Find 4 Star Hotels in Depew, NY from $138

  • Upfront pricing

    Our total price for your stay includes taxes and fees

  • Treat yourself

    Save 10% or more on over 100,000 hotels worldwide with Member Prices
    Learn about One Key

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
Nov 5 - Nov 6
Tomorrow
Nov 6 - Nov 7
This weekend
Nov 6 - Nov 8
Next weekend
Nov 13 - Nov 15

Our top choices for Depew 4-star hotels

A spacious lobby with high ceilings, a grand staircase, and a gift shop.

1. The Delavan Hotel & Spa

The Delavan Hotel & Spa
4.0 star property
Bowmansville
8.8 out of 10, Excellent, (1,001 reviews)
"Amazing place to stay!"
United States
Tiffany
$209 nightly
The price is $238
Dec 6 - Dec 7
Total with taxes and fees
The Delavan Hotel & Spa
A grand entrance with a staircase leading to a door, surrounded by lush greenery and a well-maintained garden.

2. The Mansion On Delaware Ave

The Mansion On Delaware Ave
4.0 star property
Downtown Buffalo
9.4 out of 10, Exceptional, (1,001 reviews)
"Great place to stay!"
United States
Marilyn
$184 nightly
The price is $211
Dec 6 - Dec 7
Total with taxes and fees
The Mansion On Delaware Ave
A hotel room with two beds, a desk, a sofa, and a large abstract mural on the wall.

3. DoubleTree by Hilton Hotel Buffalo - Amherst

DoubleTree by Hilton Hotel Buffalo - Amherst
4.0 star property
Buffalo
7.8 out of 10, Good, (1,000 reviews)
"Very clean room and friendly staff"
United States
Alexander
$121 nightly
The price is $138
Nov 14 - Nov 15
Total with taxes and fees
DoubleTree by Hilton Hotel Buffalo - Amherst
A two-story building with a white exterior, a red door, and large windows.

4. Buffalo Guesthouse

Buffalo Guesthouse
4.0 star property
Downtown Buffalo
9.4 out of 10, Exceptional, (230 reviews)
"Excellent location and service."
United States
Jose
$146 nightly
The price is $168
Nov 9 - Nov 10
Total with taxes and fees
Buffalo Guesthouse
A spacious lobby with modern furniture, large windows, and a high ceiling with exposed beams.

5. The Westin Buffalo

The Westin Buffalo
4.0 star property
Downtown Buffalo
9.2 out of 10, Wonderful, (437 reviews)
"Nice brunch"
United States
Sarah
$272 nightly
The price is $318
Nov 15 - Nov 16
Total with taxes and fees
The Westin Buffalo
A lobby with teal armchairs, a round table, a flat-screen TV, and a stone wall with a fireplace.

6. The Mosey Buffalo Williamsville, Tapestry Collection by Hilton

The Mosey Buffalo Williamsville, Tapestry Collection by Hilton
4.0 star property
Buffalo
9.4 out of 10, Exceptional, (1,001 reviews)
"The people working the front desk were very nice and responsive."
United States
Andres
$166 nightly
The price is $189
Nov 15 - Nov 16
Total with taxes and fees
The Mosey Buffalo Williamsville, Tapestry Collection by Hilton
A hotel with a prominent entrance, a clock tower, and the name "REIKART HOUSE" displayed above the entrance.

7. Reikart House, Buffalo, a Tribute Portfolio Hotel

Reikart House, Buffalo, a Tribute Portfolio Hotel
4.0 star property
Buffalo
9.6 out of 10, Exceptional, (755 reviews)
"Great stay"
United States
Jonathon
$233 nightly
The price is $265
Nov 15 - Nov 16
Total with taxes and fees
Reikart House, Buffalo, a Tribute Portfolio Hotel
A spacious room with a wooden floor, a fireplace, a dining table, and several chairs.

8. Buffalo Harmony House

Buffalo Harmony House
4.5 star property
Downtown Buffalo
10.0 out of 10, Exceptional, (57 reviews)
"Beautiful place. Great breakfasts. Wonderful staff."
United States
John
$330 nightly
The price is $378
Nov 8 - Nov 9
Total with taxes and fees
Buffalo Harmony House
A two-story house with a stone accent wall, multiple windows, and outdoor lighting.

