$135 Cheap American Airlines flights Detroit (DTW) to Key West (EYW)

Finding cheap one-way American Airlines flights from DTW to EYW from $135 on Expedia couldn't be simpler — just filter by "Price (lowest to highest)." Or check out our affordable round-trip fares from $260 for your next break.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

For cheap American Airlines fares from Detroit Metropolitan Wayne County Airport (DTW) to Key West Intl. Airport (EYW), start searching one to three months before your planned departure. Reserving domestic flights 34 to 86 days in advance could save you 25% compared to booking just 6 to 12 days ahead. The day you book can also affect what you pay. Sunday is generally the most affordable, while Monday is often the most expensive for domestic flights. You can save 6% on average by choosing to book on a Sunday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC's global airline sales database.

To find the earliest departure from DTW to EYW with American Airlines, filter your search by "Morning" and "Early Morning." Booking an early flight usually means you're less likely to experience cancellations.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.