A seal swimming in clear water.
Photo by Elizabeth Oates
Open Photo by Elizabeth Oates

Santa Fe Island Vacations from $471

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The Latest Santa Fe Island Vacation Packages

Price found within the past 48 hours. Click for updated prices.
  • A covered outdoor seating area with wooden furniture and a view of the sea.
    Dec 15 - Dec 18

    BAY VIEW HOUSE + Flight

    Puerto Ayora
    3 nights
    3.5 star property
    9.0/10 - Wonderful (11 reviews)
    "The location was great and very convenient. Unfortunately, our apartment faced the main street, so there was quite a bit of traffic and street noise, especially at night. It did make it difficult to sleep, so if you’re a light sleeper, I would recommend requesting an apartment away from the main street."
    Reviewed September 19, 2026
    Roundtrip • Guayaquil (GYE) - Santa Cruz Island (GPS)
    GYE - GPS • Nonstop GPS - GYE • Nonstop
    $706
    $471
    per traveler
    found 14 hours ago
    BAY VIEW HOUSE
  • A wooden deck with outdoor seating, a green umbrella, and a view of the beach.
    Dec 15 - Dec 18

    Mi Playa Galapagos Beachfront + Flight

    Puerto Villamil
    3 nights
    3.0 star property
    9.6/10 - Exceptional (11 reviews)
    "We had a wonderful stay here. The view, location, the staff and the amazing breakfast makes this place a standout. We were fortunate to be able to stay here for 4 nights and would have loved to stay longer. It has everything you need with the beach and wildlife literally at your door step. Shirley and the staff were great. Always a whatsapp message away with any questions we had. I truly can't recommend this place enough!"
    Reviewed September 20, 2026
    Roundtrip • Guayaquil (GYE) - Santa Cruz Island (GPS)
    GYE - GPS • Nonstop GPS - GYE • Nonstop
    Save 100% on your flight
    $1,179
    $793
    per traveler
    found 14 hours ago
    Mi Playa Galapagos Beachfront
  • A hotel room with a large bed, a desk, and a view of the sea.
    Dec 23 - Dec 26

    Galapagos Sunset Hotel + Flight

    Puerto Baquerizo Moreno
    3 nights
    3.0 star property
    9.4/10 - Exceptional (221 reviews)
    Roundtrip • Guayaquil (GYE) - San Cristobal (SCY)
    GYE - GPS • 1 stop GPS - GYE • Nonstop
    $965
    $732
    per traveler
    found 10 hours ago
    Galapagos Sunset Hotel
  • A balcony with a view of the sea, white furniture, and a table with a drink.
    Jan 23 - Jan 30

    Angermeyer Waterfront Inn + Flight

    Puerto Ayora
    6 nights
    3.5 star property
    9.4/10 - Exceptional (151 reviews)
    "Great staff, great location."
    Reviewed October 22, 2026
    Roundtrip • Boston (BOS) - Santa Cruz Island (GPS)
    BOS - GPS • 2 stops GPS - BOS • 2 stops
    $2,572
    $1,970
    per traveler
    found 5 hours ago
    Angermeyer Waterfront Inn
  • A restaurant with outdoor seating, a sign for 'Marlyn's Cafe-Arte', and a 'Roland' store across the street.
    Dec 15 - Dec 18

    Plaza Luna Suites + Flight

    Puerto Ayora
    3 nights
    3.0 star property
    9.8/10 - Exceptional (44 reviews)
    "Sandra was an amazingly helpful host. Strongly recommend this place for both service and location."
    Reviewed October 17, 2026
    Roundtrip • Guayaquil (GYE) - Santa Cruz Island (GPS)
    GYE - GPS • Nonstop GPS - GYE • Nonstop
    $651
    $510
    per traveler
    found 16 hours ago
    Plaza Luna Suites

Santa Fe Island Hotel Deals

A table with fruit, a drink, and a laptop on a balcony with a view of the sea and boats.

Hotel La Casa de Judy

Hotel La Casa de Judy
3.0 star property
18.5 mi from Santa Fe Island
9.0 out of 10, Wonderful, (183 reviews)
"This hotel was a great choice. Close enough to walk into town, great views, clean room (including bathroom) and friendly and helpful staff."
$87 nightly
The price is $87
Nov 22 - Nov 23
Hotel La Casa de Judy
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
See all properties in Santa Fe Island
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.