$542 Cheap Flights from Panama City (PTY) to Brussels (BRU)

View $542 flight on Wed, Aug 13, 2025Opens in a new window

Popular airlines from Tocumen Intl. Airport (PTY) to Brussels Airport (BRU)

Cheap Flights from Panama City to Brussels (PTY-BRU)

Prices were available within the past 7 days and start at $542 for one-way flights and $750 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Condor
Mon, Sep 22 - Wed, Sep 24
PTY
Panama City
BRU
Brussels
$750 Roundtrip, found 17 hours ago
$750
Roundtrip
found 17 hours ago
Select Condor flight, departing Mon, Sep 22 from Panama City to Brussels, returning Wed, Sep 24, priced at $750 found 17 hours ago
Turkish Airlines
Wed, Oct 8 - Wed, Oct 15
PTY
Panama City
BRU
Brussels
$757 Roundtrip, found 6 days ago
$757
Roundtrip
found 6 days ago
Select Turkish Airlines flight, departing Wed, Oct 8 from Panama City to Brussels, returning Wed, Oct 15, priced at $757 found 6 days ago
Condor
Mon, Sep 22 - Wed, Sep 24
PTY
Panama City
BRU
Brussels
$770 Roundtrip, found 17 hours ago
$770
Roundtrip
found 17 hours ago
Select Condor flight, departing Mon, Sep 22 from Panama City to Brussels, returning Wed, Sep 24, priced at $770 found 17 hours ago
Air Europa
Thu, Nov 6 - Sun, Nov 16
PTY
Panama City
BRU
Brussels
$785 Roundtrip, found 1 day ago
$785
Roundtrip
found 1 day ago
Select Air Europa flight, departing Thu, Nov 6 from Panama City to Brussels, returning Sun, Nov 16, priced at $785 found 1 day ago
Turkish Airlines
Fri, Oct 10 - Wed, Oct 15
PTY
Panama City
BRU
Brussels
$787 Roundtrip, found 6 days ago
$787
Roundtrip
found 6 days ago
Select Turkish Airlines flight, departing Fri, Oct 10 from Panama City to Brussels, returning Wed, Oct 15, priced at $787 found 6 days ago
Turkish Airlines
Thu, Oct 9 - Wed, Oct 15
PTY
Panama City
BRU
Brussels
$792 Roundtrip, found 6 days ago
$792
Roundtrip
found 6 days ago
Select Turkish Airlines flight, departing Thu, Oct 9 from Panama City to Brussels, returning Wed, Oct 15, priced at $792 found 6 days ago
Air Europa
Thu, Nov 6 - Wed, Nov 19
PTY
Panama City
BRU
Brussels
$796 Roundtrip, found 1 day ago
$796
Roundtrip
found 1 day ago
Select Air Europa flight, departing Thu, Nov 6 from Panama City to Brussels, returning Wed, Nov 19, priced at $796 found 1 day ago
Iberia
Mon, Nov 10 - Mon, Nov 24
PTY
Panama City
BRU
Brussels
$815 Roundtrip, found 1 day ago
$815
Roundtrip
found 1 day ago
Select Iberia flight, departing Mon, Nov 10 from Panama City to Brussels, returning Mon, Nov 24, priced at $815 found 1 day ago
Turkish Airlines
Wed, Oct 8 - Thu, Oct 16
PTY
Panama City
BRU
Brussels
$816 Roundtrip, found 2 days ago
$816
Roundtrip
found 2 days ago
Select Turkish Airlines flight, departing Wed, Oct 8 from Panama City to Brussels, returning Thu, Oct 16, priced at $816 found 2 days ago
KLM
Sun, Oct 19 - Sun, Oct 26
PTY
Panama City
BRU
Brussels
$853 Roundtrip, found 1 day ago
$853
Roundtrip
found 1 day ago
Select KLM flight, departing Sun, Oct 19 from Panama City to Brussels, returning Sun, Oct 26, priced at $853 found 1 day ago

Alternative airports near Brussels

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Brussels - National BRU. Cheapest and Closest option available. Average driving time to city center is 15 minutes. Flights from $1,100
BRU
Brussels - National
CheapestClosest
Average driving time to city center15 min
Flights from $1,100
Flights from Panama City (PTY) to Brussels (BRU)
Origin airport
Tocumen Intl.
Destination airport
Brussels - National
Airlines serving
Air Europa, American Airlines, Delta, Iberia, KLM, Turkish Airlines, United
Roundtrip price
$750
Distance
5466 mi

Panama City to Brussels Flights

The cheapest times to fly from Panama City to Brussels

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Panama City to Brussels are during the month of September. You can find some of the cheapest flights from Panama City to Brussels with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Panama City to Brussels

Sunday is one of the best days to book for cheap flights from Panama City to Brussels: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Panama City to Brussels

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Panama City to Brussels in 2025. You can also book with separate airlines for your outbound and return journeys, from $542 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Panama City to Brussels flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Panama City to Brussels airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Tocumen Intl. Airport (PTY) to Brussels - National Airport (BRU) cost?
Discover the latest flight deals from PTY to BRU by entering your preferred travel dates and searching on Expedia. Easily compare prices by departure date if you have flexibility with your schedule and use handy filters to explore prices for your preferred journey. As a member of One Key™, our free loyalty program, you can use Price Tracking to watch fares and receive notifications if prices go up or down.
What is the cheapest month to fly from PTY to BRU?
The cheapest flights from PTY to BRU are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
What is the cheapest airline that flies from PTY to BRU?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that'll take you from PTY to BRU. Sort your results by "Price (lowest to highest)" to snap up a great deal.
How many flights per day from Tocumen Intl. Airport (PTY) to Brussels - National Airport (BRU)?
You'll need to take a flight with a layover if you're traveling from Tocumen Intl. Airport (PTY) to Brussels - National Airport (BRU). Direct flights don't operate daily on this route. However, simply filter your search to include one or more stops to find an option that works for you.
What day of the week has the most flights from PTY to BRU?
You'll usually find Tuesday the quietest day for flights, while Fridays tend to be the busiest.* However this can vary from season to season and during public holidays or peak travel times.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Tocumen Intl. Airport (PTY) to Brussels - National Airport (BRU)?
To avoid potential delays on the Tocumen Intl. Airport (PTY) to Brussels - National Airport (BRU) route, aim to fly before 3 PM. Later departures are 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Tocumen Intl. Airport (PTY) to Brussels - National Airport (BRU) last-minute?
Last-minute bookings from PTY to BRU are generally more expensive. To lock in the best prices, start looking for flights ahead of time. That said, if your travel plans are flexible, you may land a cheap ticket right before your trip.
Is it cheaper to book a PTY to BRU flight and hotel package?
Compared with arranging hotels and flights separately, booking a PTY to BRU flight and hotel package with Expedia could result in significant savings. Better still, managing everything in one place takes the hassle out of travel planning. Simply secure your flights and choose from our wide range of hotels, then personalize your trip with other add-ons like activities, tours and car rentals.
Can I cancel or change the date of my flight from Tocumen Intl. Airport (PTY) to Brussels - National Airport (BRU)?
Typically, it's possible to reschedule or cancel your PTY to BRU flight. However, for bookings made more than 24 hours ago, additional fees may apply. Check your airline's policies in your itinerary to see what changes are allowed and if any costs are involved. You'll also find more details on our Customer Service portal.

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*Available to One Key members.