Southern Illinois Vacations from $497

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Photo by Southernmost Illinois Tourism Bureau

Your Southern Illinois Vacation

When adventure is calling, answer it with a vacation package to Southern Illinois. Well known for its culture and history, this is one destination you'll never forget. Start your trip to Southern Illinois with a few nights in O'Fallon visiting popular sights like O'Fallon Family Sports Park and FanDuel Sportsbook and Horse Racing. Effingham is another city that draws travelers from far and wide. Lake Sara and Effingham Performance Center are two of the leading places to see in this destination. Quit dreaming and get packing, because your Southern Illinois vacation is just clicks away with Expedia.

The Latest Southern Illinois vacation packages

Price found within the past 48 hours. Click for updated prices.
Hilton Garden Inn Chesterfield
The Wildwood Hotel
Angad Arts Hotel St. Louis, Tapestry Collection by Hilton
Riverside Inn Hannibal
Hampton Inn By Hilton St Louis Airport
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Where to stay in Southern Illinois

Find the best Southern Illinois areas and neighborhoods for the activities you enjoy most. Learn more about Southern Illinois

Discover the most popular places to visit in Southern Illinois

Southern Illinois Hotel Deals

Drury Plaza Hotel Mt. Vernon

Drury Plaza Hotel Mt. Vernon

3 out of 5
145 North 44th Street , Mount Vernon, IL
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $106 total per night from Oct 26 to Oct 27
$106 total
Oct 26 - Oct 27
Total with taxes and fees
9.6/10 Exceptional! (1,498 reviews)
"Nice place"

Reviewed on Oct 17, 2025

Drury Plaza Hotel Mt. Vernon
Super 8 by Wyndham O'Fallon

Super 8 by Wyndham O'Fallon

2 out of 5
1100 Eastgate Dr, O'Fallon, IL
Fully refundableReserve now, pay when you stay
$48 nightly
The price is $56 total per night from Oct 26 to Oct 27
$56 total
Oct 26 - Oct 27
Total with taxes and fees
7.2/10 Good! (1,004 reviews)
"Here's what you need to know....I honestly appreciated the Super 8 staff doing so much with so little. The warm breakfast [waffles, eggs, biscuits and gravy (no meat). Other: cereal, milk, yogurt, apples, pastries, juice] helps so many without many convenient options outside the motel. It's quiet ..."

Reviewed on Oct 14, 2025

Super 8 by Wyndham O'Fallon
Drury Inn & Suites St. Louis Fairview Heights

Drury Inn & Suites St. Louis Fairview Heights

3 out of 5
12 Ludwig Dr, Fairview Heights, IL
Fully refundableReserve now, pay when you stay
$93 nightly
The price is $106 total per night from Oct 27 to Oct 28
$106 total
Oct 27 - Oct 28
Total with taxes and fees
9/10 Wonderful! (1,017 reviews)
"Loved the pool and hot tub, plus the drinks and dinner. Terrific!"

Reviewed on Oct 18, 2025

Drury Inn & Suites St. Louis Fairview Heights
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Southern Illinois Essential Information

Language
English
Currency
U.S dollars
Closest Airport
Lambert-St. Louis Intl. Airport (STL)

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.