Cheap Flights from Des Moines (DSM) to St. Louis (CPS)

Popular airlines from Des Moines International Airport (DSM) to St. Louis, MO (CPS-St. Louis Downtown)

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Alternative airports near St. Louis

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Lambert-St. Louis Intl. STL. Cheapest option available. Average driving time to city center is 20 minutes. Flights from $295
STL
Lambert-St. Louis Intl.
Cheapest
Average driving time to city center20 min
Flights from $295

Frequently asked questions

How much does a flight from Des Moines Intl. Airport (DSM) to St. Louis Downtown Airport (CPS) cost?
Grab a cheap one-way flight or cheap return flight from Des Moines Intl. Airport (DSM) to St. Louis Downtown Airport (CPS) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight deals on this route.
What is the cheapest month to fly from Des Moines Intl. Airport (DSM) to St. Louis Downtown Airport (CPS)?
Planning your trip for is a great way to save, as it's the cheapest month for flights between DSM and CPS. You'll usually find the lowest prices during off-peak months.
What is the cheapest airline that flies from Des Moines Intl. Airport (DSM) to St. Louis Downtown Airport (CPS)?
To find the cheapest airline flying from DSM to CPS, use Expedia's filter tool. Customize your search based on what's important to you, such as preferred carriers and seat class. You can then sort your results by "Price (lowest to highest)" to list the most affordable options first.
How many flights per day from Des Moines Intl. Airport (DSM) to St. Louis Downtown Airport (CPS)?
You'll need to book a flight with a layover if you're traveling from Des Moines Intl. Airport (DSM) to St. Louis Downtown Airport (CPS). Direct flights don't operate daily on this route. However, simply filter your search to include one or two stops to discover the best option for your trip.
What day of the week has the most flights from DSM to CPS?
Typically you'll find the largest variety of flight choices on a Friday. Tuesdays are often the quietest.* But this can vary depending on the time of year, airline and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Des Moines Intl. Airport (DSM) to St. Louis Downtown Airport (CPS)?
To arrive at St. Louis Downtown Airport (CPS) on time, opt for a flight that takes off from Des Moines Intl. Airport (DSM) before 3 PM. The likelihood of cancellations is 22% higher, on average, for departures after this time.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
What airports do you fly into for East St. Louis from Des Moines Intl. Airport (DSM)?
If you're flying on a direct flight from Des Moines Intl. Airport (DSM) to East St. Louis, Lambert-St. Louis Intl. Airport (STL) is the only airport you can touch down at.
Is it cheaper to buy a plane ticket from Des Moines Intl. Airport (DSM) to St. Louis Downtown Airport (CPS) last-minute?
Holding off until right before your break to book your flight from DSM to CPS generally means paying more. While you may come across some last-minute discounts, they aren't always guaranteed. Keep your travel schedule open for the best chance of landing a bargain.
Is it cheaper to book a DSM to CPS flight and hotel package?
Opting for a DSM to CPS flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your trip in one place. Choose from our wide range of hotels and then add activities, flights and car rentals to your booking. Bundle it all together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Des Moines Intl. Airport (DSM) to St. Louis Downtown Airport (CPS)?
You can usually cancel or reschedule your DSM to CPS flight. However, if it's been more than 24 hours since booking, additional charges may apply. Check your airline's policies in your itinerary to see what changes are possible and if any costs are involved. You'll also find further details on our Customer Service portal.

Travel information

Travel information

Origin airport
Des Moines Intl.
Destination airport
St. Louis Downtown
Distance
275 mi

Book with confidence

Book with confidence

Des Moines to St. Louis Flights

The cheapest times to fly from Des Moines to St. Louis

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Des Moines to St. Louis are during the month of . You can find some of the cheapest flights from Des Moines to St. Louis with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Des Moines to St. Louis

Sunday is one of the best days to book for cheap flights from Des Moines to St. Louis: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Des Moines to St. Louis

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Des Moines to St. Louis in 2025. You can also book with separate airlines for your outbound and return journeys, from one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Des Moines to St. Louis flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Des Moines to St. Louis airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Des Moines to St. Louis Flights

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