$100 Cheap Flights from Myrtle Beach (MYR) to Key West (EYW)

View $100 flight on Wed, Dec 31, 2025Opens in a new window

Popular airlines from Myrtle Beach Intl. Airport (MYR) to Key West Intl. Airport (EYW)

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Cheap Flights from Myrtle Beach to Key West (MYR-EYW)

Prices were available within the past 7 days and start at $100 for one-way flights and $224 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Wed, Dec 31 - Fri, Jan 9
MYR
Myrtle Beach
EYW
Key West
$224 Roundtrip, found 3 hours ago
$224
Roundtrip
found 3 hours ago
Select American Airlines flight, departing Wed, Dec 31 from Myrtle Beach to Key West, returning Fri, Jan 9, priced at $224 found 3 hours ago
American Airlines
Tue, Jan 13 - Sat, Jan 17
MYR
Myrtle Beach
EYW
Key West
$225 Roundtrip, found 3 days ago
$225
Roundtrip
found 3 days ago
Select American Airlines flight, departing Tue, Jan 13 from Myrtle Beach to Key West, returning Sat, Jan 17, priced at $225 found 3 days ago
Delta
Thu, Jan 1 - Thu, Jan 8
MYR
Myrtle Beach
EYW
Key West
$233 Roundtrip, found 3 hours ago
$233
Roundtrip
found 3 hours ago
Select Delta flight, departing Thu, Jan 1 from Myrtle Beach to Key West, returning Thu, Jan 8, priced at $233 found 3 hours ago
Delta
Tue, Dec 9 - Thu, Dec 25
MYR
Myrtle Beach
EYW
Key West
$234 Roundtrip, found 4 days ago
$234
Roundtrip
found 4 days ago
Select Delta flight, departing Tue, Dec 9 from Myrtle Beach to Key West, returning Thu, Dec 25, priced at $234 found 4 days ago
Delta
Tue, Oct 28 - Sun, Nov 2
MYR
Myrtle Beach
EYW
Key West
$249 Roundtrip, found 1 hour ago
$249
Roundtrip
found 1 hour ago
Select Delta flight, departing Tue, Oct 28 from Myrtle Beach to Key West, returning Sun, Nov 2, priced at $249 found 1 hour ago
Delta
Tue, Oct 28 - Wed, Oct 29
MYR
Myrtle Beach
EYW
Key West
$251 Roundtrip, found 1 hour ago
$251
Roundtrip
found 1 hour ago
Select Delta flight, departing Tue, Oct 28 from Myrtle Beach to Key West, returning Wed, Oct 29, priced at $251 found 1 hour ago
American Airlines
Wed, Dec 31 - Fri, Jan 9
MYR
Myrtle Beach
EYW
Key West
$254 Roundtrip, found 3 hours ago
$254
Roundtrip
found 3 hours ago
Select American Airlines flight, departing Wed, Dec 31 from Myrtle Beach to Key West, returning Fri, Jan 9, priced at $254 found 3 hours ago
Delta
Wed, Dec 31 - Thu, Jan 15
MYR
Myrtle Beach
EYW
Key West
$263 Roundtrip, found 4 days ago
$263
Roundtrip
found 4 days ago
Select Delta flight, departing Wed, Dec 31 from Myrtle Beach to Key West, returning Thu, Jan 15, priced at $263 found 4 days ago
Breeze Airways
Thu, Nov 27 - Mon, Dec 8
MYR
Myrtle Beach
EYW
Key West
$547 Roundtrip, found 5 days ago
$547
Roundtrip
found 5 days ago
Select Breeze Airways flight, departing Thu, Nov 27 from Myrtle Beach to Key West, returning Mon, Dec 8, priced at $547 found 5 days ago
United
Fri, Jul 17 - Mon, Jul 20
MYR
Myrtle Beach
EYW
Key West
$749 Roundtrip, found 15 hours ago
$749
Roundtrip
found 15 hours ago
Select United flight, departing Fri, Jul 17 from Myrtle Beach to Key West, returning Mon, Jul 20, priced at $749 found 15 hours ago

Find the cheapest month to fly from Myrtle Beach (MYR) to Key West (EYW)

May is typically the cheapest month to fly

From $199 - $538 per traveler.

