Southern Illinois Vacations from $264
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Your Southern Illinois Vacation
When adventure is calling, answer it with a vacation package to Southern Illinois. Well known for its culture and history, this is one destination you'll never forget. Start your trip to Southern Illinois with a few nights in O'Fallon visiting popular sights like O'Fallon Family Sports Park and FanDuel Sportsbook and Horse Racing. Effingham is another city that draws travelers from far and wide. Lake Sara and Effingham Performance Center are two of the leading places to see in this destination. Quit dreaming and get packing, because your Southern Illinois vacation is just clicks away with Expedia.
The Latest Southern Illinois vacation packages
Price found within the past 48 hours. Click for updated prices.
The Wildwood Hotel
Save 100% on your flight
Price was $474, price is now $271 per person
$271
per person
Dec 15 - Dec 18
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
9.2/10 Wonderful! (1,581 reviews)
Hot tub is fantastic having your own in your own room is unbeatable
Reviewed on Oct 4, 2025
Angad Arts Hotel St. Louis, Tapestry Collection by Hilton
Grand Center
Price was $428, price is now $302 per person
$302
per person
Dec 15 - Dec 18
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
8.8/10 Excellent! (1,005 reviews)
Not even a bottle of water in the overpriced room nor paper towels in kitchen. Creamer for coffee was expired. Staff just said it was an “oversight”. Not even an apology or offer to give fresh creamer.
Reviewed on Oct 4, 2025
Hampton Inn By Hilton St Louis Airport
Woodson Terrace
Price was $423, price is now $307 per person
$307
per person
Dec 15 - Dec 18
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
8.8/10 Excellent! (62 reviews)
All areas was kept clean and breakfast options was great
Reviewed on Oct 4, 2025
Don't see what you're looking for?
See all available trips from Columbus to Southern Illinois
View all tripsWhere to stay in Southern Illinois
Find the best Southern Illinois areas and neighborhoods for the activities you enjoy most. Learn more about Southern Illinois
Eastport
If you're spending some time in Eastport, Gateway Conference Center and Splash City Family Waterpark are top sights worth seeing.
Discover the most popular places to visit in Southern Illinois
Southern Illinois University
4.5/5(173 reviews)
Take a campus tour or just explore the area of Southern Illinois University, during your trip to Carbondale. Check out the shops and top-notch restaurants in this family-friendly area.
Garden of the Gods Recreation Area
5/5(6 reviews)
See for yourself why Harrisburg’s unearthly sandstone formations, tucked within lush Shawnee National Forest, earn their ethereal name.
Giant City State Park
4.5/5(78 reviews)
Walk amid mystical woodland, admire geological wonders, go horseback riding and camp in the wilderness in the spectacular countryside of Southwest Illinois.
Southern Illinois Hotel Deals
Drury Plaza Hotel Mt. Vernon
145 North 44th Street , Mount Vernon, IL
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $106 total per night from Oct 19 to Oct 20
$106 total
Oct 19 - Oct 20
Total with taxes and fees
9.6/10 Exceptional! (1,479 reviews)
"I liked the evening drinks and dinner"
Reviewed on Sep 30, 2025
Super 8 by Wyndham O'Fallon
1100 Eastgate Dr, O'Fallon, IL
Fully refundableReserve now, pay when you stay
$51 nightly
The price is $59 total per night from Oct 12 to Oct 13
$59 total
Oct 12 - Oct 13
Total with taxes and fees
7.2/10 Good! (1,000 reviews)
"Nice room"
Reviewed on Sep 30, 2025
Drury Inn & Suites St. Louis Fairview Heights
12 Ludwig Dr, Fairview Heights, IL
Fully refundableReserve now, pay when you stay
$93 nightly
The price is $106 total per night from Oct 13 to Oct 14
$106 total
Oct 13 - Oct 14
Total with taxes and fees
9/10 Wonderful! (1,027 reviews)
Fantastic!
"The check-in process was easy as it should be. The room was clean with everything in good working order. This was a simple overnight stop but it was superb. Now, the breakfast. This is easily one of the best breakfast setups I’ve ever encountered on a road trip. There was a ton of room to move around ..."
Reviewed on Sep 29, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Southern Illinois Essential Information
Language | English |
|---|---|
Currency | U.S dollars |
Closest Airport | Lambert-St. Louis Intl. Airport (STL) |
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.
