Photo by Carl Anderson

Find Adults Only Resorts & Hotels in Southwest Illinois, IL from $75

Start date: Check-in selected.
To Date
End date: Check-out
  • Upfront pricing

    Our total price for your stay includes taxes and fees
  • Treat yourself

    Save 10% or more on over 100,000 hotels worldwide with Member Prices
  • Be picky

    Search almost a million properties worldwide

Check availability on Southwest Illinois Adults Only Resorts & Hotels

No exact matches found, but these alternatives could be just right

Recommended hotels in Southwest Illinois

Drury Inn & Suites Marion

Drury Inn & Suites Marion
3.0 star property
Marion
9.4 out of 10, Exceptional, (1007)
"Hotel is very clean and staff is also friendly."
United States
Tonya
$65 nightly
The price is $78
Jan 2 - Jan 3, 2026
Total with taxes and fees
Drury Inn & Suites Marion

Comfort Suites Mount Vernon

Comfort Suites Mount Vernon
2.5 star property
Mount Vernon
9.0 out of 10, Wonderful, (1012)
"Rooms have been painted great breakfast close to interstate and restaurants"
United States
Stephen
$109 nightly
The price is $123
Dec 17 - Dec 18
Total with taxes and fees
Comfort Suites Mount Vernon

Holiday Inn Express & Suites Mount Vernon by IHG

Holiday Inn Express & Suites Mount Vernon by IHG
2.5 star property
Mount Vernon
9.0 out of 10, Wonderful, (1004)
"Great stay"
United States
Cindy
$99 nightly
The price is $112
Jan 4 - Jan 5, 2026
Total with taxes and fees
Holiday Inn Express & Suites Mount Vernon by IHG

Drury Plaza Hotel Mt. Vernon

Drury Plaza Hotel Mt. Vernon
3.0 star property
Mount Vernon
9.6 out of 10, Exceptional, (1576)
"Great place to stay. Check in is easy and the hotel people are very nice."
United States
Duane
$94 nightly
The price is $106
Dec 25 - Dec 26
Total with taxes and fees
Drury Plaza Hotel Mt. Vernon

SureStay Hotel by Best Western Whittington Rend Lake

SureStay Hotel by Best Western Whittington Rend Lake
2.5 star property
Whittington
8.8 out of 10, Excellent, (904)
"Great place to stay."
United States
Stephen
$68 nightly
The price is $75
Dec 31 - Jan 1, 2026
Total with taxes and fees
SureStay Hotel by Best Western Whittington Rend Lake

Super 8 by Wyndham Mt. Vernon IL

Super 8 by Wyndham Mt. Vernon IL
2.5 star property
Mount Vernon
7.8 out of 10, Good, (1005)
"reception was great, room clean, and the price was right."
United States
tom
$67 nightly
The price is $76
Jan 4 - Jan 5, 2026
Total with taxes and fees
Super 8 by Wyndham Mt. Vernon IL

Best Western Plus Centralia Hotel & Suites

Best Western Plus Centralia Hotel & Suites
2.5 star property
Centralia
9.6 out of 10, Exceptional, (601)
"Very beautiful place to stay "
United States
Valerie
$121 nightly
The price is $135
Jan 1 - Jan 2, 2026
Total with taxes and fees
Best Western Plus Centralia Hotel & Suites

The Principal Hotel

The Principal Hotel
3.5 star property
Columbia
9.8 out of 10, Exceptional, (191)
"Great place. Very nice rooms, new and clean."
United States
Jeff
$104 nightly
The price is $116
Dec 25 - Dec 26
Total with taxes and fees
The Principal Hotel

Baymont by Wyndham Marion

Baymont by Wyndham Marion
2.5 star property
Marion
8.4 out of 10, Very Good, (1070)
"This place was nice for the money and our 1 night stay. "
United States
Charles
$73 nightly
The price is $88
Jan 16 - Jan 17, 2026
Total with taxes and fees
Baymont by Wyndham Marion

Best Western Marion Hotel

Best Western Marion Hotel
2.5 star property
Marion
8.2 out of 10, Very Good, (1005)
"Front staff (Cari) was so friendly and helpful during our stay. Our room was clean and the bed was comfortable."
United States
Wendy
$67 nightly
The price is $80
Jan 5 - Jan 6, 2026
Total with taxes and fees
Best Western Marion Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find out more about Southwest Illinois

