Santa Cruz

Seville

A narrow cobblestone street lined with colorful buildings, shops, and a prominent white archway in the distance.
A historic plaza with ornate Gothic architecture, palm trees, and people walking.
A narrow street lined with trees and buildings, with people sitting at outdoor cafes.
A sunny urban square with tram tracks, historic buildings, and pedestrians.
A historic building with ornate columns, a large archway, and a statue.
Wander through a maze of cobbled streets in one of Seville's most picturesque areas, an ancient neighborhood that's home to major landmarks and medieval buildings.

Santa Cruz is one of the oldest neighborhoods in the city. The former medieval Jewish quarter is known for its squares framed by orange trees, narrow streets that keep out the sun, whitewashed homes adorned by flower-filled balconies and Seville's main monuments, the cathedral and the Giralda. Visit Santa Cruz on foot and discover insights into its long and fascinating past.

Nestled in the heart of the neighborhood or barrio is the 15th-century Seville Cathedral, a massive gothic structure that is one of the largest churches in the world. Marvel at centuries-old frescoes that adorn chapels, visit the tomb of explorer Christopher Columbus and climb up the bell tower, the Giralda. This was the tallest building in the city for hundreds of years, and its oldest part is a minaret from the 12th century.

Then walk over to the 14th-century mudejar-style Royal Alcazar of Seville, which is still used by the Spanish royal family when they're in the city.

Meander down extremely narrow pedestrianized streets called kissing lanes because the houses on opposite sides are so close. The streets were designed like this to maximize shade. Pause to admire tiled patios of mansions and townhouses through their wrought-iron gates.

Visit the Casa Fabiola for its collection of paintings, sculptures and religious pieces. Adjoining this renaissance Sevillian palace is a section of the wall that encircled the old Jewish quarter.

Trace the history of Seville's Jewish community by studying the artifacts and information panels at the Centro de Interpretación Judería de Sevilla.

Unwind in one of the beautiful squares that dot the neighborhood, such as Plaza Doña Elvira with its fountain, tiled benches and orange trees. Enjoy more tranquil moments in the Jardines de Murillo, a peaceful oasis of flowerbeds, fountains, arbors and magnolia trees, among other species.

Find the Santa Cruz neighborhood in the historic center of the city and enjoy its charm, beauty and atmosphere as you stroll through the cobblestone streets.


Stay near popular Santa Cruz attractions

Things to do


Santa Cruz Hotel Deals

Las Casas de la Judería, Sevilla Historic City Center

Las Casas de la Judería, Sevilla Historic City Center

4 out of 5
Calle Santa Maria La Blanca 5 Seville Seville
$196 nightly
The price is $215 total per night from Sep 20 to Sep 21
$215 total
Sep 20 - Sep 21
Total with taxes and fees
Book a stay at this spa hotel in Seville. Enjoy free WiFi, an outdoor pool, and a full-service spa. Our guests praise the pool and the helpful staff in our reviews. ...
9.4/10 Exceptional! (1,011 reviews)
"This is a funky hotel. comprised of merged houses. We really enjoyed walking through the halls and finding something unexpected, unexpected around each corner. The hotel is extremely convenient, the breakfast choices were excellent, and the staff was very friendly. Highly recommend staying here."

Reviewed on Sep 18, 2026

Las Casas de la Judería, Sevilla Historic City Center
Hotel Alfonso XIII, a Luxury Collection Hotel, Seville

Hotel Alfonso XIII, a Luxury Collection Hotel, Seville

5 out of 5
San Fernando 2 Seville Seville
Fully refundableReserve now, pay when you stay
$697 nightly
The price is $767 total per night from Oct 19 to Oct 20
$767 total
Oct 19 - Oct 20
Total with taxes and fees
Book a stay at this luxury hotel in Seville. Enjoy 2 restaurants, breakfast (surcharge), and 24-hour room service. Our guests praise the helpful staff in our ...
Hotel Alfonso XIII, a Luxury Collection Hotel, Seville
Hotel Fernando III

Hotel Fernando III

4 out of 5
San Jose 21 Seville Seville
$233 nightly
The price is $256 total per night from Oct 4 to Oct 5
$256 total
Oct 4 - Oct 5
Total with taxes and fees
Book a stay at this business-friendly hotel in Seville. Enjoy free WiFi, an outdoor pool, and a rooftop terrace. Our guests praise the breakfast and the pool ...
9.6/10 Exceptional! (1,422 reviews)
"Fantastic stay… very comfortable rooms.. spotlessly clean… brilliant staff.. superb rooftop pool with views of the city… great location for the city Highly recommend this hotel"

Reviewed on Sep 13, 2026

Hotel Fernando III
Hotel Amadeus Sevilla

Hotel Amadeus Sevilla

4 out of 5
Calle Farnesio 6 Seville Seville
$186 nightly
The price is $205 total per night from Oct 15 to Oct 16
$205 total
Oct 15 - Oct 16
Total with taxes and fees
Book a stay at this boutique hotel in Seville. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Our guests praise the breakfast and the bar in ...
9.6/10 Exceptional! (1,275 reviews)
"Very nice"

Reviewed on Sep 18, 2026

Hotel Amadeus Sevilla
Hotel Murillo

Hotel Murillo

2 out of 5
Calle Lope de Rueda, 7-9 Seville Seville
$108 nightly
The price is $119 total per night from Sep 20 to Sep 21
$119 total
Sep 20 - Sep 21
Total with taxes and fees
Book a stay at this family-friendly hotel in Seville. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Our guests praise the helpful staff and ...
Hotel Murillo
Hotel Rey Alfonso X

Hotel Rey Alfonso X

4 out of 5
Calle Ximenez De Enciso, 35 Seville Seville
$241 nightly
The price is $265 total per night from Sep 20 to Sep 21
$265 total
Sep 20 - Sep 21
Total with taxes and fees
Stay at this hotel in Seville. Enjoy free WiFi, an outdoor pool, and a rooftop terrace. Our guests praise the breakfast and the pool in our reviews. Popular ...
9.4/10 Exceptional! (1,219 reviews)
"We were affected by the UK air traffic control glitch. The receptionist (Inez) could not have been more reassuring that our room would be held. To aid us in our compensation claim they provided a formal document stating we had missed 2 Ishtar of our pre-paid stay - thank you. On arrival the receptionist ..."

Reviewed on Sep 12, 2026

Hotel Rey Alfonso X
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Santa Cruz

Find the best Santa Cruz areas and neighborhoods for the activities you enjoy most. Learn more about Santa Cruz
Learn more about Santa Cruz

Historical Center

Casa de la Memoria Cultural Center and Calle Sierpes are a few top attractions in Historical Center. Hop around the city on the metro at Plaza Nueva Tram Stop or Archivo de Indias Tram Stop and check out the area's fantastic nightlife, stunning cathedral, and popular shops.

El Arenal

Travelers choose El Arenal for its ample dining options. Hop aboard the metro at Plaza Nueva Tram Stop or Archivo de Indias Tram Stop and check out top sights like Paseo de Cristóbal Colón.

Alfalfa

Unique features of Alfalfa include the bars and historic sites. Make a stop by Calle Sierpes or Casa de la Memoria Cultural Center while you're exploring the area.

Triana

Known for its abundant dining options and stunning river views, there's plenty to explore in Triana. Top attractions like Triana Market and Triana Bridge are major draws, and you can catch the metro at Plaza de Cuba Station or Cartuja Station to see more of the city.

San Bartolomé

Travelers come to San Bartolomé for its lively bars, and you can see top attractions like Pilate's House and Zurbarán Statue while you're in town.



Santa Cruz

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