Find 4 Star Hotels in Southern Indiana from $106

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Check availability on Southern Indiana 4 Star Hotels

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Dec 12 - Dec 14

Compare Southern Indiana 4 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.

4 restaurants, breakfast, lunch, dinner served; American cuisine
Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham

4.0 star property
Downtown Louisville
9.0 out of 10, Wonderful, (3811)
"10/10 best hotel in Louisville "
United States
James
$109 nightly
The price is $128
Dec 15 - Dec 16
Total with taxes and fees
Galt House Hotel Trademark Collection by Wyndham
Sauna, body treatments, aromatherapy, hot stone massages
Omni Louisville Hotel

Omni Louisville Hotel

4.0 star property
Downtown Louisville
9.2 out of 10, Wonderful, (1698)
"Wonderful property and staff. Would love to stay again. "
United States
Hanna
$167 nightly
The price is $197
Jan 1 - Jan 2, 2026
Total with taxes and fees
Omni Louisville Hotel
Dinner served
Embassy Suites Louisville Downtown

Embassy Suites Louisville Downtown

4.0 star property
Downtown Louisville
9.0 out of 10, Wonderful, (1101)
"Clean, hotel was amazing, great breakfast "
United States
Alana
$119 nightly
The price is $140
Dec 21 - Dec 22
Total with taxes and fees
Embassy Suites Louisville Downtown
Lobby
The Brown Hotel

The Brown Hotel

4.5 star property
Downtown Louisville
9.4 out of 10, Exceptional, (1147)
"I loved everything about this place"
United States
Steven
$118 nightly
The price is $139
Dec 4 - Dec 5
Total with taxes and fees
The Brown Hotel
Hypo-allergenic bedding, in-room safe, desk, laptop workspace
Hotel Genevieve part of JdV by Hyatt

Hotel Genevieve part of JdV by Hyatt

4.0 star property
Downtown Louisville
9.2 out of 10, Wonderful, (1011)
"Nice hotel and rooms. "
United States
James
$135 nightly
The price is $159
Dec 8 - Dec 9
Total with taxes and fees
Hotel Genevieve part of JdV by Hyatt
Front of property
21c Museum Hotel Louisville

21c Museum Hotel Louisville

4.5 star property
Downtown Louisville
9.2 out of 10, Wonderful, (1000)
" Loved our stay, would definitely plan to come back if we are ever in the area again."
United States
Erica
$143 nightly
The price is $169
Jan 1 - Jan 2, 2026
Total with taxes and fees
21c Museum Hotel Louisville
Breakfast, lunch and dinner served
Hyatt Regency Louisville

Hyatt Regency Louisville

4.0 star property
Downtown Louisville
8.8 out of 10, Excellent, (1010)
"Enjoyed our stay "
United States
Jedediah
$116 nightly
The price is $136
Dec 14 - Dec 15
Total with taxes and fees
Hyatt Regency Louisville
Deluxe Single Room, 1 King Bed, River View | View from room
The Grady

The Grady

4.0 star property
Downtown Louisville
9.4 out of 10, Exceptional, (1016)
"The location was outstanding and atmosphere was very nice."
United States
Malcolm
$139 nightly
The price is $164
Dec 21 - Dec 22
Total with taxes and fees
The Grady
Restaurant
Louisville Marriott Downtown

Louisville Marriott Downtown

4.0 star property
Downtown Louisville
9.0 out of 10, Wonderful, (1000)
"Room was great, but the service by the attendant that wait on me was exceptional in what she done for me."
United States
Michael
$171 nightly
The price is $201
Dec 14 - Dec 15
Total with taxes and fees
Louisville Marriott Downtown
Exterior
Hotel Distil, Autograph Collection

Hotel Distil, Autograph Collection

4.0 star property
Downtown Louisville
9.6 out of 10, Exceptional, (427)
"Great location. Great restraunt, great staff. Pleasurable experience!"
United States
Harrison
$169 nightly
The price is $199
Dec 14 - Dec 15
Total with taxes and fees
Hotel Distil, Autograph Collection
View from room
DoubleTree by Hilton Evansville

DoubleTree by Hilton Evansville

4.0 star property
Downtown Evansville
8.6 out of 10, Excellent, (1000)
"The staff were extremely friendly "
United States
Jill
$105 nightly
The price is $121
Dec 14 - Dec 15
Total with taxes and fees
DoubleTree by Hilton Evansville
Exterior
Hotel Bourré Bonne Louisville, Curio Collection by Hilton

Hotel Bourré Bonne Louisville, Curio Collection by Hilton

4.0 star property
Downtown Louisville
9.0 out of 10, Wonderful, (51)
"Lovely hotel in downtown Louisville. Well appointed room, comfy bed and outstanding dining. "
United States
Michelle
$144 nightly
The price is $169
Dec 21 - Dec 22
Total with taxes and fees
Hotel Bourré Bonne Louisville, Curio Collection by Hilton
Lobby
Seelbach Hilton Louisville Downtown

Seelbach Hilton Louisville Downtown

4.0 star property
Downtown Louisville
8.6 out of 10, Excellent, (1008)
"Room looked very nice when we checked in"
United States
Todd
$127 nightly
The price is $149
Dec 22 - Dec 23
Total with taxes and fees
Seelbach Hilton Louisville Downtown
Signature Suite, 1 Queen Bed, Non Smoking | Premium bedding, down comforters, memory foam beds
Stellar Suites

