$205 Cheap Flights from Medellín (MDE) to Santiago (SCL)

View $205 flight on Thu, Dec 4, 2025Opens in a new window

Popular airlines from Jose Maria Cordova Intl. Airport (MDE) to Santiago Intl. Airport (SCL)

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Cheap Flights from Medellín to Santiago (MDE-SCL)

Prices were available within the past 7 days and start at $205 for one-way flights and $343 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Jetsmart SPA
Fri, Dec 19 - Mon, Dec 29
MDE
Medellin
SCL
Santiago
$343 Roundtrip, found 5 days ago
$343
Roundtrip
found 5 days ago
Select Jetsmart SPA flight, departing Fri, Dec 19 from Medellin to Santiago, returning Mon, Dec 29, priced at $343 found 5 days ago
Jetsmart SPA
Mon, Dec 1 - Tue, Mar 3
MDE
Medellin
SCL
Santiago
$343 Roundtrip, found 1 day ago
$343
Roundtrip
found 1 day ago
Select Jetsmart SPA flight, departing Mon, Dec 1 from Medellin to Santiago, returning Tue, Mar 3, priced at $343 found 1 day ago
Jetsmart SPA
Mon, Oct 13 - Mon, Oct 27
MDE
Medellin
SCL
Santiago
$348 Roundtrip, found 4 days ago
$348
Roundtrip
found 4 days ago
Select Jetsmart SPA flight, departing Mon, Oct 13 from Medellin to Santiago, returning Mon, Oct 27, priced at $348 found 4 days ago
Jetsmart SPA
Sun, Dec 14 - Mon, Dec 29
MDE
Medellin
SCL
Santiago
$350 Roundtrip, found 5 days ago
$350
Roundtrip
found 5 days ago
Select Jetsmart SPA flight, departing Sun, Dec 14 from Medellin to Santiago, returning Mon, Dec 29, priced at $350 found 5 days ago
Jetsmart SPA
Fri, Dec 12 - Mon, Dec 29
MDE
Medellin
SCL
Santiago
$353 Roundtrip, found 2 days ago
$353
Roundtrip
found 2 days ago
Select Jetsmart SPA flight, departing Fri, Dec 12 from Medellin to Santiago, returning Mon, Dec 29, priced at $353 found 2 days ago
Jetsmart SPA
Mon, Dec 29 - Fri, Jan 16
MDE
Medellin
SCL
Santiago
$354 Roundtrip, found 2 days ago
$354
Roundtrip
found 2 days ago
Select Jetsmart SPA flight, departing Mon, Dec 29 from Medellin to Santiago, returning Fri, Jan 16, priced at $354 found 2 days ago
Jetsmart SPA
Tue, Jan 27 - Wed, Mar 25
MDE
Medellin
SCL
Santiago
$356 Roundtrip, found 2 days ago
$356
Roundtrip
found 2 days ago
Select Jetsmart SPA flight, departing Tue, Jan 27 from Medellin to Santiago, returning Wed, Mar 25, priced at $356 found 2 days ago
Copa
Mon, Sep 15 - Tue, Sep 23
MDE
Medellin
SCL
Santiago
$394 Roundtrip, found 5 days ago
$394
Roundtrip
found 5 days ago
Select Copa flight, departing Mon, Sep 15 from Medellin to Santiago, returning Tue, Sep 23, priced at $394 found 5 days ago
LATAM Airlines Group
Mon, Oct 6 - Fri, Oct 17
MDE
Medellin
SCL
Santiago
$414 Roundtrip, found 6 days ago
$414
Roundtrip
found 6 days ago
Select LATAM Airlines Group flight, departing Mon, Oct 6 from Medellin to Santiago, returning Fri, Oct 17, priced at $414 found 6 days ago
avianca
Thu, Oct 23 - Thu, Oct 30
MDE
Medellin
SCL
Santiago
$447 Roundtrip, found 5 days ago
$447
Roundtrip
found 5 days ago
Select avianca flight, departing Thu, Oct 23 from Medellin to Santiago, returning Thu, Oct 30, priced at $447 found 5 days ago

Find the cheapest month to fly from Medellín (MDE) to Santiago (SCL)

March is typically the cheapest month to fly

From $328 - $563 per traveler.

Alternative airports near Santiago

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Arturo Merino Benitez SCL. Cheapest and Closest option available. Average driving time to city center is 17 minutes. Flights from $520
SCL
Arturo Merino Benitez
CheapestClosest
Average driving time to city center17 min
Flights from $520
Flights from Medellín (MDE) to Santiago (SCL)
Origin airport
José María Córdova Intl.
Destination airport
Arturo Merino Benitez
Airlines serving
Copa, Jetsmart SPA, LATAM Airlines Group, avianca
Roundtrip price
$342
Distance
2750 mi

Medellín to Santiago Flights

The cheapest times to fly from Medellín to Santiago

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Medellín to Santiago are during the month of December. You can find some of the cheapest flights from Medellín to Santiago with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Medellín to Santiago

