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Our top choices for Wykoff hotels

Indoor pool

Kahler Grand Hotel

Kahler Grand Hotel
3.0 star property
Downtown Rochester
8.4 out of 10, Very Good, (2,168 reviews)
"Convenient hotel for Mayo Clinic patients. The restaurant inside the hotel is very nice."
United States
Mary
3 days ago
$124 nightly
The price is $143
Jul 1 - Jul 2
Total with taxes and fees
Kahler Grand Hotel
Courtyard

EVEN Hotel Rochester - Mayo Clinic Area by IHG

EVEN Hotel Rochester - Mayo Clinic Area by IHG
4.0 star property
Kutzky Park
9.4 out of 10, Exceptional, (1,001 reviews)
"Nice clean space, easy commute to Mayo."
United States
Colin
3 days ago
$130 nightly
The price is $149
Jul 4 - Jul 5
Total with taxes and fees
EVEN Hotel Rochester - Mayo Clinic Area by IHG
Serves lunch, dinner, and happy hour

AmericInn by Wyndham Rochester Near Mayo Clinic

AmericInn by Wyndham Rochester Near Mayo Clinic
3.0 star property
Rochester
8.0 out of 10, Very Good, (1,368 reviews)
"Loved the full size bath tub only complaints. Everything was clean comfortable."
United States
William
4 days ago
$76 nightly
The price is $88
Jul 12 - Jul 13
Total with taxes and fees
AmericInn by Wyndham Rochester Near Mayo Clinic
Terrace/patio

Hyatt House Rochester/Mayo Clinic Area

Hyatt House Rochester/Mayo Clinic Area
3.0 star property
Downtown Rochester
9.0 out of 10, Wonderful, (1,004 reviews)
"The staff were excellent. Great location to the Mayo Clinic."
United States
Rick
2 days ago
$169 nightly
The price is $195
Jun 29 - Jun 30
Total with taxes and fees
Hyatt House Rochester/Mayo Clinic Area
Front of property

Aspen Suites

Aspen Suites
3.0 star property
Rochester
9.0 out of 10, Wonderful, (864 reviews)
"Clean with room for a pack n play. The suite was spacious."
United States
Erika
6 days ago
$149 nightly
The price is $171
Jul 12 - Jul 13
Total with taxes and fees
Aspen Suites
Exterior

Hotel Indigo Rochester – Mayo Clinic Area by IHG

Hotel Indigo Rochester – Mayo Clinic Area by IHG
3.5 star property
Downtown Rochester
8.8 out of 10, Excellent, (1,002 reviews)
"Wonderful location in downtown Rochester. It is a treat to have Crave bar."
United States
Brian
6 days ago
$120 nightly
The price is $138
Jul 1 - Jul 2
Total with taxes and fees
Hotel Indigo Rochester – Mayo Clinic Area by IHG
Indoor pool, open 7:00 AM to 10:00 PM, sun loungers

Kahler Inn and Suites - Mayo Clinic Area

Kahler Inn and Suites - Mayo Clinic Area
3.5 star property
Downtown Rochester
8.0 out of 10, Very Good, (1,601 reviews)
"Clean rooms, good breakfast, great location for Mayo appointments!"
United States
Amanda
8 days ago
$124 nightly
The price is $143
Jun 29 - Jun 30
Total with taxes and fees
Kahler Inn and Suites - Mayo Clinic Area
Reception

Spark by Hilton Rochester South

Spark by Hilton Rochester South
3.0 star property
Rochester
9.2 out of 10, Wonderful, (514 reviews)
"Very nice clean rooms. The staff is super nice. Really happy with our stay here."
United States
Timothy
6 days ago
$74 nightly
The price is $86
Jul 6 - Jul 7
Total with taxes and fees
Spark by Hilton Rochester South
Deluxe Double Room | Down comforters, pillowtop beds, individually decorated

Country Trails Inn & Suites

Country Trails Inn & Suites
2.0 star property
Preston
9.4 out of 10, Exceptional, (123 reviews)
"A convenience store gas station right next door helped make the night more enjoyable."
United States
James
27 days ago
$126 nightly
The price is $140
Jun 29 - Jun 30
Total with taxes and fees
Country Trails Inn & Suites
Lobby

Staybridge Suites Rochester - Mayo Clinic Area by IHG

Staybridge Suites Rochester - Mayo Clinic Area by IHG
3.0 star property
Kutzky Park
9.4 out of 10, Exceptional, (492 reviews)
"Clean nice lobby. Nice workout facility."
United States
Mike
3 days ago
$124 nightly
The price is $142
Jul 5 - Jul 6
Total with taxes and fees
Staybridge Suites Rochester - Mayo Clinic Area by IHG
Lobby

The Berkman

The Berkman
3.0 star property
Folwell
9.6 out of 10, Exceptional, (420 reviews)
"Absolutely beautiful property with great amenities. Perfect for a 10 day stay."
Canada
Jason
8 days ago
$242 nightly
The price is $279
Jun 29 - Jun 30
Total with taxes and fees
The Berkman
Lobby sitting area

