Uptown, CO

Denver

A city street with cars, buildings, and a church steeple.
A city intersection with modern buildings, a crosswalk, and a traffic light.
A street with a restaurant named 'Steuben's Food Service' and a parked vintage car.
A tree-lined street with historic buildings, a green wave sign, and a clear blue sky.
A historic church with a pointed steeple, modern high-rise buildings, and a clear blue sky.

Stay near popular Uptown attractions

Cathedral of the Immaculate Conception

After visiting Cathedral of the Immaculate Conception, make a plan to see the other sights and activities in Denver. Amble around this vibrant area's picturesque gardens or experience its acclaimed art scene.
See properties

Things to do

General Admission to Denver Botanic Gardens Ticket

General Admission to Denver Botanic Gardens Ticket

$16
per adult
96% of travellers recommend
General Admission to Denver Botanic Gardens Ticket
Denver: Meow Wolf's Convergence Station Admission Ticket

Denver: Meow Wolf Convergence Station Ticket

$37
per adult
92% of travellers recommend
Denver: Meow Wolf Convergence Station Ticket
Denver: Puff Pass and Painting Class

Denver: Puff Pass and Painting Class

$39
per adult
100% of travellers recommend
Denver: Puff Pass and Painting Class
Denver: Museum of Nature and Science Entry Ticket

Denver: Museum of Nature and Science Entry Ticket

$28
per adult
84% of travellers recommend
Denver: Museum of Nature and Science Entry Ticket
Rocky Mountain Escape

Rocky Mountain Escape

$99
per traveler
96% of travellers recommend
Rocky Mountain Escape
Denver: Get High on a Mountain Tour with Sunset Views

Denver: Get High on a Mountain Tour with Sunset Views

$89
per adult
88% of travellers recommend
Denver: Get High on a Mountain Tour with Sunset Views
See all activities in Denver

Uptown Hotel Deals

Hampton Inn & Suites Denver-Downtown

Hampton Inn & Suites Denver-Downtown

3 out of 5
1845 Sherman St Denver CO
$114 nightly
The price is $132 total per night from Oct 17 to Oct 18
$132 total
Oct 17 - Oct 18
Total with taxes and fees
Book a stay at this business-friendly hotel in Denver. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
8.4/10 Very Good! (2,146 reviews)
"👎 well the only good thing was the front desk attendant (blonde male) knew the area and was extremely helpful. Breakfast was like a tornado hit it with no one assisting in tidying up, the batter for waffles was everywhere trash everywhere. We decided to go out for breakfast. The elevators were broken ..."

Reviewed on Sep 28, 2026

Hampton Inn & Suites Denver-Downtown
Warwick Denver

Warwick Denver

4 out of 5
1776 Grant Street Denver CO
$168 nightly
The price is $194 total per night from Oct 18 to Oct 19
$194 total
Oct 18 - Oct 19
Total with taxes and fees
Book a stay at this business-friendly hotel in Denver. Enjoy breakfast (surcharge), room service, and a 24-hour fitness center. Our guests praise the pool and ...
Warwick Denver
Hyatt Place Peña Station/Denver Airport

Hyatt Place Peña Station/Denver Airport

3 out of 5
6110 NORTH PANASONIC WAY Denver CO
$113 nightly
The price is $131 total per night from Oct 25 to Oct 26
$131 total
Oct 25 - Oct 26
Total with taxes and fees
Book a stay at this business-friendly hotel in Denver. Enjoy free breakfast, free WiFi, and a free airport shuttle. Our guests praise the breakfast and the restaurant ...
Hyatt Place Peña Station/Denver Airport
Sonesta Denver Downtown

Sonesta Denver Downtown

4 out of 5
1450 Glenarm Place Denver CO
$129 nightly
The price is $149 total per night from Oct 18 to Oct 19
$149 total
Oct 18 - Oct 19
Total with taxes and fees
Book a stay at this business-friendly hotel in Denver. Enjoy an outdoor pool, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
Sonesta Denver Downtown
Hyatt Centric Downtown Denver

Hyatt Centric Downtown Denver

4 out of 5
1776 Champa St Denver CO
$139 nightly
The price is $161 total per night from Oct 25 to Oct 26
$161 total
Oct 25 - Oct 26
Total with taxes and fees
Stay at this hotel in Denver. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Our guests praise the restaurant and the helpful staff in our reviews. ...
9/10 Wonderful! (2,797 reviews)
"Location, location, location Walkable from Union station Our room does not have a fridge and microwave, but still we can manage it."

Reviewed on Sep 28, 2026

Hyatt Centric Downtown Denver
Plaza Hotel Denver

Plaza Hotel Denver

3 out of 5
4849 Bannock Street Denver CO
$70 nightly
The price is $80 total per night from Sep 29 to Sep 30
$80 total
Sep 29 - Sep 30
Total with taxes and fees
Stay at this hotel in Denver. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
Plaza Hotel Denver
See all 4,935 properties in Uptown
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Uptown

Find the best Uptown areas and neighborhoods for the activities you enjoy most. Learn more about Uptown
Learn more about Uptown
A modern architectural complex with geometric shapes and a prominent red sculpture.

Downtown Denver

Enjoy the popular shops in Downtown Denver. Paramount Theater is a worthwhile stop, and you can jump on the metro at 16th - California Station or 16th - Stout Station to see more of Denver.

A city street with a large canopy structure, modern buildings, and potted plants.

Cherry Creek

Abundant dining options and stunning river views are well-reviewed features of Cherry Creek. Make a stop by top sights like Cherry Creek Shopping Center while you're exploring the area.

A cityscape with modern buildings and a forested area in the foreground.

Denver Tech Center

Known for its ample dining options and great live music, there's plenty to explore in Denver Tech Center. You can visit top attractions like Fiddler's Green Amphitheatre and The Landmark Theatre Greenwood Village, and jump on the metro at Orchard Station or Arapahoe at Village Center Station to see more of the city.

A brightly lit train station with a large Christmas tree and illuminated decorations.

LoDo

Take time in LoDo to visit attractions like Union Station and McGregor Square. You might also appreciate the abundant dining options, and you can hop on the metro at Union Station-Coors Field-16th St. Mall Station to see more of the city.

A rural landscape with a field of corn, a bridge, and houses in the background.

Highlands Ranch

Highlands Ranch is popular for its abundant dining options, and if you're looking for more to see and do, you might think about a trip to Highlands Ranch Golf Club or South Suburban Sports Complex.

Uptown, CO

Choose one or more items to build your trip:

Explore a world of travel with Expedia