119400/119307/9bba734f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Laundry room](https://images.trvl-media.com/lodging/1000000/120000/119400/119307/d9118f52.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business center](https://images.trvl-media.com/lodging/1000000/120000/119400/119307/86b65f12.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 2 Double Beds, Non Smoking | Desk, laptop workspace, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/120000/119400/119307/3a194c80.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western U. S. Inn [](https://www.expedia.com/Carlyle-Lake-Hotels-Best-Western-U-S-Inn.h119307.Hotel-Information) Nashville 8.6/10 Excellent (402 reviews) "Good staff " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jose Diego $88 nightly $96 total Feb 27 - Feb 28 Total with taxes and fees [](https://www.expedia.com/Carlyle-Lake-Hotels-Best-Western-U-S-Inn.h119307.Hotel-Information) ![Breakfast, dinner and brunch served](https://images.trvl-media.com/lodging/107000000/106860000/106856200/106856168/b212e706.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, blackout drapes, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/107000000/106860000/106856200/106856168/41c6fbb4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/107000000/106860000/106856200/106856168/5d07ff1f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room amenity](https://images.trvl-media.com/lodging/107000000/106860000/106856200/106856168/224b65ce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Principal Hotel [](https://www.expedia.com/Columbia-Hotels-The-Principal-Hotel.h106856168.Hotel-Information) Columbia 9.8/10 Exceptional (206 reviews) "Great stay and very clean!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) David $107 nightly $119 total Mar 8 - Mar 9 Total with taxes and fees [](https://www.expedia.com/Columbia-Hotels-The-Principal-Hotel.h106856168.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/2000000/1390000/1387400/1387309/5b15716e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free buffet breakfast](https://images.trvl-media.com/lodging/2000000/1390000/1387400/1387309/cd6d884a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed, Accessible, Non Smoking | In-room safe, desk, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/2000000/1390000/1387400/1387309/b3496784.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1390000/1387400/1387309/5c7b1e92.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Suites Mount Vernon [](https://www.expedia.com/Mount-Vernon-Hotels-Comfort-Suites-Mount-Vernon.h1387309.Hotel-Information) Mount Vernon 9.0/10 Wonderful (1,004 reviews) "Very clean and safe stay!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Dale $108 nightly $122 total Mar 8 - Mar 9 Total with taxes and fees [](https://www.expedia.com/Mount-Vernon-Hotels-Comfort-Suites-Mount-Vernon.h1387309.Hotel-Information) ![Front of property - evening/night](https://images.trvl-media.com/lodging/1000000/920000/914400/914400/cb0960c2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/920000/914400/914400/a72de9ce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free continental breakfast](https://images.trvl-media.com/lodging/1000000/920000/914400/914400/cbdc6ef6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed, Non Smoking | Desk, soundproofing, iron/ironing board, rollaway beds](https://images.trvl-media.com/lodging/1000000/920000/914400/914400/69929aee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Country Inn & Suites by Radisson, Effingham, IL [](https://www.expedia.com/Effingham-Hotels-Country-Inn-Suites-By-Radisson.h914400.Hotel-Information) Effingham 8.8/10 Excellent (1,002 reviews) "Clean, friendly staff and good breakfast. Location is excellent. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Maria $89 nightly $99 total Mar 22 - Mar 23 Total with taxes and fees [](https://www.expedia.com/Effingham-Hotels-Country-Inn-Suites-By-Radisson.h914400.