Book a Hotel + Flight or Car together to unlock savings
Plan, book, travel with confidence
Better together
Save up to $2,000 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place
Your Upstate South Carolina Vacation
With a Upstate South Carolina vacation package, you can forget about the stress of planning and simply focus on experiencing what this thrilling destination has on offer. With so much to do and see on a trip to Upstate South Carolina, it can be hard to know where to begin. Kick off your travels in Greenville at Falls Park on the Reedy and Bon Secours Wellness Arena — two popular attractions here. Another top city worthy of a spot on your itinerary is Spartanburg. Don't miss WestGate Mall and Tyger River Park. Expedia is your one-stop shop for planning your Upstate South Carolina vacation. From hotels and flights, to car rentals and more, we're here to help you create a travel experience like no other.
The Latest Upstate South Carolina Vacation Packages
Price found within the past 48 hours. Click for updated prices.
"Right in the middle of everything! Sports bar and games downstairs is a plus! Breakout next door was fun and multiple restaurants in walking distance. The Hotel left a little box of fruit, cheese, pound cake or coffee cake at your door every morning.. it was good to! Sodas and waters were included in the room which was nice to. Def staying staying again if we return to Asheville."
Reviewed November 13, 2026
Roundtrip • Fort Lauderdale (FLL) - Asheville (AVL)
Discover the most popular places to visit in Upstate South Carolina
Clemson University
Rating: 9.6/10 (1,439 reviews)
Enjoy the collegiate vibe when you visit Clemson University, during your travels in Clemson. Experience the area's theater scene or attend a football game.
Falls Park on the Reedy is just one of the places to see in Greenville, so why not enjoy the other things to explore during your travels? Experience the acclaimed theater scene or attend a sporting event in this family-friendly area.
You can make plans for a show at The Peace Center during your stay in Greenville. Amble around this family-friendly area's riverfront or attend a sporting event.
Catch an event at Bon Secours Wellness Arena during your trip to Greenville. Stroll along the riverfront or experience the great live music in this family-friendly area.
Learn about the events happening at Greenville Convention Center during your trip to Greenville. Attend a sporting event or visit the shops in this family-friendly area.
During your trip to Greenville, you can browse for the perfect souvenirs at Haywood Mall. Experience the great live music or attend a sporting event in this family-friendly area.
You can spend an afternoon browsing the exhibits at BMW Performance Center during your travels in Greer. While in this family-friendly area, you can savor the charming coffeehouses.
Address: 895 Spartan Blvd, Spartanburg, SC, 29301-1372, US
Location: 22.8 mi from Upstate South Carolina
Star rating: 2.5/5
Guest rating: 9/10 (Wonderful, 819 reviews)
Price: $102 nightly, $113 total, Dec 13 - Dec 14, Total with taxes and fees
Review: IHG is doing a wonderful job with staff quality and friendliness everyone was very nice, and said hello at every opportunity. Clean rooms, good beds, and nice breakfast. Thanks we will be back
Address: 104 Spartangreen Blvd., Duncan, SC, 29334, US
Location: 17 mi from Upstate South Carolina
Star rating: 3/5
Guest rating: 9.4/10 (Exceptional, 336 reviews)
Price: $122 nightly, $136 total, Nov 29 - Nov 30, Total with taxes and fees
Review: The breakfast looked awesome although I was sick and didn’t get to enjoy it ! Cookies were great! Room was amazing Beds were super comfy We were confused about the room cuz I saw pics of one with a separate bedroom which I thought I picked but it worked out.
Address: 670 Verdae Blvd, Greenville, SC, 29607-4022, US
Location: 8.4 mi from Upstate South Carolina
Star rating: 3.5/5
Guest rating: 9/10 (Wonderful, 1482 reviews)
Price: $108 nightly, $120 total, Nov 23 - Nov 24, Total with taxes and fees
Review: I highly recommend. They offer a shuttle service to and from the airport and other necessary runs like downtown. Every staff member was so delightful. You can tell they really enjoyed their jobs.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
