
Isla Grande Vacations from $598
Book a Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
Better together
Save up to $1,045 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place
Your Isla Grande Vacation
With a Isla Grande vacation package, say goodbye to endless planning and hello to stress-free adventure. Every detail of your getaway has been taken care of before you go, so you can enjoy each moment discovering this lively city. If taking in the sights is a priority during your trip to Isla Grande, be sure to swing by famous attractions like Isla Mamey and Portobelo National Park. Whoever you're heading away with and whatever you want to spend, your dream Isla Grande vacation is just a few clicks away with Expedia.
The Latest Isla Grande vacation packages
Price found within the past 48 hours. Click for updated prices.

Villa Botero By Casa Mojito B&B
Save 100% on your flight
per person
Sep 7 - Sep 13
found 1 day ago
Roundtrip flight included
Miami (MIA) to Panama City (PTY)
9.8/10 Exceptional! (60 reviews)
Host was excellent. Great communication and very helpful. The rooms were nice and great value.
Reviewed on Apr 18, 2025




Don't see what you're looking for?
See all available trips from Columbus to Isla Grande
View all tripsIsla Grande Hotel Deals

Ordovician Beach Resort
Isla Grande, Isla Grande, Colon
Superou as expectativas
"Excelente para casais"
Reviewed on May 5, 2025

Brother Sun Villas
Camino Al Faro, Isla Grande
Wrong advertisement
"This is where advertisement they told me that display have AC Wi-Fi TV and they don’t have to bring a lot of money for this room and he’s not worth it I wanted to cancel the second night and the lady didn’t want to return my money back I call hotels.com and complained about it and they didn’t do ..."
Reviewed on Oct 15, 2017

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Find the Best Isla Grande Vacation Packages
Isla Grande Essential Information
Language | Spanish |
---|---|
Currency | Panamanian balboas |
Local Welcome | ¡Hola! |
Local Goodbye | Adiós |
Max Temp Winter | 80ºF |
Max Temp Summer | 85ºF |
Top Sights | Blanca Beach, Portobelo National Park and Mirador Perú |
More vacations you might like
Frequently asked questions
Explore a world of travel with Expedia
Explore a world of travel with Expedia
- La Guaira Hotels
- 4 Star Hotels in La Guaira
- 3 Star Hotels in La Guaira
- 5 Star Hotels in La Guaira
- Hotels near Portobelo National Park
- Puerto Lindo Hotels
- Lodges in Puerto Lindo
- Hotels near Isla Mamey
- 4 Star Hotels in Cacique
- Hotels near Blanca Beach
- Nombre de Dios Hotels
- Vacation Homes in Nombre de Dios
- 3 Star Hotels in Nombre de Dios
- Hotels near San Felipe Church
- Guest Houses in Puerto Lindo
- Villas in Nombre de Dios
- Hostels in La Guaira
- Cacique Hotels
- Hotels near Real Aduana de Portobelo
- Apartments in La Guaira
- Villas in Puerto Lindo
- Hotels near Fuerte San Jerónimo
- Apartments in Nombre de Dios
- 5 Star Hotels in Puerto Lindo
- Resorts in La Guaira
- Car rentals near La Guaira
- Car rentals near Puerto Lindo
- Car rentals near Isla Mamey
- Car rentals near Nombre de Dios
- Thrifty EU Rental Cars in Puerto Lindo
- Rent A Wreck Rental Cars in Puerto Lindo
- Localiza Argentina Rental Cars in Puerto Lindo
- Car rentals near San Felipe Church
- Car rentals near Fuerte San Jerónimo
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.