Title: $45 Car Rental UC Irvine Medical Center, CA - Expedia.com [Orange Travel Guide](https://expedia.com/Orange.dx9063)[UC Irvine Medical Center Hotels](https://expedia.com/UC-Irvine-Medical-Center-Hotels.0-l6282680-0.Travel-Guide-Filter-Hotels)[Flights to Orange](https://expedia.com/Cheap-Flights-To-Orange.d9063.Travel-Guide-Flights)[Things to do in Orange](https://expedia.com/Things-To-Do-In-Orange.d9063.Travel-Guide-Activities)[UC Irvine Medical Center Vacations](https://expedia.com/UC-Irvine-Medical-Center-Orange.d6282680.Vacation-Attraction) ## Featured car rental suppliers Compare from agencies ![car suppliers logo](https://forever.travel-assets.com/flex/flexmanager/images/2022/02/16/car-suppliers-logo-desktop.jpg) - ![protection illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__protection.svg) ### Change your mind Penalty-free cancellation on many/select car rentals - ![trophy illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__trophy.svg) ### Treat yourself One Key members save 10% or more on over 1 million car rentals [Learn about One Key](https://www.expedia.com/welcome-one-key) - ![package illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__package.svg) ### Shop smart Compare car suppliers and package your flight, hotel, and car to save ## Top Car Deals in UC Irvine Medical Center \* Price found within the past 6 days. Click for updated prices. Tue, Mar 3 - Wed, Mar 4 ### Special Supplier Choice - Compact or larger or similar - 5 people - Unlimited mileage ![U-Save](//mediaim.expedia.com/cars/logos/SV.png) Irvine, California, USA ![Supplier Choice - Compact or larger](//mediaim.expedia.com/cars/34/2bc25045-b7e7-4bbc-83b9-f880546f8ecc.jpg) #### $45 includes taxes & fees $35 per day found 2 hours ago [](https://expedia.com/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&olat=33.668070&olon=-117.865610&date1=3/3/2026&date2=3/4/2026&pprfrr=35.0&tprfrr=45.45&cvrfrr=SV&ctrfrr=XX&crfrr=pricefeedResponseFlex&SearchType=Place&selCC=[%22other%22]) Tue, Mar 3 - Wed, Mar 4 ### Economy Hyundai Accent or similar - 5 people - Unlimited mileage ![U-Save](//mediaim.expedia.com/cars/logos/SV.png) Irvine, California, USA ![Hyundai Accent](//mediaim.expedia.com/cars/34/cf1b954e-ce0f-4c41-ad5f-a928110df0a3.jpg) #### $51 includes taxes & fees $39 per day found 2 hours ago [](https://expedia.com/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&olat=33.668070&olon=-117.865610&date1=3/3/2026&date2=3/4/2026&pprfrr=39.0&tprfrr=50.52&cvrfrr=SV&ctrfrr=EC&crfrr=pricefeedResponseFlex&SearchType=Place&selCC=[%22economy%22]) Sat, Mar 7 - Sun, Mar 8 ### Midsize SUV Nissan Rogue or similar - 5 people - Unlimited mileage ![Dollar](//mediaim.expedia.com/cars/logos/ZR.png) Santa Ana, California, USA ![Nissan Rogue](//mediaim.expedia.com/cars/43/b6e9269d-6a75-4e13-9def-306857fa7ff3.jpg) #### $52 includes taxes & fees $40 per day found 2 hours ago [](https://expedia.com/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&olat=33.666660&olon=-117.866700&date1=3/7/2026&date2=3/8/2026&pprfrr=40.33&tprfrr=51.59&cvrfrr=ZR&ctrfrr=IF&crfrr=pricefeedResponseFlex&SearchType=Place&selCC=[%22suv%22]) Tue, Mar 3 - Wed, Mar 4 ### Compact Nissan Versa or similar - 5 people - Unlimited mileage ![U-Save](//mediaim.expedia.com/cars/logos/SV.png) Irvine, California, USA ![Nissan Versa](//mediaim.expedia.com/cars/34/49ce558f-c892-4928-b537-92c26f9088b0.jpg) #### $53 includes taxes & fees $41 per day found 2 hours ago [](https://expedia.com/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&olat=33.668070&olon=-117.865610&date1=3/3/2026&date2=3/4/2026&pprfrr=41.0&tprfrr=53.06&cvrfrr=SV&ctrfrr=CC&crfrr=pricefeedResponseFlex&SearchType=Place&selCC=[%22compact%22]) Sat, Mar 7 - Sun, Mar 8 ### Standard SUV Chevrolet Blazer or similar - 5 people - Unlimited mileage ![Hertz](//mediaim.expedia.com/cars/logos/ZE.png) Santa Ana, California, USA ![Chevrolet Blazer](//mediaim.expedia.com/cars/40/a53d5abd-e776-4b0c-a0df-58a61985baeb.jpg) #### $55 includes taxes & fees $43 per day found 2 hours ago [](https://expedia.com/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&olat=33.666660&olon=-117.866700&date1=3/7/2026&date2=3/8/2026&pprfrr=42.69&tprfrr=55.09&cvrfrr=ZE&ctrfrr=SF&crfrr=pricefeedResponseFlex&SearchType=Place&selCC=[%22suv%22]) Fri, Mar 6 - Sat, Mar 7 ### Premium Pickup Regular Cab Ford F150 or similar - 5 people - Unlimited mileage ![Alamo](//mediaim.expedia.com/cars/logos/AL.png) Santa Ana, California, USA ![Ford F150](//mediaim.expedia.com/cars/6/a9d17556-0fbf-437d-906c-b0f1dd727f74.jpg) #### $60 includes taxes & fees $46 per day found 5 hours ago [](https://expedia.com/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&olat=33.668087&olon=-117.866543&date1=3/6/2026&date2=3/7/2026&pprfrr=45.95&tprfrr=60.32&cvrfrr=AL&ctrfrr=PP&crfrr=pricefeedResponseFlex&SearchType=Place&selCC=[%22pickup%22]) Sat, Mar 7 - Sun, Mar 8 ### Fullsize Recreational Vehicle Nissan Pathfinder or similar - 7 people - Unlimited mileage ![Hertz](//mediaim.expedia.com/cars/logos/ZE.png) Santa Ana, California, USA ![Nissan Pathfinder](//mediaim.expedia.com/cars/40/a7eb6fc0-1286-4813-b18e-d9e2613e3268.jpg) #### $61 includes taxes & fees $47 per day found 2 hours ago [](https://expedia.com/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&olat=33.666660&olon=-117.866700&date1=3/7/2026&date2=3/8/2026&pprfrr=46.96&tprfrr=60.54&cvrfrr=ZE&ctrfrr=FR&crfrr=pricefeedResponseFlex&SearchType=Place&selCC=[%22fullsize%22]) Sat, Mar 7 - Sun, Mar 8 ### Midsize Elite Telsa Short Range Model 3 or similar - 5 people - Unlimited mileage ![Budget](//mediaim.expedia.com/cars/logos/ZD.png) Santa Ana, California, USA ![Telsa Short Range Model 3](//mediaim.expedia.com/cars/39/cdea7be4-fba3-47a5-a509-0bc2297220b8.jpg) #### $83 includes taxes & fees $65 per day found 2 hours ago [](https://expedia.com/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&olat=33.666660&olon=-117.866700&date1=3/7/2026&date2=3/8/2026&pprfrr=64.99&tprfrr=82.87&cvrfrr=ZD&ctrfrr=JC&crfrr=pricefeedResponseFlex&SearchType=Place&selCC=[%22midsize%22]) Sat, Mar 7 - Sun, Mar 8 ### Standard Elite Special Ford Mustang Mach-E or similar - 5 people - Unlimited mileage ![Budget](//mediaim.expedia.com/cars/logos/ZD.png) Santa Ana, California, USA ![Ford Mustang Mach-E](//mediaim.expedia.com/cars/39/9eb70d2f-e3e7-4e36-9e24-1505e077c35a.jpg) #### $84 includes taxes & fees $65 per day found 2 hours ago [](https://expedia.com/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&olat=33.666660&olon=-117.866700&date1=3/7/2026&date2=3/8/2026&pprfrr=64.99&tprfrr=84.14&cvrfrr=ZD&ctrfrr=RX&crfrr=pricefeedResponseFlex&SearchType=Place&selCC=[%22standard%22]) Sat, Mar 7 - Sun, Mar 8 ### Luxury Elite Genesis G80E or similar - 5 people - Unlimited mileage ![Budget](//mediaim.expedia.com/cars/logos/ZD.png) Santa Ana, California, USA ![Genesis G80E](//mediaim.expedia.com/cars/39/8cfce1f9-4e0c-482d-8c45-0b135c4d0b15.jpg) #### $97 includes taxes & fees $75 per day found 2 hours ago [](https://expedia.com/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&olat=33.666660&olon=-117.866700&date1=3/7/2026&date2=3/8/2026&pprfrr=74.99&tprfrr=96.92&cvrfrr=ZD&ctrfrr=WC&crfrr=pricefeedResponseFlex&SearchType=Place&selCC=[%22luxury%22]) Tue, Mar 3 - Wed, Mar 4 ### Mini Van CHRYSLER PACIFICA or similar - 7 people - Unlimited mileage ![Hertz](//mediaim.expedia.com/cars/logos/ZE.png) Santa Ana, California, USA ![CHRYSLER PACIFICA](//mediaim.expedia.com/cars/40/fa7b40ac-31b6-4a2b-8c39-f9d06089df5f.jpg) #### $100 includes taxes & fees $79 per day found 5 hours ago [](https://expedia.com/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&olat=33.666660&olon=-117.866700&date1=3/3/2026&date2=3/4/2026&pprfrr=79.34&tprfrr=100.35&cvrfrr=ZE&ctrfrr=MV&crfrr=pricefeedResponseFlex&SearchType=Place&selCC=[%22minivan%22]) Fri, Mar 6 - Sat, Mar 7 ### Luxury Audi A4 or BMW 3 Series or similar - 5 people - Unlimited mileage ![Alamo](//mediaim.expedia.com/cars/logos/AL.png) Santa Ana, California, USA ![Audi A4 or BMW 3 Series](//mediaim.expedia.com/cars/6/e34fcad5-de08-479b-bf77-4b93fbde6fd0.jpg) #### $100 includes taxes & fees $80 per day found 5 hours ago [](https://expedia.com/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&olat=33.668087&olon=-117.866543&date1=3/6/2026&date2=3/7/2026&pprfrr=79.67&tprfrr=100.36&cvrfrr=AL&ctrfrr=LC&crfrr=pricefeedResponseFlex&SearchType=Place&selCC=[%22luxury%22]) Thu, Mar 5 - Fri, Mar 6 ### Premium Elite Mercedes GLE BMW X5 or similar - 5 people - Unlimited mileage ![Enterprise](//mediaim.expedia.com/cars/logos/ET.png) Santa Ana, California, USA ![Mercedes GLE BMW X5](//mediaim.expedia.com/cars/15/2d9e947d-7c65-40f5-9fe7-f178e52de3ad.jpg) #### $114 includes taxes & fees $90 per day found 12 hours ago [](https://expedia.com/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&olat=33.680499&olon=-117.860367&date1=3/5/2026&date2=3/6/2026&pprfrr=89.98&tprfrr=114.31&cvrfrr=ET&ctrfrr=UD&crfrr=pricefeedResponseFlex&SearchType=Place&selCC=[%22premium%22]) Sat, Mar 7 - Sun, Mar 8 ### Fullsize Elite Special Audi A5 Sportback or similar - 5 people - Unlimited mileage ![National](//mediaim.expedia.com/cars/logos/ZL.png) Santa Ana, California, USA ![Audi A5 Sportback](//mediaim.expedia.com/cars/42/e1da5231-b0dd-4a3b-99bc-a26b2701f71f.jpg) #### $126 includes taxes & fees $100 per day found 2 hours ago [](https://expedia.com/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&olat=33.669900&olon=-117.867000&date1=3/7/2026&date2=3/8/2026&pprfrr=99.69&tprfrr=125.7&cvrfrr=ZL&ctrfrr=GX&crfrr=pricefeedResponseFlex&SearchType=Place&selCC=[%22fullsize%22]) Thu, Mar 5 - Fri, Mar 6 ### Oversize SUV Lincoln Navigator L Jeep Grand Wagoneer L or similar - 7 people - Unlimited mileage ![Enterprise](//mediaim.expedia.com/cars/logos/ET.png) SANTA ANA, USA ![Lincoln Navigator L Jeep Grand Wagoneer L](//mediaim.expedia.com/cars/15/8ec48088-7b14-4511-9f7f-d085a5b93e47.jpg) #### $189 includes taxes & fees $150 per day found 12 hours ago [](https://expedia.com/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&olat=33.680499&olon=-117.860367&date1=3/5/2026&date2=3/6/2026&pprfrr=150.0&tprfrr=188.62&cvrfrr=ET&ctrfrr=OF&crfrr=pricefeedResponseFlex&SearchType=Place&selCC=[%22suv%22]) ### Don't see what you're looking for? See all car rentals in UC Irvine Medical Center [View all cars](https://expedia.com/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&locn=UC%20Irvine%20Medical%20Center,%20Orange,%20California,%20United%20States%20of%20America&dpln=6282680&date1=3/8/2026&date2=3/10/2026&crfrr=defaultFlex&SearchType=Place) Lowest prices found within the past 2 hours. Prices and availability subject to change. Additional terms may apply. ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Vacation Sale Members save up to 40% on hotels and homes. Plan this year’s big trip and save. [Book now](https://expedia.com/deals?rfrr=CTG_SPRING_PROMO_6282680) ## Frequently asked questions ### Can I rent a car near UC Irvine Medical Center? ### How much is car rental near UC Irvine Medical Center? ### Which car rental companies have a drop off near UC Irvine Medical Center? ### How much is parking near UC Irvine Medical Center? ### Are there electric car charging stations near UC Irvine Medical Center? ### What is the closest airport to UC Irvine Medical Center? ### Where is UC Irvine Medical Center in Orange? ### What else is there to do near UC Irvine Medical Center? ### What time does UC Irvine Medical Center open and close? ## Car Rental Information | Popular car types | [SUV](https://www.expedia.com/lp/b/car-rental/suv?rfrr=car.table.SUV), [Full Size](https://www.expedia.com/lp/b/car-rental/fullsize?rfrr=car.table.FullSize), [Economy](https://www.expedia.com/lp/b/car-rental/economy?rfrr=car.table.Economy) | | ------------------------------------------------ | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- | | Car suppliers available | | | Our best deal of the day | $45 | | Our second best deal of the day | $51 | | Our third best deal of the day | $52 | | From the airport to your hotel | [Airport Transportation](https://www.expedia.com/ground-transfers?rfrr=car.table.AirportTransportation) | | From popular domestic and international airports | [Airport Car Rentals](https://www.expedia.com/lp/b/car-rental/airport) | ## Explore a world of travel with Expedia - 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