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/2000000/1330000/1322000/1321975/868ce541.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, sun loungers](https://images.trvl-media.com/lodging/2000000/1330000/1322000/1321975/0e3527f4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1330000/1322000/1321975/cc771758.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/2000000/1330000/1322000/1321975/11916b3a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn & Suites Effingham [](https://www.expedia.com/Effingham-Hotels-Hampton-Inn-Suites-Effingham.h1321975.Hotel-Information) Effingham 9.6/10 Exceptional (715 reviews) "Very clean, nice hot breakfast, and kind staff. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Erin $137 nightly $153 total Feb 28 - Mar 1 Total with taxes and fees [](https://www.expedia.com/Effingham-Hotels-Hampton-Inn-Suites-Effingham.h1321975.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/17000000/16350000/16341900/16341844/80512ba4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/17000000/16350000/16341900/16341844/e5a5d8e5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/17000000/16350000/16341900/16341844/7d4409d9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/17000000/16350000/16341900/16341844/fcbb2184.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Mount Vernon by IHG [](https://www.expedia.com/Mount-Vernon-Hotels-Holiday-Inn-Express-Suites-Mount-Vernon.h16341844.Hotel-Information) Mount Vernon 9.0/10 Wonderful (1,001 reviews) "Breakfast very good staff excellent room clean and comfortable " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Scott $103 nightly $117 total Mar 8 - Mar 9 Total with taxes and fees [](https://www.expedia.com/Mount-Vernon-Hotels-Holiday-Inn-Express-Suites-Mount-Vernon.h16341844.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/108000000/107480000/107471700/107471617/w3840h2557x0y3-d7191bd7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/108000000/107480000/107471700/107471617/64b5aed1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Studio Suite, 2 Queen Beds, Accessible, Bathtub | Living area](https://images.trvl-media.com/lodging/108000000/107480000/107471700/107471617/w3840h2557x0y3-d46d0aad.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/108000000/107480000/107471700/107471617/w3837h2560x3y0-1e0aa062.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Home2 Suites By Hilton Effingham [](https://www.expedia.com/Effingham-Hotels-Home2-Suites-By-Hilton-Effingham.h107471617.Hotel-Information) Effingham 9.8/10 Exceptional (38 reviews) "Very kind staff, very clean, very pleased. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Erin $137 nightly $154 total Feb 28 - Mar 1 Total with taxes and fees [](https://www.expedia.com/Effingham-Hotels-Home2-Suites-By-Hilton-Effingham.h107471617.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/8000000/7220000/7214300/7214281/1c773b5e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/8000000/7220000/7214300/7214281/2700f966.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/8000000/7220000/7214300/7214281/1f46b3f5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, pillowtop beds, individually decorated](https://images.trvl-media.com/lodging/8000000/7220000/7214300/7214281/89141360.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### SureStay Hotel by Best Western Whittington Rend Lake [](https://www.expedia.com/Whittington-Hotels-SureStay-Hotel-By-Best-Western-Whittington-Rend-Lake.h7214281.Hotel-Information) Whittington 8.8/10 Excellent (933 reviews) "Great place to stay." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Stephen $72 nightly $80 total Mar 4 - Mar 5 Total with taxes and fees [](https://www.expedia.com/Whittington-Hotels-SureStay-Hotel-By-Best-Western-Whittington-Rend-Lake.h7214281.Hotel-Information) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/3000000/2670000/2662200/2662110/2c407788.