$259 Cheap Flights from La Crosse (LSE) to Key West (EYW)

View $259 flight on Mon, Dec 1, 2025Opens in a new window

Popular airlines from La Crosse, WI (LSE-La Crosse Municipal) to Key West Intl. Airport (EYW)

Cheap Flights from La Crosse to Key West (LSE-EYW)

Prices were available within the past 7 days and start at $259 for one-way flights and $410 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Tue, Jan 27 - Sat, Jan 31
LSE
La Crosse
EYW
Key West
$410 Roundtrip, found 4 days ago
$410
Roundtrip
found 4 days ago
Select American Airlines flight, departing Tue, Jan 27 from La Crosse to Key West, returning Sat, Jan 31, priced at $410 found 4 days ago
American Airlines
Tue, Dec 9 - Thu, Dec 18
LSE
La Crosse
EYW
Key West
$437 Roundtrip, found 8 hours ago
$437
Roundtrip
found 8 hours ago
Select American Airlines flight, departing Tue, Dec 9 from La Crosse to Key West, returning Thu, Dec 18, priced at $437 found 8 hours ago
American Airlines
Wed, Feb 18 - Wed, Mar 4
LSE
La Crosse
EYW
Key West
$441 Roundtrip, found 6 days ago
$441
Roundtrip
found 6 days ago
Select American Airlines flight, departing Wed, Feb 18 from La Crosse to Key West, returning Wed, Mar 4, priced at $441 found 6 days ago
American Airlines
Sat, Jan 3 - Tue, Jan 13
LSE
La Crosse
EYW
Key West
$490 Roundtrip, found 1 day ago
$490
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sat, Jan 3 from La Crosse to Key West, returning Tue, Jan 13, priced at $490 found 1 day ago
American Airlines
Tue, Feb 10 - Wed, Feb 25
LSE
La Crosse
EYW
Key West
$496 Roundtrip, found 1 day ago
$496
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Feb 10 from La Crosse to Key West, returning Wed, Feb 25, priced at $496 found 1 day ago
American Airlines
Thu, Nov 13 - Sat, Nov 15
LSE
La Crosse
EYW
Key West
$500 Roundtrip, found 6 days ago
$500
Roundtrip
found 6 days ago
Select American Airlines flight, departing Thu, Nov 13 from La Crosse to Key West, returning Sat, Nov 15, priced at $500 found 6 days ago
American Airlines
Wed, Feb 11 - Wed, Feb 25
LSE
La Crosse
EYW
Key West
$501 Roundtrip, found 1 day ago
$501
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Feb 11 from La Crosse to Key West, returning Wed, Feb 25, priced at $501 found 1 day ago
American Airlines
Mon, Mar 2 - Thu, Mar 12
LSE
La Crosse
EYW
Key West
$502 Roundtrip, found 6 days ago
$502
Roundtrip
found 6 days ago
Select American Airlines flight, departing Mon, Mar 2 from La Crosse to Key West, returning Thu, Mar 12, priced at $502 found 6 days ago
American Airlines
Wed, Mar 11 - Thu, Mar 19
LSE
La Crosse
EYW
Key West
$510 Roundtrip, found 6 days ago
$510
Roundtrip
found 6 days ago
Select American Airlines flight, departing Wed, Mar 11 from La Crosse to Key West, returning Thu, Mar 19, priced at $510 found 6 days ago
American Airlines
Mon, Mar 2 - Thu, Mar 12
LSE
La Crosse
EYW
Key West
$512 Roundtrip, found 1 day ago
$512
Roundtrip
found 1 day ago
Select American Airlines flight, departing Mon, Mar 2 from La Crosse to Key West, returning Thu, Mar 12, priced at $512 found 1 day ago
American Airlines
Wed, Feb 18 - Wed, Mar 4
LSE
La Crosse
EYW
Key West
$513 Roundtrip, found 6 days ago
$513
Roundtrip
found 6 days ago
Select American Airlines flight, departing Wed, Feb 18 from La Crosse to Key West, returning Wed, Mar 4, priced at $513 found 6 days ago
American Airlines
Tue, Dec 9 - Thu, Dec 18
LSE
La Crosse
EYW
Key West
$517 Roundtrip, found 8 hours ago
$517
Roundtrip
found 8 hours ago
Select American Airlines flight, departing Tue, Dec 9 from La Crosse to Key West, returning Thu, Dec 18, priced at $517 found 8 hours ago
American Airlines
Wed, Nov 12 - Wed, Nov 19
LSE
La Crosse
EYW
Key West
$519 Roundtrip, found 5 days ago
$519
Roundtrip
found 5 days ago
Select American Airlines flight, departing Wed, Nov 12 from La Crosse to Key West, returning Wed, Nov 19, priced at $519 found 5 days ago
American Airlines
Tue, Jan 6 - Sat, Jan 24
LSE
La Crosse
EYW
Key West
$520 Roundtrip, found 4 days ago
$520
Roundtrip
found 4 days ago
Select American Airlines flight, departing Tue, Jan 6 from La Crosse to Key West, returning Sat, Jan 24, priced at $520 found 4 days ago
American Airlines
Mon, Feb 9 - Wed, Feb 25
LSE
La Crosse
EYW
Key West
$523 Roundtrip, found 1 day ago
$523
Roundtrip
found 1 day ago
Select American Airlines flight, departing Mon, Feb 9 from La Crosse to Key West, returning Wed, Feb 25, priced at $523 found 1 day ago

