Title: The Best 5 Star Hotels in Durham, NC from $109 | Expedia.com [Durham Travel Guide](https://expedia.com/Durham.dx6049)[Hotels in Durham](https://expedia.com/Durham-Hotels.d6049.Travel-Guide-Hotels)[Vacation Rentals in Durham](https://expedia.com/Durham-Vacation-Rentals.d6049.Travel-Guide-VacationRentals)[Flights to Durham](https://expedia.com/Cheap-Flights-To-Durham.d6049.Travel-Guide-Flights)[Things to do in Durham](https://expedia.com/Things-To-Do-In-Durham.d6049.Travel-Guide-Activities)[Car Rentals in Durham](https://expedia.com/Car-Rentals-In-Durham.d6049.Car-Rental-Guide)[Durham Vacation Packages](https://expedia.com/Durham.d6049.Destination-Travel-Guides) ![The Revitalized Retail and Office Center of The American Tobacco Historical District, Durham, North Carolina, USA](https://images.trvl-media.com/place/6049/f06d1ddf-5cba-425b-9bd9-b78c3d5444f6.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/6049/f06d1ddf-5cba-425b-9bd9-b78c3d5444f6.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Upfront pricing Our total price for your stay includes taxes and fees - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save 10% or more on over 100,000 hotels worldwide with Member Prices [Learn about One Key](https://www.expedia.com/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Durham 5 Star Hotels Tonight [Feb 25 - Feb 26](https://www.expedia.com/Hotel-Search?regionId=6049&startDate=2026-02-25&endDate=2026-02-26&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Feb 26 - Feb 27](https://www.expedia.com/Hotel-Search?regionId=6049&startDate=2026-02-26&endDate=2026-02-27&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Feb 27 - Mar 1](https://www.expedia.com/Hotel-Search?regionId=6049&startDate=2026-02-27&endDate=2026-03-01&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Mar 6 - Mar 8](https://www.expedia.com/Hotel-Search?regionId=6049&startDate=2026-03-06&endDate=2026-03-08&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Durham-Hotels.s50-0-d6049.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Durham-Hotels.s50-0-d6049.Travel-Guide-Filter-Hotels) ## Explore similar 4-star hotels Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Durham. ![JB Duke Hotel](https://images.trvl-media.com/lodging/16000000/15940000/15936000/15935986/22366c65_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### JB Duke Hotel 230 Science Drive Durham NC $199 nightly $226 total Mar 2 - Mar 3 Total with taxes and fees 9.4/10 Exceptional! (567 reviews) [](https://expedia.com/Raleigh-Hotels-JB-Duke-Hotel.h15935986.Hotel-Information) ![21c Museum Hotel Durham](https://images.trvl-media.com/lodging/9000000/8730000/8720800/8720744/a66cf407_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### 21c Museum Hotel Durham 111 North Corcoran Street Durham NC $165 nightly $187 total Mar 18 - Mar 19 Total with taxes and fees 8.4/10 Very Good! (1,009 reviews) [](https://expedia.com/Raleigh-Hotels-21c-Museum-Hotel-Durham.h8720744.Hotel-Information) ![DoubleTree Suites by Hilton Raleigh - Durham](https://images.trvl-media.com/lodging/1000000/20000/13200/13139/7fb5aa3f_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### DoubleTree Suites by Hilton Raleigh - Durham 2515 Meridian Pkwy Durham NC $96 nightly $109 total Mar 6 - Mar 7 Total with taxes and fees [](https://expedia.com/Raleigh-Hotels-DoubleTree-Suites-By-Hilton-Raleigh-Durham.h13139.Hotel-Information) Still don't see what you're looking for? [See all properties in Durham.](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=2%2F26%2F2026&endDate=2%2F27%2F2026®ionId=6049&star=50) You can also use these popular filters to refine your search. [Pool](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=2%2F26%2F2026&endDate=2%2F27%2F2026®ionId=6049&star=50&star=50&amenities=POOL)[Spa](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=2%2F26%2F2026&endDate=2%2F27%2F2026®ionId=6049&star=50&star=50&amenities=SPA_ON_SITE)[Hot