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pillowtop beds, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/3000000/2670000/2662200/2662110/ce62cabd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed, Non Smoking, Refrigerator & Microwave (with Sofabed) | Pillowtop beds, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/3000000/2670000/2662200/2662110/665cbd23.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/3000000/2670000/2662200/2662110/244ed839.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Plus MidAmerica Hotel [](https://www.expedia.com/Collinsville-Hotels-Best-Western-Plus-MidAmerica-Hotel.h2662110.Hotel-Information) Mascoutah 9.0/10 Wonderful (1,000 reviews) "Very clean room, friendly staff and wonderful hot breakfast! This was our third stay, Highly recommend!!!!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Amber $102 nightly $116 total Mar 1 - Mar 2 Total with taxes and fees [](https://www.expedia.com/Collinsville-Hotels-Best-Western-Plus-MidAmerica-Hotel.h2662110.Hotel-Information) ![Hiking](https://images.trvl-media.com/lodging/2000000/1490000/1489300/1489254/189476cd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast meal](https://images.trvl-media.com/lodging/2000000/1490000/1489300/1489254/9e93654e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1490000/1489300/1489254/dfbf7d71.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast meal](https://images.trvl-media.com/lodging/2000000/1490000/1489300/1489254/bc470bb1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Carbondale-Conference Center by IHG [](https://www.expedia.com/Carbondale-Hotels-Holiday-Inn-Carbondale-Conference-Center.h1489254.Hotel-Information) Carbondale 8.8/10 Excellent (657 reviews) "nice stay! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) James $111 nightly $128 total Mar 1 - Mar 2 Total with taxes and fees [](https://www.expedia.com/Carbondale-Hotels-Holiday-Inn-Carbondale-Conference-Center.h1489254.Hotel-Information) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/10000/3400/3382/w3840h2556x0y4-dd5ad558.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business center](https://images.trvl-media.com/lodging/1000000/10000/3400/3382/5f2b59be.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/3400/3382/w3837h2560x3y0-d7de35fc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/10000/3400/3382/w3837h2560x3y0-57613b0f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Delta Inn [](https://www.expedia.com/Effingham-Hotels-Best-Western-Delta-Inn.h3382.Hotel-Information) Effingham 9.2/10 Wonderful (1,000 reviews) "Staff very friendly!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) C. Mark $83 nightly $93 total Mar 8 - Mar 9 Total with taxes and fees [](https://www.expedia.com/Effingham-Hotels-Best-Western-Delta-Inn.h3382.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/42100/42031/0b5cdb7e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/42100/42031/cfa73157.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, iron/ironing board, rollaway beds](https://images.trvl-media.com/lodging/1000000/50000/42100/42031/31aacfd2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/42100/42031/c1ed5cfc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Suites Effingham Central [](https://www.expedia.com/Effingham-Hotels-Comfort-Suites-Effingham.h42031.Hotel-Information) Effingham 8.8/10 Excellent (586 reviews) "This hotel is a great value for the price. Friendly staff, clean room, good nights sleep. I emphasize great value!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Richard $91 nightly $102 total Mar 8 - Mar 9 Total with taxes and fees [](https://www.expedia.com/Effingham-Hotels-Comfort-Suites-Effingham.h42031.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/10800/10742/6986ef65.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/10800/10742/9d9434fc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/20000/10800/10742/b790ca00.