Discover top Southwest Illinois attractions

Southwest Illinois is a hidden gem for adventurous travelers seeking unique experiences. Start your journey in the charming town of Alton, where you can explore the picturesque Riverfront Park, perfect for a family picnic with stunning views of the Mississippi River. Don’t miss the historic Piasa Bird mural, a fascinating piece of local lore that dates back to Native American history. For those interested in the great outdoors, the scenic trails of the Lewis and Clark State Historic Site provide an educational and exhilarating hiking experience. Meanwhile, the Cahokia Mounds State Historic Site offers a glimpse into ancient civilizations with its impressive earthen mounds, ideal for a captivating family outing. After a day of exploration, consider staying in the vibrant downtown Edwardsville area. Here, you can unwind in boutique hotels that offer personalized service and modern amenities, making your family feel truly pampered while being conveniently located near local dining and shopping spots. With an array of activities and high-top hotels, Southwest Illinois promises a memorable trip without the hassle.

Top Southwest Illinois Hotel Reviews

Frequently asked questions

Are there any adult-only all-inclusive resorts in Southwest Illinois?
Southwest Illinois doesn't have any adults-only all-inclusive resorts or hotels. However, you'll still find some outstanding stays to pick from, especially if romance is in the air. If cupid's arrow takes you to Murphysboro, you'll fall hard for the charms of Kite Hill Vineyards Bed And Breakfast. An attached winery and a fireplace in the lobby are among its many amenities. Another option where you can enjoy some "us" time is Home2 Suites by Hilton Carbondale. Also in Murphysboro, it comes with a terrace, a 24-hour front desk and much more.
What is there to do in Southwest Illinois near my adults-only hotel?
Southwest Illinois offers so much to see and do, it can be difficult to know where to begin. If you're staying a while in Murphysboro, Lake Murphysboro State Park is a favorite with visitors.
How can I find cheap adults-only hotels in Southwest Illinois?
Expedia can help you look for cheap adults-only hotels in Southwest Illinois. Simply try out our handy filter tool to select star rating, budget and amenities to refine your search and book the perfect stay in just a few keystrokes.
From what age can you stay in an adult-only hotel in Southwest Illinois?
Adult-only hotels and resorts in Southwest Illinois generally have an age restriction of 16, 18 or 21. As regulations can differ, you'll want to check the rules of the property you're interested in for accurate information. Whether you're organizing a get-together with friends or getting away with your partner, Expedia will help you find a perfect adult-only stay.
Are all adult-only resorts all-inclusive in Southwest Illinois?
If you're pining for a hassle-free vacation, an adult-only all-inclusive resort serves up some serious R&R. To check what's available in Southwest Illinois, enter your dates of travel and then select the "all-inclusive" filter. Keep an eye out for stays marked as "adults only." Click on the properties you want to view to find out what you'll get for the price. The rate usually includes food, drinks and the room, entertainment and on-site activities.
Why book your adults-only hotel in Southwest Illinois with Expedia?
Expedia has an impressive selection of adults-only hotels at economical rates in Southwest Illinois. Use our filter tool to select how much you want to spend and then sort the results by price. Whether you're planning a relaxing couples break or taking a solo vacation, we'll help you find a perfect space.
When is the best time to stay at an adult-only all-inclusive resort in Southwest Illinois?
Almost any time is a great time to stay at an adult-only all-inclusive hotel in Southwest Illinois, but there are a few things worth thinking about. Start with the time of the year you want to travel. Peak season is popular and lively, but there may be a higher demand for flights and accommodations. Low season is not as hectic and kinder to your bank balance. Of course, the weather plays an important part in making or breaking a getaway, so do some research before locking in your adult-only hotel or resort.
Can I cancel or change my adult-only resort booking?
Yes, you can. And there may be no charge depending on the kind of adult-only hotel or resort you reserved. Read the fine print in your itinerary or make your way to Expedia's Trips portal for more details. Haven't booked a place yet? You can search for Southwest Illinois adult-only hotels that are fully refundable — should you need one. Reserve your grown-up adventure with the knowledge that wherever you stay, you'll have nothing to worry about!

Explore a world of travel with Expedia