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Your Southern Illinois Vacation
When adventure is calling, answer it with a vacation package to Southern Illinois. Well known for its culture and history, this is one destination you'll never forget. Start your trip to Southern Illinois with a few nights in O'Fallon visiting popular sights like O'Fallon Family Sports Park and FanDuel Sportsbook and Horse Racing. Effingham is another city that draws travelers from far and wide. Lake Sara and Effingham Performance Center are two of the leading places to see in this destination. Quit dreaming and get packing, because your Southern Illinois vacation is just clicks away with Expedia.
The Latest Southern Illinois vacation packages


The Wildwood Hotel
Reviewed on Oct 4, 2025

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton
Reviewed on Oct 4, 2025


Hampton Inn By Hilton St Louis Airport
Reviewed on Oct 4, 2025
Where to stay in Southern Illinois

Eastport
If you're spending some time in Eastport, Gateway Conference Center and Splash City Family Waterpark are top sights worth seeing.
Discover the most popular places to visit in Southern Illinois

Southern Illinois University
Take a campus tour or just explore the area of Southern Illinois University, during your trip to Carbondale. Check out the shops and top-notch restaurants in this family-friendly area.

Garden of the Gods Recreation Area
See for yourself why Harrisburg’s unearthly sandstone formations, tucked within lush Shawnee National Forest, earn their ethereal name.

Giant City State Park
Walk amid mystical woodland, admire geological wonders, go horseback riding and camp in the wilderness in the spectacular countryside of Southwest Illinois.
Southern Illinois Hotel Deals

Drury Plaza Hotel Mt. Vernon
Reviewed on Sep 30, 2025

Super 8 by Wyndham O'Fallon
Reviewed on Sep 30, 2025

Drury Inn & Suites St. Louis Fairview Heights
Reviewed on Sep 29, 2025
Southern Illinois Essential Information
Language | English |
---|---|
Currency | U.S dollars |
Closest Airport | Lambert-St. Louis Intl. Airport (STL) |
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