$518 Cheap Flights from Myrtle Beach (MYR) to Santiago (SCL)

View $518 flight on Thu, Feb 26, 2026Opens in a new window

Popular airlines from Myrtle Beach Intl. Airport (MYR) to Santiago Intl. Airport (SCL)

Cheap Flights from Myrtle Beach to Santiago (MYR-SCL)

Prices were available within the past 7 days and start at $518 for one-way flights and $714 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Tue, Feb 24 - Wed, Mar 4
MYR
Myrtle Beach
SCL
Santiago
$714 Roundtrip, found 1 day ago
$714
Roundtrip
found 1 day ago
Select Delta flight, departing Tue, Feb 24 from Myrtle Beach to Santiago, returning Wed, Mar 4, priced at $714 found 1 day ago
Delta
Sun, Mar 1 - Mon, Mar 9
MYR
Myrtle Beach
SCL
Santiago
$721 Roundtrip, found 1 day ago
$721
Roundtrip
found 1 day ago
Select Delta flight, departing Sun, Mar 1 from Myrtle Beach to Santiago, returning Mon, Mar 9, priced at $721 found 1 day ago
LATAM Airlines Group
Wed, Feb 25 - Wed, Mar 4
MYR
Myrtle Beach
SCL
Santiago
$739 Roundtrip, found 1 day ago
$739
Roundtrip
found 1 day ago
Select LATAM Airlines Group flight, departing Wed, Feb 25 from Myrtle Beach to Santiago, returning Wed, Mar 4, priced at $739 found 1 day ago
LATAM Airlines Group
Wed, Feb 25 - Sun, Mar 8
MYR
Myrtle Beach
SCL
Santiago
$744 Roundtrip, found 1 day ago
$744
Roundtrip
found 1 day ago
Select LATAM Airlines Group flight, departing Wed, Feb 25 from Myrtle Beach to Santiago, returning Sun, Mar 8, priced at $744 found 1 day ago
LATAM Airlines Group
Sun, Mar 1 - Sun, Mar 8
MYR
Myrtle Beach
SCL
Santiago
$746 Roundtrip, found 1 day ago
$746
Roundtrip
found 1 day ago
Select LATAM Airlines Group flight, departing Sun, Mar 1 from Myrtle Beach to Santiago, returning Sun, Mar 8, priced at $746 found 1 day ago
LATAM Airlines Group
Sun, Feb 1 - Tue, Feb 10
MYR
Myrtle Beach
SCL
Santiago
$749 Roundtrip, found 3 days ago
$749
Roundtrip
found 3 days ago
Select LATAM Airlines Group flight, departing Sun, Feb 1 from Myrtle Beach to Santiago, returning Tue, Feb 10, priced at $749 found 3 days ago
Delta
Tue, Feb 24 - Fri, Mar 6
MYR
Myrtle Beach
SCL
Santiago
$754 Roundtrip, found 1 day ago
$754
Roundtrip
found 1 day ago
Select Delta flight, departing Tue, Feb 24 from Myrtle Beach to Santiago, returning Fri, Mar 6, priced at $754 found 1 day ago
LATAM Airlines Group
Sun, Feb 1 - Tue, Feb 10
MYR
Myrtle Beach
SCL
Santiago
$763 Roundtrip, found 3 days ago
$763
Roundtrip
found 3 days ago
Select LATAM Airlines Group flight, departing Sun, Feb 1 from Myrtle Beach to Santiago, returning Tue, Feb 10, priced at $763 found 3 days ago
LATAM Airlines Group
Fri, Feb 27 - Wed, Mar 4
MYR
Myrtle Beach
SCL
Santiago
$779 Roundtrip, found 1 day ago
$779
Roundtrip
found 1 day ago
Select LATAM Airlines Group flight, departing Fri, Feb 27 from Myrtle Beach to Santiago, returning Wed, Mar 4, priced at $779 found 1 day ago
Air Canada
Fri, Nov 21 - Sat, Nov 29
MYR
Myrtle Beach
SCL
Santiago
$2,864 Roundtrip, found 3 days ago
$2,864
Roundtrip
found 3 days ago
Select Air Canada flight, departing Fri, Nov 21 from Myrtle Beach to Santiago, returning Sat, Nov 29, priced at $2,864 found 3 days ago
Flights from Myrtle Beach (MYR) to Santiago (SCL)
Origin airport
Myrtle Beach Intl.
Destination airport
Arturo Merino Benitez
Airlines serving
American Airlines, Delta, LATAM Airlines Group, United
Roundtrip price
$714
Distance
4664 mi

