$543 Cheap Flights from McAllen (MFE) to Santiago (SCL)

View $543 flight on Mon, Jan 19, 2026Opens in a new window

Popular airlines from Miller Intl. Airport (MFE) to Santiago Intl. Airport (SCL)

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Cheap Flights from McAllen to Santiago (MFE-SCL)

Prices were available within the past 7 days and start at $543 for one-way flights and $764 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Thu, Jan 15 - Thu, Jan 22
MFE
McAllen
SCL
Santiago
$764 Roundtrip, found 4 hours ago
$764
Roundtrip
found 4 hours ago
Select American Airlines flight, departing Thu, Jan 15 from McAllen to Santiago, returning Thu, Jan 22, priced at $764 found 4 hours ago
Delta
Tue, Dec 30 - Mon, Jan 19
MFE
McAllen
SCL
Santiago
$769 Roundtrip, found 18 hours ago
$769
Roundtrip
found 18 hours ago
Select Delta flight, departing Tue, Dec 30 from McAllen to Santiago, returning Mon, Jan 19, priced at $769 found 18 hours ago
United
Tue, Dec 23 - Mon, Dec 29
MFE
McAllen
SCL
Santiago
$771 Roundtrip, found 5 days ago
$771
Roundtrip
found 5 days ago
Select United flight, departing Tue, Dec 23 from McAllen to Santiago, returning Mon, Dec 29, priced at $771 found 5 days ago
American Airlines
Mon, Oct 27 - Mon, Nov 3
MFE
McAllen
SCL
Santiago
$772 Roundtrip, found 2 days ago
$772
Roundtrip
found 2 days ago
Select American Airlines flight, departing Mon, Oct 27 from McAllen to Santiago, returning Mon, Nov 3, priced at $772 found 2 days ago
Delta
Mon, Oct 27 - Mon, Nov 3
MFE
McAllen
SCL
Santiago
$775 Roundtrip, found 2 days ago
$775
Roundtrip
found 2 days ago
Select Delta flight, departing Mon, Oct 27 from McAllen to Santiago, returning Mon, Nov 3, priced at $775 found 2 days ago
United
Thu, Mar 12 - Thu, Mar 19
MFE
McAllen
SCL
Santiago
$778 Roundtrip, found 1 day ago
$778
Roundtrip
found 1 day ago
Select United flight, departing Thu, Mar 12 from McAllen to Santiago, returning Thu, Mar 19, priced at $778 found 1 day ago
American Airlines
Mon, Oct 27 - Mon, Nov 3
MFE
McAllen
SCL
Santiago
$779 Roundtrip, found 2 days ago
$779
Roundtrip
found 2 days ago
Select American Airlines flight, departing Mon, Oct 27 from McAllen to Santiago, returning Mon, Nov 3, priced at $779 found 2 days ago
Delta
Sun, Jan 25 - Tue, Feb 3
MFE
McAllen
SCL
Santiago
$784 Roundtrip, found 5 days ago
$784
Roundtrip
found 5 days ago
Select Delta flight, departing Sun, Jan 25 from McAllen to Santiago, returning Tue, Feb 3, priced at $784 found 5 days ago
Delta
Mon, Oct 27 - Mon, Nov 3
MFE
McAllen
SCL
Santiago
$784 Roundtrip, found 2 days ago
$784
Roundtrip
found 2 days ago
Select Delta flight, departing Mon, Oct 27 from McAllen to Santiago, returning Mon, Nov 3, priced at $784 found 2 days ago
Air Canada
Sun, Jan 18 - Mon, Jan 19
MFE
McAllen
SCL
Santiago
$2,108 Roundtrip, found 18 hours ago
$2,108
Roundtrip
found 18 hours ago
Select Air Canada flight, departing Sun, Jan 18 from McAllen to Santiago, returning Mon, Jan 19, priced at $2,108 found 18 hours ago

Alternative airports near Santiago

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Arturo Merino Benitez SCL. Cheapest and Closest option available. Average driving time to city center is 17 minutes. Flights from $764
SCL
Arturo Merino Benitez
CheapestClosest
Average driving time to city center17 min
Flights from $764

Frequently asked questions

How much does a flight from Miller Intl. Airport (MFE) to Arturo Merino Benitez Airport (SCL) cost?
Lock in a cheap one-way flight from $543 or cheap return flight from $764 from Miller Intl. Airport (MFE) to Arturo Merino Benitez Airport (SCL) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight deals on this route.
What is the cheapest month to fly from Miller Intl. Airport (MFE) to Arturo Merino Benitez Airport (SCL)?
January is the least expensive month to fly from MFE to SCL. Traveling outside of peak seasons is often the key to finding better deals on flights.
What is the cheapest airline that flies from Miller Intl. Airport (MFE) to Arturo Merino Benitez Airport (SCL)?
Use the filter tool on Expedia to compare different airlines and find the cheapest carrier that'll fly you from MFE to SCL. Then, sort your results by "Price (lowest to highest)" to snap up a great deal.
How many flights per day from Miller Intl. Airport (MFE) to Arturo Merino Benitez Airport (SCL)?
There are no daily nonstop flights departing from Miller Intl. Airport (MFE) to Arturo Merino Benitez Airport (SCL). But you can opt for flights with layovers. Filter your search results on Expedia to include one or two stops, and you'll be cruising above the clouds before you know it.
What day of the week has the most flights from MFE to SCL?
Usually you'll find the greatest selection of flight options on a Friday. Tuesdays tend to be the quietest.* However, this can vary depending on the airline, time of year and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Miller Intl. Airport (MFE) to Arturo Merino Benitez Airport (SCL)?
Choose a flight from Miller Intl. Airport (MFE) to Arturo Merino Benitez Airport (SCL) that takes off before 3 PM to reduce the likelihood of delays and cancellations. Later departures are on average 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Miller Intl. Airport (MFE) to Arturo Merino Benitez Airport (SCL) last-minute?
Booking your flight from MFE to SCL just before your getaway is typically more expensive. But if there's some wiggle room with your schedule, you could score a cheap last-minute fare.
Is it cheaper to book a MFE to SCL flight and hotel package?
You'll generally save money by securing a MFE to SCL flight and hotel package compared to booking separately. In fact, travelers could save hundreds of dollars by bundling with Expedia. And it's easy to manage everything in one convenient place. Once you've chosen your ideal flights and accommodations, you can add extras like tours, activities and car rentals.
Can I cancel or change the date of my flight from Miller Intl. Airport (MFE) to Arturo Merino Benitez Airport (SCL)?
Typically, you can reschedule or cancel your MFE to SCL flight. However, there may be additional charges, especially if you booked more than 24 hours ago. Check your itinerary for the airline's fees and rules on flight changes, or if you need more details, visit our Customer Service portal.

Travel information

Origin airport
Miller Intl.
Destination airport
Arturo Merino Benitez
Airlines serving
Air Canada, American Airlines, Delta, United
Roundtrip price
$764
Distance
4493 mi

Book with confidence

McAllen to Santiago Flights

The cheapest times to fly from McAllen to Santiago

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from McAllen to Santiago are during the month of January. You can find some of the cheapest flights from McAllen to Santiago with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from McAllen to Santiago

Sunday is one of the best days to book for cheap flights from McAllen to Santiago: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from McAllen to Santiago

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from McAllen to Santiago in 2025. You can also book with separate airlines for your outbound and return journeys, from $543 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap McAllen to Santiago flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your McAllen to Santiago airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

McAllen to Santiago Flights

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*Available to One Key members.