Find 4 Star Hotels in Upstate South Carolina, SC from $125
Upfront pricing
Our total price for your stay includes taxes and fees
Treat yourself
Save 10% or more on over 100,000 hotels worldwide with Member Prices
Be picky
Search almost a million properties worldwide
Check availability on Upstate South Carolina 4 Star Hotels
Compare Upstate South Carolina 4 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.
Grand Bohemian Lodge Greenville, Autograph Collection
Grand Bohemian Lodge Greenville, Autograph Collection
9.6 out of 10, Exceptional, (394)
"Very expensive but great location. "
Mary Ellen
$287 nightly
The price is $316
Nov 16 - Nov 17
Total with taxes and fees
The Shepherd Hotel Downtown Clemson
The Shepherd Hotel Downtown Clemson
9.8 out of 10, Exceptional, (713)
"Very nice hotel, great staff"
Erin
$189 nightly
The price is $210
Oct 27 - Oct 28
Total with taxes and fees
The Westin Poinsett Greenville
The Westin Poinsett Greenville
9.2 out of 10, Wonderful, (1005)
"Very courteous and helpful staff "
ANDREW
$189 nightly
The price is $208
Nov 23 - Nov 24
Total with taxes and fees
Hotel Hartness
Hotel Hartness
9.8 out of 10, Exceptional, (605)
"Wonderful boutique hotel!!"
Mary Ellen
$199 nightly
The price is $219
Nov 16 - Nov 17
Total with taxes and fees
Greenville Marriott
Greenville Marriott
8.6 out of 10, Excellent, (600)
"we enjoyed the bar"
Elizabeth
$114 nightly
The price is $125
Nov 23 - Nov 24
Total with taxes and fees
Mint House Greenville - Downtown
Mint House Greenville - Downtown
9.2 out of 10, Wonderful, (753)
"Excellent stay as always! "
Elena
The Abernathy of Clemson
The Abernathy of Clemson
9.6 out of 10, Exceptional, (548)
"Great place for visiting the university "
Guy
$164 nightly
The price is $183
Oct 28 - Oct 29
Total with taxes and fees
Park Place Apartments by Landing
Park Place Apartments by Landing
7.8 out of 10, Good, (40)
"This was false advertising. Property name is not the same and their app did not work and we could not get into the property NOR get anyone on the phone. We spent 2 hours on the phone to try and get in and finally had to book another hotel. And it’s been a week and my money has yet to be returned even though Expedia said they would refund me "
Ashley
Save an average of 15% on thousands of hotels when you're signed in
Learn more about Upstate South Carolina
Venture to sights like Discovery Island Water Park and Heritage Park as you discover Upstate South Carolina.
Photo by Visit Greenville, South Carolina
Open Photo by Visit Greenville, South Carolina
Top Upstate South Carolina Hotel Reviews
Grand Bohemian Lodge Greenville, Autograph Collection
10/10 Excellent
Find out more about Upstate South Carolina
Upstate South Carolina Four Star Hotel Information
When you need to book a room with luxurious amazing amenities and the best rates, the 4 star hotels in Upstate South Carolina, South Carolina are incredible options. Known for their extra perks, first-rate service, and fantastic locations, each of the Upstate South Carolina 4 star hotels offers the ultimate experience for globe-trotting travelers. Relax in your expertly designed room. Kick back with around-the-clock room service.
Get a good night’s sleep with the ultra-plush bedding, and freshen up in the morning with designer-inspired body products. It’s all available when you stay at one of the top book a four star hotels in Upstate South Carolina. What’s more, thanks to Expedia you might even score a cheap great deal on a 4 star hotel in Upstate South Carolina, South Carolina, areas near the hottest attractions, so you can plan a sightseeing adventure and take advantage of unbeatable discounts in one fell swoop.
Whether you’re putting together a serene getaway or want to revel in the most vibrant entertainment district, 4 star Upstate South Carolina hotels offer everything your heart desires.
Explore a world of travel with Expedia
- 3 Star Hotels in Woodruff
- 4 Star Hotels in Woodruff
- Woodruff Hotels
- Cabin Rentals in Woodruff
- Motels in Woodruff
- B&B in Woodruff
- Pet-friendly Hotels in Woodruff
- RV Parks in Woodruff
- Vacation Homes in Woodruff
- Cottages in Woodruff
- Hotels near Tyger-10 Nature Park
- 4 Star Hotels in Roebuck
- 5 Star Hotels in Roebuck
- Roebuck Hotels
- Apartments in Roebuck
- Cabin Rentals in Roebuck
- B&B in Roebuck
- Cottages in Roebuck
- Motels in Roebuck
- Vacation Homes in Roebuck
- RV Parks in Roebuck
- Moore Hotels
- Hotels near Walnut Grove Plantation
- Enoree Hotels
- Cottages in Enoree
- RV Parks in Enoree
- Cabin Rentals in Enoree
- 5 Star Hotels in Pauline
- 4 Star Hotels in Reidville
- 3 Star Hotels in Reidville
- Hotels near Willow Creek Golf Club
- Pauline Hotels
- Motels in Pauline
- B&B in Pauline
- Reidville Hotels
- Cabin Rentals in Reidville
- Hotels near Tyger River Park
- Hotels near River Falls Golf Course
- Hotels near Tyger River Park
- Anglewood Hotels
- Flights to Woodruff
- Flights from Woodruff
- Flights to Roebuck
- Flights from Roebuck
- Flights from Moore
- Flights from Enoree
- Flights from Pauline
- Flights from Reidville
- Flights from Charlotte (CLT) to Spartanburg (SPA)
- Flights from Spartanburg Downtown Memorial
- Flights from Asheville (AVL) to Spartanburg (SPA)
- Flights from Atlanta (ATL) to Spartanburg (SPA)
- Flights from New York (JFK) to Spartanburg (SPA)
- Flights from Columbia (CAE) to Spartanburg (SPA)
- Flights from Greenville (GSP) to Spartanburg (SPA)
- Flights from Raleigh (RDU) to Spartanburg (SPA)
- Flights from Miami (MIA) to Spartanburg (SPA)
- Flights from Seattle (SEA) to Spartanburg (SPA)
- Flights from Buffalo (BUF) to Spartanburg (SPA)
- Flights from Hickory (HKY) to Spartanburg (SPA)
- Flights from Richmond (RIC) to Spartanburg (SPA)
- Flights from Charleston (CHS) to Spartanburg (SPA)
- Flights from Los Angeles (LAX) to Spartanburg (SPA)
- Flights from Tampa (TPA) to Spartanburg (SPA)
- Flights from Trenton (TTN) to Spartanburg (SPA)
- Flights from Philadelphia (PHL) to Spartanburg (SPA)
- Flights from Punta Gorda Airport (PGD) to Spartanburg (SPA)
- Flights from Vero Beach (VRB) to Spartanburg (SPA)
- Flights from Chicago (ORD) to Spartanburg (SPA)
- Flights from Latrobe (LBE) to Spartanburg (SPA)
- Flights from Evansville (EVV) to Spartanburg (SPA)
- Flights from Washington (DCA) to Spartanburg (SPA)
- Flights from Cape Girardeau (CGI) to Spartanburg (SPA)
- Flights from Wilmington (ILM) to Spartanburg (SPA)
- Flights from Boston (BOS) to Spartanburg (SPA)
- Flights from Dallas (DFW) to Spartanburg (SPA)
- Flights from Fort Lauderdale (FLL) to Spartanburg (SPA)
- Flights from Syracuse (SYR) to Spartanburg (SPA)
- Flights from Detroit (DTW) to Spartanburg (SPA)