Brentwood Inn & Suites

Brentwood Inn & Suites
2.5 star property
Downtown Rochester
8.8 out of 10, Excellent, (1,003 reviews)
"Brentwood Inn was in a very convenient location for appointments at the Mayo facilities."
United States
Barbara
6 days ago
$110 nightly
The price is $127
Jul 3 - Jul 4
Total with taxes and fees
Brentwood Inn & Suites
Reception

Hampton Inn Rochester-South

Hampton Inn Rochester-South
2.5 star property
Rochester
9.0 out of 10, Wonderful, (1,001 reviews)
"The room was nice. Staff was helpful and friendly."
United States
al
2 days ago
$89 nightly
The price is $103
Jul 4 - Jul 5
Total with taxes and fees
Hampton Inn Rochester-South
Presidential Suite, Multiple Beds | Living area | 55-inch LCD TV with satellite channels, TV

Hilton Rochester Mayo Clinic Area

Hilton Rochester Mayo Clinic Area
3.5 star property
Downtown Rochester
9.6 out of 10, Exceptional, (612 reviews)
"Good location in downtown Rochester. Lots of good eateries nearby. Art walk tour is interesting."
United States
Gayle
18 days ago
$171 nightly
The price is $197
Jul 4 - Jul 5
Total with taxes and fees
Hilton Rochester Mayo Clinic Area
Terrace/patio

Home2 Suites by Hilton Rochester Mayo Clinic Area

Home2 Suites by Hilton Rochester Mayo Clinic Area
3.0 star property
Rochester
9.6 out of 10, Exceptional, (995 reviews)
"The place was well maintained and breakfast was very good."
United States
Gary
6 days ago
$127 nightly
The price is $146
Jul 4 - Jul 5
Total with taxes and fees
Home2 Suites by Hilton Rochester Mayo Clinic Area
Lobby

Americas Best Value Inn & Suites Spring Valley

Americas Best Value Inn & Suites Spring Valley
2.0 star property
Spring Valley
8.2 out of 10, Very Good, (454 reviews)
"Good for overnight stay. Clean and safe area."
United States
Donna
6 days ago
$87 nightly
The price is $96
Jul 5 - Jul 6
Total with taxes and fees
Americas Best Value Inn & Suites Spring Valley
Dining

Quiet, comfortable bed & breakfast in a gorgeous rural setting!

Quiet, comfortable bed & breakfast in a gorgeous rural setting!
Spring Valley
10.0 out of 10, Exceptional, (101 reviews)
"Was very welcoming. My kids really enjoyed. The breakfast was unbelievably delicious."
United States
Theresa
27 days ago
$133 nightly
The price is $142
Jun 29 - Jun 30
Total with taxes and fees
Quiet, comfortable bed & breakfast in a gorgeous rural setting!
Exterior

Holiday Inn Express Rochester South - Mayo Area by IHG

Holiday Inn Express Rochester South - Mayo Area by IHG
2.5 star property
Rochester
8.8 out of 10, Excellent, (1,003 reviews)
"Room was clean, nice shower, and the breakfast was tasty with good variety."
United States
Nicole
May 26th, 2026
$96 nightly
The price is $111
Jul 3 - Jul 4
Total with taxes and fees
Holiday Inn Express Rochester South - Mayo Area by IHG
Lobby

SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys

SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys
3.0 star property
Kutzky Park
8.6 out of 10, Excellent, (1,001 reviews)
"Staff is very friendly. Great for patients who are being seen at Mayo."
United States
Tori
6 days ago
$103 nightly
The price is $118
Jul 12 - Jul 13
Total with taxes and fees
SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys
Indoor pool, open 9:00 AM to 10:00 PM, pool umbrellas, sun loungers

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
2.5 star property
Rochester
8.2 out of 10, Very Good, (958 reviews)
"The hotel Was very clean."
United States
Kenniesha
2 days ago
$79 nightly
The price is $91
Jul 12 - Jul 13
Total with taxes and fees
Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay near Wykoff

Wykoff offers a perfect blend of outdoor adventures and scenic beauty, ideal for family-friendly excursions. Explore nearby neighborhoods for relaxing atmospheres filled with art and romance, making your getaway both exciting and budget-friendly. Discover the charm of this hidden gem on your vacation!

Forestville

For travelers seeking a weekend getaway, Forestville offers a delightful escape into nature, perfect for families and adventure enthusiasts alike. With attractions like the Forestville Mystery Cave State Park, Ed's Museum, and the scenic Root River, visitors can immerse themselves in a variety of outdoor activities. Located about 10 miles by car from Wykoff, Forestville provides easy access to its charming recreational areas and shopping venues. Choosing Forestville for your stay ensures a memorable experience surrounded by breathtaking scenery.

An aerial view of a rural landscape with fields, a small cluster of houses, and a large, curved field.

Spring Valley

Plan your stay in Spring Valley, a top-rated choice for families and outdoor enthusiasts looking for a perfect blend of adventure and scenery. With attractions like the Forestville Mystery Cave State Park and Masonic Park, visitors can enjoy hiking trails and recreational areas, making it a vibrant destination year-round. Located about 6 miles by car from Wykoff, Spring Valley offers easy access to its captivating natural beauty and local museums, ensuring a delightful experience for every traveler.

