$304 Cheap Flights from Mexico City (MEX) to Santiago (SCL)

View $304 flight on Tue, Jan 27, 2026Opens in a new window

Popular airlines from Benito Juarez International Airport (MEX) to Santiago Intl. Airport (SCL)

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Cheap Flights from Mexico City to Santiago (MEX-SCL)

Prices were available within the past 7 days and start at $304 for one-way flights and $566 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Copa
Sun, Aug 24 - Thu, Aug 28
MEX
Mexico City
SCL
Santiago
$566 Roundtrip, found 1 hour ago
$566
Roundtrip
found 1 hour ago
Select Copa flight, departing Sun, Aug 24 from Mexico City to Santiago, returning Thu, Aug 28, priced at $566 found 1 hour ago
Copa
Tue, Aug 12 - Mon, Aug 18
MEX
Mexico City
SCL
Santiago
$587 Roundtrip, found 19 hours ago
$587
Roundtrip
found 19 hours ago
Select Copa flight, departing Tue, Aug 12 from Mexico City to Santiago, returning Mon, Aug 18, priced at $587 found 19 hours ago
Copa
Thu, Oct 2 - Mon, Oct 13
MEX
Mexico City
SCL
Santiago
$588 Roundtrip, found 14 hours ago
$588
Roundtrip
found 14 hours ago
Select Copa flight, departing Thu, Oct 2 from Mexico City to Santiago, returning Mon, Oct 13, priced at $588 found 14 hours ago
Copa
Thu, Oct 30 - Thu, Dec 4
MEX
Mexico City
SCL
Santiago
$595 Roundtrip, found 5 days ago
$595
Roundtrip
found 5 days ago
Select Copa flight, departing Thu, Oct 30 from Mexico City to Santiago, returning Thu, Dec 4, priced at $595 found 5 days ago
Copa
Tue, Aug 12 - Tue, Aug 19
MEX
Mexico City
SCL
Santiago
$598 Roundtrip, found 1 day ago
$598
Roundtrip
found 1 day ago
Select Copa flight, departing Tue, Aug 12 from Mexico City to Santiago, returning Tue, Aug 19, priced at $598 found 1 day ago
Aeromexico
Mon, Dec 1 - Tue, Dec 9
MEX
Mexico City
SCL
Santiago
$600 Roundtrip, found 2 hours ago
$600
Roundtrip
found 2 hours ago
Select Aeromexico flight, departing Mon, Dec 1 from Mexico City to Santiago, returning Tue, Dec 9, priced at $600 found 2 hours ago
Aeromexico
Tue, Jan 27 - Sat, Feb 7
MEX
Mexico City
SCL
Santiago
$601 Roundtrip, found 4 hours ago
$601
Roundtrip
found 4 hours ago
Select Aeromexico flight, departing Tue, Jan 27 from Mexico City to Santiago, returning Sat, Feb 7, priced at $601 found 4 hours ago
avianca
Tue, Aug 19 - Wed, Aug 27
MEX
Mexico City
SCL
Santiago
$605 Roundtrip, found 2 days ago
$605
Roundtrip
found 2 days ago
Select avianca flight, departing Tue, Aug 19 from Mexico City to Santiago, returning Wed, Aug 27, priced at $605 found 2 days ago
LATAM Airlines Group
Wed, Oct 29 - Wed, Nov 12
MEX
Mexico City
SCL
Santiago
$625 Roundtrip, found 23 hours ago
$625
Roundtrip
found 23 hours ago
Select LATAM Airlines Group flight, departing Wed, Oct 29 from Mexico City to Santiago, returning Wed, Nov 12, priced at $625 found 23 hours ago
United
Tue, Nov 18 - Wed, Jan 28
MEX
Mexico City
SCL
Santiago
$1,348 Roundtrip, found 3 hours ago
$1,348
Roundtrip
found 3 hours ago
Select United flight, departing Tue, Nov 18 from Mexico City to Santiago, returning Wed, Jan 28, priced at $1,348 found 3 hours ago

Find the cheapest month to fly from Mexico City (MEX) to Santiago (SCL)

May is typically the cheapest month to fly

From $336 - $668 per traveler.

Graph displaying average flight prices per month

Alternative airports near Santiago

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Arturo Merino Benitez SCL. Cheapest and Closest option available. Average driving time to city center is 17 minutes. Flights from $659
SCL
Arturo Merino Benitez
CheapestClosest
Average driving time to city center17 min
Flights from $659
Flights from Santa Lucía (NLU) to Santiago (SCL)
Origin airport
Felipe Ángeles Intl.
Destination airport
Arturo Merino Benitez
Airlines serving
Aerolineas Argentinas, Aeromexico, Air Canada, American Airlines, Copa, Delta, LATAM Airlines Group, United, avianca
Roundtrip price
$454
Distance
4115 mi
Average flight time
7 hours 40 mins

Mexico City to Santiago Flights

The cheapest times to fly from Mexico City to Santiago

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Mexico City to Santiago are during the month of August. You can find some of the cheapest flights from Mexico City to Santiago with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Mexico City to Santiago

