Title: Isla Grande Vacation Rentals from $108: Search Short-Term Rentals | Expedia.com

[Isla Grande Travel Guide](https://expedia.com/Isla-Grande.dx6053183)[Hotels in Isla Grande](https://expedia.com/Isla-Grande-Hotels.d6053183.Travel-Guide-Hotels)[Flights to Isla Grande](https://expedia.com/Cheap-Flights-To-Isla-Grande.d6053183.Travel-Guide-Flights)[Things to do in Isla Grande](https://expedia.com/Things-To-Do-In-Isla-Grande.d6053183.Travel-Guide-Activities)[Car Rentals in Isla Grande](https://expedia.com/Car-Rentals-In-Isla-Grande.d6053183.Car-Rental-Guide)[Isla Grande Vacation Packages](https://expedia.com/Isla-Grande.d6053183.Destination-Travel-Guides)

![Palm trees forest and houses in Isla Grande shore. Colon province, Panama, Caribbean, Central America.](https://images.trvl-media.com/place/6053183/8bba6d27-3102-43e6-89e4-9ef59409f2b6.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

![](https://images.trvl-media.com/place/6053183/8bba6d27-3102-43e6-89e4-9ef59409f2b6.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

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## Check prices for these dates

In two weeks

[Mar 13 - Mar 15](https://www.expedia.com/Hotel-Search?regionId=6053183&startDate=2026-03-13&endDate=2026-03-15&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In two months

[Apr 24 - Apr 26](https://www.expedia.com/Hotel-Search?regionId=6053183&startDate=2026-04-24&endDate=2026-04-26&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In three months

[May 22 - May 24](https://www.expedia.com/Hotel-Search?regionId=6053183&startDate=2026-05-22&endDate=2026-05-24&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In four months

[Jun 19 - Jun 21](https://www.expedia.com/Hotel-Search?regionId=6053183&startDate=2026-06-19&endDate=2026-06-21&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

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## Find vacation rentals that suit your style

Villas

[](https://www.expedia.com/Hotel-Search?destination=Isla+Grande%2C+Col%C3%B3n%2C+Panama&regionId=6053183&latLong=9.634628%2C-79.562556&adults=2&startDate=2026-05-29&d1=2026-05-29&endDate=2026-06-01&d2=2026-06-01&lodging=VILLA)

Private vacation homes

[](https://www.expedia.com/Hotel-Search?destination=Isla+Grande%2C+Col%C3%B3n%2C+Panama&regionId=6053183&latLong=9.634628%2C-79.562556&adults=2&startDate=2026-05-29&d1=2026-05-29&endDate=2026-06-01&d2=2026-06-01&lodging=VACATION_HOME)

Cottages

[](https://www.expedia.com/Hotel-Search?destination=Isla+Grande%2C+Col%C3%B3n%2C+Panama&regionId=6053183&latLong=9.634628%2C-79.562556&adults=2&startDate=2026-05-29&d1=2026-05-29&endDate=2026-06-01&d2=2026-06-01&lodging=COTTAGE)

Condos

[](https://www.expedia.com/Hotel-Search?destination=Isla+Grande%2C+Col%C3%B3n%2C+Panama&regionId=6053183&latLong=9.634628%2C-79.562556&adults=2&startDate=2026-05-29&d1=2026-05-29&endDate=2026-06-01&d2=2026-06-01&lodging=CONDO)

Apartments

[](https://www.expedia.com/Hotel-Search?destination=Isla+Grande%2C+Col%C3%B3n%2C+Panama&regionId=6053183&latLong=9.634628%2C-79.562556&adults=2&startDate=2026-05-29&d1=2026-05-29&endDate=2026-06-01&d2=2026-06-01&lodging=APARTMENT)

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## Top Isla Grande Hotel Reviews

![Casa Congo - Rayo Verde - Restaurante](https://images.trvl-media.com/lodging/16000000/15370000/15362800/15362713/8f40c1a0_y.jpg)

### Casa Congo - Rayo Verde - Restaurante

10/10 Excellent

"Great staff. Loved the balcony in our room, Ray Congo, with hammock overlooking the water. Lots to do!"

[](https://expedia.com/Portobelo-Hotels-Casa-Congo-Rayo-Verde-Restaurante.h15362713.Hotel-Information)

![Ordovician Beach Resort](https://images.trvl-media.com/lodging/104000000/103770000/103761600/103761591/4a052041_y.jpg)

### Ordovician Beach Resort

10/10 Excellent

"The resort was outstanding. It exceeded expectations in every way. The service was the best we had in Panama. The cocktails were fun and the food was delicious and they have a vegan menu. We stayed in a king room and it was very private, pristine and well appointed."

