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Our top choices for Southwest Illinois hotels

A hotel kitchen with wooden cabinets, a coffee station, and a dining area with tables and chairs.

1. Best Western U. S. Inn

Nashville

Steven

$120 nightly

Oct 30 - Oct 31

Total with taxes and fees

A modern dining area with multiple tables and chairs, a kitchen area with appliances, and a ceiling with recessed lighting and a circular light fixture.

2. Best Western Plus MidAmerica Hotel

Mascoutah

Alice

$101 nightly

Nov 1 - Nov 2

Total with taxes and fees

A hotel reception desk with a digital display, a desk phone, and a computer. There is a sign indicating the hotel's name and services.

3. Holiday Inn Express Hotel & Suites Sparta by IHG

Sparta

Jo Ann

$94 nightly

Nov 29 - Nov 30

Total with taxes and fees

A neatly made bed with a patterned bedspread, a framed picture above it, a chair, a lamp, and a checkered floor.

4. Powhatan Motel

Pocahontas

Bob

$97 nightly

Oct 30 - Oct 31

Total with taxes and fees

A hotel room with two beds, a wooden headboard, a nightstand with a lamp, and a window with curtains.

5. Drury Inn & Suites St. Louis O'Fallon, IL

O'Fallon

Karissa

$102 nightly

Nov 8 - Nov 9

Total with taxes and fees

A spacious lobby with a stone fireplace, a seating area with a sofa and chairs, and a television mounted on the wall.

6. SureStay Hotel by Best Western Whittington Rend Lake

Whittington

Tad

$81 nightly

Nov 5 - Nov 6

Total with taxes and fees

A hotel room with two beds, a desk, a television, and a window with a view of the outdoors.

7. Red Bud Country Inn

Red Bud

James

$98 nightly

Oct 30 - Oct 31

Total with taxes and fees

A neatly made bed with white linens and a dark headboard, flanked by two bedside tables with lamps.

8. The Principal Hotel

Columbia

Jeffrey

$89 nightly

Nov 3 - Nov 4

Total with taxes and fees

A modern kitchen with wooden cabinets, a refrigerator, a coffee machine, and a microwave. There are red chairs and a table in the dining area.

9. Quality Inn Mount Vernon, IL

Mount Vernon

Ryan

$70 nightly

Nov 29 - Nov 30

Total with taxes and fees

A covered porch with a metal railing, a red carpet, and a green chair.

10. K-River Motel & Campground

Baldwin

Joyce

$65 nightly

Oct 30 - Oct 31

Total with taxes and fees

A hotel room with a large bed, a red bedspread, a bathtub, a nightstand with a lamp, and two framed pictures on the wall.

11. Seasons Inn & Suites Highland

Highland

Jeffrey

$94 nightly

Nov 29 - Nov 30

Total with taxes and fees

A multi-story hotel with a central entrance, illuminated by exterior lights, and a clear sky in the background.

12. Best Western Plus Centralia Hotel & Suites

Centralia

Jeremy

$139 nightly

Nov 1 - Nov 2

Total with taxes and fees

A hotel with a covered entrance, stone pillars, and a modern design.

13. Holiday Inn Express & Suites Mount Vernon by IHG

Mount Vernon

Doug

$111 nightly

Nov 29 - Nov 30

Total with taxes and fees

A modern living room with a fireplace, blue sofa, red chairs, and a flat-screen TV mounted on a textured wall.

14. Comfort Inn & Suites Greenville I-70

Greenville

Debbie

$98 nightly

Nov 22 - Nov 23

Total with taxes and fees

A hotel lobby with a Kitchen+Bar area, seating arrangements, and a view to the outside.

15. Drury Plaza Hotel Mt. Vernon

Mount Vernon

Richard

$110 nightly

Nov 5 - Nov 6

Total with taxes and fees

A hotel lobby with a large sofa, armchairs, a Christmas tree, and a patterned carpet.

16. Fairfield Inn & Suites by Marriott Mt. Vernon Rend Lake

Mount Vernon

Susan

$100 nightly

Nov 21 - Nov 22

Total with taxes and fees

A small, clean room with a microwave, a vending machine, and a table with chairs.

17. Rodeway Inn Mount Vernon, IL

Mount Vernon

Karalee

$65 nightly

Nov 1 - Nov 2

Total with taxes and fees

A hotel room with a bed, a desk, a chair, a TV, and a window with curtains.

18. Super 8 by Wyndham Mt. Vernon IL

Mount Vernon

Leslie

$73 nightly

Nov 9 - Nov 10

Total with taxes and fees

A spacious lobby with a patterned carpet, a fireplace, seating area, and a staircase.

19. Baymont by Wyndham Marion

Marion

Sunil

$94 nightly

Nov 8 - Nov 9

Total with taxes and fees

A hotel room with a large bed, two bedside tables with lamps, a window with curtains, a painting on the wall, and a radiator.

20. Laketree Inn And Suites Marion

Marion

Karen

$80 nightly

Nov 22 - Nov 23

Total with taxes and fees

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Hotels recommended for families in Southwest Illinois

Best Western U. S. Inn

Nashville

$120 nightly

Oct 30 - Oct 31

Total with taxes and fees

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Stay near popular Southwest Illinois attractions

Giant City State Park

9.2/10 (141 reviews)

Walk amid mystical woodland, admire geological wonders, go horseback riding and camp in the wilderness in the spectacular countryside of Southwest Illinois.

See properties

Learn more about Southwest Illinois

Explore a “natural city” of trees, enjoy incredible hilltop views, marvel at geological wonders and hop between small towns in this beautiful region.

See all hotels in Southwest Illinois

A tall, cylindrical structure with a red and white striped pattern and a label reading "Brock's Old Original Catsup."

Top Southwest Illinois Hotel Reviews

Drury Inn & Suites St. Louis O'Fallon, IL

8/10 Good

"Beautiful hotel, free dinner and drinks your 1st night. Very clean. Only reason I didn't give 5 stars was only 1 elevator was working. Definitely stay here again."

Country Inn & Suites by Radisson, Marion, IL

8/10 Good

"It was pretty good. Bed’s not comfortable ! Room was not nice and really clean! Breakfast was good, not tons of choices. Tub had a Nasty crack in it near the drain . You could bathe a kid in it without worrying about them!. I have stayed in better Country Inn & Suites, which is why I chose the “Brand”. But overall, it was a good stay!"

Quality Inn O'Fallon - St. Louis - Shiloh

8/10 Good

"The staff was awesome! The bathroom however had some stains on the shower curtain. It should have been washed . The bed was so very comfortable! We slept great! Thank you… The staff came right to the room when we couldn’t get the tv remote to work. Asked if we needed anything else.."