Cheap Flights from Chicago (MDW) to Greenville (GMU)

Popular airlines from Chicago Midway Airport (MDW) to Greenville, SC (GMU-Greenville Downtown)

Alternative airports near Greenville

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Greenville-Spartanburg Intl. GSP. Cheapest option available. Average driving time to city center is 18 minutes. Flights from $267
GSP
Greenville-Spartanburg Intl.
Cheapest
Average driving time to city center18 min
Flights from $267

Frequently asked questions

How much does a flight from Midway Intl. Airport (MDW) to Greenville, SC (GMU-Greenville Downtown) cost?
Secure a cheap one-way flight or cheap return flight from Midway Intl. Airport (MDW) to Greenville, SC (GMU-Greenville Downtown) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight deals on this route.
What is the cheapest month to fly from Midway Intl. Airport (MDW) to Greenville, SC (GMU-Greenville Downtown)?
Flying in is a good way to save, as it's the cheapest month for flights between MDW and GMU. You'll often find the lowest prices during the off-season.
What is the cheapest airline that flies from Midway Intl. Airport (MDW) to Greenville, SC (GMU-Greenville Downtown)?
Expedia's filter tool lets you easily compare different airlines, flight durations and fares all in one place. Select your preferences, then sort by "Price (lowest to highest)" to see which carrier offers the cheapest MDW to GMU flight.
How many flights per day from Midway Intl. Airport (MDW) to Greenville, SC (GMU-Greenville Downtown)?
Nonstop flights from Midway Intl. Airport (MDW) to Greenville, SC (GMU-Greenville Downtown) aren't available daily, so you'll have to take a flight with a layover. Explore your options with Expedia's filter tool. Enter your dates and click on either "1 Stop" or "2+ Stops."
What day of the week has the most flights from MDW to GMU?
Friday is usually the busiest day for flights, while Tuesday tends to be the quietest.* Remember that flight schedules can vary depending on various factors, including the time of year and carrier.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Midway Intl. Airport (MDW) to Greenville, SC (GMU-Greenville Downtown)?
To reach Greenville, SC (GMU-Greenville Downtown) on time, pick a flight that takes off from Midway Intl. Airport (MDW) before 3 PM. The chance of cancellations is 22% higher, on average, for departures after this time.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Midway Intl. Airport (MDW) to Greenville, SC (GMU-Greenville Downtown) last-minute?
Waiting until right before your break to book a ticket from MDW to GMU generally means paying more. While you may find some last-minute discounts, they aren't always guaranteed. Keep your travel schedule open for the best chance of snagging a bargain.
Is it cheaper to book a MDW to GMU flight and hotel package?
You'll typically save money by booking a MDW to GMU flight and hotel package compared to booking separately. In fact, travelers could save hundreds of dollars by bundling with Expedia. And it's simple to manage it all in one place. After choosing your ideal accommodations and flights, consider adding extras including tours, activities and car rentals.
Can I cancel or change the date of my flight from Midway Intl. Airport (MDW) to Greenville, SC (GMU-Greenville Downtown)?
If you booked your MDW to GMU flight in the last 24 hours, you may be able to modify or cancel it at no cost. Depending on the airline and the ticket type you purchased, additional charges may apply for changes after that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal for further details.

Travel information

Origin airport
Midway Intl.
Destination airport
Greenville Downtown
Distance
561 mi

Book with confidence

Chicago to Greenville Flights

The cheapest times to fly from Chicago to Greenville

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Chicago to Greenville are during the month of . You can find some of the cheapest flights from Chicago to Greenville with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Chicago to Greenville

Sunday is one of the best days to book for cheap flights from Chicago to Greenville: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Chicago to Greenville

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Chicago to Greenville in 2026. You can also book with separate airlines for your outbound and return journeys, from one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Chicago to Greenville flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Chicago to Greenville airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Chicago to Greenville Flights

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*Available to One Key members.