$316 Cheap Flights from Panama City (PTY) to Santiago (SCL)

View $316 flight on Wed, Dec 10, 2025Opens in a new window

Popular airlines from Tocumen Intl. Airport (PTY) to Santiago Intl. Airport (SCL)

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Cheap Flights from Panama City to Santiago (PTY-SCL)

Prices were available within the past 7 days and start at $316 for one-way flights and $513 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Copa
Wed, Jan 7 - Wed, Jan 21
PTY
Panama City
SCL
Santiago
$513 Roundtrip, found 6 days ago
$513
Roundtrip
found 6 days ago
Select Copa flight, departing Wed, Jan 7 from Panama City to Santiago, returning Wed, Jan 21, priced at $513 found 6 days ago
Copa
Tue, Dec 16 - Tue, Dec 23
PTY
Panama City
SCL
Santiago
$529 Roundtrip, found 6 days ago
$529
Roundtrip
found 6 days ago
Select Copa flight, departing Tue, Dec 16 from Panama City to Santiago, returning Tue, Dec 23, priced at $529 found 6 days ago
Copa
Sat, Jan 10 - Sat, Jan 24
PTY
Panama City
SCL
Santiago
$530 Roundtrip, found 6 days ago
$530
Roundtrip
found 6 days ago
Select Copa flight, departing Sat, Jan 10 from Panama City to Santiago, returning Sat, Jan 24, priced at $530 found 6 days ago
Copa
Sat, Jan 10 - Sat, Jan 24
PTY
Panama City
SCL
Santiago
$545 Roundtrip, found 6 days ago
$545
Roundtrip
found 6 days ago
Select Copa flight, departing Sat, Jan 10 from Panama City to Santiago, returning Sat, Jan 24, priced at $545 found 6 days ago
Copa
Wed, Jan 7 - Sat, Jan 24
PTY
Panama City
SCL
Santiago
$561 Roundtrip, found 6 days ago
$561
Roundtrip
found 6 days ago
Select Copa flight, departing Wed, Jan 7 from Panama City to Santiago, returning Sat, Jan 24, priced at $561 found 6 days ago
Copa
Mon, Jan 19 - Thu, Mar 19
PTY
Panama City
SCL
Santiago
$572 Roundtrip, just found
$572
Roundtrip
just found
Select Copa flight, departing Mon, Jan 19 from Panama City to Santiago, returning Thu, Mar 19, priced at $572 just found
avianca
Mon, Jan 19 - Thu, Mar 19
PTY
Panama City
SCL
Santiago
$604 Roundtrip, just found
$604
Roundtrip
just found
Select avianca flight, departing Mon, Jan 19 from Panama City to Santiago, returning Thu, Mar 19, priced at $604 just found
Aeromexico
Sat, Mar 21 - Wed, Mar 25
PTY
Panama City
SCL
Santiago
$1,066 Roundtrip, found 3 hours ago
$1,066
Roundtrip
found 3 hours ago
Select Aeromexico flight, departing Sat, Mar 21 from Panama City to Santiago, returning Wed, Mar 25, priced at $1,066 found 3 hours ago
American Airlines
Wed, Aug 19 - Thu, Sep 10
PTY
Panama City
SCL
Santiago
$1,551 Roundtrip, found 1 day ago
$1,551
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Aug 19 from Panama City to Santiago, returning Thu, Sep 10, priced at $1,551 found 1 day ago
Delta
Sun, Dec 21 - Sun, Dec 28
PTY
Panama City
SCL
Santiago
$2,979 Roundtrip, found 1 day ago
$2,979
Roundtrip
found 1 day ago
Select Delta flight, departing Sun, Dec 21 from Panama City to Santiago, returning Sun, Dec 28, priced at $2,979 found 1 day ago

Find the cheapest month to fly from Panama City (PTY) to Santiago (SCL)

October is typically the cheapest month to fly

From $465 - $735 per traveler.

Alternative airports near Santiago

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Arturo Merino Benitez SCL. Cheapest and Closest option available. Average driving time to city center is 17 minutes. Flights from $753
SCL
Arturo Merino Benitez
CheapestClosest
Average driving time to city center17 min
Flights from $753
Flights from Panama City (PTY) to Santiago (SCL)
Origin airport
Tocumen Intl.
Destination airport
Arturo Merino Benitez
Airlines serving
Aeromexico, American Airlines, Copa, avianca
Roundtrip price
$513
Distance
2987 mi
Average flight time
8 hours 32 mins

Panama City to Santiago Flights

The cheapest times to fly from Panama City to Santiago

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Panama City to Santiago are during the month of January. You can find some of the cheapest flights from Panama City to Santiago with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Panama City to Santiago

Sunday is one of the best days to book for cheap flights from Panama City to Santiago: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Panama City to Santiago

