$681 Cheap Flights from Santa Fe (SAF) to Key West (EYW)

View $681 flight on Tue, Nov 18, 2025Opens in a new window

Popular airlines from Santa Fe Municipal Airport (SAF) to Key West Intl. Airport (EYW)

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Cheap Flights from Santa Fe to Key West (SAF-EYW)

Prices were available within the past 7 days and start at $681 for one-way flights and $434 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Mon, Nov 17 - Wed, Nov 26
SAF
Santa Fe
EYW
Key West
$434 Roundtrip, found 6 days ago
$434
Roundtrip
found 6 days ago
Select American Airlines flight, departing Mon, Nov 17 from Santa Fe to Key West, returning Wed, Nov 26, priced at $434 found 6 days ago
American Airlines
Mon, Nov 10 - Wed, Nov 26
SAF
Santa Fe
EYW
Key West
$444 Roundtrip, found 1 day ago
$444
Roundtrip
found 1 day ago
Select American Airlines flight, departing Mon, Nov 10 from Santa Fe to Key West, returning Wed, Nov 26, priced at $444 found 1 day ago
American Airlines
Mon, Nov 3 - Tue, Nov 18
SAF
Santa Fe
EYW
Key West
$449 Roundtrip, found 1 day ago
$449
Roundtrip
found 1 day ago
Select American Airlines flight, departing Mon, Nov 3 from Santa Fe to Key West, returning Tue, Nov 18, priced at $449 found 1 day ago
American Airlines
Tue, Oct 21 - Mon, Nov 3
SAF
Santa Fe
EYW
Key West
$459 Roundtrip, found 1 day ago
$459
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Oct 21 from Santa Fe to Key West, returning Mon, Nov 3, priced at $459 found 1 day ago
American Airlines
Tue, Oct 21 - Fri, Oct 31
SAF
Santa Fe
EYW
Key West
$469 Roundtrip, found 1 day ago
$469
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Oct 21 from Santa Fe to Key West, returning Fri, Oct 31, priced at $469 found 1 day ago
American Airlines
Mon, Oct 20 - Fri, Oct 31
SAF
Santa Fe
EYW
Key West
$474 Roundtrip, found 1 day ago
$474
Roundtrip
found 1 day ago
Select American Airlines flight, departing Mon, Oct 20 from Santa Fe to Key West, returning Fri, Oct 31, priced at $474 found 1 day ago
American Airlines
Wed, Oct 22 - Mon, Nov 3
SAF
Santa Fe
EYW
Key West
$499 Roundtrip, found 1 day ago
$499
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Oct 22 from Santa Fe to Key West, returning Mon, Nov 3, priced at $499 found 1 day ago
American Airlines
Wed, Oct 22 - Fri, Oct 31
SAF
Santa Fe
EYW
Key West
$509 Roundtrip, found 1 day ago
$509
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Oct 22 from Santa Fe to Key West, returning Fri, Oct 31, priced at $509 found 1 day ago
American Airlines
Tue, Nov 18 - Thu, Nov 27
SAF
Santa Fe
EYW
Key West
$512 Roundtrip, found 6 days ago
$512
Roundtrip
found 6 days ago
Select American Airlines flight, departing Tue, Nov 18 from Santa Fe to Key West, returning Thu, Nov 27, priced at $512 found 6 days ago
American Airlines
Mon, Nov 3 - Thu, Nov 20
SAF
Santa Fe
EYW
Key West
$514 Roundtrip, found 1 day ago
$514
Roundtrip
found 1 day ago
Select American Airlines flight, departing Mon, Nov 3 from Santa Fe to Key West, returning Thu, Nov 20, priced at $514 found 1 day ago
American Airlines
Tue, Nov 18 - Thu, Nov 27
SAF
Santa Fe
EYW
Key West
$518 Roundtrip, found 6 days ago
$518
Roundtrip
found 6 days ago
Select American Airlines flight, departing Tue, Nov 18 from Santa Fe to Key West, returning Thu, Nov 27, priced at $518 found 6 days ago
United
Sun, Nov 16 - Wed, Nov 26
SAF
Santa Fe
EYW
Key West
$639 Roundtrip, found 6 days ago
$639
Roundtrip
found 6 days ago
Select United flight, departing Sun, Nov 16 from Santa Fe to Key West, returning Wed, Nov 26, priced at $639 found 6 days ago

