A bridge over a calm river with a sunset sky.

Vacation Rentals in St. Charles County

Top Cities in St. Charles County

Our top choices for St. Charles County vacation rentals

1. Prime Loft of Main Street

Prime Loft of Main Street
St. Charles Historic District
9.8 out of 10, Exceptional, (120 reviews)
"Host was great. The cutest place in the perfect spot! "
United States
Anonymous traveler
$207 nightly
The price is $222
Sep 29 - Sep 30
Total with taxes and fees
Prime Loft of Main Street

2. The Lofts of North Main Street

The Lofts of North Main Street
St. Charles Historic District
9.6 out of 10, Exceptional, (193 reviews)
"Very comfortable bed. Well stocked kitchen. Nice covered porch. Great neighborhood."
United States
Carla K.
$221 nightly
The price is $237
Sep 29 - Sep 30
Total with taxes and fees
The Lofts of North Main Street

3. Amazing Renovated Historic Loft on Main Street

Amazing Renovated Historic Loft on Main Street
St. Charles Historic District
10.0 out of 10, Exceptional, (68 reviews)
"Lovely accommodations, very clean, well equipped, great location. "
United States
Emily B.
$249 nightly
The price is $267
Oct 1 - Oct 2
Total with taxes and fees
Amazing Renovated Historic Loft on Main Street

4. Stunning 1890's Home - Sleeps 8!

Stunning 1890's Home - Sleeps 8!
St. Charles Historic District
10.0 out of 10, Exceptional, (136 reviews)
"Super cute property, fantastic location. Very well maintained and clean, would definitely stay here again. "
United States
Jason T.
$357 nightly
The price is $383
Sep 29 - Sep 30
Total with taxes and fees
Stunning 1890's Home - Sleeps 8!

5. St. Charles 1860's Gem - Sleeps 6!

St. Charles 1860's Gem - Sleeps 6!
St. Charles Historic District
9.8 out of 10, Exceptional, (164 reviews)
"Very nice very clean property. Very much enjoyed our stay"
United States
Joe R.
$236 nightly
The price is $253
Sep 29 - Sep 30
Total with taxes and fees
St. Charles 1860's Gem - Sleeps 6!

6. New Remodel in St. Charles - Sleeps 10! New patio! Large Fenced-in backyard!

New Remodel in St. Charles - Sleeps 10! New patio! Large Fenced-in backyard!
St. Charles Historic District
9.6 out of 10, Exceptional, (79 reviews)
"Excellent location and neighborhood!!! House was as described and communication was great."
United States
David C.
New Remodel in St. Charles - Sleeps 10! New patio! Large Fenced-in backyard!

7. Aunt Doodle’s House 8 blocks from Historic Main Street.. Convenient location!

Aunt Doodle’s House 8 blocks from Historic Main Street.. Convenient location!
St. Charles Historic District
9.6 out of 10, Exceptional, (87 reviews)
"Quaint and quiet, with easy access to downtown St Charles."
United States
Jeffrey E.
$235 nightly
The price is $252
Oct 11 - Oct 12
Total with taxes and fees
Aunt Doodle’s House 8 blocks from Historic Main Street.. Convenient location!

8. Spacious, Beautiful St. Charles Home-Remodeled-Sleeps 10! New Patio!

Spacious, Beautiful St. Charles Home-Remodeled-Sleeps 10! New Patio!
St. Charles Historic District
9.8 out of 10, Exceptional, (63 reviews)
"We enjoyed our stay in St Charles. Amazingly clean and very close to st Charles downtown. "
United States
JonandBeth T.
Spacious, Beautiful St. Charles Home-Remodeled-Sleeps 10! New Patio!