Sunday is one of the best days to book for cheap flights from Medellín to Santiago: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Medellín to Santiago

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Medellín to Santiago in 2025. You can also book with separate airlines for your outbound and return journeys, from $205 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Medellín to Santiago flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Medellín to Santiago airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Jose Maria Cordova Intl. Airport (MDE) to Arturo Merino Benitez Airport (SCL) cost?
Grab a cheap one-way flight from $205 or cheap return flight from $343 from Jose Maria Cordova Intl. Airport (MDE) to Arturo Merino Benitez Airport (SCL) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight deals on this route.
What is the cheapest month to fly from Jose Maria Cordova Intl. Airport (MDE) to Arturo Merino Benitez Airport (SCL)?
The cheapest month to fly from MDE to SCL is December, when there's less demand. Off-peak months are generally when you'll find lower airfares between these airports.
Which airlines fly direct from Jose Maria Cordova Intl. Airport (MDE) to Arturo Merino Benitez Airport (SCL)?
You can fly nonstop from Jose Maria Cordova Intl. Airport (MDE) to Arturo Merino Benitez Airport (SCL) on a JetSMART flight.
What is the cheapest airline that flies from Jose Maria Cordova Intl. Airport (MDE) to Arturo Merino Benitez Airport (SCL)?
AVIANCA and JetSMART are some popular airlines offering reasonable fares. Don't forget that flight prices from Jose Maria Cordova Intl. Airport (MDE) to Arturo Merino Benitez Airport (SCL) can change depending on demand, travel dates and how early you book. With Expedia's filter tool, you can easily find a MDE to SCL flight that matches your preferences and budget.
How many flights per day from Jose Maria Cordova Intl. Airport (MDE) to Arturo Merino Benitez Airport (SCL)?
On average, there is just 1 nonstop flight taking off from Jose Maria Cordova Intl. Airport (MDE) to Arturo Merino Benitez Airport (SCL) every day. If this doesn't work for you, consider flights with a layover. Just customize your search results on Expedia to include one stop or more to find the next best option.
What are the most popular departure times for flights from Jose Maria Cordova Intl. Airport (MDE) to Arturo Merino Benitez Airport (SCL)?
More travelers fly between MDE and SCL at 1 PM than at any other time. Looking for a quieter experience? Travel outside of rush hours and you could save on your ticket as well.
What day of the week has the most flights from MDE to SCL?
Jet off on a Friday if you're after the best selection of flights from Jose Maria Cordova Intl. Airport (MDE) to Arturo Merino Benitez Airport (SCL).
What is the earliest flight from Jose Maria Cordova Intl. Airport (MDE) to Arturo Merino Benitez Airport (SCL)?
Hop on the earliest flight at around 1:13PM UTC-5, departing from Jose Maria Cordova Intl. Airport (MDE). You'll be flying for about 6h 8m, coming in to land at Arturo Merino Benitez Airport (SCL) at approximately 9:21PM UTC-3.
How long does it take to fly from Jose Maria Cordova Intl. Airport (MDE) to Arturo Merino Benitez Airport (SCL)?
Flights from MDE to SCL have an average travel time of 5 hours and 59 minutes. The distance between these two airports is 2,800 mi.
What airline has the least delays from MDE to SCL?
With 82% of flights usually arriving on schedule, JetSMART has the best on-time performance for direct flights from Jose Maria Cordova Intl. Airport (MDE) to Arturo Merino Benitez Airport (SCL). To check your flight status and get notifications about any changes, head to the Expedia App.
What is the best time to fly from Jose Maria Cordova Intl. Airport (MDE) to Arturo Merino Benitez Airport (SCL)?
To avoid possible delays on the Jose Maria Cordova Intl. Airport (MDE) to Arturo Merino Benitez Airport (SCL) route, aim to fly before 3 PM. Later departures have a 22% higher chance of cancellation.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
What airports do you fly into for Santiago from Jose Maria Cordova Intl. Airport (MDE)?
Arturo Merino Benitez Airport (SCL) is the only airport in Santiago with direct flights from Jose Maria Cordova Intl. Airport (MDE). Consider the available options and find affordable fares on Expedia.
Is it cheaper to buy a plane ticket from Jose Maria Cordova Intl. Airport (MDE) to Arturo Merino Benitez Airport (SCL) last-minute?
Waiting until just before your trip to book a ticket from MDE to SCL generally means paying more. While you may find some last-minute discounts, they're not always guaranteed. Be flexible with your itinerary to maximize your chances of landing a bargain.
Is it cheaper to book a MDE to SCL flight and hotel package?
Securing a MDE to SCL flight and hotel package is generally cheaper than booking separately. With Expedia, you can enjoy the convenience of organizing your trip all in one place. Select from our extensive range of hotels and then add car rentals, activities and flights to your booking. Bundle it all together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Jose Maria Cordova Intl. Airport (MDE) to Arturo Merino Benitez Airport (SCL)?
If you booked your MDE to SCL flight in the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, go to our Customer Service portal for more information.

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*Available to One Key members.