Sioux Empire Medical Museum Tours

Keep your curious mind busy and discover more about the world at Sioux Empire Medical Museum. Study the displays and discover the story behind every piece.

Sioux Empire Medical Museum is an ideal place to begin your day of discovery in Sioux Falls. This museum comes recommended by fellow travelers, but it isn't the only thing to do here. Save time for other sights like Denny Sanford Premier Center, Empire Mall, and Falls Park to fully experience what the area has to offer.

Plan a trip to see Sioux Empire Medical Museum

Price found within the past 48 hours. Click for updated prices.
Motel 6 North Sioux City, SD – I-29 North

Motel 6 North Sioux City, SD – I-29 North

2 out of 5
Price was $502, price is now $460 per person
$460
per person
Oct 24 - Oct 27
found 1 day ago
Roundtrip non-stop flight included
Sacramento (SMF) to Sioux Falls (FSD)
6.4/10 (350 reviews)
For the most part I really enjoyed our stay however, when I got up and walked to the lobby I was not pleased to find no coffee waiting as was promised. There are also no coffee machines in the room. Not being able to start my day with coffee was not good.

Reviewed on Aug 31, 2025

Cobblestone Inn & Suites - Sheldon

Cobblestone Inn & Suites - Sheldon

2.5 out of 5
Price was $676, price is now $526 per person
$526
per person
Oct 7 - Oct 11
found 1 day ago
Roundtrip non-stop flight included
San Diego (SAN) to Sioux Falls (FSD)
8.8/10 Excellent! (165 reviews)
Close to the highway and had a few different places to eat nearby.

Reviewed on Aug 28, 2025

GrandStay Hotel & Suites Rock Valley

GrandStay Hotel & Suites Rock Valley

3 out of 5
Price was $623, price is now $559 per person
$559
per person
Oct 7 - Oct 11
found 1 day ago
Roundtrip non-stop flight included
San Diego (SAN) to Sioux Falls (FSD)
9.2/10 Wonderful! (309 reviews)
Clean, comfortable room.

Reviewed on Aug 25, 2025

Popular places to visit

Explore the fascinating life of South Dakota's first U.S. Senator R. F. Pettigrew, who was also an explorer and collector of artifacts and archaeology from across the globe. Beautiful Victorian home and a museum of his collections and contributions to the development of Sioux Falls.

Pettigrew Home and Museum

You can spend time browsing the exhibits at Pettigrew Home and Museum during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

Pettigrew Home and Museum
Guests can feed the giraffes in the African exhibit at the Great Plains Zoo.

Great Plains Zoo

4.5/5(74 reviews)

Why not visit the native and exotic animals who live at Great Plains Zoo during your travels in Sioux Falls? Attend a sporting event or discover the area's beautiful waterfalls.

Great Plains Zoo
An interesting museum

Old Courthouse Museum

4.5/5(60 reviews)

You can spend time browsing the exhibits at Old Courthouse Museum in Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

Old Courthouse Museum

Sanford USD Medical Center

4.5/5(84 reviews)

Though Sanford USD Medical Center might be what brings you to town, perhaps you'll have a chance to explore more of Sioux Falls while you are here.

Sanford USD Medical Center

University of Sioux Falls

4/5(73 reviews)

Take a campus tour or just explore the area of University of Sioux Falls, during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

University of Sioux Falls

Edith Mortenson Theatre Center

You can get tickets for a performance at Edith Mortenson Theatre Center on your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

Edith Mortenson Theatre Center

Best Lodging Options Near Sioux Empire Medical Museum

Hotel On Phillips

Hotel On Phillips

2.5 out of 5
100 N Phillips Ave, Sioux Falls, SD
Hotel On Phillips
Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

3 out of 5
1301 West Russell, I-29 and Exit 81, Sioux Falls, SD
Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr
Days Inn by Wyndham Sioux Falls Empire

Days Inn by Wyndham Sioux Falls Empire

2 out of 5
3401 Gateway Blvd, I-29 and 41st Street Exit 77, Sioux Falls, SD
Days Inn by Wyndham Sioux Falls Empire
Holiday Inn Sioux Falls-City Centre by IHG

Holiday Inn Sioux Falls-City Centre by IHG

3 out of 5
100 W 8th St, Sioux Falls, SD
Holiday Inn Sioux Falls-City Centre by IHG
Clubhouse Hotel Suites Sioux Falls

Clubhouse Hotel Suites Sioux Falls

3 out of 5
2320 South Louise Avenue, Sioux Falls, SD
Clubhouse Hotel Suites Sioux Falls
Valley Inn

Valley Inn

2.5 out of 5
1000 S. Grange Ave, Sioux Falls, SD
Valley Inn
Baymont by Wyndham Sioux Falls

Baymont by Wyndham Sioux Falls

2.5 out of 5
3200 South Meadow Avenue, Sioux Falls, SD
Baymont by Wyndham Sioux Falls
Country Inn & Suites by Radisson, Sioux Falls, SD

Country Inn & Suites by Radisson, Sioux Falls, SD

3 out of 5
200 E 8th St, Sioux Falls, SD
Country Inn & Suites by Radisson, Sioux Falls, SD
The Center Inn

The Center Inn

2.5 out of 5
900 E 20th St, Sioux Falls, SD
The Center Inn
See all 386 properties in Sioux Empire Medical Museum
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Explore a world of travel with Expedia

Explore a world of travel with Expedia