Southern Illinois Vacations from $264

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Your Southern Illinois Vacation

When adventure is calling, answer it with a vacation package to Southern Illinois. Well known for its culture and history, this is one destination you'll never forget. Start your trip to Southern Illinois with a few nights in O'Fallon visiting popular sights like O'Fallon Family Sports Park and FanDuel Sportsbook and Horse Racing. Effingham is another city that draws travelers from far and wide. Lake Sara and Effingham Performance Center are two of the leading places to see in this destination. Quit dreaming and get packing, because your Southern Illinois vacation is just clicks away with Expedia.

The Latest Southern Illinois vacation packages

Price found within the past 48 hours. Click for updated prices.
Hilton Garden Inn Chesterfield
The Wildwood Hotel
Angad Arts Hotel St. Louis, Tapestry Collection by Hilton
The Principal Hotel
Hampton Inn By Hilton St Louis Airport
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Where to stay in Southern Illinois

Find the best Southern Illinois areas and neighborhoods for the activities you enjoy most. Learn more about Southern Illinois

Discover the most popular places to visit in Southern Illinois

Southern Illinois Hotel Deals

Drury Plaza Hotel Mt. Vernon

Drury Plaza Hotel Mt. Vernon

3 out of 5
145 North 44th Street , Mount Vernon, IL
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $106 total per night from Oct 19 to Oct 20
$106 total
Oct 19 - Oct 20
Total with taxes and fees
9.6/10 Exceptional! (1,479 reviews)
"I liked the evening drinks and dinner"

Reviewed on Sep 30, 2025

Drury Plaza Hotel Mt. Vernon
Super 8 by Wyndham O'Fallon

Super 8 by Wyndham O'Fallon

2 out of 5
1100 Eastgate Dr, O'Fallon, IL
Fully refundableReserve now, pay when you stay
$51 nightly
The price is $59 total per night from Oct 12 to Oct 13
$59 total
Oct 12 - Oct 13
Total with taxes and fees
7.2/10 Good! (1,000 reviews)
"Nice room"

Reviewed on Sep 30, 2025

Super 8 by Wyndham O'Fallon
Drury Inn & Suites St. Louis Fairview Heights

Drury Inn & Suites St. Louis Fairview Heights

3 out of 5
12 Ludwig Dr, Fairview Heights, IL
Fully refundableReserve now, pay when you stay
$93 nightly
The price is $106 total per night from Oct 13 to Oct 14
$106 total
Oct 13 - Oct 14
Total with taxes and fees
9/10 Wonderful! (1,027 reviews)
Fantastic!
"The check-in process was easy as it should be. The room was clean with everything in good working order. This was a simple overnight stop but it was superb. Now, the breakfast. This is easily one of the best breakfast setups I’ve ever encountered on a road trip. There was a ton of room to move around ..."

Reviewed on Sep 29, 2025

Drury Inn & Suites St. Louis Fairview Heights
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Southern Illinois Essential Information

Language
English
Currency
U.S dollars
Closest Airport
Lambert-St. Louis Intl. Airport (STL)

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.