Title: The Best 5 Star Hotels in Roxana, IL from $126 | Expedia.com [Roxana Travel Guide](https://expedia.com/Roxana.dx3000346551)[Hotels in Roxana](https://expedia.com/Roxana-Hotels.d3000346551.Travel-Guide-Hotels)[Vacation Rentals in Roxana](https://expedia.com/Roxana-Vacation-Rentals.d3000346551.Travel-Guide-VacationRentals)[Flights to Roxana](https://expedia.com/Cheap-Flights-To-Roxana.d3000346551.Travel-Guide-Flights)[Car Rentals in Roxana](https://expedia.com/Car-Rentals-In-Roxana.d3000346551.Car-Rental-Guide)[Roxana Vacation Packages](https://expedia.com/Roxana.d3000346551.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Upfront pricing Our total price for your stay includes taxes and fees - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save 10% or more on over 100,000 hotels worldwide with Member Prices [Learn about One Key](https://www.expedia.com/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Roxana 5 Star Hotels Tonight [Feb 28 - Mar 1](https://www.expedia.com/Hotel-Search?regionId=3000346551&startDate=2026-02-28&endDate=2026-03-01&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Mar 1 - Mar 2](https://www.expedia.com/Hotel-Search?regionId=3000346551&startDate=2026-03-01&endDate=2026-03-02&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Mar 6 - Mar 8](https://www.expedia.com/Hotel-Search?regionId=3000346551&startDate=2026-03-06&endDate=2026-03-08&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Mar 13 - Mar 15](https://www.expedia.com/Hotel-Search?regionId=3000346551&startDate=2026-03-13&endDate=2026-03-15&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Roxana 5-star hotels ![Terrace/patio](https://images.trvl-media.com/lodging/3000000/2860000/2851500/2851438/ef7a5612.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Couples treatment rooms, hot tub, body treatments, aromatherapy](https://images.trvl-media.com/lodging/3000000/2860000/2851500/2851438/56a41562.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Couples treatment rooms, hot tub, body treatments, aromatherapy](https://images.trvl-media.com/lodging/3000000/2860000/2851500/2851438/941b0ba8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Luxury Suite, 1 King Bed, Non Smoking | Living area | 42-inch plasma TV with cable channels, TV, DVD player](https://images.trvl-media.com/lodging/3000000/2860000/2851500/2851438/3714f01f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Four Seasons Hotel St Louis [](https://www.expedia.com/St-Louis-Hotels-Four-Seasons-Hotel-St-Louis.h2851438.Hotel-Information) Downtown St. Louis 9.4/10 Exceptional (1,000 reviews) "Great service, great staff , room service food really good,, great view of the arch and the river. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jose $415 nightly $485 total Mar 1 - Mar 2 Total with taxes and fees [](https://www.expedia.com/St-Louis-Hotels-Four-Seasons-Hotel-St-Louis.h2851438.Hotel-Information) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/10000/6200/6132/a54897ef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/10000/6200/6132/1817cdae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Daily buffet breakfast for a fee](https://images.trvl-media.com/lodging/1000000/10000/6200/6132/f50e8b2b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/6200/6132/3f20ce75.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Ritz-Carlton, St. Louis [](https://www.expedia.com/St-Louis-Hotels-The-Ritz-Carlton.h6132.Hotel-Information) Clayton 9.2/10 Wonderful (557 reviews) "Excellent hotel with various restaurants and expansive lobby area.. staff very attentive." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Diane M $499 nightly $583 total Mar 1 - Mar 2 Total with taxes and fees [](https://www.expedia.com/St-Louis-Hotels-The-Ritz-Carlton.h6132.Hotel-Information) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Roxana-Hotels.s50-0-d3000346551.