Sunday is one of the best days to book for cheap flights from Mexico City to Santiago: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Mexico City to Santiago

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Mexico City to Santiago in 2025. You can also book with separate airlines for your outbound and return journeys, from $304 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Mexico City to Santiago flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Mexico City to Santiago airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Mexico City Intl. Airport (MEX) to Arturo Merino Benitez Airport (SCL) cost?
Cheap return fares from Mexico City Intl. Airport (MEX) to Arturo Merino Benitez Airport (SCL) start from $723. This information is based on the cheapest price found on Expedia for this return journey departing within the next three months. This airfare is for a LATAM Airlines Group flight leaving MEX on August 11 2025 and touching down at SCL. The price was last updated on July 23 2025 and has not changed since.
What is the cheapest month to fly from MEX to SCL?
The cheapest flights from MEX to SCL are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
Which airlines fly direct from Mexico City Intl. Airport (MEX) to Arturo Merino Benitez Airport (SCL)?
When flying out of Mexico City Intl. Airport (MEX), you can get on a direct flight to Arturo Merino Benitez Airport (SCL) with LATAM Airlines.
What is the cheapest airline that flies from MEX to SCL?
Book a flight from MEX to SCL with LATAM Airlines Group. This carrier currently has the lowest one-way fare for this route, starting from $590. This fare is based on the lowest price found on Expedia departing within the next three months. The flight takes off from MEX on September 17 2025. Prices were last updated on July 23 2025 and have not changed since.
How many flights per day from Mexico City Intl. Airport (MEX) to Arturo Merino Benitez Airport (SCL)?
On average, there is just 1 nonstop flight taking off from Mexico City Intl. Airport (MEX) to Arturo Merino Benitez Airport (SCL) each day. If this doesn't fit your travel plans, think about flights with a layover. Just customize your search results on Expedia to include one or more stops to discover the next best option.
What are the most popular departure times for flights from Mexico City Intl. Airport (MEX) to Arturo Merino Benitez Airport (SCL)?
More travelers fly between MEX and SCL at 7 PM than at any other time of day. Looking to skip the crowds? Pick a flight outside the busiest times and you're likely to save on your ticket as well.
What day of the week has the most flights from MEX to SCL?
Travel on a Friday if you're searching for the biggest selection of flights from Mexico City Intl. Airport (MEX) to Arturo Merino Benitez Airport (SCL).
What is the earliest flight from Mexico City Intl. Airport (MEX) to Arturo Merino Benitez Airport (SCL)?
The earliest flight leaving from Mexico City Intl. Airport (MEX) is at around 10:05AM UTC-6. Hop on this flight and you'll arrive at Arturo Merino Benitez Airport (SCL) at approximately 9:10PM UTC-3. The entire trip takes 8h 5m.
How long does it take to fly from Mexico City Intl. Airport (MEX) to Arturo Merino Benitez Airport (SCL)?
Flights from MEX to SCL have an average travel time of 8 hours and 8 minutes. The total distance between these two airports is 4,100 mi.
What airline has the least delays from MEX to SCL?
Consider traveling with LATAM Airlines if you'd like to fly straight from Mexico City Intl. Airport (MEX) to Arturo Merino Benitez Airport (SCL) without any delays. This carrier has the strongest track record for punctuality, with an on-time performance of 90%. Want to be notified if anything changes? You can keep an eye on your flight status using the Expedia App.
What is the best time to fly from Mexico City Intl. Airport (MEX) to Arturo Merino Benitez Airport (SCL)?
To avoid possible delays on the Mexico City Intl. Airport (MEX) to Arturo Merino Benitez Airport (SCL) route, aim to travel before 3 PM. Later departures have a 22% higher chance of cancellation.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
What airports do you fly into for Santiago from Mexico City Intl. Airport (MEX)?
Arturo Merino Benitez Airport (SCL) is the only airport in Santiago with direct flights from Mexico City Intl. Airport (MEX). Consider your options and discover cheap fares on Expedia.
Is it cheaper to buy a plane ticket from Mexico City Intl. Airport (MEX) to Arturo Merino Benitez Airport (SCL) last-minute?
Booking your ticket from MEX to SCL shortly before your getaway is generally more expensive. However, if there's some wiggle room with your schedule, you could snag a cheap last-minute fare.
Is it cheaper to book a MEX to SCL flight and hotel package?
Compared with arranging flights and hotels separately, booking a MEX to SCL flight and hotel package with Expedia could lead to significant savings. What's more, managing everything in one place takes the hassle out of travel planning. Simply secure your flights and choose from our wide range of hotels, then tailor your trip with other add-ons like activities and car rentals.
Can I cancel or change the date of my flight from Mexico City Intl. Airport (MEX) to Arturo Merino Benitez Airport (SCL)?
If you booked your MEX to SCL flight in the last 24 hours, you may be able to cancel or modify it without fees. Depending on the airline and the ticket type you purchased, additional charges may apply for changes after that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal for more information.

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*Available to One Key members.