Alternative airports near Key West

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Key West Intl. EYW. Cheapest and Closest option available. Average driving time to city center is 8 minutes. Flights from $584
EYW
Key West Intl.
CheapestClosest
Average driving time to city center8 min
Flights from $584

Frequently asked questions

How much does a flight from Santa Fe Municipal Airport (SAF) to Key West Intl. Airport (EYW) cost?
Secure a cheap one-way flight from $681 or cheap return flight from $434 from Santa Fe Municipal Airport (SAF) to Key West Intl. Airport (EYW) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight offers on this route.
What is the cheapest month to fly from Santa Fe Municipal Airport (SAF) to Key West Intl. Airport (EYW)?
The cheapest month to fly from SAF to EYW is November, when there's less demand. Off-peak season is typically when airlines offer better prices between these airports.
What is the cheapest airline that flies from Santa Fe Municipal Airport (SAF) to Key West Intl. Airport (EYW)?
Expedia's filter tool lets you easily compare airlines, flight times and fares all in one place. Select your preferences, then sort by "Price (lowest to highest)" to find the carrier with the cheapest SAF to EYW flight.
How many flights per day from Santa Fe Municipal Airport (SAF) to Key West Intl. Airport (EYW)?
Direct flights from Santa Fe Municipal Airport (SAF) to Key West Intl. Airport (EYW) aren't available daily, so you'll need to take a flight with a layover. Explore your options with Expedia's filter tool. Enter your travel dates and click on either "1 Stop" or "2+ Stops."
What day of the week has the most flights from SAF to EYW?
You'll usually find Tuesday the quietest day for flights, while Fridays tend to be the busiest.* However this can change from season to season and during public holidays or peak travel times.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Santa Fe Municipal Airport (SAF) to Key West Intl. Airport (EYW)?
To avoid possible delays on the Santa Fe Municipal Airport (SAF) to Key West Intl. Airport (EYW) route, travel before 3 PM. Departures after this hour have a 22% higher chance of cancellation.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Santa Fe Municipal Airport (SAF) to Key West Intl. Airport (EYW) last-minute?
Waiting until just before your trip to book a flight from SAF to EYW generally means paying more. While you might find some last-minute offers, there's no guarantee. Keep your travel schedule open for the best chance of scoring a bargain.
Is it cheaper to book a SAF to EYW flight and hotel package?
Compared with arranging flights and hotels separately, booking a SAF to EYW flight and hotel package with Expedia could result in significant savings. Better yet, having everything in one easy place will take the hassle out of travel planning. Simply pick your flights and choose from our wide range of hotels, then tailor your trip with other add-ons like tours, activities and car rentals.
Can I cancel or change the date of my flight from Santa Fe Municipal Airport (SAF) to Key West Intl. Airport (EYW)?
It's usually possible to cancel or reschedule your SAF to EYW flight. However, if the booking was made more than 24 hours ago, additional charges may apply. Check your airline's policies in your itinerary to see what changes are possible and if any costs are involved. You'll also find further details on our Customer Service portal.

Travel information

Travel information

Origin airport
Santa Fe Municipal
Destination airport
Key West Intl.
Roundtrip price
$434
Distance
1636 mi

Book with confidence

Book with confidence

Santa Fe to Key West Flights

The cheapest times to fly from Santa Fe to Key West

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Santa Fe to Key West are during the month of November. You can find some of the cheapest flights from Santa Fe to Key West with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Santa Fe to Key West

Sunday is one of the best days to book for cheap flights from Santa Fe to Key West: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Santa Fe to Key West

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Santa Fe to Key West in 2025. You can also book with separate airlines for your outbound and return journeys, from $681 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Santa Fe to Key West flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Santa Fe to Key West airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Santa Fe to Key West Flights

Explore a world of travel with Expedia

Explore a world of travel with Expedia

*Available to One Key members.