Stellar Suites

4.5 star property
Downtown Louisville
9.6 out of 10, Exceptional, (117)
"Clean and great location "
United States
Greg
$154 nightly
The price is $179
Dec 16 - Dec 17
Total with taxes and fees
Stellar Suites
Deluxe Room, 1 King Bed (Culbertson Suite) | Balcony
The Pepin Mansion Historic B&B

The Pepin Mansion Historic B&B

4.0 star property
New Albany
9.8 out of 10, Exceptional, (646)
"Have stayed here once before. Accommodations are wonderful and the sit down breakfast is lovely. Highly recommend this beautiful property."
United States
Kathy
$93 nightly
The price is $106
Dec 7 - Dec 8
Total with taxes and fees
The Pepin Mansion Historic B&B
Seasonal outdoor pool
CozySuites at Nulu

CozySuites at Nulu

4.0 star property
Downtown Louisville
8.2 out of 10, Very Good, (26)
"The unit was clean, all communications were timely, the property has all the amenities, and NULU is very walkable. A perfect stay! My only regret is that I wasn't able to extend the stay. Highly recommended if you're in the Louisville area "
United States
William
$173 nightly
The price is $201
Dec 7 - Dec 8
Total with taxes and fees
CozySuites at Nulu
BBQ/picnic area
stayAPT Suites Louisville North-Clarksville

stayAPT Suites Louisville North-Clarksville

4.0 star property
Clarksville
9.8 out of 10, Exceptional, (43)
"Excellent stay. One of my favorite hotels in the area. They never disappoint "
United States
Julia
stayAPT Suites Louisville North-Clarksville
32-inch Smart TV with cable channels
The Reserve on Main

The Reserve on Main

4.0 star property
Downtown Louisville
10.0 out of 10, Exceptional, (1)
"Incredible stay. This stay was clean and inspiring for anyone wishing to take a break and recharge. We highly recommend this stay to everyone staying in the city. "
Canada
georgios
$182 nightly
The price is $204
Dec 7 - Dec 8
Total with taxes and fees
The Reserve on Main
Exterior detail
Spacious 3 BR Ranch House W Patio Yard in a Quiet Suburb

Spacious 3 BR Ranch House W Patio Yard in a Quiet Suburb

4.0 star property
Sellersburg
9.4 out of 10, Exceptional, (10)
"Very nice house in a nice neighborhood, spacious home environmental, felt more that at home there,"
United States
Tammy
$334 nightly
The price is $352
Dec 31 - Jan 1, 2026
Total with taxes and fees
Spacious 3 BR Ranch House W Patio Yard in a Quiet Suburb
Lounge
Holiday Inn Evansville Airport

Holiday Inn Evansville Airport

4.0 star property
Evansville
8.0 out of 10, Very Good, (604)
"Nice hotel but it doesn’t have a fridge in the room or microwave."
United States
Anonymous traveler
Holiday Inn Evansville Airport
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Learn more about Southern Indiana

Hoosier traditions add a unique slant to your trip to the towns of this region, while the forest offers a serene spot for a picnic beside old buffalo grounds.

See all hotels in Southern Indiana
Belle of Louisville featuring a bay or harbor and a ferry as well as a small group of people

Top Southern Indiana Hotel Reviews

DoubleTree by Hilton Evansville

DoubleTree by Hilton Evansville

10/10 Excellent
"Great stay!"
Amy 1-night trip
Posted 2 weeks ago
DoubleTree by Hilton Evansville

Find out more about Southern Indiana

Southern Indiana Four Star Hotel Information

When you need to book a room with luxurious amazing amenities and the best rates, the 4 star hotels in Southern Indiana, United States of America are incredible options. Known for their extra perks, first-rate service, and fantastic locations, each of the Southern Indiana 4 star hotels offers the ultimate experience for globe-trotting travelers. Relax in your expertly designed room. Kick back with around-the-clock room service.

Get a good night’s sleep with the ultra-plush bedding, and freshen up in the morning with designer-inspired body products. It’s all available when you stay at one of the top book a four star hotels in Southern Indiana. What’s more, thanks to Expedia you might even score a cheap great deal on a 4 star hotel in Southern Indiana, United States of America, areas near the hottest attractions, so you can plan a sightseeing adventure and take advantage of unbeatable discounts in one fell swoop.

Whether you’re putting together a serene getaway or want to revel in the most vibrant entertainment district, 4 star Southern Indiana hotels offer everything your heart desires.

Frequently asked questions

What are the best 4-star hotels in Southern Indiana?
If your Southern Indiana vacation leads you to Louisville, consider Galt House Hotel Trademark Collection by Wyndham. With lots of amenities such as massage services and a swimming pool, it scores top marks from many Expedia customers. Another popular pick here is Hyatt Regency Louisville. It also has 4 stars and offers designer toiletries and a swimming pool.
How much does it cost to stay in a 4-star hotel in Southern Indiana?
To book a 4-star hotel in Southern Indiana that's within your budget, use Expedia's handy filter tool. Browse the availability during your chosen dates and use our pricing filter to set your limit. You can also sort your results by the cheapest option first.

  • Search for the lowest price from $106

What's the difference between 5-star and 4-star hotels in Southern Indiana?
Offering an inviting traveler experience and upscale décor, 4-star hotels are an excellent option for your Southern Indiana break. These kinds of accommodations generally feature loads of handy amenities that make it easy to unpack and recharge — think pillowtop mattresses, restaurants and pools. Or live in the lap of luxury at a 5-star hotel designed to spoil you with exclusive perks and amenities. 24-hour front desk, oversized bathrooms and gourmet dining are typically featured at these swanky properties.

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