Alternative airports near Key West

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Key West Intl. EYW. Cheapest and Closest option available. Average driving time to city center is 8 minutes. Flights from $526
EYW
Key West Intl.
CheapestClosest
Average driving time to city center8 min
Flights from $526

Frequently asked questions

How much does a flight from La Crosse Municipal Airport (LSE) to Key West Intl. Airport (EYW) cost?
Lock in a cheap one-way flight from $259 or cheap return flight from $410 from La Crosse Municipal Airport (LSE) to Key West Intl. Airport (EYW) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight deals on this route.
What is the cheapest month to fly from La Crosse Municipal Airport (LSE) to Key West Intl. Airport (EYW)?
January is the cheapest month to fly from LSE to EYW. Avoiding peak travel times is often the key to finding better fares.
What is the cheapest airline that flies from La Crosse Municipal Airport (LSE) to Key West Intl. Airport (EYW)?
Expedia's filter tool lets you easily compare different airlines, flight durations and fares all in one place. Select your preferences, then sort by "Price (lowest to highest)" to see which carrier offers the cheapest LSE to EYW flight.
How many flights per day from La Crosse Municipal Airport (LSE) to Key West Intl. Airport (EYW)?
You'll need to hop on a flight with a layover when traveling from La Crosse Municipal Airport (LSE) to Key West Intl. Airport (EYW). There are no daily direct flights on this route. However, simply filter your search to include one or more stops to find the best option for your trip.
What day of the week has the most flights from LSE to EYW?
Generally you'll find the largest variety of flight choices on a Friday. Tuesdays are often the quietest.* But this can vary based on the season, airline and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from La Crosse Municipal Airport (LSE) to Key West Intl. Airport (EYW)?
Opt for a flight from La Crosse Municipal Airport (LSE) to Key West Intl. Airport (EYW) that leaves before 3 PM to reduce the likelihood of delays. Departures later than this have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from La Crosse Municipal Airport (LSE) to Key West Intl. Airport (EYW) last-minute?
Holding off until just before your departure to book your flight from LSE to EYW often results in higher prices. While you may find some last-minute deals, they're not always guaranteed. Be flexible with your travel plans for the best chance of landing a bargain.
Is it cheaper to book a LSE to EYW flight and hotel package?
Compared with arranging flights and hotels separately, booking a LSE to EYW flight and hotel package with Expedia could lead to significant savings. Better yet, managing everything in one place takes the hassle out of planning your trip. Simply secure your flights and choose from our wide range of stays, then tailor your trip with other add-ons like tours, car rentals and activities.
Can I cancel or change the date of my flight from La Crosse Municipal Airport (LSE) to Key West Intl. Airport (EYW)?
Generally, it's possible to cancel or reschedule your LSE to EYW flight. However, if it's been more than 24 hours since booking, additional charges may apply. Refer to your airline's policies in your itinerary to see what changes are possible and whether any costs are involved. You'll also find more information on our Customer Service portal.

Travel information

Origin airport
La Crosse Municipal
Destination airport
Key West Intl.
Airlines serving
American Airlines
Roundtrip price
$410
Distance
1438 mi

Book with confidence

La Crosse to Key West Flights

The cheapest times to fly from La Crosse to Key West

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from La Crosse to Key West are during the month of January. You can find some of the cheapest flights from La Crosse to Key West with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from La Crosse to Key West

Sunday is one of the best days to book for cheap flights from La Crosse to Key West: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from La Crosse to Key West

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from La Crosse to Key West in 2025. You can also book with separate airlines for your outbound and return journeys, from $259 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap La Crosse to Key West flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your La Crosse to Key West airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

La Crosse to Key West Flights

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*Available to One Key members.