Isla Grande Vacations from $821

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Your Isla Grande Vacation

With a Isla Grande vacation package, say goodbye to endless planning and hello to stress-free adventure. Every detail of your getaway has been taken care of before you go, so you can enjoy each moment discovering this lively city. If taking in the sights is a priority during your trip to Isla Grande, be sure to swing by famous attractions like Isla Mamey and Portobelo National Park. Whoever you're heading away with and whatever you want to spend, your dream Isla Grande vacation is just a few clicks away with Expedia.

The Latest Isla Grande vacation packages

Price found within the past 48 hours. Click for updated prices.
Punta Chame Club and Resort

Punta Chame Club and Resort

4 out of 5
Price was $1,111, price is now $821 per person
$821
per person
Aug 7 - Aug 14
found 1 day ago
Roundtrip non-stop flight included
Miami (MIA) to Panama City (PTY)
9.2/10 Wonderful! (5 reviews)
We Spent 15 days there and had a great time. It's in a great location.

Reviewed on Jan 2, 2020

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Bella Vista
Price was $1,575, price is now $1,042 per person
$1,042
per person
Jul 9 - Jul 15
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
9/10 Wonderful! (5,456 reviews)
Great breakfast great gym perfect location comfortable beds quick elevators all is well!!!

Reviewed on May 29, 2026

Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
San Francisco
Price was $1,439, price is now $1,027 per person
$1,027
per person
Jul 6 - Jul 10
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
8.4/10 Very Good! (1,528 reviews)
La habitación tenia una hermosa vista, muy limpia, desde nuestra llegada su personal fue correcta, amable y muy servicial, los desayunos fueron exquisitos a otro nivel y había de todo muy cerca de todo.

Reviewed on May 26, 2026

Villa Marina Hotel

Villa Marina Hotel

3.5 out of 5
Price was $1,442, price is now $1,035 per person
$1,035
per person
Aug 3 - Aug 10
found 1 hour ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
9/10 Wonderful! (159 reviews)
Todo muy bien y personal muy amable

Reviewed on May 3, 2026

Casa Lefevre By Wynwood House

Casa Lefevre By Wynwood House

3.5 out of 5
Casco Viejo
Price was $1,632, price is now $1,220 per person
$1,220
per person
Aug 12 - Aug 19
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
9.6/10 Exceptional! (14 reviews)
If you want to explore Casco Viejo, the location does not get any better than this. The balcony faces Cathedral Plaza and is a quick walk to many galleries, restaurants and clubs. The apartment I was in had lots of charm and a great use of space. The check in and check out process was super easy. Also, the Wynwood team is always available on WhatsApp if there are any issues or if you need anything.

Reviewed on May 19, 2026

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Isla Grande Hotel Deals

Ordovician Beach Resort

Ordovician Beach Resort

4.5 out of 5
Isla Grande Isla Grande Colon
$419 nightly
The price is $465 total per night from May 31 to Jun 1
$465 total
May 31 - Jun 1
Total with taxes and fees
10/10 Exceptional! (9 reviews)
"The resort was outstanding. It exceeded expectations in every way. The service was the best we had in Panama. The cocktails were fun and the food was delicious and they have a vegan menu. We stayed in a king room and it was very private, pristine and well appointed."

Reviewed on Feb 21, 2026

Ordovician Beach Resort
Hotel Cocotal

Hotel Cocotal

2.5 out of 5
La Guaira Isla Grande Provincia de Colón
Fully refundableReserve now, pay when you stay
$97 nightly
The price is $107 total per night from Jun 8 to Jun 9
$107 total
Jun 8 - Jun 9
Total with taxes and fees
Hotel Cocotal
HOTEL ISLA GRANDE

HOTEL ISLA GRANDE

3 out of 5
Final de paseo La Punta Isla Grande, 01 Isla Grande Colón Province
$99 nightly
The price is $109 total per night from May 31 to Jun 1
$109 total
May 31 - Jun 1
Total with taxes and fees
HOTEL ISLA GRANDE
See all 58 properties in Isla Grande
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Isla Grande Vacation Packages

Isla Grande Essential Information

Language
Spanish
Currency
Panamanian balboas
Local Welcome
¡Hola!
Local Goodbye
Adiós
Max Temp Winter
80ºF
Max Temp Summer
85ºF
Top Sights
Blanca Beach, Portobelo National Park and Mirador Perú

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Frequently asked questions

How much does an Isla Grande vacation package cost?
You'll find cheap prices from $821 on Expedia for your Isla Grande getaway. However, factors like the season, choice of hotel and length of stay will influence how much your vacation to Isla Grande costs.
What are the cheapest months to go to Isla Grande?
August, November and December are great times to search for cheap Isla Grande vacation packages. Opting to travel in quieter months means you can generally find lower prices on accommodations and flights.
How many days is enough for Isla Grande?
Generally, a handful of days is enough to check out the major attractions during your Isla Grande vacation. But if you prefer to have time to relax or go on day tours, think about extending your itinerary.
How to find the best Isla Grande package deals?
Bagging a cheap Isla Grande package deal is a breeze with Expedia. After you've entered your destination and preferred dates under our "Packages" tab, set your budget, add a few filters and browse what's available. You can customize your search by "Property class," "Number of bedrooms," "Traveler experience" and more. Sort the results by "Price: low to high" to view the most pocket-friendly Isla Grande package deals. Want a simple trick to score even more savings? Be flexible with your departure dates and consider going away on a weekday, when prices are typically lower.
Is it cheaper to book an Isla Grande vacation as a package?
You can enjoy significant savings on your Isla Grande getaway by booking a personalized vacation package. Check the "Package" heading, then select your destination and travel dates to view the best flight and hotel prices. Bundling can save travelers hundreds of dollars. Consider adding a rental car and you may land a better deal.
When to book a vacation package to Isla Grande?
Secure incredible bargains by booking your flights in advance with Expedia. If being spontaneous is more your style, grab one of our last-minute deals for an impromptu Isla Grande break.
How to plan a trip to Isla Grande?

  1. Pick your dates: What you'd like to do in Isla Grande and your preferred season will help you decide when to get away.
  2. Set a budget: Consider expenses such as transportation, flights and meals when calculating how much to save for your trip to Isla Grande. Then, select a hotel that fits your budget, whether that's a wallet-friendly option or a lavish getaway.
  3. Use Expedia's trip planning tool to discover Isla Grande: Research every part of your trip to Isla Grande with this handy planner. Invite family or friends to collaborate on a group getaway, search for stays or things to do and make bookings.
  4. Decide how long to go away for: Now that you know more about Isla Grande, you can work out the ideal length of your vacation. Put together a draft itinerary and give yourself enough time to cover everything you want to see.
  5. Bundle your airfare and accommodations: Once you've settled on your dates and duration, book the perfect Isla Grande vacation package for you.
  6. Book any day trips or activities: Now to the fun part — organizing everything you want to do and see. Explore some of the exciting things to do in Isla Grande and reserve your tickets early to save time (and maybe some cash too!).

Does Expedia offer Book Now, Pay Later Isla Grande vacation packages?
Your Isla Grande break should be a relaxing escape from your busy life, not a reason for money-related stress. So to give you more flexibility, we've partnered with online lender Affirm to offer our Book Now, Pay Later vacations. Pick one of our vacation packages with payment plans and split up the cost over 3, 6 or 12 months. Plus, there aren't any late payment fees or hidden costs to worry about.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.