Myrtle Beach to Santiago Flights

The cheapest times to fly from Myrtle Beach to Santiago

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Myrtle Beach to Santiago are during the month of February. You can find some of the cheapest flights from Myrtle Beach to Santiago with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Myrtle Beach to Santiago

Sunday is one of the best days to book for cheap flights from Myrtle Beach to Santiago: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Myrtle Beach to Santiago

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Myrtle Beach to Santiago in 2025. You can also book with separate airlines for your outbound and return journeys, from $518 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Myrtle Beach to Santiago flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Myrtle Beach to Santiago airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Myrtle Beach Intl. Airport (MYR) to Arturo Merino Benitez Airport (SCL) cost?
Snag a cheap one-way flight from $518 or cheap return flight from $714 from Myrtle Beach Intl. Airport (MYR) to Arturo Merino Benitez Airport (SCL) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from Myrtle Beach Intl. Airport (MYR) to Arturo Merino Benitez Airport (SCL)?
February is the cheapest month to fly from MYR to SCL. Avoiding peak travel times is often the key to better flight prices.
What is the cheapest airline that flies from Myrtle Beach Intl. Airport (MYR) to Arturo Merino Benitez Airport (SCL)?
Use the filters on Expedia to compare airlines and find the cheapest carrier that'll take you from MYR to SCL. Then, sort your results by "Price (lowest to highest)" to score a great deal.
How many flights per day from Myrtle Beach Intl. Airport (MYR) to Arturo Merino Benitez Airport (SCL)?
Nonstop flights from Myrtle Beach Intl. Airport (MYR) to Arturo Merino Benitez Airport (SCL) aren't available daily, so you'll need to take a flight with a layover. Explore your options with Expedia's filters. Enter your dates and choose either "1 Stop" or "2+ Stops."
What day of the week has the most flights from MYR to SCL?
Generally you'll find the most flight options available on a Friday. Tuesdays tend to be the quietest.* However, this can change based on the airline, season and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Myrtle Beach Intl. Airport (MYR) to Arturo Merino Benitez Airport (SCL)?
To touch down at Arturo Merino Benitez Airport (SCL) without delays, select a flight that takes off from Myrtle Beach Intl. Airport (MYR) before 3 PM. The likelihood of cancellations is 22% higher, on average, for departures after this time.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Myrtle Beach Intl. Airport (MYR) to Arturo Merino Benitez Airport (SCL) last-minute?
Holding off until just before your departure to book a flight from MYR to SCL often results in higher prices. While you may find some last-minute discounts, they aren't always guaranteed. Allow some flexibility in your schedule for a better chance of scoring a bargain.
Is it cheaper to book a MYR to SCL flight and hotel package?
Compared with arranging flights and hotels separately, booking a MYR to SCL flight and hotel package with Expedia could result in significant savings. What's more, having it all in one place will take the hassle out of planning your trip. Just pick your flights and select from our wide range of stays, then customize your trip with extras like activities and car rentals.
Can I cancel or change the date of my flight from Myrtle Beach Intl. Airport (MYR) to Arturo Merino Benitez Airport (SCL)?
If you booked your MYR to SCL flight in the last 24 hours, you may be able to cancel or modify it without any fees. Depending on the airline and the type of fare you have, additional charges may apply for changes after that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, go to our Customer Service portal for more details.

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*Available to One Key members.