9. Adorable 2 King Bed Frenchtown Home

Adorable 2 King Bed Frenchtown Home
Saint Charles
10.0 out of 10, Exceptional, (5 reviews)
"Great location. Pet friendly. Perfect space for my wife and I to work remotely. So many great local places in close proximity. Host was quick to answer any and all questions. Would absolutely book again."
United States
Don S.
$309 nightly
The price is $348
Sep 29 - Sep 30
Total with taxes and fees
Adorable 2 King Bed Frenchtown Home

10. Home Near Main Street-Covered Patio-Hot Tub!

Home Near Main Street-Covered Patio-Hot Tub!
Saint Charles
9.6 out of 10, Exceptional, (40 reviews)
"Great house and great location"
United States
Mike L.
Home Near Main Street-Covered Patio-Hot Tub!

11. Historic Main St. Customs House Upstairs Apartment

Historic Main St. Customs House Upstairs Apartment
St. Charles Historic District
9.6 out of 10, Exceptional, (39 reviews)
"Lovely place to stay!"
United States
Margaret A.
$302 nightly
The price is $334
Oct 1 - Oct 2
Total with taxes and fees
Historic Main St. Customs House Upstairs Apartment

12. 6th street 101 - Walk to Main St

6th street 101 - Walk to Main St
St. Charles Historic District
10.0 out of 10, Exceptional, (3 reviews)
"Excellent"
United States
Scott N.
$244 nightly
The price is $275
Sep 29 - Sep 30
Total with taxes and fees
6th street 101 - Walk to Main St

13. HotTub-2br2b-near Historic Main Street

HotTub-2br2b-near Historic Main Street
St. Charles Historic District
10.0 out of 10, Exceptional, (23 reviews)
"Comfy beds, great location!"
United States
Jessie W.
$269 nightly
The price is $289
Oct 12 - Oct 13
Total with taxes and fees
HotTub-2br2b-near Historic Main Street

14. WELCOME TO THE OWL'S NEST - 2 BEDROOM HOME IN AUGUSTA, WINERIES & THE KATY TRAIL

WELCOME TO THE OWL'S NEST - 2 BEDROOM HOME IN AUGUSTA, WINERIES & THE KATY TRAIL
Augusta
10.0 out of 10, Exceptional, (40 reviews)
"Comfortable place to stay. We appreciated the snacks and that there is a pack n play!"
United States
Samantha E.
$263 nightly
The price is $281
Sep 29 - Sep 30
Total with taxes and fees
WELCOME TO THE OWL'S NEST - 2 BEDROOM HOME IN AUGUSTA, WINERIES & THE KATY TRAIL

15. Music House · Music House on Main Street at The Wine Garden

Music House · Music House on Main Street at The Wine Garden
Saint Charles
9.2 out of 10, Wonderful, (20 reviews)
"Nice area nice place and communication"
United States
Zack P.
$531 nightly
The price is $601
Sep 29 - Sep 30
Total with taxes and fees
Music House · Music House on Main Street at The Wine Garden

16. Walk to Main | Pet-Friendly Yard & Workspace

Walk to Main | Pet-Friendly Yard & Workspace
St. Charles Historic District
10.0 out of 10, Exceptional, (12 reviews)
"Very close to downtown St. Charles and the Kati Trail. The home is cute and bed is comfortable. Easy check in process and fenced in back yard was nice to have."
United States
Jessica S.
$257 nightly
The price is $284
Oct 12 - Oct 13
Total with taxes and fees
Walk to Main | Pet-Friendly Yard & Workspace

17. Driftwood Den | Boho 2BR | Dog-Friendly

Driftwood Den | Boho 2BR | Dog-Friendly
St. Charles Historic District
9.2 out of 10, Wonderful, (7 reviews)
"Loved our stay here. Clean, comfortable, convenient. Couldn’t have been easier, in all aspects. Already plan to stay there again!!!"
United States
Kourtney S.
$280 nightly
The price is $310
Oct 4 - Oct 5
Total with taxes and fees
Driftwood Den | Boho 2BR | Dog-Friendly

