$364 Cheap Flights from Panama City (PTY) to Santiago (SCL)

View $364 flight on Mon, Aug 11, 2025Opens in a new window

Popular airlines from Tocumen Intl. Airport (PTY) to Santiago Intl. Airport (SCL)

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Cheap Flights from Panama City to Santiago (PTY-SCL)

Prices were available within the past 7 days and start at $364 for one-way flights and $564 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Copa
Mon, Aug 11 - Mon, Aug 18
PTY
Panama City
SCL
Santiago
$564 Roundtrip, just found
$564
Roundtrip
just found
Select Copa flight, departing Mon, Aug 11 from Panama City to Santiago, returning Mon, Aug 18, priced at $564 just found
Copa
Mon, Aug 11 - Mon, Aug 18
PTY
Panama City
SCL
Santiago
$580 Roundtrip, just found
$580
Roundtrip
just found
Select Copa flight, departing Mon, Aug 11 from Panama City to Santiago, returning Mon, Aug 18, priced at $580 just found
Copa
Mon, Aug 11 - Mon, Aug 18
PTY
Panama City
SCL
Santiago
$596 Roundtrip, just found
$596
Roundtrip
just found
Select Copa flight, departing Mon, Aug 11 from Panama City to Santiago, returning Mon, Aug 18, priced at $596 just found
Copa
Tue, Aug 12 - Sat, Aug 16
PTY
Panama City
SCL
Santiago
$612 Roundtrip, found 2 hours ago
$612
Roundtrip
found 2 hours ago
Select Copa flight, departing Tue, Aug 12 from Panama City to Santiago, returning Sat, Aug 16, priced at $612 found 2 hours ago
Copa
Tue, Aug 19 - Tue, Aug 26
PTY
Panama City
SCL
Santiago
$628 Roundtrip, found 9 hours ago
$628
Roundtrip
found 9 hours ago
Select Copa flight, departing Tue, Aug 19 from Panama City to Santiago, returning Tue, Aug 26, priced at $628 found 9 hours ago
Copa
Sun, Sep 7 - Sat, Sep 20
PTY
Panama City
SCL
Santiago
$656 Roundtrip, found 4 days ago
$656
Roundtrip
found 4 days ago
Select Copa flight, departing Sun, Sep 7 from Panama City to Santiago, returning Sat, Sep 20, priced at $656 found 4 days ago
Copa
Sun, Sep 7 - Sat, Sep 20
PTY
Panama City
SCL
Santiago
$672 Roundtrip, found 4 days ago
$672
Roundtrip
found 4 days ago
Select Copa flight, departing Sun, Sep 7 from Panama City to Santiago, returning Sat, Sep 20, priced at $672 found 4 days ago
avianca
Mon, Aug 11 - Mon, Aug 18
PTY
Panama City
SCL
Santiago
$701 Roundtrip, just found
$701
Roundtrip
just found
Select avianca flight, departing Mon, Aug 11 from Panama City to Santiago, returning Mon, Aug 18, priced at $701 just found
Aeromexico
Tue, Dec 2 - Wed, Dec 17
PTY
Panama City
SCL
Santiago
$880 Roundtrip, just found
$880
Roundtrip
just found
Select Aeromexico flight, departing Tue, Dec 2 from Panama City to Santiago, returning Wed, Dec 17, priced at $880 just found
American Airlines
Mon, Dec 1 - Tue, Dec 16
PTY
Panama City
SCL
Santiago
$1,551 Roundtrip, just found
$1,551
Roundtrip
just found
Select American Airlines flight, departing Mon, Dec 1 from Panama City to Santiago, returning Tue, Dec 16, priced at $1,551 just found

Find the cheapest month to fly from Panama City (PTY) to Santiago (SCL)

August is typically the cheapest month to fly

From $401 - $700 per traveler.

Graph displaying average flight prices per month

Alternative airports near Santiago

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Arturo Merino Benitez SCL. Cheapest and Closest option available. Average driving time to city center is 17 minutes. Flights from $564
SCL
Arturo Merino Benitez
CheapestClosest
Average driving time to city center17 min
Flights from $564
Flights from Panama City (PTY) to Santiago (SCL)
Origin airport
Tocumen Intl.
Destination airport
Arturo Merino Benitez
Airlines serving
Aeromexico, American Airlines, Copa, avianca
Roundtrip price
$563
Distance
2987 mi
Average flight time
7 hours 36 mins

Panama City to Santiago Flights

The cheapest times to fly from Panama City to Santiago

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Panama City to Santiago are during the month of August. You can find some of the cheapest flights from Panama City to Santiago with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Panama City to Santiago

Sunday is one of the best days to book for cheap flights from Panama City to Santiago: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Panama City to Santiago

