Title: $79 Cheap Flights to Santa Cruz - Expedia.com ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_flights_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_flights_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # $79 Cheap Flights to Santa Cruz [View $79 flight on Mon, Mar 30, 2026](https://expedia.com/Flights-Search?trip=oneway&leg1=from:FLL,to:MDE,departure:3/30/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:78.49&airProductToken=AQoqCigIzpYBEgMyMzcY5Vog7CAo5IGJAzCug4kDOEdAAFgBagJSUHIDR05SEgoIARABGAEqAk5LGAEiBAgBEAEoAigDKAQwDQ) [Hotels in Santa Cruz](https://expedia.com/Santa-Cruz-Hotels.d553248635976386952.Travel-Guide-Hotels)[Car Rentals in Santa Cruz](https://expedia.com/Car-Rentals-In-Santa-Cruz.d553248635976386952.Car-Rental-Guide)[Santa Cruz Vacation Packages](https://expedia.com/Santa-Cruz.d553248635976386952.Destination-Travel-Guides) ## Popular airlines - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_AV.svg) Avianca [](https://www.expedia.com/Flights-Search?leg1=from:CMH,to:Santa Cruz, Medellín, Antioquia, Colombia,departure:4/5/2026TANYT&leg2=from:Santa Cruz, Medellín, Antioquia, Colombia,to:CMH,departure:4/12/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"AV"}}]) - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_AA.svg) American Airlines [](https://www.expedia.com/Flights-Search?leg1=from:CMH,to:Santa Cruz, Medellín, Antioquia, Colombia,departure:4/5/2026TANYT&leg2=from:Santa Cruz, Medellín, Antioquia, Colombia,to:CMH,departure:4/12/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"AA"}}]) - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_B6.svg) JetBlue Airways [](https://www.expedia.com/Flights-Search?leg1=from:CMH,to:Santa Cruz, Medellín, Antioquia, Colombia,departure:4/5/2026TANYT&leg2=from:Santa Cruz, Medellín, Antioquia, Colombia,to:CMH,departure:4/12/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"B6"}}]) - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_CM.svg) Copa [](https://www.expedia.com/Flights-Search?leg1=from:CMH,to:Santa Cruz, Medellín, Antioquia, Colombia,departure:4/5/2026TANYT&leg2=from:Santa Cruz, Medellín, Antioquia, Colombia,to:CMH,departure:4/12/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"CM"}}]) - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_AM.svg) Aeromexico [](https://www.expedia.com/Flights-Search?leg1=from:CMH,to:Santa Cruz, Medellín, Antioquia, Colombia,departure:4/5/2026TANYT&leg2=from:Santa Cruz, Medellín, Antioquia, Colombia,to:CMH,departure:4/12/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"AM"}}]) - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_UA.svg) United [](https://www.expedia.com/Flights-Search?leg1=from:CMH,to:Santa Cruz, Medellín, Antioquia, Colombia,departure:4/5/2026TANYT&leg2=from:Santa Cruz, Medellín, Antioquia, Colombia,to:CMH,departure:4/12/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"UA"}}]) - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_NK.svg) Spirit Airlines [](https://www.expedia.com/Flights-Search?leg1=from:CMH,to:Santa Cruz, Medellín, Antioquia, Colombia,departure:4/5/2026TANYT&leg2=from:Santa Cruz, Medellín, Antioquia, Colombia,to:CMH,departure:4/12/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"NK"}}]) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__notification.svg) ### Be in the know Get alerts if flight prices drop or rise\* - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Book smarter Save up to 30% on select hotels after you book a flight\* - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__trophy.svg) ### Earn twice Earn your airline miles on top of our OneKeyCash [Learn about One Key](https://www.expedia.com/welcome-one-key) ## How much is the cheapest flight to Santa Cruz? Prices were available within the past 7 days and start at $79 for one-way flights and $203 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply. All deals One way Roundtrip ![Arajet](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/DM.gif) Mon, Sep 21 - Sat, Sep 26 SJU San Juan MDE Medellin $203 Roundtrip found 6 hours ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:SJU,to:MDE,departure:9/21/2026TANYT&leg2=from:MDE,to:SJU,departure:9/26/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:202.55&airProductToken=AQpqCjMIxJoBEgM1MDEYsqIBIPKAASjItJgDMI21mAM4waABQABYAWoFQkFTSUNyB0FQQkFTT1cKMwjEmgESBDE3MzQY8oABIOwgKO21mAMwiLeYAzjBoAFAAFgBagVCQVNJQ3IHQVBCQVNPVwpqCjMIxJoBEgQxNzM3GOwgIPKAASjp6pgDMIHsmAM4waABQABYAWoFQkFTSUNyB0FQQkFTT1cKMwjEmgESAzUwMhjygAEgsqIBKPLsmAMwt-2YAzjBoAFAAFgBagVCQVNJQ3IHQVBCQVNPVxIMCAsQARgIKgJETTIAGAEiBAgBEAEoAjAD) ![Spirit Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/nk.gif) Sat, Apr 11 - Tue, Apr 14 MCO Orlando MDE Medellin $207 Roundtrip just found [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:MCO,to:MDE,departure:4/11/2026TANYT&leg2=from:MDE,to:MCO,departure:4/14/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:206.11&airProductToken=AQouCiwIzpYBEgQxNDczGMxwIOwgKLKIigMwkIqKAzhHQABYAWoCUlByBkdBMTROUgouCiwIzpYBEgQxNDc0GOwgIMxwKKysigMwma6KAzhHQABYAWoCUlByBkdBMTROUhIKCAEQARgBKgJOSxgBIgQIARABKAIoAygEMA0) ![Copa](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/CM.gif) Wed, Apr 15 - Wed, Apr 22 SJU San Juan MDE Medellin $221 Roundtrip just found [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:SJU,to:MDE,departure:4/15/2026TANYT&leg2=from:MDE,to:SJU,departure:4/22/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:220.44&airProductToken=AQpjCjAIw5oBEgMxNDMYsqIBIO_EASiUuYoDMMm6igM4QUAAWAFqA0JBU3IIQUxBN09aMlMKLwjDmgESAzE1MBjvxAEg7CAox7-KAzCbwIoDOEFAAFgBagNCQVNyCEFMQTdPWjJTCmMKLwjDmgESAzM5OBjsICDvxAEol4SLAzDvhIsDOEFAAFgBagNCQVNyCEFMQTdPWjJTCjAIw5oBEgMxNDIY78QBILKiASjRhYsDMPmGiwM4QUAAWAFqA0JBU3IIQUxBN09aMlMSCggBEAEYASoCQ00YASIECAEQASgCKAMoBDAL) ![JetBlue Airways](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/b6.gif) Wed, Sep 16 - Sun, Sep 20 SJU San Juan MDE Medellin $274 Roundtrip just found [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:SJU,to:MDE,departure:9/16/2026TANYT&leg2=from:MDE,to:SJU,departure:9/20/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:273.94&airProductToken=AQowCi4IwmwSBDE3MDMYsqIBIOwgKJf6lwMwtfuXAzhMQABYAWoCRE5yCFVJMkFSRUwxCjAKLgjCbBIEMTcwNBjsICCyogEo2qmYAzCQq5gDOExAAFgBagJETnIIVUkyQVJFTDESDAgBEAEYASoCQjYyABgBIgQIARABKAIoBCgGMAE) ![American Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/AA.gif) Wed, May 27 - Sun, Jun 7 MIA Miami MDE Medellin $293 Roundtrip just found [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:MIA,to:MDE,departure:5/27/2026TANYT&leg2=from:MDE,to:MIA,departure:6/7/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:292.13&airProductToken=AQoyCjAIwYIBEgM5MjMYjAIg7CAolpOOAzDilI4DOEJAAFgBagVCQVNJQ3IIT0xON05UQloKMgowCMGCARIDOTI0GOwgIIwCKJSIjwMw94mPAzhCQABYAWoFQkFTSUNyCE9MTjBBSEJaEgoIARABGAEqAkFBGAEiBAgBEAEoAigDKAQwCw) ## Alternative airports near Santa Cruz Prices were available within the past 7 days. Prices and availability are subject to change. [](https://www.expedia.com/Flights-Search?leg1=from:CMH,to:MDE,departure:4/5/2026TANYT&leg2=from:MDE,to:CMH,departure:4/9/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&sortOrder=INCREASING&sortType=PRICE) MDE Jose Maria Cordova Intl. Cheapest 35 min [Flights from $502 ](https://www.expedia.com/Flights-Search?leg1=from:CMH,to:MDE,departure:4/5/2026TANYT&leg2=from:MDE,to:CMH,departure:4/9/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&sortOrder=INCREASING&sortType=PRICE) ## Find the cheapest month to fly from Columbus (CMH) to Medellín (MDE) ### September is typically the cheapest month to fly From $257 - $654 per traveler. ## Frequently asked questions ### What month is the cheapest to fly to Santa Cruz? ### Which US cities fly direct to Santa Cruz? ### How to find a cheap flight to Santa Cruz? ### How to get a cheap last-minute flight to Santa Cruz? ### How far in advance should I book a flight to Santa Cruz? ### Which day of the week is the cheapest day to buy a plane ticket to Santa Cruz? ### Can I save money by booking a Santa Cruz trip package? ### Can I change or cancel my flight to Santa Cruz? \*Flight schedules are subject to change. ## Book with confidence # Tips to find the cheapest flights to Santa Cruz **The cheapest day to fly** Get started finding a cheap flight to Santa Cruz on Expedia by either choosing a deal on this page or entering into the search bar your travel dates, origin airport, and whether you want roundtrip or one-way airfare. You can filter for flexibility, number of stops, airline, and departure/arrival times to find the best flight for you. **The cheapest month to fly** September is the cheapest month to fly to Santa Cruz. This coincides with the low season when fewer people travel. Whichever month you travel in, though, be sure to book at least a month in advance if you want to score cheap tickets to Santa Cruz. ARC's data shows that domestic flights booked 28 days or more before departure are typically 24% cheaper than those booked last minute. **The most affordable time to book a flight** Typically, a Sunday can be the cheapest time to book a flight to Santa Cruz, according to ARC’s data. On average, you could save between 6% and 13% by booking on a Sunday instead of a Friday, which is the most expensive day to make a reservation. **The cheapest round-trip tickets to Santa Cruz** The lowest price for round-trip flights to Santa Cruz in 2026 starts from from $203, while one-way tickets start from from $79\. Expedia's effective search tool is one of the best ways to find a budget airfare. Simply enter your dates, and within seconds, it'll