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Panama City to Santiago in 2026. You can also book with separate airlines for your outbound and return journeys, from $316 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Panama City to Santiago flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Panama City to Santiago airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Tocumen Intl. Airport (PTY) to Arturo Merino Benitez Airport (SCL) cost?
Lock in a cheap one-way flight from $316 or cheap return flight from $513 from Tocumen Intl. Airport (PTY) to Arturo Merino Benitez Airport (SCL) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from Tocumen Intl. Airport (PTY) to Arturo Merino Benitez Airport (SCL)?
The cheapest month to fly from PTY to SCL is January, when there's less demand. Off-peak months are often when airlines offer lower prices between these airports.
Which airlines fly direct from Tocumen Intl. Airport (PTY) to Arturo Merino Benitez Airport (SCL)?
If you're departing from Tocumen Intl. Airport (PTY), you can board a direct flight to Arturo Merino Benitez Airport (SCL) with Copa Airlines.
What is the cheapest airline that flies from Tocumen Intl. Airport (PTY) to Arturo Merino Benitez Airport (SCL)?
To find the cheapest airline that'll fly you from PTY to SCL, use Expedia's filter tool. Customize your search based on what matters most to you, such as preferred carriers and seat class. You can then sort your results by "Price (lowest to highest)" to list the most affordable options first.
How many flights per day from Tocumen Intl. Airport (PTY) to Arturo Merino Benitez Airport (SCL)?
When taking off from Tocumen Intl. Airport (PTY), you can pick from an average of 5 daily nonstop flights to Arturo Merino Benitez Airport (SCL).
What are the most popular departure times for flights from Tocumen Intl. Airport (PTY) to Arturo Merino Benitez Airport (SCL)?
Flights between PTY and SCL are their busiest at 3 PM. For a quieter experience and possibly cheaper tickets, choose a departure that's outside typical rush times.
What day of the week has the most flights from PTY to SCL?
Friday offers the most flights from Tocumen Intl. Airport (PTY) to Arturo Merino Benitez Airport (SCL). Consider jetting off on this day and you'll have a greater chance of finding a departure that fits your plans.
What is the earliest flight from Tocumen Intl. Airport (PTY) to Arturo Merino Benitez Airport (SCL)?
Catch the earliest flight at around 11:47AM UTC-5, leaving from Tocumen Intl. Airport (PTY). You'll be flying for around 6h 32m, landing at Arturo Merino Benitez Airport (SCL) at approximately 8:19PM UTC-3.
How long does it take to fly from Tocumen Intl. Airport (PTY) to Arturo Merino Benitez Airport (SCL)?
The average flight time from PTY to SCL is 6 hours and 35 minutes, covering a total distance of 3,000 mi.
What airline has the least delays from PTY to SCL?
Consider traveling with American Airlines if you'd like to go straight from Tocumen Intl. Airport (PTY) to Arturo Merino Benitez Airport (SCL) without any delays. This airline has the best track record for punctuality, with an on-time score of 100%. Want real-time updates? You can check your flight status using the Expedia App.
What is the best time to fly from Tocumen Intl. Airport (PTY) to Arturo Merino Benitez Airport (SCL)?
Opt for a flight from Tocumen Intl. Airport (PTY) to Arturo Merino Benitez Airport (SCL) that leaves before 3 PM to reduce the likelihood of delays and cancellations. Departures after this hour have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
What airports do you fly into for Santiago from Tocumen Intl. Airport (PTY)?
Arturo Merino Benitez Airport (SCL) is the only airport in Santiago with direct flights from Tocumen Intl. Airport (PTY). Consider the options and discover cheap fares on Expedia.
Is it cheaper to buy a plane ticket from Tocumen Intl. Airport (PTY) to Arturo Merino Benitez Airport (SCL) last-minute?
Last-minute fares from PTY to SCL are generally more expensive. To secure the lowest rates, start looking for flights as early as possible. That said, if you can play around with your travel dates, you may land a cheap fare right before your trip.
Is it cheaper to book a PTY to SCL flight and hotel package?
Compared with arranging flights and hotels separately, booking a PTY to SCL flight and hotel package with Expedia could lead to significant savings. Better yet, having it all in one place takes the hassle out of travel planning. Simply secure your flights and select from our wide range of stays, then customize your trip with other add-ons like tours, car rentals and activities.
Can I cancel or change the date of my flight from Tocumen Intl. Airport (PTY) to Arturo Merino Benitez Airport (SCL)?
Typically, you're able to cancel or reschedule your PTY to SCL flight. However, there may be additional fees, especially if your booking was made over 24 hours ago. Double-check your itinerary for the airline's fees and guidelines on flight changes, or if you need further details, visit our Customer Service portal.

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*Available to One Key members.