$149 Cheap Flights from Myrtle Beach (MYR) to Buffalo (BUF)

View $149 flight on Sat, Jan 10, 2026Opens in a new window

Popular airlines from Myrtle Beach Intl. Airport (MYR) to Buffalo Niagara Intl. Airport (BUF)

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Cheap Flights from Myrtle Beach to Buffalo (MYR-BUF)

Prices were available within the past 7 days and start at $149 for one-way flights and $295 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Sat, Jan 17 - Sun, Jan 18
MYR
Myrtle Beach
BUF
Buffalo
$295 Roundtrip, found 19 hours ago
$295
Roundtrip
found 19 hours ago
Select American Airlines flight, departing Sat, Jan 17 from Myrtle Beach to Buffalo, returning Sun, Jan 18, priced at $295 found 19 hours ago
American Airlines
Sat, Dec 13 - Sat, Jan 17
MYR
Myrtle Beach
BUF
Buffalo
$297 Roundtrip, found 19 hours ago
$297
Roundtrip
found 19 hours ago
Select American Airlines flight, departing Sat, Dec 13 from Myrtle Beach to Buffalo, returning Sat, Jan 17, priced at $297 found 19 hours ago
Delta
Wed, Dec 31 - Tue, Jan 6
MYR
Myrtle Beach
BUF
Buffalo
$297 Roundtrip, found 16 hours ago
$297
Roundtrip
found 16 hours ago
Select Delta flight, departing Wed, Dec 31 from Myrtle Beach to Buffalo, returning Tue, Jan 6, priced at $297 found 16 hours ago
United
Wed, Jan 7 - Wed, Jan 14
MYR
Myrtle Beach
BUF
Buffalo
$297 Roundtrip, found 1 day ago
$297
Roundtrip
found 1 day ago
Select United flight, departing Wed, Jan 7 from Myrtle Beach to Buffalo, returning Wed, Jan 14, priced at $297 found 1 day ago
Southwest Airlines
Sat, Dec 13 - Sat, Jan 17
MYR
Myrtle Beach
BUF
Buffalo
$297 Roundtrip, found 19 hours ago
$297
Roundtrip
found 19 hours ago
Select Southwest Airlines flight, departing Sat, Dec 13 from Myrtle Beach to Buffalo, returning Sat, Jan 17, priced at $297 found 19 hours ago
American Airlines
Mon, Jan 19 - Tue, Jan 20
MYR
Myrtle Beach
BUF
Buffalo
$298 Roundtrip, found 2 days ago
$298
Roundtrip
found 2 days ago
Select American Airlines flight, departing Mon, Jan 19 from Myrtle Beach to Buffalo, returning Tue, Jan 20, priced at $298 found 2 days ago
American Airlines
Wed, Jan 7 - Wed, Jan 14
MYR
Myrtle Beach
BUF
Buffalo
$299 Roundtrip, found 1 day ago
$299
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Jan 7 from Myrtle Beach to Buffalo, returning Wed, Jan 14, priced at $299 found 1 day ago
American Airlines
Thu, Jan 1 - Tue, Jan 6
MYR
Myrtle Beach
BUF
Buffalo
$301 Roundtrip, found 14 hours ago
$301
Roundtrip
found 14 hours ago
Select American Airlines flight, departing Thu, Jan 1 from Myrtle Beach to Buffalo, returning Tue, Jan 6, priced at $301 found 14 hours ago
American Airlines
Sat, Jan 17 - Sun, Jan 18
MYR
Myrtle Beach
BUF
Buffalo
$302 Roundtrip, found 19 hours ago
$302
Roundtrip
found 19 hours ago
Select American Airlines flight, departing Sat, Jan 17 from Myrtle Beach to Buffalo, returning Sun, Jan 18, priced at $302 found 19 hours ago
Southwest Airlines
Thu, Dec 11 - Sat, Jan 10
MYR
Myrtle Beach
BUF
Buffalo
$305 Roundtrip, found 1 day ago
$305
Roundtrip
found 1 day ago
Select Southwest Airlines flight, departing Thu, Dec 11 from Myrtle Beach to Buffalo, returning Sat, Jan 10, priced at $305 found 1 day ago

Find the cheapest month to fly from Myrtle Beach (MYR) to Buffalo (BUF)

August is typically the cheapest month to fly

From $170 - $440 per traveler.