Frequently asked questions

How much does a flight from Myrtle Beach Intl. Airport (MYR) to Key West Intl. Airport (EYW) cost?
Snag a cheap one-way flight from $100 or cheap return flight from $224 from Myrtle Beach Intl. Airport (MYR) to Key West Intl. Airport (EYW) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight deals on this route.
What is the cheapest month to fly from Myrtle Beach Intl. Airport (MYR) to Key West Intl. Airport (EYW)?
December is the least expensive month to fly from MYR to EYW. Timing your trip outside of the busy season is often the key to finding better fares.
What is the cheapest airline that flies from Myrtle Beach Intl. Airport (MYR) to Key West Intl. Airport (EYW)?
Expedia's filter tool lets you easily compare airlines, flight times and baggage options all in one place. Customize the search to your preferences, then sort by "Price (lowest to highest)" to find out which carrier offers the cheapest MYR to EYW flight.
How many flights per day from Myrtle Beach Intl. Airport (MYR) to Key West Intl. Airport (EYW)?
There are no daily nonstop flights from Myrtle Beach Intl. Airport (MYR) to Key West Intl. Airport (EYW). But you can choose flights with layovers. Filter your search on Expedia to include one or more stops, and you'll be on your way before you know it.
What day of the week has the most flights from MYR to EYW?
You'll usually find Tuesday the quietest day for flights, while Fridays are often the busiest.* However this can change from season to season and during public holidays or peak travel times.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Myrtle Beach Intl. Airport (MYR) to Key West Intl. Airport (EYW)?
To avoid possible delays on the Myrtle Beach Intl. Airport (MYR) to Key West Intl. Airport (EYW) route, travel before 3 PM. Later flights have a 22% higher chance of cancellation.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Myrtle Beach Intl. Airport (MYR) to Key West Intl. Airport (EYW) last-minute?
Booking your ticket from MYR to EYW just before your journey is generally more expensive. But if you're flexible with your travel times and dates, you could score a cheap last-minute fare.
Is it cheaper to book a MYR to EYW flight and hotel package?
Securing a MYR to EYW flight and hotel package tends to be cheaper than booking separately. With Expedia, you can enjoy the convenience of organizing your travels in one place. Pick from our extensive range of accommodations and then add car rentals, activities and flights to your booking. Bundle it all together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Myrtle Beach Intl. Airport (MYR) to Key West Intl. Airport (EYW)?
Generally, it's possible to reschedule or cancel your MYR to EYW flight. However, for bookings made more than 24 hours ago, additional charges may apply. Check your airline's policies in your itinerary to see what changes are allowed and if any costs are involved. You'll also find more details on our Customer Service portal.

Travel information

Travel information

Origin airport
Myrtle Beach Intl.
Destination airport
Key West Intl.
Airlines serving
American Airlines, Breeze Airways, Delta, United
Roundtrip price
$223
Distance
653 mi

Book with confidence

Book with confidence

Myrtle Beach to Key West Flights

The cheapest times to fly from Myrtle Beach to Key West

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Myrtle Beach to Key West are during the month of December. You can find some of the cheapest flights from Myrtle Beach to Key West with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Myrtle Beach to Key West

Sunday is one of the best days to book for cheap flights from Myrtle Beach to Key West: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Myrtle Beach to Key West

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Myrtle Beach to Key West in 2025. You can also book with separate airlines for your outbound and return journeys, from $100 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Myrtle Beach to Key West flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Myrtle Beach to Key West airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Myrtle Beach to Key West Flights

Explore a world of travel with Expedia

Explore a world of travel with Expedia

*Available to One Key members.