Southern Illinois Vacations from $497
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Photo by Southernmost Illinois Tourism Bureau
Your Southern Illinois Vacation
When adventure is calling, answer it with a vacation package to Southern Illinois. Well known for its culture and history, this is one destination you'll never forget. Start your trip to Southern Illinois with a few nights in O'Fallon visiting popular sights like O'Fallon Family Sports Park and FanDuel Sportsbook and Horse Racing. Effingham is another city that draws travelers from far and wide. Lake Sara and Effingham Performance Center are two of the leading places to see in this destination. Quit dreaming and get packing, because your Southern Illinois vacation is just clicks away with Expedia.
The Latest Southern Illinois vacation packages
Price found within the past 48 hours. Click for updated prices.
The Wildwood Hotel
Price was $806, price is now $573 per person
$573
per person
Nov 26 - Nov 29
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
9.2/10 Wonderful! (1,591 reviews)
We love this hotel. Please check the alarm system we overheard a man saying it was not functioning properly. He said it appeared to not be connected. That’s all I know.
Reviewed on Oct 17, 2025
Angad Arts Hotel St. Louis, Tapestry Collection by Hilton
Grand Center
Price was $636, price is now $499 per person
$499
per person
Nov 26 - Nov 29
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
8.8/10 Excellent! (1,013 reviews)
Charming hotel full of amazing works of art. The roof top bar is a great place for drinks and views of the city.
Reviewed on Oct 15, 2025
Riverside Inn Hannibal
Price was $1,043, price is now $829 per person
$829
per person
Dec 23 - Dec 28
found 1 day ago
Roundtrip non-stop flight included
Atlanta (ATL) to St. Louis (STL)
9.4/10 Exceptional! (156 reviews)
Perfect spot for our visit to Hannibal during its fall festival. Everything was within walking distance, the room was spacious and comfortable and the communication with the property was prompt and helpful. I enjoyed the window view overlooking the levee and Mississippi River. We chatted with passengers getting back on the Viking River cruise at the port. A nice selection of casual dining options on Main.
Reviewed on Oct 18, 2025
Hampton Inn By Hilton St Louis Airport
Woodson Terrace
Price was $633, price is now $507 per person
$507
per person
Nov 26 - Nov 29
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
8.8/10 Excellent! (81 reviews)
Very close to the airport so that’s a plus but was not the best as far as Hampton inns go
Reviewed on Oct 19, 2025
Don't see what you're looking for?
See all available trips from Los Angeles to Southern Illinois
View all tripsWhere to stay in Southern Illinois
Find the best Southern Illinois areas and neighborhoods for the activities you enjoy most. Learn more about Southern Illinois
Eastport
If you're spending some time in Eastport, Gateway Conference Center and Splash City Family Waterpark are top sights worth seeing.
Discover the most popular places to visit in Southern Illinois
Southern Illinois University
4.5/5(173 reviews)
Take a campus tour or just explore the area of Southern Illinois University, during your trip to Carbondale. Check out the shops and top-notch restaurants in this family-friendly area.
Garden of the Gods Recreation Area
5/5(6 reviews)
See for yourself why Harrisburg’s unearthly sandstone formations, tucked within lush Shawnee National Forest, earn their ethereal name.
Giant City State Park
4.5/5(78 reviews)
Walk amid mystical woodland, admire geological wonders, go horseback riding and camp in the wilderness in the spectacular countryside of Southwest Illinois.
Southern Illinois Hotel Deals
Drury Plaza Hotel Mt. Vernon
145 North 44th Street , Mount Vernon, IL
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $106 total per night from Oct 26 to Oct 27
$106 total
Oct 26 - Oct 27
Total with taxes and fees
9.6/10 Exceptional! (1,498 reviews)
"Nice place"
Reviewed on Oct 17, 2025
Super 8 by Wyndham O'Fallon
1100 Eastgate Dr, O'Fallon, IL
Fully refundableReserve now, pay when you stay
$48 nightly
The price is $56 total per night from Oct 26 to Oct 27
$56 total
Oct 26 - Oct 27
Total with taxes and fees
7.2/10 Good! (1,004 reviews)
"Here's what you need to know....I honestly appreciated the Super 8 staff doing so much with so little. The warm breakfast [waffles, eggs, biscuits and gravy (no meat). Other: cereal, milk, yogurt, apples, pastries, juice] helps so many without many convenient options outside the motel. It's quiet ..."
Reviewed on Oct 14, 2025
Drury Inn & Suites St. Louis Fairview Heights
12 Ludwig Dr, Fairview Heights, IL
Fully refundableReserve now, pay when you stay
$93 nightly
The price is $106 total per night from Oct 27 to Oct 28
$106 total
Oct 27 - Oct 28
Total with taxes and fees
9/10 Wonderful! (1,017 reviews)
"Loved the pool and hot tub, plus the drinks and dinner. Terrific!"
Reviewed on Oct 18, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Southern Illinois Essential Information
Language | English |
|---|---|
Currency | U.S dollars |
Closest Airport | Lambert-St. Louis Intl. Airport (STL) |
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.