$213 Cheap American Airlines flights Buffalo (BUF) to Key West (EYW)

Make use of the “Price (lowest to highest)” filter on Expedia to look for cheap American Airlines round-trip flights from $269 from BUF to EYW. Affordable one-way tickets from $213 are also available.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

American Airlines flights to Key West are typically cheaper in the low-season months of September and August. Whether you need a one-way or round-trip ticket, you could land a better deal then.

For cheap American Airlines fares from Buffalo Niagara Intl. Airport (BUF) to Key West Intl. Airport (EYW), start searching one to three months before your planned departure. Securing domestic flights 34 to 86 days in advance could save you 25% compared to booking just 6 to 12 days ahead. The day you book can also impact what you pay. Sunday is usually the cheapest, while Monday is often the most expensive for domestic flights. You can save 6% on average by booking your journey on a Sunday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC’s global airline sales database.

Click on the “Nonstop” filter when browsing for direct American Airlines flights from BUF to EYW. It’s also an easy way to compare other carriers offering the same nonstop journey.

Find American Airlines’s earliest flights from BUF to EYW by selecting our “Early Morning” and “Morning” filters. Not only will you get to where you’re going sooner, early departures are also 20% less likely to be canceled.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.

American Airlines flights from Buffalo Niagara Intl. Airport (BUF) to Key West touch down at Key West Intl. Airport (EYW). This is the main gateway here.

Changes are usually free within 24 hours of booking, but your airline may charge a fee after that time. For further details about modifying your flights, go to your “Trips,” select your flight and click on “Manage Booking.” If you want the freedom to update your itinerary without extra charges, check the “Changes included” or “No cancel fee” filter when organizing your next escape.