Alternative airports near Buffalo

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Buffalo Niagara Intl. BUF. Cheapest and Closest option available. Average driving time to city center is 16 minutes. Flights from $407
BUF
Buffalo Niagara Intl.
CheapestClosest
Average driving time to city center16 min
Flights from $407

Frequently asked questions

How much does a flight from Myrtle Beach Intl. Airport (MYR) to Buffalo Niagara Intl. Airport (BUF) cost?
Snag a cheap one-way flight from $149 or cheap return flight from $295 from Myrtle Beach Intl. Airport (MYR) to Buffalo Niagara Intl. Airport (BUF) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight deals on this route.
What is the cheapest month to fly from Myrtle Beach Intl. Airport (MYR) to Buffalo Niagara Intl. Airport (BUF)?
January is the least expensive month to fly from MYR to BUF. Avoiding peak travel times is often the key to landing a great deal.
What is the cheapest airline that flies from Myrtle Beach Intl. Airport (MYR) to Buffalo Niagara Intl. Airport (BUF)?
Use the filter tool on Expedia to compare different airlines and find the cheapest carrier that'll fly you from MYR to BUF. Then, sort your results by "Price (lowest to highest)" to pick up a good deal.
How many flights per day from Myrtle Beach Intl. Airport (MYR) to Buffalo Niagara Intl. Airport (BUF)?
You'll need to book a flight with a layover when traveling from Myrtle Beach Intl. Airport (MYR) to Buffalo Niagara Intl. Airport (BUF). Direct flights don't operate daily on this route. However, just filter your search to include one or more stops to find the best option for your trip.
What day of the week has the most flights from MYR to BUF?
Generally you'll find the most flight options available on a Friday. Tuesdays are often the quietest.* But this can vary depending on the season, airline and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Myrtle Beach Intl. Airport (MYR) to Buffalo Niagara Intl. Airport (BUF)?
To avoid possible delays on the Myrtle Beach Intl. Airport (MYR) to Buffalo Niagara Intl. Airport (BUF) route, aim to travel before 3 PM. Flights after this time have a 22% higher chance of being canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Myrtle Beach Intl. Airport (MYR) to Buffalo Niagara Intl. Airport (BUF) last-minute?
Booking your flight from MYR to BUF shortly before your trip is generally more expensive. But if there's some wiggle room with your departure times and dates, you could bag a cheap last-minute fare.
Is it cheaper to book a MYR to BUF flight and hotel package?
Compared with arranging hotels and flights separately, booking a MYR to BUF flight and hotel package with Expedia could lead to significant savings. Better yet, having everything in one easy place will take the hassle out of travel planning. Simply secure your flights and select from our wide range of stays, then tailor your trip with extras like tours, activities and car rentals.
Can I cancel or change the date of my flight from Myrtle Beach Intl. Airport (MYR) to Buffalo Niagara Intl. Airport (BUF)?
If you reserved your MYR to BUF flight in the last 24 hours, you may be able to cancel or modify it without fees. Depending on the airline and the type of ticket you purchased, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, go to our Customer Service portal if you want more information.

Travel information

Origin airport
Myrtle Beach Intl.
Destination airport
Buffalo Niagara Intl.
Airlines serving
American Airlines, Delta, Southwest Airlines, United
Roundtrip price
$295
Distance
639 mi

Book with confidence

Myrtle Beach to Buffalo Flights

The cheapest times to fly from Myrtle Beach to Buffalo

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Myrtle Beach to Buffalo are during the month of January. You can find some of the cheapest flights from Myrtle Beach to Buffalo with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Myrtle Beach to Buffalo

Sunday is one of the best days to book for cheap flights from Myrtle Beach to Buffalo: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Myrtle Beach to Buffalo

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Myrtle Beach to Buffalo in 2025. You can also book with separate airlines for your outbound and return journeys, from $149 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Myrtle Beach to Buffalo flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Myrtle Beach to Buffalo airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Myrtle Beach to Buffalo Flights

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*Available to One Key members.