Photo by Ryan Watts
Find 4 Star Hotels in Upstate South Carolina, SC from $106
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Our top choices for Upstate South Carolina 4-star hotels
Grand Bohemian Lodge Greenville, Autograph Collection
Greenville Downtown
9.6 out of 10, Exceptional, (418)
"Absolutely one of the best hotels to stay at. "
stephen
$295 nightly
The price is $324
Jan 4 - Jan 5, 2026
Total with taxes and fees
The Westin Poinsett Greenville
Greenville Downtown
9.2 out of 10, Wonderful, (1003)
"Awesome place "
Dominick
$169 nightly
The price is $186
Dec 14 - Dec 15
Total with taxes and fees
The Shepherd Hotel Downtown Clemson
Clemson
9.8 out of 10, Exceptional, (739)
"Staff was amazing and our room was clean and comfortable. "
Amanda R
$166 nightly
The price is $185
Dec 11 - Dec 12
Total with taxes and fees
Hotel Hartness
Greenville
9.8 out of 10, Exceptional, (624)
"Beautiful location, friendly staff"
Andrew
$199 nightly
The price is $219
Dec 15 - Dec 16
Total with taxes and fees
Greenville Marriott
Greenville
8.6 out of 10, Excellent, (608)
"Front desk was so pleasant and helpful! Rooms were clean. Housekeeping was great too!"
Kimberlee
$96 nightly
The price is $106
Dec 21 - Dec 22
Total with taxes and fees
Mint House Greenville - Downtown
Greenville Downtown
9.2 out of 10, Wonderful, (772)
"Excellent stay as always! "
Elena
$119 nightly
The price is $131
Dec 24 - Dec 25
Total with taxes and fees
The Abernathy of Clemson
Clemson
9.6 out of 10, Exceptional, (555)
"location is amazing! "
colleen
$134 nightly
The price is $149
Jan 8 - Jan 9, 2026
Total with taxes and fees
Park Place Apartments by Landing
Greenville
7.6 out of 10, Good, (42)
"Loved the apartment! Very spacious, clean, brand new. Access to bike paths. Seemed like a quirky location but everything is close by car or bike.
"
Kathie
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Learn more about Upstate South Carolina
Venture to sights like Discovery Island Water Park and Heritage Park as you discover Upstate South Carolina.
Photo by Ryan Watts
Open Photo by Ryan Watts
Top Upstate South Carolina Hotel Reviews
Grand Bohemian Lodge Greenville, Autograph Collection
10/10 Excellent
The Westin Poinsett Greenville
10/10 Excellent
Find out more about Upstate South Carolina
Upstate South Carolina Four Star Hotel Information
When you need to book a room with luxurious amazing amenities and the best rates, the 4 star hotels in Upstate South Carolina, South Carolina are incredible options. Known for their extra perks, first-rate service, and fantastic locations, each of the Upstate South Carolina 4 star hotels offers the ultimate experience for globe-trotting travelers. Relax in your expertly designed room. Kick back with around-the-clock room service.
Get a good night’s sleep with the ultra-plush bedding, and freshen up in the morning with designer-inspired body products. It’s all available when you stay at one of the top book a four star hotels in Upstate South Carolina. What’s more, thanks to Expedia you might even score a cheap great deal on a 4 star hotel in Upstate South Carolina, South Carolina, areas near the hottest attractions, so you can plan a sightseeing adventure and take advantage of unbeatable discounts in one fell swoop.
Whether you’re putting together a serene getaway or want to revel in the most vibrant entertainment district, 4 star Upstate South Carolina hotels offer everything your heart desires.
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