18. 5th Street #1 · Historic 5th Street House - Fully Rehabbed # 1

5th Street #1 · Historic 5th Street House - Fully Rehabbed # 1
St. Charles Historic District
8.8 out of 10, Excellent, (16 reviews)
"House was beautiful. Very nice quiet stay"
United States
Amy S.
$219 nightly
The price is $247
Sep 29 - Sep 30
Total with taxes and fees
5th Street #1 · Historic 5th Street House - Fully Rehabbed # 1

19. Cottage on Main st- Low Cleaning Fee

Cottage on Main st- Low Cleaning Fee
St. Charles Historic District
10.0 out of 10, Exceptional, (10 reviews)
"Good location. Decorated very nicely. "
United States
Debbie A.
$262 nightly
The price is $281
Oct 5 - Oct 6
Total with taxes and fees
Cottage on Main st- Low Cleaning Fee

20. The Chalet | St Charles 2BR Private Retreat on 1.2 Acres | By Mercer Stays

The Chalet | St Charles 2BR Private Retreat on 1.2 Acres | By Mercer Stays
Saint Charles
9.2 out of 10, Wonderful, (5 reviews)
"We loved the location for our travel needs and we had everything we needed for a family of two adults and two dogs. "
United States
Leslie R.
$559 nightly
The price is $633
Sep 29 - Sep 30
Total with taxes and fees
The Chalet | St Charles 2BR Private Retreat on 1.2 Acres | By Mercer Stays
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top St. Charles County Hotel Reviews

Find out more about St. Charles County

Discover your perfect St. Charles County vacation rental with Expedia

How many vacation rentals are available in St. Charles County?


Expedia has plenty of vacation rentals to choose from in and around  St. Charles County, so you’re guaranteed to find the right one for you. 


How much is a vacation rental in St. Charles County?


The selection of St. Charles County vacation rentals we have selected for you start as low as $67 per night. Entering your travel dates in the search wizard you might find even better deals!


What type of vacation rental can I get in St. Charles County?


Vacation rentals in St. Charles County come in all shapes and sizes, and your options depend on your chosen travel dates. You could entertain in a blissful vacation home, chill in a private apartment, or find family fun at a resort. Expedia offers a superb choice of St. Charles County vacation rentals to suit everyone. 


Why should I choose a vacation rental in St. Charles County?


Expedia’s vacation rentals provide cozy comforts you can sink into on your own schedule. You’ll enjoy your own space in a property with a kitchen, a pool, a garden etc. Maybe you’ll prefer somewhere with a spa or kids activities. A St. Charles County vacation rental often works out to be a fantastic, cost-effective option for groups and families visiting for a few nights or longer. And if a hotel room is just too small, get a vacation rental with multiple bedrooms and shared living spaces to kick back in. 


How do I find the best deal on a vacation rental in St. Charles County?


Find vacation rentals in St. Charles County by viewing Expedia’s latest deals, or enter your travel dates and use the filters to select by amenities, price, or rating. Dive into the reviews to get a true feeling of which is your favorite vacation rental in St. Charles County.  


What amenities are available in a vacation rental in St. Charles County?


The choice is yours! Perhaps you love cooking in a well-equipped kitchen. Or maybe a late breakfast and a swimming pool is more your thing. Of course, there’s always the treat of having your own hot tub. Expedia has a vast range of amenities in St. Charles County vacation rentals designed to suit every budget and trip type.


When is the best time to stay in a vacation rental in St. Charles County?   


Everytime is a great time to head to St. Charles County! Staying in a St. Charles County vacation rentals you will always find lots going on to keep you entertained. 


Why book a vacation rental with Expedia?


Expedia has locked in amazing deals on a huge selection of impressive vacation rentals in St. Charles County. We give you the information and inspiration you need all in one place. With so many properties to choose from, you know you can book your perfect St. Charles County vacation rental with confidence. ANd don’t forget, if you bundle with a flight or a car rental in St. Charles County, you can save even more.


Can I cancel my vacation rental through Expedia?  


Yes, you can cancel or change your St. Charles County vacation rental by contacting your property manager directly. Contact details are easy to find on your itinerary in Trips. For more information, check out our Customer Service Portal and we’ll help you get everything sorted.