Southern Illinois Vacations from $540

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Your Southern Illinois Vacation

When adventure is calling, answer it with a vacation package to Southern Illinois. Well known for its culture and history, this is one destination you'll never forget. Start your trip to Southern Illinois with a few nights in O'Fallon visiting popular sights like O'Fallon Family Sports Park and FanDuel Sportsbook and Horse Racing. Effingham is another city that draws travelers from far and wide. Lake Sara and Effingham Performance Center are two of the leading places to see in this destination. Quit dreaming and get packing, because your Southern Illinois vacation is just clicks away with Expedia.

The Latest Southern Illinois vacation packages

Price found within the past 48 hours. Click for updated prices.
Riverside Inn Hannibal
The Wildwood Hotel
 White House at Grand Central
The Knight Center at Washington University
Hermann Grain Bins BNB
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Where to stay in Southern Illinois

Find the best Southern Illinois areas and neighborhoods for the activities you enjoy most. Learn more about Southern Illinois

Discover the most popular places to visit in Southern Illinois

Southern Illinois Hotel Deals

Drury Plaza Hotel Mt. Vernon

Drury Plaza Hotel Mt. Vernon

3 out of 5
145 North 44th Street  Mount Vernon IL
Fully refundableReserve now, pay when you stay
$107 nightly
The price is $121 total per night from Jan 18 to Jan 19
$121 total
Jan 18 - Jan 19
Total with taxes and fees
9.6/10 Exceptional! (1,621 reviews)
Room was very clean, staff is very friendly and the food and drinks amenities were really nice.

Reviewed on Jan 11, 2026

Drury Plaza Hotel Mt. Vernon
Drury Inn & Suites St. Louis Fairview Heights

Drury Inn & Suites St. Louis Fairview Heights

3 out of 5
12 Ludwig Dr Fairview Heights IL
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $106 total per night from Jan 18 to Jan 19
$106 total
Jan 18 - Jan 19
Total with taxes and fees
9/10 Wonderful! (1,004 reviews)
I didn’t try the breakfast so I can’t rate that. Room was spacious, clean, and comfortable. Lots of parking available. Easy access to highway, shopping, and dining.

Reviewed on Jan 12, 2026

Drury Inn & Suites St. Louis Fairview Heights
Super 8 by Wyndham O'Fallon

Super 8 by Wyndham O'Fallon

2 out of 5
1100 Eastgate Dr O'Fallon IL
Fully refundableReserve now, pay when you stay
$43 nightly
The price is $49 total per night from Jan 25 to Jan 26
$49 total
Jan 25 - Jan 26
Total with taxes and fees
7/10 Good! (1,000 reviews)
The staff was very friendly and the room looked fantastic

Reviewed on Jan 6, 2026

Super 8 by Wyndham O'Fallon
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Southern Illinois Vacation Packages

Things to do near Southern Illinois

Southern Illinois offers a perfect blend of outdoor adventures and romantic escapes. Visitors can enjoy thrilling ziplines, scenic wine tastings, and extensive hiking trails that showcase the area's natural beauty. With its charming campgrounds and recreational areas, Southern Illinois is ideal for those seeking both excitement and relaxation in a picturesque setting.

Shopping

King City Square Shopping Center, located 5 miles from Southern Illinois, offers a vibrant shopping experience with a mix of entertainment and family-friendly activities. Explore various stores for unique gifts and souvenirs that capture the essence of the region.

Recreation

Experience the vibrant culture at the Benton Civic Center, where entertainment meets romance. Enjoy the serene wellness vibes of Lincoln Park, perfect for relaxation, or visit Waltonville Public Use Area for a peaceful retreat in nature, fostering rejuvenation and tranquility just a short drive away.

Adventure

The I-57 Drag Strip offers thrilling motor racing experiences, located 23 miles from Southern Illinois. Feel the adrenaline rush as cars zoom past, surrounded by a vibrant atmosphere filled with sports enthusiasts. It's an exhilarating spot for anyone looking to embrace high-speed excitement.

Nightlife

Southern Illinois boasts a vibrant nightlife with unique bars and live music venues. Check out the Hangar 9 in Carbondale for great live performances and craft brews. For a relaxed vibe, visit Pheasant Hollow Winery to enjoy local wines and scenic views while unwinding with friends.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Find the best attractions near Southern Illinois

Southern Illinois is perfect for outdoor enthusiasts and those seeking romantic getaways, offering stunning scenery and adventure. Explore its beautiful lakes, national and state parks, and modern colleges and universities. The area's attractions cater to travelers looking for unforgettable outdoor experiences amidst breathtaking landscapes.

  • Jefferson County Fairgrounds: Located 3 miles from Southern Illinois, the Jefferson County Fairgrounds offers a lively atmosphere perfect for family outings. Experience local culture through seasonal fairs, exhibitions, and events, with plenty of outdoor space for relaxing and enjoying the festivities.
  • Rend Lake: A scenic 13 miles from Southern Illinois, Rend Lake is a picturesque destination ideal for beach lovers and romantics. With its stunning views, outdoor activities, and serene environment, it's perfect for picnics, boating, and sunset strolls along the shore.
  • Veterans Memorial Park: Situated 4 miles from Southern Illinois, this memorial park provides a contemplative space to honor those who served. With its cultural significance and beautiful landscaping, it's an excellent spot for reflection and appreciation of local history.

Best time to go to Southern Illinois

The best time to visit Southern Illinois is dependent on what kind of holiday you are seeking. July is its hottest month on average. At this time, visitor numbers are slightly high and weather is mostly sunny with light rain. January is its coolest month on average. At this time, visitor numbers are slightly low and weather is mostly cloudy with light rain.

calendarCalendar MonthtemperatureTemperaturerainPrecipitationmostlyCloudinessoccupationOccupancypricePricing
January30.9°F (-0.6000000000000001°C)Light RainMostly CloudySlightly LowSlightly Low
February36.9°F (2.7°C)Light RainMostly CloudySlightly LowSlightly Low
March48.0°F (8.9°C)Light RainMostly SunnyAverageAverage
April55.2°F (12.9°C)Light RainMostly SunnyAverageSlightly High
May66.7°F (19.3°C)Light RainMostly SunnySlightly HighAverage
June75.9°F (24.4°C)Light RainMostly SunnySlightly HighSlightly High
July78.8°F (26.0°C)Light RainMostly SunnySlightly HighSlightly High
August77.0°F (25.0°C)Light RainMostly SunnyAverageAverage
September71.2°F (21.8°C)Light RainMostly SunnyAverageAverage
October56.7°F (13.7°C)Light RainMostly SunnyAverageAverage
November46.6°F (8.1°C)Light RainMostly SunnyAverageSlightly Low
December39.0°F (3.9°C)Light RainMostly SunnySlightly LowAverage

Tips to save on your trip to Southern Illinois

  • Take advantage of package deals on Expedia and combine flights, hotels, or car rentals for a convenient and cost-effective trip to Southern Illinois.
  • Consider traveling during the off-peak season (typically January to February and November) for more affordable package holidays to Southern Illinois.
  • Use the Price per traveler filter on Expedia to find a package deal that suits your budget.
  • Check the VIP Access properties filter to discover outstanding hotels with added member perks at select properties.

Southern Illinois Essential Information

Language
English
Currency
U.S dollars
Closest Airport
Lambert-St. Louis Intl. Airport (STL)

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.