[](https://expedia.com/Ordovician-Beach-Resort.h103761591.Hotel-Information)

![Ranchos de Chalia](https://images.trvl-media.com/lodging/106000000/105450000/105444000/105443903/5fee50e0_y.jpg)

### Ranchos de Chalia

10/10 Excellent

"Amazing location, beautiful vistas of mountains, forest and ocean. Very relaxing environment with infinity pool. Well maintained grounds. Wonderful breakfast and dinners. Jose and Anna were amazing hosts. Marijka and Garth"

[](https://expedia.com/Puerto-Lindo-Hotels-Ranchos-De-Chalia.h105443903.Hotel-Information)

![Ciel y Miel ](https://images.trvl-media.com/lodging/97000000/96740000/96735000/96734959/7979d8c3_y.jpg)

### Ciel y Miel 

10/10 Excellent

"The views from this mountain-top boutique hotel are extraordinary."

[](https://expedia.com/Cacique-Hotels-Ciel-Y-Miel.h96734959.Hotel-Information)

![Bala Bliss Charming 2-bedroom apartment with WiFi, AC in Maria Chiquita](https://images.trvl-media.com/lodging/116000000/115840000/115832800/115832785/cf8e1124_y.jpg)

### Bala Bliss Charming 2-bedroom apartment with WiFi, AC in Maria Chiquita

10/10 Excellent

"Well-appointed apartment, view of the ocean, big pool, fast Internet, attentive security. We had a great time here, thanks!"

[](https://expedia.com/Maria-Chiquita-Hotels-Bala-Bliss-Charming-2-Bedroom-Apartment-With-WiFi.h115832785.Hotel-Information)

![Hotel Cocotal](https://images.trvl-media.com/lodging/117000000/116790000/116790000/116789972/c828cfe9_y.jpg)

### Hotel Cocotal

10/10 Excellent

"Excelente hospedaje lo mejor la amabilidad de José Ángel y los demás muchachos... Con decirles que hasta te llevan a la habitación si te has tomado algunos tragos.. recomendada al 100"

[](https://expedia.com/La-Guaira-Hotels-Hotel-Cocotal.h116789972.Hotel-Information)

![La Posada del Buzo](https://images.trvl-media.com/lodging/91000000/90300000/90295300/90295300/984fa3bd_y.jpg)

### La Posada del Buzo

10/10 Excellent

"Great spot for scuba diving, amazing staff, family owned and operated dive facility and hotel. Restaurant on site with delicious food."

[](https://expedia.com/Portobelo-Hotels-Hotel-Panama-Dive-Adventure.h90295300.Hotel-Information)

![BEAUTIFUL APARTMENT IN FRONT OF THE SEA](https://images.trvl-media.com/lodging/75000000/74060000/74054900/74054867/w1064h805x0y11-7ae51d02_y.jpg)

### BEAUTIFUL APARTMENT IN FRONT OF THE SEA

10/10 Excellent

"All of it! Gabriel is a marvelous host; absolutely above and beyond. The house is lovely, very unique, and the location, right on the water, superb. We'll be back!"

[](https://expedia.com/Portobelo-Hotels-BEAUTIFUL-APARTMENT-IN-FRONT-OF-THE-SEA.h74054867.Hotel-Information)

![Piscina Mar en el Paraíso Caribe](https://images.trvl-media.com/lodging/100000000/99550000/99543300/99543203/87160e38_y.jpg)

### Piscina Mar en el Paraíso Caribe

6/10 Okay

"Staff, especially William, was helpful. The elevator did not work for a couple of days and 8th floor was a bit of a walk. The driveway access is in a really poor condition. The room was just fine. "

[](https://expedia.com/Maria-Chiquita-Hotels-Piscina-Mar-En-El-Paraiso-Caribe.h99543203.Hotel-Information)

## Find out more about Isla Grande

**Everything you need to know about Isla Grande vacation rentals**

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Isla Grande vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Isla Grande vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

**Isla Grande vacation rentals: An excellent choice for every season**

Whenever you want to travel, a warm welcome awaits you in Isla Grande. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Isla Grande in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $108 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

**How to find incredible deals on Isla Grande rentals**

At Expedia, we put the best Isla Grande vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Isla Grande rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Isla Grande vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Isla Grande. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

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## Frequently asked questions

