$603 Cheap Flights from Panama City (PTY) to Istanbul (IST)

View $603 flight on Fri, Mar 6, 2026Opens in a new window

Popular airlines from Tocumen Intl. Airport (PTY) to Istanbul Airport (IST)

Cheap Flights from Panama City to Istanbul (PTY-IST)

Prices were available within the past 7 days and start at $603 for one-way flights and $994 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Air Europa
Mon, May 4 - Sun, May 10
PTY
Panama City
IST
Istanbul
$994 Roundtrip, found 13 hours ago
$994
Roundtrip
found 13 hours ago
Select Air Europa flight, departing Mon, May 4 from Panama City to Istanbul, returning Sun, May 10, priced at $994 found 13 hours ago
Air Europa
Wed, Mar 11 - Thu, Mar 19
PTY
Panama City
IST
Istanbul
$1,031 Roundtrip, found 11 hours ago
$1,031
Roundtrip
found 11 hours ago
Select Air Europa flight, departing Wed, Mar 11 from Panama City to Istanbul, returning Thu, Mar 19, priced at $1,031 found 11 hours ago
Lufthansa
Mon, Mar 9 - Mon, Mar 16
PTY
Panama City
IST
Istanbul
$1,067 Roundtrip, found 1 day ago
$1,067
Roundtrip
found 1 day ago
Select Lufthansa flight, departing Mon, Mar 9 from Panama City to Istanbul, returning Mon, Mar 16, priced at $1,067 found 1 day ago
Air Europa
Tue, Feb 10 - Mon, Mar 30
PTY
Panama City
IST
Istanbul
$1,069 Roundtrip, found 8 hours ago
$1,069
Roundtrip
found 8 hours ago
Select Air Europa flight, departing Tue, Feb 10 from Panama City to Istanbul, returning Mon, Mar 30, priced at $1,069 found 8 hours ago
Air Europa
Tue, Mar 3 - Thu, Mar 12
PTY
Panama City
IST
Istanbul
$1,069 Roundtrip, just found
$1,069
Roundtrip
just found
Select Air Europa flight, departing Tue, Mar 3 from Panama City to Istanbul, returning Thu, Mar 12, priced at $1,069 just found
Lufthansa
Fri, Mar 6 - Sat, Mar 14
PTY
Panama City
IST
Istanbul
$1,071 Roundtrip, just found
$1,071
Roundtrip
just found
Select Lufthansa flight, departing Fri, Mar 6 from Panama City to Istanbul, returning Sat, Mar 14, priced at $1,071 just found
Lufthansa
Fri, Feb 13 - Fri, Feb 20
PTY
Panama City
IST
Istanbul
$1,088 Roundtrip, found 1 day ago
$1,088
Roundtrip
found 1 day ago
Select Lufthansa flight, departing Fri, Feb 13 from Panama City to Istanbul, returning Fri, Feb 20, priced at $1,088 found 1 day ago
Copa
Tue, Feb 10 - Mon, Feb 23
PTY
Panama City
IST
Istanbul
$1,114 Roundtrip, found 21 hours ago
$1,114
Roundtrip
found 21 hours ago
Select Copa flight, departing Tue, Feb 10 from Panama City to Istanbul, returning Mon, Feb 23, priced at $1,114 found 21 hours ago
United
Sun, Feb 15 - Mon, Feb 23
PTY
Panama City
IST
Istanbul
$1,115 Roundtrip, found 1 day ago
$1,115
Roundtrip
found 1 day ago
Select United flight, departing Sun, Feb 15 from Panama City to Istanbul, returning Mon, Feb 23, priced at $1,115 found 1 day ago
Turkish Airlines
Wed, Feb 4 - Fri, Feb 6
PTY
Panama City
IST
Istanbul
$1,311 Roundtrip, found 22 hours ago
$1,311
Roundtrip
found 22 hours ago
Select Turkish Airlines flight, departing Wed, Feb 4 from Panama City to Istanbul, returning Fri, Feb 6, priced at $1,311 found 22 hours ago

Find the cheapest month to fly from Panama City (PTY) to Istanbul (IST)

February is typically the cheapest month to fly

From $870 - $1,569 per traveler.

Alternative airports near Istanbul

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Istanbul Airport IST. Cheapest option available. Average driving time to city center is 35 minutes. Flights from $1,416
IST
Istanbul Airport
Cheapest
Average driving time to city center35 min
Flights from $1,416
Flights from Panama City (PTY) to Istanbul (IST)
Origin airport
Tocumen Intl.
Destination airport
Istanbul
Airlines serving
Air Europa, Air France, American Airlines, Copa, Delta, Iberia, KLM, Lufthansa, Turkish Airlines, United, avianca
Roundtrip price
$993
Distance
6722 mi
Average flight time
20 hours 46 mins

Panama City to Istanbul Flights

The cheapest times to fly from Panama City to Istanbul

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Panama City to Istanbul are during the month of May. You can find some of the cheapest flights from Panama City to Istanbul with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Panama City to Istanbul

Sunday is one of the best days to book for cheap flights from Panama City to Istanbul: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Panama City to Istanbul

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Panama City to Istanbul in 2026. You can also book with separate airlines for your outbound and return journeys, from $603 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Panama City to Istanbul flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Panama City to Istanbul airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Tocumen Intl. Airport (PTY) to Istanbul (IST) cost?
Get a cheap one-way flight from $603 or cheap return flight from $994 from Tocumen Intl. Airport (PTY) to Istanbul (IST) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from Tocumen Intl. Airport (PTY) to Istanbul (IST)?
Flying in May can help you save, as it's the cheapest month for flights between PTY and IST. You'll often find the lowest fares during the off-season.
What is the cheapest airline that flies from Tocumen Intl. Airport (PTY) to Istanbul (IST)?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that'll take you from PTY to IST. Then, sort your results by "Price (lowest to highest)" to snap up the best deal available.
How many flights per day from Tocumen Intl. Airport (PTY) to Istanbul (IST)?
You'll need to catch a flight with a layover when traveling from Tocumen Intl. Airport (PTY) to Istanbul (IST). There are no daily direct flights on this route. However, just filter your search to include one or two stops to find an option that works for you.
What day of the week has the most flights from PTY to IST?
Friday is generally the busiest day for flights, while Tuesday is often the quietest.* Remember that flight schedules can vary based on various factors, including the airline and season.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What airline has the least delays from PTY to IST?
With 100% of journeys generally arriving on time, Turkish Airlines has the best on-time performance for nonstop flights from Tocumen Intl. Airport (PTY) to Istanbul (IST). To keep track of your flight status and receive notifications about any changes, use the Expedia App.
What is the best time to fly from Tocumen Intl. Airport (PTY) to Istanbul (IST)?
To touch down at Istanbul (IST) on time, choose a flight that leaves Tocumen Intl. Airport (PTY) before 3 PM. The chance of cancellations is 22% higher, on average, for departures after this hour.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Tocumen Intl. Airport (PTY) to Istanbul (IST) last-minute?
Last-minute fares from PTY to IST are typically more expensive. To lock in the cheapest rates, start looking for flights well in advance. That said, if you can play around with your travel dates, you may find a cheap ticket right before your journey.
Can I cancel or change the date of my flight from Tocumen Intl. Airport (PTY) to Istanbul (IST)?
Typically, you're able to reschedule or cancel your PTY to IST flight. However, additional charges may apply, especially if you booked more than 24 hours ago. Double-check your itinerary for the airline's fees and policies on flight changes, or if you need more details, visit our Customer Service portal.

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*Available to One Key members.