9. River Spring Lodge

River Spring Lodge
4.0 star property
Darien Center
10.0 out of 10, Exceptional, (81 reviews)
"Carolyn and Cuddles were most excellent hosts for us - would highly recommend for anyone visiting the area, particularly for a long weekend getaway!"
Canada
Matthew
River Spring Lodge

Top Depew Hotel Reviews

A lobby with teal armchairs, a round table, a flat-screen TV, and a stone wall with a fireplace.
The Mosey Buffalo Williamsville, Tapestry Collection by Hilton

The Mosey Buffalo Williamsville, Tapestry Collection by Hilton

The Mosey Buffalo Williamsville, Tapestry Collection by Hilton
Buffalo

10/10 Excellent

Very nice
United States
Marc
Reviewed April 16, 2022
The Mosey Buffalo Williamsville, Tapestry Collection by Hilton

Find out more about Depew

Depew Four Star Hotel Information

When you need to book a room with luxurious amazing amenities and the best rates, the 4 star hotels in Depew, New York are incredible options. Known for their extra perks, first-rate service, and fantastic locations, each of the Depew 4 star hotels offers the ultimate experience for globe-trotting travelers. Relax in your expertly designed room. Kick back with around-the-clock room service.

Get a good night’s sleep with the ultra-plush bedding, and freshen up in the morning with designer-inspired body products. It’s all available when you stay at one of the top book a four star hotels in Depew. What’s more, thanks to Expedia you might even score a cheap great deal on a 4 star hotel in Depew, New York, areas near the hottest attractions, so you can plan a sightseeing adventure and take advantage of unbeatable discounts in one fell swoop.

Whether you’re putting together a serene getaway or want to revel in the most vibrant entertainment district, 4 star Depew hotels offer everything your heart desires.

Frequently Asked Questions

What are the best 4-star hotels in Depew?

The Delavan Hotel & Spa is a 4-star hotel in Depew that rates highly among Expedia travelers. Massage services and beauty services are some of its many amenities. Travelers also love staying at The Mosey Buffalo Williamsville, Tapestry Collection by Hilton. From a swimming pool to concierge services, it features conveniences that cater to all aspects of your enjoyment and relaxation.

How much does it cost to stay in a 4-star hotel in Depew?

With Expedia's handy filter tool, locking in an awesome deal on a 4-star hotel in Depew just got easier. Start by keying in your chosen arrival date and length of your vacation. Then sort the results by price and choose a property that best suits your budget and style.

  • Search for the lowest price from $138

What's the difference between 5-star and 4-star hotels in Depew?

Offering a friendly guest experience and upscale surroundings, 4-star hotels are a wonderful option for your Depew break. These types of accommodations generally come with loads of handy amenities that make it easy to unpack and unwind — think 24-hour room service, gyms and restaurants. Or live the high life at a 5-star hotel designed to spoil you with luxury perks and amenities. Concierge assistance, oversized bathrooms and fine dining are typically featured at these plush properties.

Does Depew have any 4-star all-inclusive resorts?

Use our handy filters to look for all-inclusive Depew getaways where your room, food, on-site entertainment and lots of other things are included in a single upfront payment. Can't find anything suitable? You can also kick back and relax in upscale surroundings at other 4-star stays in the city. The Mosey Buffalo Williamsville, Tapestry Collection by Hilton and The Delavan Hotel & Spa are two popular options.

Are there any 4-star casino hotels in Depew?

To find your perfect escape in Depew, simply use our handy filter to narrow your search. Offering resort-style amenities and a premium level of service, staying in a 4-star casino hotel is a sure bet for a good time.

What are the top 4-star hotels in downtown Depew?

Around 4 mi north from the heart of Depew, The Delavan Hotel & Spa will place you within close proximity to all the action. This 4-star hotel also features premium bedding and front desk services for your comfort and convenience.

Explore a world of travel with Expedia