$162 Cheap Flights from Medellín (MDE) to Chicago (ORD)

View $162 flight on Wed, Dec 10, 2025Opens in a new window

Popular airlines from Jose Maria Cordova Intl. Airport (MDE) to Chicago O'Hare Intl. Airport (ORD)

Cheap Flights from Medellín to Chicago (MDE-ORD)

Prices were available within the past 7 days and start at $162 for one-way flights and $238 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Spirit Airlines
Wed, Nov 12 - Sun, Nov 16
MDE
Medellin
ORD
Chicago
$238 Roundtrip, found 4 days ago
$238
Roundtrip
found 4 days ago
Select Spirit Airlines flight, departing Wed, Nov 12 from Medellin to Chicago, returning Sun, Nov 16, priced at $238 found 4 days ago
Spirit Airlines
Wed, Nov 12 - Sun, Nov 16
MDE
Medellin
ORD
Chicago
$240 Roundtrip, found 4 days ago
$240
Roundtrip
found 4 days ago
Select Spirit Airlines flight, departing Wed, Nov 12 from Medellin to Chicago, returning Sun, Nov 16, priced at $240 found 4 days ago
Spirit Airlines
Thu, Jan 22 - Tue, Jan 27
MDE
Medellin
ORD
Chicago
$246 Roundtrip, found 4 days ago
$246
Roundtrip
found 4 days ago
Select Spirit Airlines flight, departing Thu, Jan 22 from Medellin to Chicago, returning Tue, Jan 27, priced at $246 found 4 days ago
Spirit Airlines
Thu, Nov 20 - Sat, Dec 6
MDE
Medellin
ORD
Chicago
$248 Roundtrip, found 2 hours ago
$248
Roundtrip
found 2 hours ago
Select Spirit Airlines flight, departing Thu, Nov 20 from Medellin to Chicago, returning Sat, Dec 6, priced at $248 found 2 hours ago
Spirit Airlines
Thu, Jan 22 - Tue, Jan 27
MDE
Medellin
ORD
Chicago
$259 Roundtrip, found 4 days ago
$259
Roundtrip
found 4 days ago
Select Spirit Airlines flight, departing Thu, Jan 22 from Medellin to Chicago, returning Tue, Jan 27, priced at $259 found 4 days ago
Spirit Airlines
Tue, Nov 11 - Sun, Nov 16
MDE
Medellin
ORD
Chicago
$261 Roundtrip, found 4 days ago
$261
Roundtrip
found 4 days ago
Select Spirit Airlines flight, departing Tue, Nov 11 from Medellin to Chicago, returning Sun, Nov 16, priced at $261 found 4 days ago
Copa
Tue, Nov 18 - Tue, Dec 9
MDE
Medellin
ORD
Chicago
$325 Roundtrip, found 5 hours ago
$325
Roundtrip
found 5 hours ago
Select Copa flight, departing Tue, Nov 18 from Medellin to Chicago, returning Tue, Dec 9, priced at $325 found 5 hours ago
American Airlines
Sat, Nov 8 - Wed, Nov 12
MDE
Medellin
ORD
Chicago
$337 Roundtrip, found 1 day ago
$337
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sat, Nov 8 from Medellin to Chicago, returning Wed, Nov 12, priced at $337 found 1 day ago
United
Thu, Nov 13 - Sat, Nov 29
MDE
Medellin
ORD
Chicago
$337 Roundtrip, found 1 hour ago
$337
Roundtrip
found 1 hour ago
Select United flight, departing Thu, Nov 13 from Medellin to Chicago, returning Sat, Nov 29, priced at $337 found 1 hour ago
avianca
Thu, Nov 13 - Mon, Nov 17
MDE
Medellin
ORD
Chicago
$379 Roundtrip, found 1 day ago
$379
Roundtrip
found 1 day ago
Select avianca flight, departing Thu, Nov 13 from Medellin to Chicago, returning Mon, Nov 17, priced at $379 found 1 day ago

Find the cheapest month to fly from Medellín (MDE) to Chicago (ORD)

November is typically the cheapest month to fly

From $285 - $612 per traveler.

