Top 10 Hotels in Southwest Illinois, IL (from $72) 2026 - Competitive Prices

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Our top choices for Southwest Illinois hotels

A hotel kitchen with wooden cabinets, a coffee station, and a dining area with tables and chairs.

1. Best Western U. S. Inn

Nashville

Steven

$120 nightly

Nov 12 - Nov 13

Total with taxes and fees

A buffet with various food items, including omelets and other dishes, arranged on a counter with a patterned tile backsplash.

2. Holiday Inn Express Hotel & Suites Sparta by IHG

Sparta

Jo Ann

$88 nightly

Nov 15 - Nov 16

Total with taxes and fees

A modern dining area with multiple tables and chairs, a kitchen area with appliances, and a ceiling with recessed lighting and a circular light fixture.

3. Best Western Plus MidAmerica Hotel

Mascoutah

Charles

$101 nightly

Nov 15 - Nov 16

Total with taxes and fees

A neatly made bed with a patterned bedspread, a framed picture above it, a chair, a lamp, and a checkered floor.

4. Powhatan Motel

Pocahontas

Bob

$97 nightly

Nov 12 - Nov 13

Total with taxes and fees

A restaurant with multiple tables and booths, large windows, and a modern interior design.

5. The Principal Hotel

Columbia

Michael

$94 nightly

Nov 15 - Nov 16

Total with taxes and fees

An indoor swimming pool area with multiple lanes, lounge chairs, and a small seating area.

6. Drury Inn & Suites St. Louis O'Fallon, IL

O'Fallon

Karissa

$102 nightly

Nov 22 - Nov 23

Total with taxes and fees

A modern kitchen with wooden cabinets, a refrigerator, a coffee machine, and a microwave. There are red chairs and a table in the dining area.

7. Quality Inn Mount Vernon, IL

Mount Vernon

Ryan

$72 nightly

Nov 22 - Nov 23

Total with taxes and fees

A spacious lobby with a stone fireplace, a seating area with a sofa and chairs, and a television mounted on the wall.

8. SureStay Hotel by Best Western Whittington Rend Lake

Whittington

Tad

$76 nightly

Dec 1 - Dec 2

Total with taxes and fees

A hotel room with a large bed, a red bedspread, a bathtub, a nightstand with a lamp, and two framed pictures on the wall.

9. Seasons Inn & Suites Highland

Highland

robert

$94 nightly

Nov 29 - Nov 30

Total with taxes and fees

A breakfast buffet with various pastries, a bowl of oranges, and a waffle batter dispenser.

10. Super 8 by Wyndham Mt. Vernon IL

Mount Vernon

Leslie

$73 nightly

Nov 15 - Nov 16

Total with taxes and fees

A hotel lobby with a large sofa, armchairs, a Christmas tree, and a patterned carpet.

11. Fairfield Inn & Suites by Marriott Mt. Vernon Rend Lake

Mount Vernon

Paul

$109 nightly

Dec 6 - Dec 7

Total with taxes and fees

A hotel with a covered entrance, stone pillars, and a modern design.

12. Holiday Inn Express & Suites Mount Vernon by IHG

Mount Vernon

Doug

$107 nightly

Dec 11 - Dec 12

Total with taxes and fees

A multi-story hotel with a central entrance, illuminated by exterior lights, and a clear sky in the background.

13. Best Western Plus Centralia Hotel & Suites

Centralia

Jeremy

$139 nightly

Nov 12 - Nov 13

Total with taxes and fees

A hotel room with a large bed, two bedside tables with lamps, a window with curtains, a painting on the wall, and a radiator.

14. Laketree Inn And Suites Marion

Marion

Karen

$74 nightly

Dec 1 - Dec 2

Total with taxes and fees

A modern living room with a fireplace, blue sofa, red chairs, and a flat-screen TV mounted on a textured wall.

15. Comfort Inn & Suites Greenville I-70

Greenville

Melissa

$100 nightly

Nov 15 - Nov 16

Total with taxes and fees

A spacious lobby with high ceilings, multiple seating areas, and large windows allowing natural light.

16. Drury Inn & Suites Marion

Marion

Heather

$94 nightly

Nov 22 - Nov 23

Total with taxes and fees

A covered porch with a metal railing, a red carpet, and a green chair.

17. K-River Motel & Campground

Baldwin

Joyce

$65 nightly

Nov 12 - Nov 13

Total with taxes and fees

An indoor swimming pool with a view of the outside, a hot tub, and a seating area with tables and chairs.

18. DoubleTree by Hilton Mt. Vernon

Mount Vernon

Tammi

$128 nightly

Nov 14 - Nov 15

Total with taxes and fees

A hotel room with two beds, a desk, a television, and a window with a view of the outdoors.

19. Red Bud Country Inn

Red Bud

Camille

$90 nightly

Nov 17 - Nov 18

Total with taxes and fees

A spacious lobby with a patterned carpet, a fireplace, seating area, and a staircase.

20. Baymont by Wyndham Marion

Marion

Dean

$94 nightly

Nov 23 - Nov 24

Total with taxes and fees

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Hotels recommended for families in Southwest Illinois

Best Western U. S. Inn

Nashville

$120 nightly

Nov 12 - Nov 13

Total with taxes and fees

Stay near popular Southwest Illinois attractions

Giant City State Park

9.2/10 (141 reviews)

Walk amid mystical woodland, admire geological wonders, go horseback riding and camp in the wilderness in the spectacular countryside of Southwest Illinois.