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Panama City to Santiago in 2025. You can also book with separate airlines for your outbound and return journeys, from $364 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Panama City to Santiago flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Panama City to Santiago airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Tocumen Intl. Airport (PTY) to Arturo Merino Benitez Airport (SCL) cost?
Cheap round-trip flights from Tocumen Intl. Airport (PTY) to Arturo Merino Benitez Airport (SCL) start at $706. This information is based on the cheapest price found on Expedia for this return journey departing within the next three months. This airfare is for a Copa flight leaving PTY on August 14 2025 and touching down at SCL. The price was last updated on July 23 2025 and has not changed since.
What is the cheapest month to fly from PTY to SCL?
The cheapest flights from PTY to SCL are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
Which airlines fly direct from Tocumen Intl. Airport (PTY) to Arturo Merino Benitez Airport (SCL)?
If you're departing from Tocumen Intl. Airport (PTY), you can board a direct flight to Arturo Merino Benitez Airport (SCL) with Copa Airlines.
What is the cheapest airline that flies from PTY to SCL?
Journey from PTY to SCL with Copa. This carrier currently offers the lowest one-way fare for this route, starting from $1005. This fare is based on the lowest price found on Expedia departing within the next three months. The flight takes off from PTY on August 23 2025. Prices were last updated on July 23 2025 and have not changed since.
How many flights per day from Tocumen Intl. Airport (PTY) to Arturo Merino Benitez Airport (SCL)?
When taking off from Tocumen Intl. Airport (PTY), you can pick from an average of 5 daily nonstop flights to Arturo Merino Benitez Airport (SCL).
What are the most popular departure times for flights from Tocumen Intl. Airport (PTY) to Arturo Merino Benitez Airport (SCL)?
Flights between PTY and SCL are their busiest at 3 PM. For a quieter experience and possibly cheaper tickets, choose a departure that's outside typical rush times.
What day of the week has the most flights from PTY to SCL?
Friday offers the most flights from Tocumen Intl. Airport (PTY) to Arturo Merino Benitez Airport (SCL). Consider jetting off on this day and you'll have a greater chance of finding a departure that fits your plans.
What is the earliest flight from Tocumen Intl. Airport (PTY) to Arturo Merino Benitez Airport (SCL)?
Catch the earliest flight at around 11:47AM UTC-5, leaving from Tocumen Intl. Airport (PTY). You'll be flying for around 6h 32m, landing at Arturo Merino Benitez Airport (SCL) at approximately 8:19PM UTC-3.
How long does it take to fly from Tocumen Intl. Airport (PTY) to Arturo Merino Benitez Airport (SCL)?
The average flight time from PTY to SCL is 6 hours and 35 minutes, covering a total distance of 3,000 mi.
What airline has the least delays from PTY to SCL?
Consider traveling with American Airlines if you'd like to go straight from Tocumen Intl. Airport (PTY) to Arturo Merino Benitez Airport (SCL) without any delays. This airline has the best track record for punctuality, with an on-time score of 100%. Want real-time updates? You can check your flight status using the Expedia App.
What is the best time to fly from Tocumen Intl. Airport (PTY) to Arturo Merino Benitez Airport (SCL)?
Opt for a flight from Tocumen Intl. Airport (PTY) to Arturo Merino Benitez Airport (SCL) that leaves before 3 PM to reduce the likelihood of delays and cancellations. Departures after this hour have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
What airports do you fly into for Santiago from Tocumen Intl. Airport (PTY)?
Arturo Merino Benitez Airport (SCL) is the only airport in Santiago with direct flights from Tocumen Intl. Airport (PTY). Consider the options and discover cheap fares on Expedia.
Is it cheaper to buy a plane ticket from Tocumen Intl. Airport (PTY) to Arturo Merino Benitez Airport (SCL) last-minute?
Last-minute fares from PTY to SCL are generally more expensive. To secure the lowest rates, start looking for flights as early as possible. That said, if you can play around with your travel dates, you may land a cheap fare right before your trip.
Is it cheaper to book a PTY to SCL flight and hotel package?
Compared with arranging flights and hotels separately, booking a PTY to SCL flight and hotel package with Expedia could lead to significant savings. Better yet, having it all in one place takes the hassle out of travel planning. Simply secure your flights and select from our wide range of stays, then customize your trip with other add-ons like tours, car rentals and activities.
Can I cancel or change the date of my flight from Tocumen Intl. Airport (PTY) to Arturo Merino Benitez Airport (SCL)?
Typically, you're able to cancel or reschedule your PTY to SCL flight. However, there may be additional fees, especially if your booking was made over 24 hours ago. Double-check your itinerary for the airline's fees and guidelines on flight changes, or if you need further details, visit our Customer Service portal.

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