Isla Grande Vacations from $964
Book a Hotel + Flight or Car together to unlock savings
Your Isla Grande Vacation
With a Isla Grande vacation package, say goodbye to endless planning and hello to stress-free adventure. Every detail of your getaway has been taken care of before you go, so you can enjoy each moment discovering this lively city. If taking in the sights is a priority during your trip to Isla Grande, be sure to swing by famous attractions like Isla Mamey and Portobelo National Park. Whoever you're heading away with and whatever you want to spend, your dream Isla Grande vacation is just a few clicks away with Expedia.
The Latest Isla Grande vacation packages
Price found within the past 48 hours. Click for updated prices.
Decapolis Hotel Panama City
San Francisco
$964
per person
Nov 1 - Nov 7
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
8.6/10 Excellent! (1,716 reviews)
The property is excellent the fact that it’s connected to the mall and casino put it over the top. The staff are polite and always ready to assist you. Will definitely stay again.
Reviewed on Aug 28, 2026
Central Hotel Panama Casco Viejo
Casco Viejo
$1,220
per person
Nov 1 - Nov 7
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
9.2/10 Wonderful! (1,005 reviews)
Don’t expect to sleep
Upon checkin I was out in my “Jr Suite”. It was just a room. But worse, I tried to soon and heard a rhythmic banging that was impossible to sleep through. It was so bad that I decided to see what it was. My room was DIRECTLY UNDER the gym, in a centuries old building?! If anyone is on the treadmill- you’re screwed! Anyone dropping weights, anything. Walls were paper thin. Outside of that… the place was beautiful, and fantastic location!
Reviewed on Aug 29, 2026
Megapolis Hotel Panamá
San Francisco
$1,046
per person
Nov 1 - Nov 7
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
8.4/10 Very Good! (1,671 reviews)
El agua caliente no funcionaba me cambiaron de habitación y no funcionaba el control del
TV y no hubo quien lo arreglara
Reviewed on Aug 28, 2026
Don't see what you're looking for?
See all available trips from Columbus to Isla Grande
View all tripsWhat to do in Isla Grande
Snorkel in Panama's Caribbean and visit Portobleo WHS
$150
per adult
Snorkeling and Kayak Adventures in Portobelo beach
$390
per adult
Private Catamaran Escape: Caribbean Beaches, Snorkeling & Lunch
$2,125
per traveler
Isla Grande Hotel Deals
Ordovician Beach Resort
Isla Grande Isla Grande Colon
$426 nightly
$470 total
Sep 18 - Sep 19
Total with taxes and fees
10/10 Exceptional! (13 reviews)
"La comida estaba deliciosa, el staff con excelente atención. La playa privada es un super plus."
Reviewed on Jul 19, 2026
HOTEL ISLA GRANDE
Final de paseo La Punta Isla Grande, 01 Isla Grande Colón Province
$99 nightly
$109 total
Aug 30 - Aug 31
Total with taxes and fees
Hotel Cocotal
La Guaira Isla Grande Provincia de Colón
8.6/10 Excellent! (11 reviews)
"Ocean view! Peaceful and the staff was SUPER attentive and friendly."
Reviewed on Jun 24, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Find the Best Isla Grande Vacation Packages
Isla Grande Essential Information
Language | Spanish |
|---|---|
Currency | Panamanian balboas |
Local Welcome | ¡Hola! |
Local Goodbye | Adiós |
Max Temp Winter | 80ºF |
Max Temp Summer | 85ºF |
Top Sights | Blanca Beach, Portobelo National Park and Mirador Perú |
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Frequently asked questions
How much does an Isla Grande vacation package cost?
You'll find cheap prices from $964 on Expedia for your Isla Grande getaway. However, factors like the season, choice of hotel and length of stay will influence how much your vacation to Isla Grande costs.
What are the cheapest months to go to Isla Grande?
August, November and December are great times to search for cheap Isla Grande vacation packages. Opting to travel in quieter months means you can generally find lower prices on accommodations and flights.
How many days is enough for Isla Grande?
Generally, a handful of days is enough to check out the major attractions during your Isla Grande vacation. But if you prefer to have time to relax or go on day tours, think about extending your itinerary.
How to find the best Isla Grande package deals?
Bagging a cheap Isla Grande package deal is a breeze with Expedia. After you've entered your destination and preferred dates under our "Packages" tab, set your budget, add a few filters and browse what's available. You can customize your search by "Property class," "Number of bedrooms," "Traveler experience" and more. Sort the results by "Price: low to high" to view the most pocket-friendly Isla Grande package deals. Want a simple trick to score even more savings? Be flexible with your departure dates and consider going away on a weekday, when prices are typically lower.
Is it cheaper to book an Isla Grande vacation as a package?
You can enjoy significant savings on your Isla Grande getaway by booking a personalized vacation package. Check the "Package" heading, then select your destination and travel dates to view the best flight and hotel prices. Bundling can save travelers hundreds of dollars. Consider adding a rental car and you may land a better deal.
When to book a vacation package to Isla Grande?
Secure incredible bargains by booking your flights in advance with Expedia. If being spontaneous is more your style, grab one of our last-minute deals for an impromptu Isla Grande break.
How to plan a trip to Isla Grande?
- Pick your dates: What you'd like to do in Isla Grande and your preferred season will help you decide when to get away.
- Set a budget: Consider expenses such as transportation, flights and meals when calculating how much to save for your trip to Isla Grande. Then, select a hotel that fits your budget, whether that's a wallet-friendly option or a lavish getaway.
- Use Expedia's trip planning tool to discover Isla Grande: Research every part of your trip to Isla Grande with this handy planner. Invite family or friends to collaborate on a group getaway, search for stays or things to do and make bookings.
- Decide how long to go away for: Now that you know more about Isla Grande, you can work out the ideal length of your vacation. Put together a draft itinerary and give yourself enough time to cover everything you want to see.
- Bundle your airfare and accommodations: Once you've settled on your dates and duration, book the perfect Isla Grande vacation package for you.
- Book any day trips or activities: Now to the fun part — organizing everything you want to do and see. Explore some of the exciting things to do in Isla Grande and reserve your tickets early to save time (and maybe some cash too!).
Does Expedia offer Book Now, Pay Later Isla Grande vacation packages?
Your Isla Grande break should be a relaxing escape from your busy life, not a reason for money-related stress. So to give you more flexibility, we've partnered with online lender Affirm to offer our Book Now, Pay Later vacations. Pick one of our vacation packages with payment plans and split up the cost over 3, 6 or 12 months. Plus, there aren't any late payment fees or hidden costs to worry about.
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.