$620 Cheap Flights from Panama City (PTY) to Istanbul (IST)

View $620 flight on Mon, Nov 17, 2025Opens in a new window

Popular airlines from Tocumen Intl. Airport (PTY) to Istanbul Airport (IST)

Cheap Flights from Panama City to Istanbul (PTY-IST)

Prices were available within the past 7 days and start at $620 for one-way flights and $871 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

KLM
Wed, Feb 4 - Sat, Feb 14
PTY
Panama City
IST
Istanbul
$871 Roundtrip, found 2 days ago
$871
Roundtrip
found 2 days ago
Select KLM flight, departing Wed, Feb 4 from Panama City to Istanbul, returning Sat, Feb 14, priced at $871 found 2 days ago
Air France
Thu, Nov 13 - Thu, Nov 27
PTY
Panama City
IST
Istanbul
$871 Roundtrip, found 1 day ago
$871
Roundtrip
found 1 day ago
Select Air France flight, departing Thu, Nov 13 from Panama City to Istanbul, returning Thu, Nov 27, priced at $871 found 1 day ago
avianca
Wed, Feb 11 - Wed, Feb 18
PTY
Panama City
IST
Istanbul
$890 Roundtrip, found 14 hours ago
$890
Roundtrip
found 14 hours ago
Select avianca flight, departing Wed, Feb 11 from Panama City to Istanbul, returning Wed, Feb 18, priced at $890 found 14 hours ago
avianca
Mon, Nov 10 - Wed, Nov 26
PTY
Panama City
IST
Istanbul
$902 Roundtrip, found 1 day ago
$902
Roundtrip
found 1 day ago
Select avianca flight, departing Mon, Nov 10 from Panama City to Istanbul, returning Wed, Nov 26, priced at $902 found 1 day ago
avianca
Mon, Feb 9 - Tue, Feb 24
PTY
Panama City
IST
Istanbul
$918 Roundtrip, found 10 hours ago
$918
Roundtrip
found 10 hours ago
Select avianca flight, departing Mon, Feb 9 from Panama City to Istanbul, returning Tue, Feb 24, priced at $918 found 10 hours ago
avianca
Mon, Nov 10 - Mon, Nov 17
PTY
Panama City
IST
Istanbul
$946 Roundtrip, found 15 hours ago
$946
Roundtrip
found 15 hours ago
Select avianca flight, departing Mon, Nov 10 from Panama City to Istanbul, returning Mon, Nov 17, priced at $946 found 15 hours ago
Copa
Mon, Jan 26 - Wed, Feb 4
PTY
Panama City
IST
Istanbul
$957 Roundtrip, found 11 hours ago
$957
Roundtrip
found 11 hours ago
Select Copa flight, departing Mon, Jan 26 from Panama City to Istanbul, returning Wed, Feb 4, priced at $957 found 11 hours ago
Copa
Fri, Feb 13 - Thu, Mar 5
PTY
Panama City
IST
Istanbul
$959 Roundtrip, found 22 hours ago
$959
Roundtrip
found 22 hours ago
Select Copa flight, departing Fri, Feb 13 from Panama City to Istanbul, returning Thu, Mar 5, priced at $959 found 22 hours ago
Air France
Tue, Dec 2 - Thu, Dec 4
PTY
Panama City
IST
Istanbul
$962 Roundtrip, found 2 days ago
$962
Roundtrip
found 2 days ago
Select Air France flight, departing Tue, Dec 2 from Panama City to Istanbul, returning Thu, Dec 4, priced at $962 found 2 days ago
Air Europa
Mon, May 4 - Sun, May 10
PTY
Panama City
IST
Istanbul
$994 Roundtrip, found 4 hours ago
$994
Roundtrip
found 4 hours ago
Select Air Europa flight, departing Mon, May 4 from Panama City to Istanbul, returning Sun, May 10, priced at $994 found 4 hours ago

Find the cheapest month to fly from Panama City (PTY) to Istanbul (IST)

November is typically the cheapest month to fly

From $879 - $1,881 per traveler.

Alternative airports near Istanbul

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Istanbul Airport IST. Cheapest option available. Average driving time to city center is 35 minutes. Flights from $1,145
IST
Istanbul Airport
Cheapest
Average driving time to city center35 min
Flights from $1,145

Frequently asked questions

How much does a flight from Tocumen Intl. Airport (PTY) to Istanbul (IST) cost?
Get a cheap one-way flight from $620 or cheap return flight from $871 from Tocumen Intl. Airport (PTY) to Istanbul (IST) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from Tocumen Intl. Airport (PTY) to Istanbul (IST)?
Flying in February can help you save, as it's the cheapest month for flights between PTY and IST. You'll often find the lowest fares during the off-season.
What is the cheapest airline that flies from Tocumen Intl. Airport (PTY) to Istanbul (IST)?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that'll take you from PTY to IST. Then, sort your results by "Price (lowest to highest)" to snap up the best deal available.
How many flights per day from Tocumen Intl. Airport (PTY) to Istanbul (IST)?
You'll need to catch a flight with a layover when traveling from Tocumen Intl. Airport (PTY) to Istanbul (IST). There are no daily direct flights on this route. However, just filter your search to include one or two stops to find an option that works for you.
What day of the week has the most flights from PTY to IST?
Friday is generally the busiest day for flights, while Tuesday is often the quietest.* Remember that flight schedules can vary based on various factors, including the airline and season.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What airline has the least delays from PTY to IST?
With 100% of journeys generally arriving on time, Turkish Airlines has the best on-time performance for nonstop flights from Tocumen Intl. Airport (PTY) to Istanbul (IST). To keep track of your flight status and receive notifications about any changes, use the Expedia App.
What is the best time to fly from Tocumen Intl. Airport (PTY) to Istanbul (IST)?
To touch down at Istanbul (IST) on time, choose a flight that leaves Tocumen Intl. Airport (PTY) before 3 PM. The chance of cancellations is 22% higher, on average, for departures after this hour.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Tocumen Intl. Airport (PTY) to Istanbul (IST) last-minute?
Last-minute fares from PTY to IST are typically more expensive. To lock in the cheapest rates, start looking for flights well in advance. That said, if you can play around with your travel dates, you may find a cheap ticket right before your journey.
Can I cancel or change the date of my flight from Tocumen Intl. Airport (PTY) to Istanbul (IST)?
Typically, you're able to reschedule or cancel your PTY to IST flight. However, additional charges may apply, especially if you booked more than 24 hours ago. Double-check your itinerary for the airline's fees and policies on flight changes, or if you need more details, visit our Customer Service portal.

Travel information

Origin airport
Tocumen Intl.
Destination airport
Istanbul
Airlines serving
Air Europa, Air France, American Airlines, Copa, Delta, KLM, Turkish Airlines, United
Roundtrip price
$871
Distance
6722 mi
Average flight time
20 hours 45 mins

Book with confidence

Panama City to Istanbul Flights

The cheapest times to fly from Panama City to Istanbul

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Panama City to Istanbul are during the month of February. You can find some of the cheapest flights from Panama City to Istanbul with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Panama City to Istanbul

Sunday is one of the best days to book for cheap flights from Panama City to Istanbul: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Panama City to Istanbul

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Panama City to Istanbul in 2025. You can also book with separate airlines for your outbound and return journeys, from $620 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Panama City to Istanbul flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Panama City to Istanbul airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Panama City to Istanbul Flights

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*Available to One Key members.