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Learn more about Southwest Illinois

Explore a “natural city” of trees, enjoy incredible hilltop views, marvel at geological wonders and hop between small towns in this beautiful region.

See all hotels in Southwest Illinois

A tall, cylindrical structure with a red and white striped pattern and a label reading "Brock's Old Original Catsup."

Top Southwest Illinois Hotel Reviews

A large, two-story house with a wrap-around porch and a central tower.

The Conner House B&B

Prairie du Rocher

10/10 Excellent

Waited until the last minute to book a place to stay for an event in Redbud. Everything there was booked so had to expand our search and boy was that a blessing. Ended up at the Conner House and found a beautifully restored 1906 bed and breakfast. Very charming and inviting and took us back in time. Had a wonderful stay, learned a little history and had a great breakfast all thanks to our hostesses Pat & Connie. Forget the national chain - this is a must see house and getting to spend the...

Anonymous traveler

A bar area with a long counter, multiple chairs, and hanging light fixtures.

Drury Plaza Hotel Mt. Vernon

Mount Vernon

10/10 Excellent

Samara

Best Western Plus Centralia Hotel & Suites

Centralia

10/10 Excellent

Omar

Drury Inn & Suites St. Louis O'Fallon, IL

O'Fallon

10/10 Excellent

Anonymous traveler

A spacious lobby with a high ceiling, large windows, and a variety of seating options including sofas and chairs.

Drury Inn & Suites St. Louis Collinsville

Eastport

10/10 Excellent

gary

Holiday Inn Express Hotel & Suites Sparta by IHG

Sparta

10/10 Excellent

stayed here for a business trip and it was perfect. Staff was very friendly, beds were comfortable, and I appreciated the "fitness center." Breakfast was also great, with a huge array of choices. My only complaint would be that there was a light right outside the window in my room (first floor) and there were no blackout curtains to hide that mean light. Even so, it was a very good overall experience and I would stay there again.

Sarah

An outdoor patio area with wicker furniture, a stone pillar, and a glass-enclosed dining area.

Holiday Inn Express & Suites Salem by IHG

Salem

10/10 Excellent

Satisfied

Best Western U. S. Inn

Nashville

10/10 Excellent

Anonymous traveler

A modern hotel lobby with a central dining area, seating arrangements, and a television screen.

Holiday Inn Express Troy by IHG

Troy

10/10 Excellent

Anonymous traveler

A modern restaurant with high tables and orange chairs, a bar area, and large windows with a view.

Holiday Inn Express & Suites Murphysboro - Carbondale by IHG

Murphysboro

10/10 Excellent

Brianna

A Comfort Inn & Suites hotel with a covered entrance, multiple floors, and a landscaped front yard.

Comfort Inn & Suites Marion I-57

Marion

10/10 Excellent

Gary

A modern spa room with a large hot tub, a glass wall with a reflective pattern, and a ceiling with a skylight.

Walker's Bluff Casino Resort

Carterville

10/10 Excellent

Gail

A stone building with a white porch and a small garden with yellow flowers.

Corner George Inn Bed & Breakfast

Maeystown

10/10 Excellent

We stayed from 3/29 through 4/1. Unique place sitting directly next to a clear babbling brook. We stayed in The Loft room and it is very big, with a claw-foot tub and full kitchen that was stocked with dishes. The pillows and bed were devine. We slept completely through the night and woke feeling so refreshed. It was so quiet in the evenings that it was easy to picture yourself there in the 1890's with the world turning much slower around you. Many places were not open though since it was still...

Richard

Best Western Plus MidAmerica Hotel

Mascoutah

10/10 Excellent

Anonymous traveler

Find hotels in Southwest Illinois, IL from $72

Upfront pricing

Treat yourself

Be picky

Go beyond your typical stay in Southwest Illinois

Check prices for these dates

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Our top choices for Southwest Illinois hotels

1. Best Western U. S. Inn

2. Holiday Inn Express Hotel & Suites Sparta by IHG

3. Best Western Plus MidAmerica Hotel

4. Powhatan Motel

5. The Principal Hotel

6. Drury Inn & Suites St. Louis O'Fallon, IL

7. Quality Inn Mount Vernon, IL

8. SureStay Hotel by Best Western Whittington Rend Lake

9. Seasons Inn & Suites Highland

10. Super 8 by Wyndham Mt. Vernon IL

11. Fairfield Inn & Suites by Marriott Mt. Vernon Rend Lake

12. Holiday Inn Express & Suites Mount Vernon by IHG

13. Best Western Plus Centralia Hotel & Suites

14. Laketree Inn And Suites Marion

15. Comfort Inn & Suites Greenville I-70

16. Drury Inn & Suites Marion

17. K-River Motel & Campground

18. DoubleTree by Hilton Mt. Vernon

19. Red Bud Country Inn

20. Baymont by Wyndham Marion

Hotels recommended for families in Southwest Illinois

Best Western U. S. Inn

Stay near popular Southwest Illinois attractions

Giant City State Park

Learn more about Southwest Illinois

Top Southwest Illinois Hotel Reviews

The Conner House B&B

10/10 Excellent

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