$142 Cheap American Airlines flights Medford (MFR) to Chicago (ORD)

Set the "Price (lowest to highest)" filter on Expedia to find cheap American Airlines return flights from $272 from MFR to ORD. Affordable one-way options from $142 are also available.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

For cheap American Airlines fares from Rogue Valley Intl. Airport (MFR) to O'Hare Intl. Airport (ORD), start searching one to three months before your intended departure. Reserving domestic flights 34 to 86 days in advance could save you 25% compared to booking just 6 to 12 days ahead. The day you book can also impact the overall price. Sunday is generally the most affordable, while Monday is often the most expensive for domestic flights. You can save 6% on average by booking your journey on a Sunday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC's global airline sales database.

Find American Airlines's earliest flights from MFR to ORD by selecting our "Early Morning" and "Morning" filters. Not only will you arrive sooner, early departures also experience 20% fewer cancellations.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.