Alternative airports near Chicago

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to O'Hare Intl. ORD. Cheapest option available. Average driving time to city center is 23 minutes. Flights from $434
ORD
O'Hare Intl.
Cheapest
Average driving time to city center23 min
Flights from $434
Flights from Medellín (MDE) to Chicago (ORD)
Origin airport
José María Córdova Intl.
Destination airport
O'Hare Intl.
Airlines serving
Aeromexico, Air Canada, American Airlines, Copa, Delta, JetBlue Airways, LATAM Airlines Group, Spirit Airlines, United, avianca
Roundtrip price
$238
Distance
2589 mi

Medellín to Chicago Flights

The cheapest times to fly from Medellín to Chicago

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Medellín to Chicago are during the month of November. You can find some of the cheapest flights from Medellín to Chicago with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Medellín to Chicago

Sunday is one of the best days to book for cheap flights from Medellín to Chicago: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Medellín to Chicago

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Medellín to Chicago in 2025. You can also book with separate airlines for your outbound and return journeys, from $162 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Medellín to Chicago flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Medellín to Chicago airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Jose Maria Cordova Intl. Airport (MDE) to O'Hare Intl. Airport (ORD) cost?
Grab a cheap one-way flight from $162 or cheap return flight from $238 from Jose Maria Cordova Intl. Airport (MDE) to O'Hare Intl. Airport (ORD) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight deals on this route.
What is the cheapest month to fly from Jose Maria Cordova Intl. Airport (MDE) to O'Hare Intl. Airport (ORD)?
November is the most affordable month to fly from MDE to ORD. Planning your trip for the off-season is often the key to finding better fares.
What is the cheapest airline that flies from Jose Maria Cordova Intl. Airport (MDE) to O'Hare Intl. Airport (ORD)?
To find the cheapest airline that'll fly you from MDE to ORD, use Expedia's filter tool. Tailor your search based on what's important to you, such as preferred carriers and flight duration. You can then sort your results by "Price (lowest to highest)" to see the cheapest flights first.
How many flights per day from Jose Maria Cordova Intl. Airport (MDE) to O'Hare Intl. Airport (ORD)?
There aren't any daily nonstop flights from Jose Maria Cordova Intl. Airport (MDE) to O'Hare Intl. Airport (ORD). But you can opt for flights with layovers. Filter your search results on Expedia to include one or two stops, and you'll be cruising above the clouds in no time.
What day of the week has the most flights from MDE to ORD?
Friday is typically the busiest day for flights, while Tuesday is often the quietest.* Remember that flight schedules can vary based on various factors, such as the time of year and airline.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Jose Maria Cordova Intl. Airport (MDE) to O'Hare Intl. Airport (ORD)?
To avoid possible delays on the Jose Maria Cordova Intl. Airport (MDE) to O'Hare Intl. Airport (ORD) route, aim to travel before 3 PM. Later flights have a 22% higher chance of being canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Jose Maria Cordova Intl. Airport (MDE) to O'Hare Intl. Airport (ORD) last-minute?
Booking your flight from MDE to ORD right before your getaway is generally more expensive. However, if you're flexible with your travel times and dates, you could grab a cheap last-minute fare.
Is it cheaper to book a MDE to ORD flight and hotel package?
You'll typically save money by booking a MDE to ORD flight and hotel package compared to booking separately. In fact, travelers could save hundreds of dollars by bundling with Expedia. And it's simple to manage it all in one place. Once you've selected your preferred accommodations and flights, you can add extras such as activities, car rentals and tours.
Can I cancel or change the date of my flight from Jose Maria Cordova Intl. Airport (MDE) to O'Hare Intl. Airport (ORD)?
Generally, it's possible to cancel or reschedule your MDE to ORD flight. However, for bookings made more than 24 hours ago, additional charges may apply. Check your airline's policies in your itinerary to see what changes are possible and if any costs are involved. You'll also find more information on our Customer Service portal.

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*Available to One Key members.