Fountain

If you are a nature-loving family traveler, look no further than Fountain, Minnesota, a charming city known for its outdoor adventures and picturesque scenery. Explore the scenic trails and recreational areas, or visit the stunning Root River and the Forestville Mystery Cave State Park for unforgettable experiences. Located about 7 miles by car from Wykoff, Fountain offers easy access to a variety of attractions. With its welcoming atmosphere and budget-friendly options, Fountain is a smart choice for your next getaway.

A river winding through a lush green landscape with dense foliage and trees.

Preston

Ideally situated for outdoor enthusiasts and families, Preston offers a gateway to stunning natural beauty and adventure. Visitors can explore the captivating Forestville Mystery Cave State Park, hike along scenic trails, or unwind by the picturesque Root River. The vibrant Lanesboro Arts Center adds a cultural touch to your stay. Located about 10 miles by car from Wykoff, Preston provides easy access to these attractions, making it a smart choice for your next getaway.

A weathered wooden structure with a conical roof, surrounded by a grassy field and trees.

Chatfield

Travelers visiting the area often choose Chatfield, especially families and nature enthusiasts seeking close proximity to outdoor adventures and scenic landscapes. With attractions like the beautiful Root River, Masonic Park, and Ed's Museum, Chatfield offers a delightful mix of recreation and culture. This charming city is located about 10 miles by car from Wykoff, making it an easily accessible destination for those looking to explore the natural beauty of Minnesota. Chatfield is a smart choice for your hotel stay, ensuring a memorable experience.

Stay near popular attractions in and around Wykoff

Nestled in the heart of scenic beauty, Wykoff invites travelers to embrace outdoor adventures and rich cultural experiences. Explore nearby parks for breathtaking landscapes, visit historic homes to delve into local history, and enjoy the vibrant atmosphere of a modern college town—all perfect for an unforgettable getaway.
A cave with a reflective pool and illuminated walls.
Photo by T. Jen
Open Photo by T. Jen

Forestville Mystery Cave State Park

9.0/5 (22 reviews)
A go-to area recognized for its adventure and scenic beauty, Forestville Mystery Cave State Park offers outdoor enthusiasts a chance to explore stunning landscapes and intriguing caves. Located about 9 miles by car from Wykoff, this park makes for a convenient day trip to enjoy nature and discover unique geological features.
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Top Wykoff Hotel Reviews

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

8/10 Good
"This hotel isn’t the most luxurious place I’ve stayed, but it’s clean, comfortable, and serves its purpose well. The biggest advantage is its location, it’s incredibly convenient if you’re visiting Mayo Clinic, making appointments and travel much less stressful. The staff was friendly, check-in was easy, and everything I needed for a comfortable stay was available. If you’re looking for a practical, affordable place to stay close to Mayo Clinic rather than a destination resort, this is a solid choice. I’d stay here again for the convenience alone."
Ashley 1-night trip
Posted less than an hour ago
Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

More cheap stays in Wykoff

Econo Lodge Mayo Clinic Area

Econo Lodge Mayo Clinic Area

1850 S Broadway Rochester MN
$70 nightly
The price is $80 total per night from Jul 26 to Jul 27
$80 total
Jul 26 - Jul 27
Total with taxes and fees
9/10 Wonderful! (1,001 reviews)

Hotels in Wykoff with star-rating

Frequently asked questions

What is the best area to stay in Wykoff?
The best area to stay in Wykoff is the village center, particularly around Main Street, as it offers the most convenient access to local amenities and the town's character.

Wykoff is a small, quiet village, and its center is defined by Main Street, where you'll find the local businesses and community gathering spots. This area provides a sense of the village's everyday life, with easy access to any shops or services you might need.

For travelers looking for a peaceful retreat, the village center is ideal. It offers a relaxed pace and a chance to experience a small Midwestern town.
When is the best time to go to Wykoff?
The best time to visit Wykoff is during the late spring, summer, and early autumn months, from May through October, when the weather is most pleasant for outdoor activities.

During these months, you'll find comfortable temperatures ideal for exploring the natural beauty of the surrounding area. This period is particularly good for families looking to enjoy activities like visiting the nearby Mystery Cave State Park, which offers guided tours and underground adventures. The local parks and trails are also easily accessible for hiking and picnics.

Couples looking for a peaceful getaway will appreciate the mild weather for leisurely drives through the scenic bluff country. Many local farms and orchards are open for seasonal produce picking during these months, offering a relaxing and authentic rural experience.
Can I cancel my hotel reservation on Expedia?
You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in Wykoff.
How can I save on a Wykoff hotel booking with Expedia?
With Expedia, you earn OneKeyCash™* on eligible Wykoff hotel bookings for every dollar you spend – just join our One Key™ travel rewards program to get started. It's free to join, and you'll unlock our lowest Member Prices as soon as you're signed in. On top of this, you could also save significantly by bundling your hotel and flights together on Expedia.

*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.
How much is the nightly rate at a Wykoff hotel?
Prices for hotels in Wykoff often vary, but you can find a great deal from $69 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.

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