### Can I find vacation rentals in Isla Grande?

### What are some of the best vacation home rentals in Isla Grande?

### How many vacation rentals will I find in Isla Grande?

### What can I see and do in Isla Grande?

### What are vacation rentals like in Isla Grande?

### Expedia's Latest Trends

Hotels

- [Maria Chiquita Pet-friendly Hotels](https://expedia.com/Maria-Chiquita-Hotels-Pet-Friendly-Hotel.0-0-d6344217-tPetfriendlyHotel.Travel-Guide-Filter-Hotels)
- [Puerto Lindo Hotels](https://expedia.com/Puerto-Lindo-Hotels.d3000007427.Travel-Guide-Hotels)
- [Colon All-inclusive Resorts](https://expedia.com/Colon-Hotels-All-Inclusive-Hotel.0-0-d601867-tAllinclusiveHotel.Travel-Guide-Filter-Hotels)
- [Colon Hotels](https://expedia.com/Colon-Hotels.d601867.Travel-Guide-Hotels)
- [Blanca Beach hotels](https://expedia.com/Blanca-Beach-Hotels.0-l6286205-0.Travel-Guide-Filter-Hotels)
- [Buenaventura Beach Hotels](https://expedia.com/Buenaventura-Hotels-Beach-Hotel.0-0-d3000409855-tBeachHotel.Travel-Guide-Filter-Hotels)
- [Gamboa Resorts & Hotels with Spas](https://expedia.com/Gamboa-Hotels-Spa-Hotel.0-0-d6025059-tSpaHotel.Travel-Guide-Filter-Hotels)
- [Portobelo Hotels](https://expedia.com/Portobelo-Hotels.d6145607.Travel-Guide-Hotels)
- [Safarick's Zoo hotels](https://expedia.com/Safaricks-Zoo-Hotels.0-l553248621574431161-0.Travel-Guide-Filter-Hotels)
- [Colon Adults Only Resorts & Hotels](https://expedia.com/Colon-Hotels-Adults-Only-Resorts.0-0-d601867-tAdultsOnlyResorts.Travel-Guide-Filter-Hotels)
- [Santa Isabel Beach Hotels](https://expedia.com/Santa-Isabel-Hotels-Beach-Hotel.0-0-d6203540-tBeachHotel.Travel-Guide-Filter-Hotels)

Flights

- [Flights to Colon](https://expedia.com/Cheap-Flights-To-Colon.d601867.Travel-Guide-Flights)
- [Flights from Colon](https://expedia.com/lp/flights/601867/flights-from-colon)

Cars

- [Car rentals in Puerto Lindo](https://expedia.com/Car-Rentals-In-Puerto-Lindo.d3000007427.Car-Rental-Guide)
- [Car rentals in Colon](https://expedia.com/Car-Rentals-In-Colon.d601867.Car-Rental-Guide)
- [Hertz Car Rentals In Colon](https://expedia.com/Hertz-Car-Rentals-In-Colon.d601867-c40.Car-Rental-Guide-Suppliers)

Activities

- [Things to do in Maria Chiquita](https://expedia.com/Things-To-Do-In-Maria-Chiquita.d6344217.Travel-Guide-Activities)
- [Things to do in Portobelo](https://expedia.com/Things-To-Do-In-Portobelo.d6145607.Travel-Guide-Activities)
- [Things to do in Colon](https://expedia.com/Things-To-Do-In-Colon.d601867.Travel-Guide-Activities)
- [Things to do in Gamboa](https://expedia.com/Things-To-Do-In-Gamboa.d6025059.Travel-Guide-Activities)

Packages

- [Safarick's Zoo](https://expedia.com/Safaricks-Zoo-Maria-Chiquita.d553248621574431161.Vacation-Attraction)
- [Trip to Nombre de Dios](https://expedia.com/Nombre-De-Dios.d3000462548.Destination-Travel-Guides)
- [Trip to Colon](https://expedia.com/Colon.d601867.Destination-Travel-Guides)
- [Real Aduana de Portobelo](https://expedia.com/Real-Aduana-De-Portobelo-Portobelo.d553248621532964863.Vacation-Attraction)

General

- [Visit Colon](https://expedia.com/Colon.dx601867)
- [Visit Fort Sherman](https://expedia.com/Fort-Sherman.dx6223313)
- [Visit Gamboa](https://expedia.com/Gamboa.dx6025059)
- [Visit La Guaira](https://expedia.com/La-Guaira.dx3000439511)
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