tub](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=2%2F26%2F2026&endDate=2%2F27%2F2026®ionId=6049&star=50&star=50&amenities=HOT_TUB)[Breakfast included](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=2%2F26%2F2026&endDate=2%2F27%2F2026®ionId=6049&star=50&star=50&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=2%2F26%2F2026&endDate=2%2F27%2F2026®ionId=6049&star=50&star=50&amenities=WATER_PARK) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Learn more about Durham Stroll through Duke University's Gothic campus before catching a Durham Bulls baseball game at their downtown stadium. Dive into the city's food scene at the renovated American Tobacco Campus, where former warehouses now house top-notch restaurants and breweries. [See all hotels in Durham](https://www.expedia.com/Hotel-Search?startDate=2026-03-11&endDate=2026-03-12&adults=2®ionId=6049) ![The Revitalized Retail and Office Center of The American Tobacco Historical District, Durham, North Carolina, USA](https://images.trvl-media.com/place/6049/f06d1ddf-5cba-425b-9bd9-b78c3d5444f6.jpg?impolicy=fcrop&w=900&h=517&p=1&q=high) ## Top Durham Hotel Reviews ## Find out more about Durham Why not request the best on your excursion to Durham? After all, you love the finer things in life, both at home and when you book a getaway. You'll join the multitudes of vacationers who have made Durham so popular in the last year. There's no reason to delay a getaway to Durham any longer. We should also mention, the hotels in this area are known for guest services, so you know you'll want for nothing during your getaway. Reserve one of our 5-star hotels in Durham and indulge in the finer things in life for a while. You deserve the great vacation you're dreaming about. ### 5-Star Hotels in Durham Don't be afraid to request the best service from your hotel, along with pristine rooms. High-end restaurants, concierges, and in-room spa sessions are all at the ready. Our numerous hotels in the area will ensure you find the perfect space to kick back after a long day. Besides that, you'll find that these hotels are kept in fantastic condition and provide a fine place to kick back after your daily adventures. How do you want to relax? A full-body massage to help your cares fall away? A concierge to help you suggest the next attraction to visit? Plush carpeting, piping hot coffees, and even a hot tub in the bathroom...these hotels will leave you amazed. Want to see for yourself? Then explore the 1,146 reviews various guests have left on Expedia and get to know these places. You won't sleep and order room service the entire time, though. You're in luck. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. No matter what's on your agenda, the 5-star hotels in Durham are the perfect place to relax after an exciting day. ### Make Your Escape The results are in, and Durham 5-star hotels are the place to be when you book your next vacation. Many visitors recommend a trip to this location, so don't wait any longer. Expedia can help you land a great deal on accommodation. It's time to plan your next great escape. Choose one of the 5-star hotels in Durham today and relax in luxe surroundings tomorrow. ## Frequently asked questions ### How much does it cost to stay in a 5-star hotel in Durham? > - Search for the lowest price per night from $109 ### What makes a hotel 5 stars in Durham? ### Are there any 5-star all-inclusive resorts in Durham? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rentals - [Hotels near Durham Performing Arts Center ](https://www.expedia.com/Durham-Performing-Arts-Center-Hotels.0-l6301058-0.Travel-Guide-Filter-Hotels) - [Hotels near Carolina Theatre ](https://www.expedia.com/Carolina-Theatre-Hotels.0-l6066237-0.Travel-Guide-Filter-Hotels) - [Hotels near Durham Convention Center ](https://www.expedia.com/Durham-Convention-Center-Hotels.0-l553248621532657774-0.Travel-Guide-Filter-Hotels) - [Hotels near Downtown Durham ](https://www.expedia.com/Downtown-Durham-Raleigh-Hotels.0-n553248635976479661-0.Travel-Guide-Filter-Hotels) - [Hotels near American Tobacco Campus ](https://www.expedia.com/American-Tobacco-Campus-Hotels.0-l553248621563220390-0.Travel-Guide-Filter-Hotels) - [Hotels near Durham Station ](https://www.expedia.com/Durham-Station-Hotels.d6194828.Travel-Guide-Hotels) - [Hotels near Durham Bulls Athletic Park ](https://www.expedia.com/Durham-Bulls-Athletic-Park-Hotels.0-l6066243-0.Travel-Guide-Filter-Hotels) - [4 Star Hotels in Golden Belt Historic District ](https://www.expedia.com/4Star-Golden-Belt-Historic-District-Raleigh-Hotels.s40-n6343383-0.Travel-Guide-Filter-Hotels) - [Hotels near Brightleaf Square ](https://www.expedia.com/Brightleaf-Square-Hotels.0-l553248621532657772-0.Travel-Guide-Filter-Hotels) - [Hotels near Honey Girl Meadery ](https://www.expedia.com/Honey-Girl-Meadery-Hotels.0-l553248621564886208-0.Travel-Guide-Filter-Hotels) - [Hotels near The Brothers Vilgalys Spirits ](https://www.expedia.com/The-Brothers-Vilgalys-Spirits-Hotels.0-l553248621564886211-0.Travel-Guide-Filter-Hotels) - [Hotels near Golden Belt Historic District ](https://www.expedia.com/Golden-Belt-Historic-District-Raleigh-Hotels.0-n6343383-0.Travel-Guide-Filter-Hotels) - [Hotels near Duke Park ](https://www.expedia.com/Duke-Park-Raleigh-Hotels.0-n553248635976477139-0.Travel-Guide-Filter-Hotels) - [Hotels near Forest Hills Park ](https://www.expedia.com/Forest-Hills-Park-Hotels.0-l553248621564886204-0.Travel-Guide-Filter-Hotels) - [Hotels near Forest Hills ](https://www.expedia.com/Forest-Hills-Raleigh-Hotels.0-n553248635976472019-0.Travel-Guide-Filter-Hotels) - [Hotels near East Durham ](https://www.expedia.com/East-Durham-Raleigh-Hotels.0-n553248635976474768-0.Travel-Guide-Filter-Hotels) - [Hotels near North Carolina Central University ](https://www.expedia.com/North-Carolina-Central-University-Hotels.0-l6066245-0.Travel-Guide-Filter-Hotels) - [Hotels near Nasher Museum of Art at Duke University ](https://www.expedia.com/Nasher-Museum-Of-Art-At-Duke-University-Hotels.0-l553248621532657768-0.Travel-Guide-Filter-Hotels) - [Hotels near 9th Street District ](https://www.expedia.com/Ninth-Street-Hotels.0-l6343384-0.Travel-Guide-Filter-Hotels) - [Hotels near Northgate Mall ](https://www.expedia.com/Northgate-Mall-Hotels.0-l553248621564886206-0.Travel-Guide-Filter-Hotels) - [Hotels near Duke University ](https://www.expedia.com/Duke-University-Hotels.0-l6066239-0.Travel-Guide-Filter-Hotels) - [Hotels near Sarah P. 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[Flights from Lowes Grove ](https://www.expedia.com/lp/flights/3000008280/flights-from-lowes-grove) - [Flights from Raleigh - Durham Intl. ](https://www.expedia.com/lp/airports/rdu/flights-from-raleigh-durham-intl-airport) - [Durham Convention Center ](https://www.expedia.com/Durham-Convention-Center-Downtown-Durham.d553248621532657774.Vacation-Attraction) - [American Tobacco Campus ](https://www.expedia.com/American-Tobacco-Campus-Downtown-Durham.d553248621563220390.Vacation-Attraction) - [Durham Bulls Athletic Park ](https://www.expedia.com/Durham-Bulls-Athletic-Park-Downtown-Durham.d6066243.Vacation-Attraction) - [Fullsteam Brewery ](https://www.expedia.com/Fullsteam-Brewery-Raleigh.d553248621564886207.Vacation-Attraction) - [Brightleaf Square ](https://www.expedia.com/Brightleaf-Square-Downtown-Durham.d553248621532657772.Vacation-Attraction) - [Honey Girl Meadery ](https://www.expedia.com/Honey-Girl-Meadery-Downtown-Durham.d553248621564886208.Vacation-Attraction) - [Visit Golden Belt Historic District ](https://www.expedia.com/Raleigh-Golden-Belt-Historic-District.dx6343383) - [Northgate Mall ](https://www.expedia.com/Northgate-Mall-Raleigh.d553248621564886206.Vacation-Attraction) - [Sarah P. 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