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Roxana-Hotels.s50-0-d3000346551.Travel-Guide-Filter-Hotels) ## Explore similar 4-star hotels Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Roxana. ![Magnolia Hotel St. Louis, a Tribute Portfolio Hotel](https://images.trvl-media.com/lodging/9000000/8140000/8132000/8131949/4b87c2a3_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Magnolia Hotel St. Louis, a Tribute Portfolio Hotel 421 N 8th St St. Louis MO $106 nightly $126 total Mar 4 - Mar 5 Total with taxes and fees 8.8/10 Excellent! (1,244 reviews) [](https://expedia.com/St-Louis-Hotels-Magnolia-Hotel-St-Louis.h8131949.Hotel-Information) ![Hyatt Regency St. Louis at The Arch](https://images.trvl-media.com/lodging/1000000/20000/14900/14877/335a172e_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Hyatt Regency St. Louis at The Arch 315 Chestnut St St. Louis MO $159 nightly $188 total Mar 28 - Mar 29 Total with taxes and fees 8.4/10 Very Good! (3,999 reviews) [](https://expedia.com/St-Louis-Hotels-Hyatt-Regency-St-Louis-At-The-Arch.h14877.Hotel-Information) ![21C Museum Hotel St Louis ](https://images.trvl-media.com/lodging/90000000/89170000/89164600/89164592/cd6b7758_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### 21C Museum Hotel St Louis 1528 Locust street St. Louis MO $131 nightly $153 total Mar 23 - Mar 24 Total with taxes and fees 9/10 Wonderful! (1,629 reviews) [](https://expedia.com/St-Louis-Hotels-21C-Museum-Hotel-St-Louis.h89164592.Hotel-Information) Still don't see what you're looking for? [See all properties in Roxana.](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F1%2F2026&endDate=3%2F2%2F2026®ionId=3000346551&star=50) You can also use these popular filters to refine your search. [Pool](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F1%2F2026&endDate=3%2F2%2F2026®ionId=3000346551&star=50&star=50&amenities=POOL)[Spa](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F1%2F2026&endDate=3%2F2%2F2026®ionId=3000346551&star=50&star=50&amenities=SPA_ON_SITE)[Hot tub](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F1%2F2026&endDate=3%2F2%2F2026®ionId=3000346551&star=50&star=50&amenities=HOT_TUB)[Breakfast included](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F1%2F2026&endDate=3%2F2%2F2026®ionId=3000346551&star=50&star=50&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F1%2F2026&endDate=3%2F2%2F2026®ionId=3000346551&star=50&star=50&amenities=WATER_PARK) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Top Roxana Hotel Reviews ## Find out more about Roxana ## Roxana Five Star Hotel Information If you’re searching for the celebrity treatment, the 5 star hotels in Roxana are your dreams come true. From sprawling resorts to fancy hot spots, theseRoxana 5 star hotels immerse each traveler in the most elite experience money can buy. Want to unwind with a VIP-worthy spa treatment? These hotels have the leisure you're looking for. Interested in sampling world-class cuisine? The on-site restaurants at the 5 stars hotels in Roxana, Illinois, let you do just that. You’ll even be able to book a room (or perhaps a penthouse?) at first-rate hotels near the region’s can’t-miss sights and most bustling shopping centers. Plus, many globe-trotters who visit Roxana five star hotels find incredible rates and deep discounts thanks to Expedia, so you can score a deal without sacrificing an ounce of quality. Everything you could possibly want (and a few things you didn’t know you needed): That’s what you’ll receive when you stay at Roxana 5 star hotels. ## Frequently asked questions ### How much does it cost to stay in a 5-star hotel in Roxana? > - Search for the lowest price per night from $126 ### What makes a hotel 5 stars in Roxana? ### Are there any 5-star all-inclusive resorts in Roxana? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rentals - Other - [Hotels near CP Pinball ](https://www.expedia.com/CP-Pinball-Hotels.0-l553248621532648632-0.Travel-Guide-Filter-Hotels) - [South Roxana Hotels ](https://www.expedia.com/South-Roxana-Hotels.d553248634983470823.Travel-Guide-Hotels) - [5 Star Hotels in Wood River ](https://www.expedia.com/5Star-Wood-River-Hotels.s50-0-d176184.Travel-Guide-Filter-Hotels) - [5 Star Hotels in Hartford ](https://www.expedia.com/5Star-Hartford-Hotels.s50-0-d6286985.Travel-Guide-Filter-Hotels) - [Wood River Hotels ](https://www.expedia.com/Wood-River-Hotels.d176184.Travel-Guide-Hotels) - 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