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/10800/10742/6dee7d6c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Clarion Pointe Mattoon near University [](https://www.expedia.com/Mattoon-Hotels-Baymont-By-Wyndham-Mattoon.h10742.Hotel-Information) Mattoon 8.4/10 Very Good (878 reviews) "The staff provided really good service and room was really clean." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) YESENIA $91 nightly $102 total Mar 7 - Mar 8 Total with taxes and fees [](https://www.expedia.com/Mattoon-Hotels-Baymont-By-Wyndham-Mattoon.h10742.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/600/574/40777397.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/10000/600/574/1fa6dae3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/600/574/268a0d05.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 1 King Bed, Accessible, Non Smoking (Mobility) | In-room safe, desk, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/10000/600/574/027b31fc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Ramada by Wyndham Vandalia [](https://www.expedia.com/Carlyle-Lake-Hotels-Ramada-By-Wyndham-Vandalia.h574.Hotel-Information) Vandalia 7.8/10 Good (819 reviews) "The room was clean, the staff was friendly, respectful and very helpful " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Dianna $68 nightly $74 total Mar 1 - Mar 2 Total with taxes and fees [](https://www.expedia.com/Carlyle-Lake-Hotels-Ramada-By-Wyndham-Vandalia.h574.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.com/Hotel-Search?startDate=2026-03-12&endDate=2026-03-13®ionId=6233859&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&openPlayBack=true) ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Vacation Sale Members save up to 40% on hotels and homes. Plan this year’s big trip and save. [Book now](https://expedia.com/deals?rfrr=AA_SPRING_PROMO_6233859) ## Find vacation rentals that suit your style Cabins [](https://www.expedia.com/Hotel-Search?destination=Southern+Illinois%2C+Illinois%2C+United+States+of+America®ionId=6233859&latLong=38.412831%2C-88.824893&adults=2&startDate=2026-05-26&d1=2026-05-26&endDate=2026-05-29&d2=2026-05-29&lodging=CABIN) Cottages [](https://www.expedia.com/Hotel-Search?destination=Southern+Illinois%2C+Illinois%2C+United+States+of+America®ionId=6233859&latLong=38.412831%2C-88.824893&adults=2&startDate=2026-05-26&d1=2026-05-26&endDate=2026-05-29&d2=2026-05-29&lodging=COTTAGE) Private vacation homes [](https://www.expedia.com/Hotel-Search?destination=Southern+Illinois%2C+Illinois%2C+United+States+of+America®ionId=6233859&latLong=38.412831%2C-88.824893&adults=2&startDate=2026-05-26&d1=2026-05-26&endDate=2026-05-29&d2=2026-05-29&lodging=VACATION_HOME) Apartments [](https://www.expedia.com/Hotel-Search?destination=Southern+Illinois%2C+Illinois%2C+United+States+of+America®ionId=6233859&latLong=38.412831%2C-88.824893&adults=2&startDate=2026-05-26&d1=2026-05-26&endDate=2026-05-29&d2=2026-05-29&lodging=APARTMENT) Villas [](https://www.expedia.com/Hotel-Search?destination=Southern+Illinois%2C+Illinois%2C+United+States+of+America®ionId=6233859&latLong=38.412831%2C-88.824893&adults=2&startDate=2026-05-26&d1=2026-05-26&endDate=2026-05-29&d2=2026-05-29&lodging=VILLA) Aparthotels [](https://www.expedia.com/Hotel-Search?destination=Southern+Illinois%2C+Illinois%2C+United+States+of+America®ionId=6233859&latLong=38.412831%2C-88.824893&adults=2&startDate=2026-05-26&d1=2026-05-26&endDate=2026-05-29&d2=2026-05-29&lodging=APART_HOTEL) Condos [](https://www.expedia.com/Hotel-Search?destination=Southern+Illinois%2C+Illinois%2C+United+States+of+America®ionId=6233859&latLong=38.412831%2C-88.824893&adults=2&startDate=2026-05-26&d1=2026-05-26&endDate=2026-05-29&d2=2026-05-29&lodging=CONDO) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FSouthern-Illinois-Residences.d6233859-aaResidences.Travel-Guide-Accommodation)[ Sign up, it's free ](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FSouthern-Illinois-Residences.d6233859-aaResidences.Travel-Guide-Accommodation) ## Top Southern Illinois Hotel Reviews ![Holiday Inn Express & Suites Mount Vernon by