show you a vast selection of the cheapest flights to Santa Cruz. If you have a preferred departure time or airline, you can use the handy filters to customize your search. **The cheapest airlines flying to Santa Cruz** Spirit Airlines, Arajet, Copa, JetBlue Airways, American Airlines are just some of the airlines that can typically offer cheap tickets to Santa Cruz. You can find their most affordable flights by using the “airline” search filter and then sorting prices from low to high. As a trusted partner of the world's leading airlines, Expedia offers you some of the best airfare deals to Santa Cruz and countless more destinations worldwide. **The most affordable airports to fly into** To view the cheapest airports to fly into for Santa Cruz, simply order your search results from lowest to highest price. Expedia's search tool compares flight prices for all airports close to your destination, so you don't have to manually search them one by one to find the cheapest flight to Santa Cruz. If you have a preferred place to fly into, take advantage of the “arrival airport” filter to narrow down your search on Expedia. **Save with a package** With Expedia's amazing [package deals](https://www.expedia.com/package-deals), you could save hundreds of dollars by booking your Santa Cruz plane tickets together with your accommodations, car rental, or activities. Just select the search wizard's “package” option to view some of the cheapest deals. Look out for the green savings label to see how much you're saving. **Date flexibility for the cheapest flights to Santa Cruz** If you can be flexible with your travel dates, it's a good idea to broaden your search by comparing prices on different days. This will open up more options, meaning you could uncover a less expensive flight to Santa Cruz. **Stopover savings** The cheapest tickets to Santa Cruz are sometimes those with a stopover. Book one of these flights, and you'll change planes at an airport en route to Santa Cruz. While the overall travel time might be longer than a non-stop flight, you may decide it's worth it for the money saved. **Get Expedia's Price Drop Protection** Price Drop Protection means that if your flight gets cheaper after booking, you'll be credited the difference\*. This gives you peace of mind that you're getting one of the cheapest flights to Santa Cruz for your chosen departure. Expedia's Price Drop Protection is available for a small fee but is free to One Key Gold and Platinum tier members. \*Terms apply. **Use our Price Tracking feature** Expedia's Price Tracking feature is another great tool that removes the guesswork from finding cheap flights to Santa Cruz. Simply download the free Expedia app to your smart device and activate Santa Cruz flight price alerts for your travel dates. There's even a price predictor tool that uses historical data to indicate the best time to book, giving you peace of mind that you'll nab the lowest prices. **Book with Expedia** As well as Price Drop Protection and Price Tracking, Expedia's close partnership with a vast selection of the world's leading airlines means you're sure to find cheap flights to Santa Cruz. Plus, the One Key rewards program lets you earn real cash rewards on most bookings that you can use to save money on future trips. Best of all, it's free to join, and members often unlock exclusive discounts, too. Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023\. The percentages you see are averages. ## Travel information | Destination airport | José María Córdova Intl. | | ----------------------------- | ------------------------ | | Destination airport IATA code | MDE | | Destination city name | Medellín | | Roundtrip price | $65 | ## Trending flights to Santa Cruz Prices were available within the past 7 days and start at $79 for one-way flights and $203 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply. All deals One way Roundtrip ![Spirit Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/nk.gif) Sat, Apr 11 - Tue, Apr 14 MCO Orlando MDE Medellin $207 Roundtrip just found [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:MCO,to:MDE,departure:4/11/2026TANYT&leg2=from:MDE,to:MCO,departure:4/14/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:206.11&airProductToken=AQouCiwIzpYBEgQxNDczGMxwIOwgKLKIigMwkIqKAzhHQABYAWoCUlByBkdBMTROUgouCiwIzpYBEgQxNDc0GOwgIMxwKKysigMwma6KAzhHQABYAWoCUlByBkdBMTROUhIKCAEQARgBKgJOSxgBIgQIARABKAIoAygEMA0) ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rentals - Other - [Hotels near Acevedo Station ](https://www.expedia.com/Acevedo-Station-Hotels.d6243631.Travel-Guide-Hotels) - [Apartments in Acevedo Station ](https://www.expedia.com/Acevedo-Station-Apartments.d6243631-aaApartments.Travel-Guide-Accommodation) - 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