IHG](https://images.trvl-media.com/lodging/17000000/16350000/16341900/16341844/20299fa2_y.jpg) ### Holiday Inn Express & Suites Mount Vernon by IHG 10/10 Excellent "very good." [](https://expedia.com/Mount-Vernon-Hotels-Holiday-Inn-Express-Suites-Mount-Vernon.h16341844.Hotel-Information) ![Drury Inn & Suites Marion](https://images.trvl-media.com/lodging/1000000/50000/42100/42025/a8315e37_y.jpg) ### Drury Inn & Suites Marion 10/10 Excellent "The room was spotless. The staff were great. The morning breakfast and evening buffet were tasty and well maintained." [](https://expedia.com/Carbondale-Hotels-Drury-Inn-Marion.h42025.Hotel-Information) ![Fairfield Inn & Suites St. Louis Pontoon Beach/Granite City](https://images.trvl-media.com/lodging/10000000/9320000/9312600/9312525/95ce096c_y.jpg) ### Fairfield Inn & Suites St. Louis Pontoon Beach/Granite City 10/10 Excellent "The homeless nice and rooms clean. Nice assortment for breakfast. Definitely will go back. " [](https://expedia.com/St-Louis-Hotels-Fairfield-Inn-Suites-St-Louis-Pontoon-BeachGranite-City.h9312525.Hotel-Information) ![Holiday Inn Express Metropolis by IHG](https://images.trvl-media.com/lodging/1000000/220000/211900/211819/0b536094_y.jpg) ### Holiday Inn Express Metropolis by IHG 10/10 Excellent "The room was clean" [](https://expedia.com/Metropolis-Hotels-Holiday-Inn-Express-Metropolis.h211819.Hotel-Information) ![Quality Inn O'Fallon IL - St. Louis](https://images.trvl-media.com/lodging/1000000/70000/64700/64675/8890354b_y.jpg) ### Quality Inn O'Fallon IL - St. Louis 10/10 Excellent "Best stuff " [](https://expedia.com/Collinsville-Hotels-Quality-Inn-OFallon-I-64.h64675.Hotel-Information) ![Comfort Suites Mount Vernon](https://images.trvl-media.com/lodging/2000000/1390000/1387400/1387309/b34f836a_y.jpg) ### Comfort Suites Mount Vernon 10/10 Excellent "clean rooms and friendly staff" [](https://expedia.com/Mount-Vernon-Hotels-Comfort-Suites-Mount-Vernon.h1387309.Hotel-Information) ![Drury Plaza Hotel Mt. Vernon](https://images.trvl-media.com/lodging/1000000/50000/42100/42021/f9296f7b_y.jpg) ### Drury Plaza Hotel Mt. Vernon 10/10 Excellent "Clean room. Lots of pot smell even though they said you would be charged 250 if you smoked or vaped in your room. Im curious how many people got charged🤔very nice staff. Quiet on the 7th floor. Perfect location. Great breakfast. Bartenders didnt know how to make a chocolate martini. First one was okay, second one was almost black. Tasted like watered down hershey syrup. But they were very nice too. I didnt complain. All in all would 100% pick this hotel to stay in Mt. Vernon again. " [](https://expedia.com/Mount-Vernon-Hotels-Drury-Inn-Suites-Mt-Vernon.h42021.Hotel-Information) ![Drury Inn & Suites St. Louis O'Fallon, IL](https://images.trvl-media.com/lodging/2000000/1550000/1544100/1544028/d2bc121f_y.jpg) ### Drury Inn & Suites St. Louis O'Fallon, IL 10/10 Excellent "Room was completely clean and organized. The staff was very friendly and helpful! No disturbances throughout the night!" [](https://expedia.com/Collinsville-Hotels-Drury-Inn-Suites-St-Louis-OFallon.h1544028.Hotel-Information) ![Super 8 by Wyndham Troy IL/St. Louis Area](https://images.trvl-media.com/lodging/2000000/1100000/1090700/1090603/6781e11c_y.jpg) ### Super 8 by Wyndham Troy IL/St. Louis Area 10/10 Excellent "Great for the price" [](https://expedia.com/St-Louis-Hotels-Super-8-By-Wyndham-Troy-ILSt-Louis-Area.h1090603.Hotel-Information) ## Find out more about Southern Illinois ## Southern Illinois Residences information | Number of reviews | 16,254 | | ----------------- | ------------ | | Accommodation | 0 Residences | | Lowest Price | $74 | | Highest Price | $154 | ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rentals - [Mount Vernon Hotels ](https://www.expedia.com/Mount-Vernon-Hotels.d2463.Travel-Guide-Hotels) - [Hotels near Jefferson County Fairgrounds ](https://www.expedia.com/Jefferson-County-Fairgrounds-Hotels.0-l6186659-0.Travel-Guide-Filter-Hotels) - 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